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Park, Jaegyu,Kwack, Myung-Joon,Joo, Jiho,Kim, Gyungock IOP 2017 Journal of optics Vol.19 No.8
<P>We investigate the single-mode operation in a silicon arrayed multi-mode waveguide grating. By introducing a double-etched structure at the boundary of a star coupler with inverse-tapered waveguides (WGs), the suppression of the mode-coupling between adjacent arrayed multi-mode WGs, and the adiabatic optical mode conversion between a FPR (free propagation region) and arrayed WGs can be achieved with a reduced phase error of the arrayed WGs. The fabricated four-channel Si arrayed waveguide grating (AWG) demonstrates a good performance level, such as a low insertion loss of 0.61 dB (0.73 dB) and low adjacent crosstalk less than −31.3 dB (−32.2 dB) for transverse-electric (TE) (transverse-magnetic, TM) polarization, in the range of ∼1300 nm wavelength.</P>
Next-generation sequencing of BRCA1/2 in breast cancer patients
Hyung Seok Park,Seo-Jin Park,Jee Ye Kim,Sanghwa Kim,Jaegyu Ryu,Joohyuk Sohn,Seho Park,Gun Min Kim,In Sik Hwang,Jong-Rak Choi,Seung Il Kim 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.5
Purpose: We evaluated the clinical role of rapid next-generation sequencing (NGS) for identifying BRCA1/2 mutations compared to traditional Sanger sequencing. Methods: Twenty-four paired samples from 12 patients were analyzed in this prospective study to compare the performance of NGS to the Sanger method. Both NGS and Sanger sequencing were performed in 2 different laboratories using blood samples from patients with breast cancer. We then analyzed the accuracy of NGS in terms of variant calling and determining concordance rates of BRCA1/2 mutation detection. Results: The overall concordance rate of BRCA1/2 mutation identification was 100%. Variants of unknown significance (VUS) were reported in two cases of BRCA1 and 3 cases of BRCA2 after Sanger sequencing, whereas NGS reported only 1 case of BRCA1 VUS, likely due to differences in reference databases used for mutation identification. The median turnaround time of Sanger sequencing was 22 days (range, 14–26 days), while the median time of NGS was only 6 days (range, 3–21 days). Conclusion: NGS yielded comparably accurate results to Sanger sequencing and in a much shorter time with respect to BRCA1/2 mutation identification. The shorter turnaround time and higher accuracy of NGS may help clinicians make more timely and informed decisions regarding surgery or neoadjuvant chemotherapy in patients with breast cancer.
Jaegyu Jang,Hyoungmin So,Kihoon Lee,Jun-Pyo Park IET 2017 IET radar, sonar & navigation Vol.11 No.4
<P>This study verifies the performance of the ionosphere-free L1 pseudorange for dual-frequency space-based augmentation systems (SBAS) users by both of theoretical analysis and experiments with actual GPS data. Although the dual-frequency pseudorange from ionosphere-free linear combinations is commonly used as a standard method, the ionosphere-free L1 range based on the weighted Hatch filter has advantages in terms of the amplification factor caused by a dual-frequency combination and filter weights optimised by the least-squares method. For the experimental analysis, RINEX data were collected from five National Geographic Information Institute reference stations on the Korean peninsula and used to generate an SBAS correction message following international SBAS specifications. The experimental results show that using the proposed method results in a 29% improvement in the range domain compared with the use of a traditional ionosphere-free linear combination filter. In the position domain, the proposed method shows a horizontal accuracy improvement of 16% after the application of post-processed SBAS orbit/clock corrections w.r.t. the traditional filter. Finally, this study also demonstrates that the accuracy of dual-frequency users can surpass than that of single-frequency SBAS users only if corrections are estimated with ionospheric delay-free measurements in the master station as well.</P>
Spatial Decorrelation of SBAS Satellite Error Corrections in the Korean Peninsular
Jaegyu Jang,Hyoungmin So,Kihoon Lee,Jun-Pyo Park 한국항공우주학회 2016 International Journal of Aeronautical and Space Sc Vol.17 No.1
The characteristics of the SBAS satellite orbit and clock corrections are highly affected by the narrow network size in the Korean peninsula, which is expected to have an important role in the future dual frequency SBAS. The correlation between satellite corrections can be analyzed in terms of the spatial decorrelation effect which should be analyzed to keep the service area as wide as possible. In this paper, the characteristics of satellite error corrections for the potential Korean dual frequency SBAS were analyzed, and an optimal filter design approach is proposed to maximize the service area.