가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

益胃升陽湯 및 加減方이 家兎의 摘出腸管 運動에 미치는 影響

李學宰,盧永範,柳道坤,韓宗鉉,康舜洙 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

In order to investigate the action of Radix Bupleuri and Radix Cimicifugae in Yikwiserugyangtang(益胃升陽湯), Yikwiseungyangtang was divided into six samples : Sample Ⅰ : Yikwiseungyangtang Sample Ⅱ : Water extract of Yikwiseungyangtang excluded R.Bupleuri and R.Cimicifugae. Sample Ⅲ : Water extract of Yikwiseungyangtang excluded R.Cimicifugae. Sample Ⅳ : Water extract of Yikwiseungyangtang excluded R.Bupleuri. Sample Ⅴ : Water extract of Yikwiseungyangtang increased R.Bupleuri and R.Cimicifugae to 3.75g Sample Ⅵ : Water extract of R.Bupleuri and R.Cimicifuage. Effects of Yikwiseungyangtang and its variants on the contractile force of isolated rabbit ileums are as follows : 1. Yikwiseungyangtang was significantly increased the contractile force of isolated rabbits ileum. 2. The contractile of Yikwiseungyangtang was significantly inhibited by atropine. 3. The contractile force of Yikwiseungyangtang was not inhibited by cyproheptadine. 4. In the contraction of Norepinephrine(10^-3M), Sample Ⅱ, Sample Ⅵ and Sample Ⅴ were increased the contractile force than that of Sample Ⅰ. 5. In the contraction of acetylcholine (10^-3M), no change observed in contractile force than that of Sample Ⅰ.

sprD 유전자의 과발현이 Streptomyces griseus HH1의 분화에 미치는 영향

이재학 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.4

방선균은 토양 속에 다양하게 존재하는 미생물의 일종으로 그람 양성 진정세균으로 이차 대사산물을 생산하는 시기와 포자 착생이 시작되는 세포분화의 시기가 밀접한 관련이 있다. S. griseus는 streptomycin을 비롯한 다양한 종류의 endopeptidase 및 exopeptidase들을 생산한다. 방선균에서의 protease 생산은 많은 경우에 이차대사산물이 형성되거나 형태분화가 유도되는 시기에 동시에 시작된다는 점에서 protease가 이차대사물질 생산 및 세포분화에 일정한 기능을 수행할 것이라는 점을 시사하고 있다. 본 연구에서는 S. griseus IFO 13350에서 클로닝한 SGPE protease가 각 strain에서 형태학적으로나 생리적으로 어떠한 gene dosage 효과를 미치는지 조사하는 것이었다. sprD 유전자가 S. lividans를 숙주로 사용한 시스템에서 대량발현이 성공적으로 되는 것을 확인한 후, 본 유전자를 클로닝한 S. griseus IFOI3350 균주와 이의 A-factor 결손주인 S. griseus HHI에 형질전환하였다. S. griseus HHI과 S. griseus IFO13350 에서는 protease activity가 벡터만 도입된 대조군과 sprD 유전자가 들어간 형질전환체에서 큰 차이를 보이지 않았다. 또한 S. griseus IFO13350 및 HHI 모두에서 생리학적·형태학적 분화의 차이를 발견하지 못하였다. Chymotrypsin 계열의 protease를 암호화하는 유전자만이 S.griseus에서 발현이 repression 된다는 사실을 본 연구 결과를 통하여 알게 되었다. 이를 바탕으로 sprD 유전자와 동일계열의 chymotrypsin 계열의 유전자들이 공통적으로 S. griseus 에서 repression되는 일반적인 기전이 있을 것으로 판단, chymotrypsin 계열 유전자들의 promoter 부분의 염기 상동성을 조사하였다. 번역개시부위 바로 상부 유전자부터 상동성을 조사한 결과 적어도 상당부분의 염기배열이 잘 보존되는 지역이 존재함을 알게 되었다. 향후 이들 발현 기구의 조절기구를 연구함으로서 protease의 기능을 밝히는데 좋은 단서를 제공할 것으로 판단된다. Sreptomyces shows a eukaryotic characteristic that vegetative cell can grow into mycelial form and has morphological and physiological differentiation at a certain period during its life cycle. Streptomyces has been used for the production of many biologically active compounds, such as antibiotics and pronase. Production of second metabolites and differentiation of the vegetative cell share the certain period of its life cycle. therefore, second metabolites may effect the differentiation of the vegetative cell. One of the microbial hormone, called A-factor, regulates the production of second metabolites, sporulation and differentiation of the cells. Streptomyces griseus produces streptomycin as well as many different kinds of proteinase. As mentioned, period or proteinases production overlaps with period of differentiation of the vegetative cells. Protease may play a important role for the differentiation of the cells. In this paper, function of the SGPD gene cloned from S. griseus IFO 13350 tested whether it affects for the differentiation of A-factor mutated S. griseus HHI and S. griseus IFO 13350. pWHM3 and pWHM3-sprD plasmid was transformed into S. griseus HHI and S. griseus IFO 13350. Chymotrypsin activity of the cultured medium of the transformants with pWHM3- sprD plasmid didn't show any change with that of the transformants with plasmid only. The transformants with pWHM3-sprD plasmid didn't show the increase of the production of actinorhodin as well as morphological change in S. griseus IFO 13350 and HHI, as well. The promoter sequences of the SGPA and SGPB gene which encode chymotrypsin-like protease, were compared with that of SGPD gene. Regulatory mechanism of gene expression of proteinase genes will be studied for the development of high production system for protease as well as the function of the proteases.

