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Jayalakshmi Krishnan,최상돈 한국유전체학회 2012 Genomics & informatics Vol.10 No.3
A variety of ligands differ in their capacity to bind the receptor, elicit gene expression, and modulate physiological responses. Such receptors include Toll-like receptors (TLRs), which recognize various patterns of pathogens and lead to primary innate immune activation against invaders, and G-protein coupled receptors (GPCRs), whose interaction with their cognate ligands activates heterotrimeric G proteins and regulates specific downstream effectors, including immuno-stimulating molecules. Once TLRs are activated, they lead to the expression of hundreds of genes together and bridge the arm of innate and adaptive immune responses. We characterized the gene expression profile of Toll-like receptor 4 (TLR4) in RAW 264.7 cells when it bound with its ligand, 2-keto-3-deoxyoctonate (KDO), the active part of lipopolysaccharide. In addition, to determine the network communications among the TLR, Janus kinase (JAK)/signal transducer and activator of transcription (STAT), and GPCR, we tested RAW 264.7 cells with KDO, interferon-β, or cAMP analog 8-Br. The ligands were also administered as a pair of double and triple combinations.
Thermal Stability and Mechanical Properties of Hydrogenated Zr-Ni-Nb-Co Amorphous Alloy
Jayalakshmi, S.,Fleury, Eric,Kim, Yu Chan,Kim, Ki Bae Trans Tech Publications, Ltd. 2005 Materials science forum Vol.486 No.-
<P>Zr50Ni27Nb18Co5 amorphous ribbons were hydrogenated using an electrochemical method. Under a current density of 30 mA/cm2, the thermal stability of the amorphous phase was found to increase with the charging time. Hardness and fracture strength were found to be independent of charging time, indicating that the Zr-Ni-Nb-Co amorphous alloys preserved its mechanical integrity.</P>
Studies on hydrogen embrittlement in Zr- and Ni-based amorphous alloys
Jayalakshmi, S.,Park, S.O.,Kim, K.B.,Fleury, E.,Kim, D.H. Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>Mechanical and structural properties of Zr<SUB>50</SUB>Ni<SUB>27</SUB>Ni<SUB>18</SUB>Co<SUB>5</SUB> (at.%) and Ni<SUB>59</SUB>Zr<SUB>16</SUB>Ti<SUB>13</SUB>Nb<SUB>7</SUB>Sn<SUB>3</SUB>Si<SUB>2</SUB> (at.%) amorphous alloys were studied before and after hydrogenation. In both alloys, upon hydrogenation, a significant reduction in mechanical properties was evident. The occurrence of hydrogen embrittlement was supported by fracture morphology and is further explained based on the corresponding structural changes induced by hydrogenation.</P>
Toll-like receptor signal transduction
Jayalakshmi Krishnan,최상돈,이광,Masa Tsuchiya,Kumar Selvarajoo 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.4
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing exogenous pathogens. Activation of TLRs is a first line of defense of the immune system, leading to the activation and recruitment of neutrophils and macrophages to sites of infection and enhances antimicrobial activity. The TLR signaling through different intracellular molecules, such as MAP kinases and IκB kinases which are conserved signaling elements for many receptors, leads to a distinct set of proinflammatory gene expressions. However, how these pathways differentially and precisely control the transcription of identical genes remains largely unknown. Our review focuses on the details of up-todate signaling molecules including negative regulators and their role in controlling innate immune response. We also stress the importance of developing systemic approaches for the global understanding of TLR signaling so that appropriate drug therapeutic targets can be identified for regulating inflammatory diseases.
ON CLASSES OF RATIONAL RESOLVING SETS OF POWER OF A PATH
JAYALAKSHMI, M.,PADMA, M.M. The Korean Society for Computational and Applied M 2021 Journal of applied mathematics & informatics Vol.39 No.5
The purpose of this paper is to optimize the number of source places required for the unique representation of the destination using the tools of graph theory. A subset S of vertices of a graph G is called a rational resolving set of G if for each pair u, v ∈ V - S, there is a vertex s ∈ S such that d(u/s) ≠ d(v/s), where d(x/s) denotes the mean of the distances from the vertex s to all those y ∈ N[x]. A rational resolving set is called minimal rational resolving set if no proper subset of it is a rational resolving set. In this paper we study varieties of minimal rational resolving sets defined on the basis of its complements and compute the minimum and maximum cardinality of such sets, respectively called as lower and upper rational metric dimensions for power of a path P<sub>n</sub> analysing various possibilities.
Suppression of gold nanoparticle agglomeration and its separation via nylon membranes
Jayalakshmi, Ayyavoo,Kim, In-Chul,Kwon, Young-Nam Elsevier 2017 Chinese journal of chemical engineering Vol.25 No.7
<P>Use of ultraporous nylon membrane is one of the most widely employed techniques for removal of hard and soft nanoparticles in the semiconductor industry, and the accurate determination of membrane pore size is necessary in order to avoid manufacturing defects caused by contamination. The gold nanoparticle has several benefits for the evaluation of polymeric membranes; however, the nanoparticles agglomerate easily on the nylon membrane and make it difficult to evaluate the membrane precisely. The properties of 2-amino-2-hydroxymethyl-1,3-propanediol (ADP) ligand in gold nanoparticle solution were systematically investigated, and ADP was utilized for improved evaluation of the nylon membranes. Nylon membrane used in this study was prepared by phase inversion techniques. Ultrathin dense layer on top of themembrane surface and Darcy structures in the microporous membrane support were observed. The gold particle rejection was carried out at various pH values from 4 to 14 and higher rejection was observed at pH 4 and 8. The suppression of gold colloid agglomeration using ADP and monodispersity of gold colloids was also analyzed by confocal laser scanning microscopy (CLSM), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). van der Waals interaction energy of the particles was reduced in the addition of ADP. The presence of ADP ligand in the gold solutions prevented the agglomeration of gold nanoparticles and reduced the adsorption of the particles on the nylon membrane surface, leading to precise evaluation of membrane pore sizes. (C) 2017 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.</P>