일개 철강 사업장에서 대사증후군의 위험요인과 γ-GTP와의 관련성

문제혁,이상준,박정덕 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 대사증후군은 심혈관계 질환의 이환과 이로 인한 사망률을 증가시키는 것으로 알려져 있으며, 비만, 고 중성지방혈증, 저 HDL-콜레스테롤혈증, 고혈압, 공복 시 고혈당 등에서 3개 항목 이상을 만족한 경우로 정의된다. 간기능 검사 중 γ-GTP는 간세포 손상에 대한 생체지표로 흔히 사용되는 검사이며, 고혈압, 제 2형 당뇨 및 뇌졸중과도 관련이 있음이 밝혀져 있다. 이번 연구에서는 일개 철강 사업장내 근로자들의 대사증후군의 유병률과 위험요인 및 대사증후군과 γ-GTP와의 관련성을 알아보았다. 방법: 수도권 소재 일개 철강 사업장 남자 근로자 1,604명을 대상으로 대사증후군의 구성요소(체질량지수, 중성지방, HDL-콜레스테롤, 수축기와 이완기 혈압, 공 복 시 혈당)와 γ-GTP, 교대근무 여부, 음주력, 흡연력, 운동 여부 및 가족병력 등을 조사하여 분석하였다. 결과: 일개 철강사업장근로자에 있어서 대사증후군의 유병률은 21.3%, 연령 보정 유병률은 15.5%이었다. 대사증후군에 영향을 미치는 역학적 요인은 연령(OR: 1.063, 95% CI: 1.033-1.094), 음주(OR: 1.657, 95% CI: 1.175. 2.337) 및 흡연(OR: 1.359, 95% CI: 1.017. 1.816) 등 이었고, 교대근무는 고혈압(OR: 1.329, 95% CI: 1.038-1.700)에만 영향을 주었다. 고 γ-GTP 혈증군에서 대사증후군의 구성인자인 비만, 고 중성지방혈증, 고혈압 및 공복시 고혈당의 위험도는 각각 2.625, 3.384, 1.887, 2.406이었고, 대사증후군의 위험도는 3.345이었다. 결론: 이번 연구결과로 볼 때, 철강 사업장에서 대사증후군에 대한 적극적인 관리를 위하여 금주와 금연 등 생활행태 개선을 위한 보건교육이 요구되었고, γ-GTP가 대사증후군의 조기 색출지표로서의 가능성이 제기되었다. Objectives: This study was performed to estimate the prevalence and possible risk factors of the metabolic syndrome in steel-mill workers, and to evaluate the relation between γ-glutamyltransferase (γ-GTP) and the metabolic syndrome. Methods: The study subjects comprised 1,604 male steel-mill workers. The indices of metabolic syndrome, such as BMI, triglyceride, HDL-cholesterol, blood pressure, fasting glucose, and γ-GTP were analyzed in each subject. We collected information about demographic characteristics, behavioral patterns, such as alcohol drinking, smoking, and exercise, and family medical history through a self-administered questionnaire. Statistical analysis was done by using the chi-square test, Mantel-Haenszel trend test and logistic regression model. Results: The crude and age-adjusted prevalences of the metabolic syndrome were 21.3% and 15.5%, respectively, in the steel-mill workers. Age (OR: 1.063, 95% CI: 1.033-1.094), alcohol drinking (OR: 1.657, 95% CI: 1.175-2.337) and smoking (OR: 1.359, 95% CI: 1.017-1.816) were risk factors for the metabolic syndrome. Meanwhile, shift work showed a significant relation with hypertension (OR: 1.329, 95% CI: 1.038-1.700), but not with other metabolic syndrome components. However, tenure, exercise and family medical history were not significant factors for the metabolic syndrome in this study. The risk ratio of the metabolic syndrome (OR: 3.345, 95 % CI: 2.534-4.416) and its components, such as obesity, hypertriglyceridemia, hypertension and hyperglycemia, were higher in the high γ-GTP group (≥63 IU/Ɩ ) than in the controls (<63 IU/Ɩ ). Conclusions: These results confirm the need for health education to control the metabolic syndrome by improving behavioral patterns, such as alcohol drinking and smoking, in factory workers. In addition, it is suggested that γ-GTP might be a useful candidate in screening for the metabolic syndrome.

다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

결정형 규산분진에 폭로된 섬유모세포의 자가증식 : Evaluation by H₂O₂and PDGF-AA 와 TGFβ

안병용,김경아,문제혁,정진숙,김은경,임영 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : The aim of this study is to find out the activity of autoproliferation of rat fibroblast exposed to crystalline silica and the role of mediators secreted from rat fibroblast. Methods : The effect of α-quartz on production of growth factor (platelet-derived growth factor-AA and transforming growth factorβ) from rat fibroblasts were evaluated by ELISA and immunocytochemical analysis. Gene expression of these growth factors in rat fibrobast exposed to crystalline silica was evaluated by RT-PCR. Furthermore, fibroblast proliferation by culture supernatant of rat fibroblast was assayed by the neutral red test. Results : The amounts of H2O2 and growth factors synthesized in rat fibroblasts were significantly increased by the stimulation of crystalline silica (α-quartz) , which showed the dose-dependent manner to the concentration of α-quartz with the maximum response at the dosage of 100 ㎍/㎠. The result of RT-PCR demonstrated that α-quartz induced gene expression of PDGF-AA and TGFβ in rat fibroblast. We also found that supernatant of α-quartz-cocultured rat fibroblast induced a significant proliferation of fibroblast. Conclusion : Crystalline silica directly induce functional change In fibroblast such as increased release of reactive oxygen species and growth factors. The products of these functional change promote fibroblast proliferation via autocrine loop.