국내 감사인 조직의 감사통제와 표본조사방법의 구조화 분석

蔡奎學,李載鳳 홍익대학교 경영연구소 1993 경영연구 Vol.17 No.-

慢性鼻炎에 있어서 鼻甲介의 Acid Mucopolysaccharide에 關한 硏究

金永學,崔在達,瀋在哲 대한이비인후과학회 1976 대한이비인후과학회지 두경부외과학 Vol.19 No.1

정신분열증 환자의 인지적 결함 : 기억 및 기억 기원의 변별 과정을 중심으로 Memory and Discrimination of The Memory Sources

박상학,신재정,이민규 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.5

The authors investigated the relation between the disturbance of thought and perception and information processing. particulary memory and discrimination of memory sources. in the schizophrenic patients by using experimental procedures. The author tested 20 schizophrenic patients and 20 normal control subjects who were matched according to age. sex and education. All subjects were given 3 types of material set. The first. experimenter presentation set. were made up of 10 opposite word pairs. The second & third set were 10 cards each. A usual word with a cue letter of an opposite word. They were instructed to imagine only with the second set. and to write the opposite word along the cue letter with the third set. After the response sheets had been collected. they were asked to recall all responses in any order. Next. a new test sheet was given for the recognition & the discrimination of the memory sources. The result of the research were as follow: 1) Free recall; A significant decrease of recall ability was found in the schizophrenic group(3.15 words) as compared with the control group(6.68). 2) Recognition(hit rate); There was no significant difference of recognition ability between the SPR group(23.15) and the control group(23.6). 3) Schizophrenic group had poorer signal sensitivity(d'). 4) SPR group had more difficulty in discriminatng what they had imagined from what they had written. SPR group and control group were not different in discriminating what they had seen. 5) Error bias of the discrimination; Schizophrenic group showed markedly poor performance on the discrimination task. They mistook what they had seen as what they had written. what they had imagined as what they had written, and what they had written as what they had seen.

전도도법에 의한 치환 피리딘들의 해리상수 측정과 그의 온도와 압력에 따른 영향

黃正儀,鄭倧在,金學成,尹永炷,朴義煥 慶北大學校 1984 論文集 Vol.38 No.-

Generally, pyridine and most of substituted pyridines act as base in aqueous solutions. The strengths of their basicities can be expressed quantitatively by the dissociation constant of base or its conjugated acid. Generally, the acidity of substituted pyridines can be expressed by K_a of the following reaction. ◁그림 삽입▷ (원문을 참조하세요) The dissociation constants of these subtituted pyridines have not been reported under high pressure but under atmospheric pressure. In this papers, the dissociation constants of some substituted pyridines were measured under high pressure by the conductometry. From the ionic conductivity of hydrogen ion, the dissociation constants (K_a) were calculated. The K_a values were increased with increasing temperature and were decreased with increasing presure. The charateristics of dissociation process of some substituted pyridines were deduced from the thermodynamic properties calculated from the dissociation constants.

