Sarcoma 180 유발 생쥐에 미치는 Evening Primrose 종자유의 영향

서재관,신인철,서대규 漢陽大學校 環境科學硏究所 1988 環境科學論文集 Vol.9 No.-

체중 25gm 내외의 ICR계 웅성 생쥐에 복수암인 Sarcoma 180을 유발시킨 후 체중 ㎏당 1.5㎖의 생리적 식염수를 경구적으로 투여한 군을 대조군으로 하고, Sarcoma 180을 이식직후 체중 kg당 1.5ml의 Evening Primrose 종자유를 매일 10일간 경구적으로 투여한 군과 체중 ㎏당 1.5㎖의 Evening Primrose 종자유를 매일 10일간 경구적으로 투여한 후 Sarcoma 180을 이식한 군으로 나누었다. 숙주의 수명은 잔존하는 악성종양세포의 수와 반비례하는 것으로 알려져 있음으로 Sarcoma 180 유발 생쥐의 생존기간, 암세포 및 백혈구 수에 미치는 Evening Primrose 종자유의 효과를 관찰하여 다음과 같은 결과를 얻었다. 1. Sarcoma 180 유발 생쥐의 생존일수의 평균치는 대조군에서는 13.9일이었으나 Evening Primrose 종자유 전처치군에서는 23.3일, 후처군에서는 26.3일로서 생존일수의 연장효과를 보여주었다. 2. Sarcoma 180 유발 생쥐의 복수에서의 암세포수는 대조군에서는 암세포수가 점차 증가되었으나, Evening Primrose 종자유 전처치 및 후처치군에서는 대조군에서 보다 적은 범위로 암세포수가 증가되어 암세포증식의 억제효과를 보여주었다. 3. Sarcoma 180 유발 생쥐의 백혈구수는 대조군에서는 백혈구수가 점차 증가되었으나, Evening Primrose 종자유 전처치 및 후처치군에서는 대조군에서보다 적은 범위로 백혈구수가 증가되어 백혈구증식의 억제효과를 보여주었다. Sarcoma 180 bearing mice, averaging 25gm of body weight, were divided into 3 groups of animals, animals administered 1.5㎖/㎏ of normal saline for 10 days after tumor implantation as control group, animals administered 1.5㎖/㎏ of Evening Primrose Seed Oil for 10 days after tumor implantation as posttreatment group, animals implanted tumor after administered 1.5㎖/㎏ of Evening Primrose Seed Oil for 10 days as pretreatment group. This study was made to elucidate the effects of Evening Primrose Seed Oil on the survival days, tumor cell count and leukocyte count in sarcoma 180 bearing mice. The results were as follows. 1. Average survival days was 13.9 days in control group, 23.3 days in pretreatment group and 26.3 days in posttreatmint group. 2. Tumor cell count in ascitic fluid was increased in control group and increased to smaller extents than control group in pretreatment and posttreatment groups. 3. Leukocyte count was increased in control group and increased to smaller extents than control group in pretreatment and posttreatment groups. Consequently, it is suggested that Evening Primrose Seed Oil has the effects of prolongation of survival days and inhibition of proliferation of tumor cells and leukocytes in sarcoma 180 bearing mice.

중증 열대열 말라리아 환자의 부검 1 예

김춘관,김성민,백경란,이정원,서연림,송재훈 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1

저자들은 아프리카 지역을 여행한 후 중증 열대열 말라리아에 이환되어 뇌형 말라리아, 급성 신부전, 급성 호흡부진 증후군, 범발성 혈관내 응고등 중증 합병증으로 사망하여 부검한 1예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. As tourism is dramatically increasing, imported infectious diseases pose a serious threat to international travelers. Malaria would be the most important one. Particularly, falciparum malaria can be complicated by cerebral malaria, acute renal failure, acute respiratory distress syndrome, dissenminated intravascular coagulation, severe anemia, and death. We report a fatal case of falciparum malaria after travel to Afrca. A 49-year-old man was admintted to the hospital because of fever, jaundice, and altered mentality. The patient did not take any chemoprophylaxis before and during his stay in Africa. Blood smear was characteristic for falciparum malaria with heavy parasitemia(>50%). Although quinine dihydrochloride was promptly instituted, the patient was complicated by comatous mentality, acute renal failure, adult respiratory distress syndrome, disseminated intravascular coagulation, and refractory hypotension. Despite of intensive care with mechanical ventilator, continuous hemofiltration, the patient expired on the 4th hospital day. Autopsy revealed parasitised red blood cells and malarial pigments in capillaries and small vessels in most organs throughout the entire body.

1994년도 法醫剖檢 통계분석

김종열,서재관 中央醫學社 1997 中央醫學 Vol.62 No.3

This is a statistical observation by authors based on the data of so called unusual death brought to this institute for medico legal autopsy by all of law enforcement agencies in Korea in the year of 1994. This report aims to reveal the facts on various causes of unusual death in Korea. The following are the summary of result:; 1. The total numbers of autopsy made for the unusual deaths were 2,123 cases, of these 1,576 cases were males and 547 cases were females. 2. Violent deaths were 1,380 cases(65.0 %), natural deaths were 657 cases(30.9 %), and unknown cases were 86(4.1 %). 3. For deaths due to injuries, blunt object injuries were the leading ahead. 4. Asphyxia deaths were 340 cases, 16.0 percents of the total and drowning were 139 cases showing the biggest number among the asphyxia] deaths. 5. Deaths from abnormal temperature and electricity were death due to fire, burning, hypothermia, heatstroke and electrocution. 6. There were 5 cases for starvation. 7. Infanticides were 8 cases, 0.4 percent of the total number. 8. For the death due to intoxication, 236 cases(11.1 %) were recorded and the biggest number among these were CO intoxication. 9. For the natural death, 657 cases, 30.9 percents of the total were recorded and the death due to the disease of the cardiovascular system was' taking the most of the total number with 323 cases. 10. Cause of death unknown due to negative autopsy and to the severe decomposition of the body were 86 cases, 4.1 percents of the total number.

