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Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation
Won, M,Park, K A,Byun, H S,Sohn, K-C,Kim, Y-R,Jeon, J,Hong, J H,Park, J,Seok, J H,Kim, J M,Yoon, W-H,Jang, I-S,Shen, H M,Liu, Z G,Hur, G M Macmillan Publishers Limited 2010 CELL DEATH AND DIFFERENTIATION Vol.17 No.12
The zinc-finger protein A20 has crucial physiological functions as a dual inhibitor of nuclear factor-κB (NF-κB) activation and apoptosis in tumor necrosis factor (TNF) receptor 1 signaling pathway. Although the molecular basis for the anti-NF-κB function of A20 has been well elucidated, the anti-apoptotic function of A20 is largely unknown. Here, we report a novel mechanism underlying the anti-apoptotic function of A20: A20 blocks TNF-induced apoptosis through suppression of c-jun N-terminal kinase (JNK) by targeting apoptosis signal-regulating kinase1 (ASK1). First, the ectopic expression of A20 drastically inhibits TNF-induced JNK activation and apoptosis in multiple cell types including those deficient of NF-κB activation. Unexpectedly, the blunting effect of A20 on TNF-induced JNK activation is not mediated by affecting the TNFR1 signaling complex formation. Instead, A20 interacts with ASK1, an important MAPKK kinase in the JNK signaling cascade. More importantly, overexpression of wild-type A20, but not of mutant A20 (ZnF4; C624A, C627A), promotes degradation of the ASK1 through the ubiquitin-proteasome system. Taken together, the results from this study reveal a novel anti-apoptotic mechanism of A20 in TNF signaling pathway: A20 binds to ASK1 and mediates ASK1 degradation, leading to suppression of JNK activation and eventually blockage of apoptosis.
Byun, Seok Yong,Byun, Seok-Joo,Lee, Jang Kyo,Kim, Jae Wan,Lee, Taek Sung,Sheen, Dongwoo,Cho, Kyuman,Tark, Sung Ju,Kim, Donghwan,Kim, Won Mok American Scientific Publishers 2012 Journal of nanoscience and nanotechnology Vol.12 No.4
<P>Optimizing the design of the surface texture is an essential aspect of Si solar cell technology as it can maximize the light trapping efficiency of the cells. The proper simulation tools can provide efficient means of designing and analyzing the effects of the texture patterns on light confinement in an active medium. In this work, a newly devised algorithm termed Slab-Outline, based on a ray tracing technique, is reported. The details of the intersection searching logic adopted in Slab-Outline algorithm are also discussed. The efficiency of the logic was tested by comparing the computing time between the current algorithm and the Constructive Solid Geometry algorithm, and its superiority in computing speed was proved. The validity of the new algorithm was verified by comparing the simulated reflectance spectra with the measured spectra from a textured Si surface.</P>
Supratentorial Leptomeningeal Hemangioblstoma : Case Report
Jang, Han Won,Byun, Woo Mok,Lee, Jae Kyo,Cho, Jae Ho,Cho, Kil ho,Hwang, Mi Soo,Park, Bok Hwan,Choi, Joon Hyuk 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2S
혈관아세포종은 소뇌에 가장 흔하게 발생하며 von Hippel-Lindau disease와 연관될 수 있다. 저자들은 천막상부 연수막에서 기원한 혈관아세포종의 자기공명영상과 병리학적 소견에 대해서 기술하고자 한다. Hemangioblastoma is a benign tumor that most commonly occurs in the cerebellum and associated with von Hippel-Lindau (VHL) disease. Supratentorial hemanigoblastomas are exceptionally rare. We describe the magnetic resonance imaging (MRI) and histopathologic findings of a supratentorial leptomeningeal hemangioblastoma.
Bilateral Medial Medullary Infarction Demonstrated by Diffusion-Weighted Imaging : Case Report
Jang, Han-Won,Byun, Woo-Mok 영남대학교 의과대학 2009 Yeungnam University Journal of Medicine Vol.26 No.1
사지의 운동 감소, 구음 장애, 어지럼증, 감각 이상을 보인 78세 여성에서 자기공명영상 촬영 결과 양측 척추 혈관의 협착 혹은 폐색을 보인 급성 양 내측 연수 경색을 문헌 고찰과 함께 보고한다. A 78-year-old woman presented with weakness of the extremities, dysarthria, dizziness, and sensory impairment. Magnetic resonance imaging showed acute bilateral medial medullary infarction. Contrast enhanced magnetic resonance angiography demonstrated stenosis or occlusion of both intracranial vertebral arteries. We present a rare case of bilateral medullary infarction seen on diffusion-weighted imaging.