Quartz 자극에 의한 iNOS 발현의 자가조절

김경아,남혜윤,문제혁,정진숙,임영,정치경 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : Rat2 섬유모세포에서 α-quartz에 의해 유도된 NOS의 조절기전을 알아보기 위하여 본 연구가시도 되었다. 방법 : Rat2 세포에 있어서 α-quartz 자극에 의한 NO와 H₂O₂의 분비 및 iNOS의 발현을 관찰하였고, iNOS 억제제인 L-NIL과 H₂O₂ 억제제인Catalase를 전처리하고 마찬가지로 NO와 H₂O₂분비 그리고 iNOS의 단백발현 정도를 western blot-ting을 이용하여 관찰하였다. 결과 : o-quartz는 Rat2 세포에서 iNOS에 의한NO와 H₂O₂의 분비를 유도하였다. L-NIL은 R3t2세포에서 D-quartz에 의한 H₂O₂의 분비와 iNOS발현을 완전히 억제하였다. Catalase로 전처리 하였을 때 o-quartz로 유도된 iNOS에 의하여 생산증가된 H2Oa가 iNOS를 억제하는 autoinhibitorypathway가 차단되어 결과적으로 H₂O₂의 분비와 iNOS의 발현이 증가하였다. 결론 : Rat2 세포에서 α-quartz에 의하여 유도된iNOS는 H₂O₂의 분비를 촉진하고 이 H₂O₂는 iNOS기능을 조절하는 자가조절기전에 중요한 역할을 하는 것으로 생각된다. Objectives : This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase (NOS) induced by α-quartz in Rat2 fibroblast. Methods : α-quartz-induced nitric Oxide (NO) anti H₂O₂ formation anti α-quarts-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor (L-N6- (1-iminoethyl) lysine hydrochloride, L-NIL) or antioxidant (catalase), we observed NO and H₂O₂ formation and iNOS protein expression in Rat2 fibroblast stimulated with α-quartz. Results : α-quartz stimulated iNOS-induced NO and H₂O₂ formation in Rat2 fibroblast. L-NIL inhibited H₂O₂ formation and iNOS protein expression by α-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOS-induced H₂O₂ therefore H₂O₂ and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with α-quartz Conclusion : α-quartz-induced iNOS Stimulated H₂O₂ formation in Rat2 fibroblast. INOS-induced H₂O₂ by α-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast

Effect of exercise program using mirrors for stroke patients

Je-Hyeok Lee,Hyun-Joo Kim 한국콘텐츠학회 2013 International Journal of Contents Vol.9 No.1

This study was performed for two of specific reasons, one is for exercise development for improving stroke patients muscle power, balance and gait and, after verifying the effect of the exercise, the other is for showing that the appling this exercise was more effective on hemi-plegic stroke patients into the clinical trial. The subjects of this study were hemi-plegic patients by stroke, 51 patients were picked up, who were agreed with this research. Close kinetic chain leg exercise using mirrors was applied to study groupⅠ, Close kinetic chain leg exercise without mirrors was applied to study groupⅡ and general physical therapy was applied to comparison group. The results of this study are as follows. The difference of the groups, study groupⅠ showed more effective than study groupⅡ on checking rectus femoris, vastus lateralis, biceps femoris, Korean version of Berg Balance Scale, Center of pressure, Functional gait assessment. In this study, Close kinetic chain leg exercise showed more effective and significant on improving for muscle power, balance and gait on stroke patients. Especially, doing exercise using mirrors is considered as more effective method than without mirrors.

Effects of Intensive Neuro Rehabilitation Intervention on the Motor Function Recovery and Balance in Stroke Patients

( Je-hyeok Lee ),( Jong-duk Choi ) 대한물리의학회 2016 대한물리의학회지 Vol.11 No.4

PURPOSE: The purpose of this study was to investigate the effects of differences in exercise time arrangement on the functional recovery of the lower limbs and balance of stroke patients. METHODS: The subjects of this study were 100 patients who were hospitalized in two hospitals located in Gyeonggi-do. Before the experiment, 60 of these patients who met the inclusion criteria and did not meet the exclusion criteria were randomly divided into an experimental group (n = 30), whose exercise time was concentrated, and a control group (n = 30), whose exercise time was diffuse. The two groups underwent six weeks of physical and occupational therapy four times a day for five days a week. One session of therapy took 30 minutes, including three sets of physical therapy and one set of occupational therapy. The rest time between the sessions was different for each group. The experimental group had five minutes of rest between each therapy session, and the control group had two hours of rest time between each session. The Fugl-Meyer assessment (FMA), an assessment of each patient`s limit of stability (LOS), and a timed up and go test (TUG) were used as test tools. RESULTS: Both groups showed statistically significant increases in their FMA results, LOS measurements, and TUG results. The FMA results of the experimental group were significantly higher than those of the control group. CONCLUSION: Thus, concentrated exercise time was more effective than diffuse exercise time for the recovery of motor function.

