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      • KCI등재SCOPUS
      • 난소성 장액성 낭선암에 특이한 단백의 분리에 관한 연구

        이상훈,장상근,고재경,김두상 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1

        In order to correlate changes in the nature of proteins in the serous cystadenocarcinoma tissue of the ovary with those in the cystic fluid and ascitic fluid of patients with the ovarian cancer, proteins in the ovarian tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma were isolated by a DEAE-cellulose column chromatography and HPLC. (1)Concentrations of protein in the ovarian cancer tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma were unchanged as compared with those of controls. (2)Proteins in the ovarian tissues were isolated by a DEAE-cellulose column chromatography into 7 peaks in both serous cystadenocarcinoma tissue and control ovarian tissue. The DEAE-peak Ⅲ protein was divided into two parts (peak ?? and ??) in the ovarian cancer, but not in the control, indicating that the DEAE-peak Ⅲ?? was specific to the ovarian cancer. The DEAE-peak Ⅴ common to both serous cystadenocarcinoma tissue and its control was further separated by a HPLC into 4 peaks each. Although the HPLC patterns for proteins of both tissues appeared to be different, presence of proteins specific to the ovarian cancer was not confirmed in the ovarian cancer tissue. (3)Proteins in the ovarian cystic fluid were isolated by a DEAE-cellulose column chromatography into 5 peaks for serous cystadenocarcinoma and 4 peaks for serous cyst as the control of which the peak Ⅳ protein was divided into two parts(peak ?? and ??) in the ovarian cancer, but not in the control. Two protein peaks (DEAE-peak ?? and ??) in the ovarian cancer, but not control. Two protein peaks (DEAE-peak ?? and Ⅷ) were observed to be specific to the ovarian cancer. (4)Proteins in the ascitic fluid were separated by a DEAE-cellulose column chromatography into 7 peaks for the ovarian cancer and 5 peaks for the serous cyst, of which the peak Ⅳ protein was also divided into two parts as in the cystic fluid of the ovarian cancer, but not in the control. Three protein peaks (peak Ⅲ, ?? and Ⅷ) appeared to be specific to the ovarian cancer. These results indicated that concentrations of proteins were unchanged, but the nature of proteins were changed in the cancer tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma and that proteins specific to the ovarian cancer were present in at least one for the ovarian cancer tissue, two for the cystic fluid and three for the ascitic fluid. The proteins specific to serous cystadenocarcinoma in the cystic and ascitic fluid appeared to be released from the ovarian cancer tissue and could be used as biochemical markers for the cancer.

      • SCOPUSKCI등재

        혈압점(血壓點)에 윤제(潤劑)의 주입이 고혈압에 미치는 영향

        위종성,한재섭,박희수,박재영,Owi, Jong-Sung,Han, Jai-Seop,Park, Hee-Soo,Park, Jai-Young 대한약침학회 2002 Journal of pharmacopuncture Vol.5 No.1

        Objective: This study was designed to evaluate the possibility of Hypertension by moistening Herbal-acupuncture at Blood Pressure Point(HN136). Methods: We reviewed 14 patients of Hypertension. They were hospitalized at oriental medical hospital of Sang-Ji university for 2002. 1. 2. - 2002. 5. 2. First, we divided into two groups; Group Ⅰ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and was not given any western medicine about Hypertension during the period of experiment. Group Ⅱ was administrated by moistening Herbal-acupuncture at Blood Pressure Point(HN136), and given western medicine about Hypertension during the period of experiment. we observed the change of systolic and diastolic for 2 weeks, and compared Group Ⅰ with Group Ⅱ . Results: The results obtained as follows: 1. The figure of systolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 2. The figure of diastolic in Group Ⅰ was decreased, but there was no signification. There was a significant decrease in Group Ⅱ (p<0.05) 3. Group Ⅱ was more effective than Group Ⅰ in the results. Conclusion: The results suggest that moistening Herbal-acupuncture at Blood Pressure Point(HN136) was effective treatment of Hypertension. So further research is needed continuously.

      • KCI등재후보
      • SCOPUSKCI등재
      • 철근 콘크리트 H.P 셀의 해석

        성재표,강호근,박성수 釜山大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.49 No.-

        본 연구는 철근 콘크리트 H.P. 쉘의 3차원 재료적 비선형 해석을 하기 위한 것이다. 콘크리트 요소는 3축 비선형 응력-변형률 거동, 균열, 파쇄 및 변형률 완화를 포함하는 3차원 16절점 고체 요소를 사용하고, 철근은 3절점 탄소성 트러스 요소를 사용한다. 거동 해석으로는 균열후 골재의 맞물림을 고려하는 유효 전단 계수를 도입하였으며, 수치 해를 얻기 위해 증분법을 사용하였다. 수치 예제로서 Lin의 철근 콘크리트 H.P. 쉘을 채택하여, 본 해석 결과와 비교하였다. This study presents the three-dimensional material nonlinear analysis of reinforced concrete H.P. shell. A concrete is idealized with three-dimensional 16-node solid element including triaxial nonlinear stress-strain behavior, cracking, crushing and strain softening; a steel with three-dimensional 3-node truss element including elastic-plastic behavior with strain hardening. The effective shear modules considering aggregate interlock after cracking and an incremental method is used to obtain a numerical solution. Numerical examples of Lin's reinforced concrete H.P. shell is selected to compare with the numerical results.