전도도법에 의한 치환 피리딘들의 해리상수 측정과 그의 온도와 압력에 따른 영향

黃正儀,鄭倧在,金學成,尹永炷,朴義煥 慶北大學校 物理化學硏究所 1985 硏究論文集 Vol.6 No.-

Generally, pyridine and most of substituted pyridines act as base in aqueous solutions. The strengths of their basicities can be expressed quantitatively by the dissociation constant of base or its conjugated acid. Generally, the acidity of substituted pyridines can be expressed by K_a of the following reaction. ◁그림삽입▷(원문을 참조하세요) The dissociation constants of these subtituted pyridines have not been reported under high pressure but under atmospheric pressure. In this papers, the dissociation constants of some substituted pyridines were measured under high pressure by the conductometry. From the ionic conductivity of hydrogen ion, the dissociation constants(K_a) were calculated. The K_a values were increased with increasing temperature and were decreased with increasing pressure. The characteristics of dissociation process of some substituted pyridines were deduced from the thermodynamic properties calculated from the dissociation constants.

우리나라 物價變動會計制度의 導入方案에 관한 硏究

朴範鎬,宋在萬,李勉榮,蔡奎學 홍익대학교 경영연구소 1985 경영연구 Vol.9 No.-

As accounting is an outgrowth of society, we can say that the accounting system of each country is derived from its economic situation and from the people's outlook no economic values. Thus when the economic situation of one country is different from that of another country, and the outlook of the people of one country is different from that of another country, they the accounting system for changing prices as well as general accounting systems may be different. Actually accounting systems of different countries are not identical. The writers of this paper try to find an accounting system for changing prices suitable to out country. The writers review various theories on accounting systems for changing prices, survey accounting systems of various countries and basic patterns of such systems, and in vestigate the actual conditions of our country in order to provide accounting information which reflects the effect of changing prices and to give a practicable accounting system. In this paper, the writers state their opinions about accounting systems for changing prices as follows: 1)The demand for the publication of accounting information about the effect of changing prices upon the financial status and operational result of a business is a world-wide trend. Considering that our industries are now aiming at opening a capital market, we should establich an accounting system for changing prices in order to follow the world-wide current. 2) As we intend to follow the world-wide current, to get useful accounting information, and to get a practicable accounting system, the most suitable system for us is the current value accounting system The current value accounting system mentioned here does not provide information supplementary to that of the financial statements based on the historical cost but it provides a substitute of the current value financial statements for those based on the historical cost. Financial statements based on current values are standard statements. 3) In our country, there are no active studies or discussions on the accounting systems for changing prices. We need to set up an organization entirely responsible for the establishment of a desirable accounting system for changing prices, responsible for the establishment of guidelines for putting the system to use, and responsible for the coordination of the interests of those concerned.

방역작업자의 브롬화메틸(methyl bromide) 노출수준과 생물학적 모니터링

이종성,이용학,신재훈,최정근,오차재,정호근 한국산업위생학회 2001 한국산업보건학회지 Vol.11 No.3

This study was performed to estimate environmental and biological monitoring of worker exposed to methyl bromide through quarantine fumigation. Airborne methyl bromide and it's metabolites were analyzed by gas chromatography and ion chromatography, respectively. The results are as followings; airborne concentration of methyl bromide(TWA) was 2.08±1.56 ppm(N=8). Dispersion and setting/degas groups were 0.67±0.12 ppm(N=2) and 2.54±1.53ppm(N=6), respectively. Bromide ion concentration in serum was 23.40±14.91㎎/ℓ(N=10) in the exposed workers and 4.74±0.82㎎/ℓ(N=21) in the non-exposed workers. Bromide ion concentration in urine was 35.56±26.89㎎/ℓ(N=11) in exposed group and 6.62±2.31㎎/ℓ(N=21) in non-exposed group. Good correlation was observed between concentration of serum and urine(r^2=0.890 p<0.01). No significant correlations of other determinanats were observed. Calcuated from a regressive curve. the biological half lifes of serum and urine were 10.7 and 5.9 days. In these results, biological monitoring of bromide ion of serum and urine provided useful information for evaluating exposure of workers to methyl bromide, so that an availability of bromide ion of biological samples was showed as biological monitoring indices for methyl bromide.