Effect of intense pulsed light (IPL) on sterilization of Bacillus cereus and spores in fresh-cut vegetables

Je-Hyeok Jeon,최찬익 한국식품과학회 2023 한국식품과학회지 Vol.55 No.4

Due to various factors, the use of fresh vegetables is increasing; however, several studies associate this food group with most food poisoning. In addition, as the vegetables are consumed raw, sterilization methods other than heating are essential. Therefore, the objective of this study is to evaluate the effect of intense pulsed light (IPL) on the sterilization of a major food-borne pathogen Bacillus cereus and its spores, in fresh-cut vegetables such as carrots, cabbage, and onions. The color changes after the treatment were also observed. The results showed that the inactivation of Bacillus cereus and spores increased with the increase in the voltage and duration of the IPL treatment. The inactivation of spores was lower than that of the vegetative cells, and it became less efficient as the spore concentration increased. The color was retained without significant changes. These results indicate that IPL treatment can effectively inactivate the pathogens in fresh-cut vegetables without altering their color.

Radiation impacts on morphological and qualitative properties in common buckwheat (Fagopyrum esculentum) and tatary buckwheat (Fagopyrum tataricum) seeds

Je-Hyeok Yu,Min-Heon Yun,Seon-Mo Yang,Dong-Seop Kim,Young-Ho Yun,Kyung-Ho Ma,Eun-Ho Son,Sok-Young Lee,Hong-Sig Kim,Sun-Hee Woo 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Breeding and cultivation techniques are being treated very severely regarding ecological and physiological development in buckwheat. This study was conducted to focus on the diversity occurring in the cultivated and tartary buckwheat and provide an overview of the characteristics and genetic resources activities. Morphological results showed that the height of common buckwheat ranges from 82-90cm, common buckwheat induced by 200Gy ranges from 52-75cm, common buckwheat induced by 300Gy ranges from 43-56cm, common buckwheat induced by 400Gy ranges from 33-60cm whereas the tartary buckwheat hight ranges from 65-87cm, and while it exposed to various radiation (200Gy, 300Gy and 400Gy), the obtained height ranges from 73-92cm, 55-80cm and 60-75cm respectively. However, the stems from the both cultivar are hollow and that’s why, the plant is very prone to lodging. The leaf color of common buckwheat was green, 200Gray, 300Gy 400Gy common buckwheat light green and green, whereas the tartary buckwheat green and bottle-green, 200Gray 300Gy 400Gy tatary buckwheat bottle-green, common buckwheat (control, 200Gy, 300Gy, 400Gy) stem color is light green and pink, flower color is white, tartary buckwheat (control, 200Gy, 300Gy, 400Gy) flower color is light green. The stem color from tartary buckwheat showed (200Gy, 300Gy, 400Gy) light green and light red color. The results revealed that the two buckwheat cultivars showed diversified characteristics.

환경제어 변수를 적용한 게임지형 자동생성 기법

연제혁 ( Je Hyeok Yeon ),최유표 ( You Pyo Choi ),유길상 ( Kil Sang Yoo ),이원형 ( Won Hyung Lee ) 한국컴퓨터게임학회 2004 한국컴퓨터게임학회논문지 Vol.4 No.-

Effect of increased <i>p</i> CO ₂ in seawater on survival rate of different developmental stages of the harpacticoid copepod <i>Tigriopus japonicus</i>

Oh, Je Hyeok,Kim, Dongsung,Kim, Tae Won,Kang, Teawook,Yu, Ok Hwan,Lee, Wonchoel ZOOLOGICAL SOCIETY OF KOREA 2017 ANIMAL CELLS AND SYSTEMS Vol.21 No.3

<P><B>ABSTRACT</B></P><P>The rapid increase in carbon dioxide levels in seawater is causing ocean acidification and is expected to have significant effects on marine life. To explore the ability of the harpacticoid copepod <I>Tigriopus japonicus</I> to adapt to an increased concentration of dissolved carbon dioxide (CO<SUB>2</SUB>) in seawater, we compared the survival rates of adult and nauplius stages at 400, 1000, and 1550 ppm <I>p</I>CO<SUB>2</SUB> over a 14-day period. The survival rate of <I>T. japonicus</I> dramatically decreased over time with increase in <I>p</I>CO<SUB>2</SUB> concentration. At 1550 ppm, the survival rate showed a decrease of more than 20% at the end of the experimental period over that at 400 ppm. Furthermore, the survival rate decreased by a greater amount at all concentrations in nauplii than in adults, with a greater effect in wild-collected specimens than in culture-derived individuals. The results suggest that future ocean acidification may negatively influence the sustainability of <I>T. japonicus</I> and thus may eventually influence benthic ecosystems.</P>