      • KCI등재
      • 광탄성 실험법에 의한 크랙을 가진 유한판의 정지구멍(Stop-Hole)의 최적크기에 관한 연구

        권오성,황재석,서경덕 영남대학교 공업기술연구소 1999 工業技術硏究所論文集 Vol.27 No.1

        Minimization of the stress concentration is very important in the life cycle extension of structures and machine parts, which have cracks or notches. Industrial field, stop-hole is drilled on the structures and machine parts to prevent the origination and propagation of cracks and to reduce the stress concentration. But, there is no a study on the optimal dimension of stop-hole for the various loading and geometrical conditions. Therefore, in this study, a study on the optimal dimension of stop-hole with various conditions is done by photoelastic experimental method.

      • KCI등재후보

        작업장 누적소음 노출과 혈압과의 관련성

        이상윤, 김재용*, 임형준, 윤기정, 최홍렬*, 고상백**, 강대희, 조수헌 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

        목적 : 작업장에서의 누적소음노출값과 혈압의 변화 사이의 관계를 관찰하기 위한 단면 연구를 시행하였다. 방법 : 소음발생 제조업체의 남성근로자 중 건강진단 자료, 설문지 자료, 인사기록이 모두 갖추어진 852명을 연구대상으로 하였다. 작업장 소음측정값은 34개 지점에서 측정된 작업환경 측정 보고서 값을 사용하였고, 혈압은 건강진단시 측정한 수축기 혈압과 이완기 혈압 각각의 평균을 이용하였다. 가능한 교란변수들을 건강진단시 설문조사를 통하여 조사하였다. 근로자의 근무기간과 근무했던 작업부서의 소음노출값을 이용하여 누적소음노출값을 추정하였고, 이에 따라 전체 연구대상 근로자를 저소음노출군, 중등도소음노출군, 고소음노출군, 과다소음노출군으로 구분하였다. 누적소음노출값으로 구분한 소음노출군 사이에 평균 수축기 혈압 및 이완기 혈압의 차이가 있는 지를 나이, 비만도지수, 혈중 콜레스테롤값, 고혈압의 가족력, 흡연력, 음주력 등의 가능한 교란변수들의 영향을 통제한 상태에서 비교하였다. 결과 : 가능한 교란변수들을 보정한 상태에서 저소음노출군에서 과다소음노출군으로 갈수록 수축기 혈압 및 이완기 혈압의 증가가 있는지를 관찰하기 위해 일반선형모델을 이용하여 분석하였을 때, 수축기 혈압 및 이완기 혈압 모두 소음노출군이 혈압 변화의 유의한 설명변수였고, 수축기 혈압 및 이완기 혈압 모두 저소음노출군에 비해 과다소음노출군이 각각 2.1 mmHg, 2.7 mmHg 만큼 높았다. 결론 : 이는 만성적으로 누적된 고소음에의 노출로 인하여 혈압 상승의 가능성이 있음을 시사한다. Objectives : The association of workplace cumulative noise exposure and blood pressure was investigated in this study using cross-sectional design. Methods : The study population comprised 852 manufacturing male workers of whom occupational health examination data, questionnaire and personnel records were available. Workplace ambient noise monitoring data was used for calculating individual cumulative noise exposure level. Mean of each systolic and diastolic blood pressure of occupational health examination data was used for individual systolic and diastolic blood pressure level. Possible confounding variables including family history of hypertension, smoking habit, alcohol drinking habit were collected by questionnaire. On the basis of job location and duration of work at the location, a cumulatlve time-weighted average noise level was calculated for each workers. According to this cumulative noise exposure level, each study subject was categorized as low noise exposure group, moderate noise exposure group, high noise exposure group, very high noise exposure group. Among noise exposure groups, mean of systolic and diastolic blood pressure was compared after adjusting possible confounding variables such as age, body mass index, serum cholesterol level, family history of hypertension, smoking history, alcohol drinking habit. Results : After adjusting possible confounding variables, noise exposure group was signnificant explanatory variables for both systolic and diastolic blood pressure, and mean of both systolic and diastolic blood pressure of very high exposure group was higher than that of low exposure group. Conclusions : These findings suggested that the high cumulative noise exposure might elevate the blood pressure.

      • 한약수치에 관한 연구(제 8보) : 오수유 탕포법 The Changes of Physico-chemical Parameter and Biological Activities by Processing of Evodia Fruit

        박성환,이우정,최혁재,송보완,김동현,김남재 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

        We have studied the physico-chemical change and pharmacological transformation of traditional herbal medicines with processing. Evodia fruit (EF) has processed for the purpose of detoxification and reduction of its bitter taste. There are various methods of processing EF in Oriental medicinal references. Among them, we processed EF according to the method of Sang-han theory, the most famous medicinal reference. We processed EF with washing in hot water, and then dried. Processed EFs(PEFs) were prepared according to the above procedure through repetition of 1,3,5 and 7 times respectively. The contents of weight loss, water extract, diluted ethanol extract, ether extract, total ash, acid insoluble ash, alkaloids and limonin in non-processed EF (NPEF) and PEFs were examined. The weight loss, and contents of water extract and dilute ethanol extract in PEF showed decrease in proportion to increase of washing time, while the contents of ether extract, total ash and acid insoluble ash showed little change as compared with those of NPEF. And the content of evodiamine and rutaecarpine was not changed distinctly. However, the content of limonin decreased in the final processed material in proportion to increase of washing times with hot water. And the intense of bitter taste in PEF was also reduced. These results were ascribed to the flowing-out of the water-soluble portion. The biological activities of NPEF and PEF were also investigated. In the test of DPPH scavenging effect, xanthine oxidase inhibition effect and TBA-Rs effect, PEF was more effective than NPEF in vitro. Also, both NPEF and PEF showed potent analgesic and anti-inflammatory effects against in mice. Especially, PEF by 3 times washing with hot water was more effective than other PEFs. From these results, it is considered that PEF should be prepared by 3 times washing with hot water.

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