外傷死 및 栓塞의 剖檢統計

尹重鎭,徐在冠 大韓法醫學會 1988 대한법의학회지 Vol.12 No.2

One who have sustained the mechanical injury may die of the damage to the vital organs, hemorrhage, asphyxia, shock or embolism as a direct cause of death, and of its complication as various secondary infections (tetanus, pertionitis, pneumonia, cystitis, osteomyelitis, meningitis, etc.) and other non-infectious sequelae(traumatic shock lung, embolism, uremia, etc.). A prevalence study was undertaken on deaths of mechanical violence or wounding, which had been autopsied during the period of 10 years from 1978 to 1987 at National Institute of Scientific Investigation. The results obtained were as follows: 1. Of 11,835 total autopsies, 3,268 cases (27.6%) were caused by mechanical violence, or wounding. 2. Among the 3,268 deaths by mechanical violences, the cases of homicide were 1,591 (48.7%), suicide 31 (0.9%), accidental death 670 (20.5%), and others undetermined. 3. According to the type of injury, the blunt force injuries were 2,424(73.3%), sharp force injuries 814 (23.7%), and injuries by gun-shot or explosives 30 (0.9%). 4. The highest prevalence age group was their twenties (29.2%) followed by thirties (22.8%), fourties (16.8%) and teens (12.8%). 5. Head injuries by blunt force was the most common cause of death of mechanical violence (43.0%), and other major injuries were stabbing (23.5%) and rupture of visceral organs (10.6%). 6. In cases of secondary complications, peritonitis occurred most commonly and followed by pneumonia, pulmonary embolism, and sepsis. 7. Twenty five cases (0.76 among 3,268 mechanical violent deaths demonstrated hemodynamic derangement as DIC, pulmonary thromboembolism, fat embolism and amniotic embolism.

야뇨증 환아들의 심리사회적 특성에 대한 다기관 연구 : 행동 및 정서 문제를 중심으로

조수철,김재원,신민섭,황준원,한상원,박관현,이상돈,김경도,김건석,서홍진,이유식,정재용,김영균,문두건,남궁미경,한창희,조원열,김영식,배기수,이종국,정우영,신의진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : The aim of this study was to examine the behavioral and emotional problems associated with nocturnal enuresis in Korean children. Methods : Three hundred eighteen children with nocturnal enuresis, together with their parents, completed the Child Behavior Checklist (CBCL), Disruptive Behavior Disorder Scale according to DSM-IV (DBDS), Children's Depression Inventory (CDI), State-Trait Anxiety Inventory for Children (STAIC), and Piers-Harris Children's Self-Concept Scale (PHCSC). Ninety-three normal students were selected as the control group. Results : Compared to the normal control group, the mean scores with regard to the withdrawn, social problems, attention problems, delinquent behavior, aggressive behavior, externalizing problems and total problems profiles were significantly higher in the nocturnal enuresis group according to the CBCL results. The nocturnal enuresis group also scored significantly higher in the ADHD and ODD profiles of the DBDS. The nocturnal enuresis group was more depressed and anxious than the control group according to the results of the CDI and STAI. The mean score of the PHCSC was significantly lower in the nocturnal enuresis group when compared to the normal control group. Conclusion : The results of this study suggest that children with nocturnal enuresis in Korea have clinically relevant behavioral and emotional problems. The findings support the link between nocturnal enuresis and psychopathology in Korean children.

KAL기 추락에 의한 대량재해의 개인식별

강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.

공원묘지 유실에 의한 대량재해의 개인식별

강신몽,이한영,윤중진,이원태,김종열,이영석,서재관,최득린,서지석,이혜경 大韓法醫學會 1992 대한법의학회지 Vol.16 No.1

Individual identification of severely decomposed or skeletonized bodies is an important part in medicolegal field. 142 bodies were torn up and carried away by flood in a park cemetry, Kwang-Ju, Kyunggi province, Korea at Sept., 10, 1990. The authors examed the 56 bodies, which were gained, through medical, anthropological, odontological, radiological methods, and superimposition for individual identification. Among them, 41 cases were successfully identified, and remaining 15 cases were not identified because of sever destruction and no adequate information.

의료관계 해부 감정예의 분석적 연구(I) : 1990년 국립과학수사연구소 감정예

姜信夢,李垣兌,李漢榮,尹順雄,全基悳,金相鉉,徐在冠,尹重鎭 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2

A study of 118 autopsy cases associated with medical care in 1990 was present according to the medical department, the mode of treatment and the cause of death. The Pediatrics showed the highest rate (25.4%), followed by the Obstetrics & Gynecology (22.9%), and Internal medicine (20.2%). According to the mode of treatment, medical accidents during operation and anesthesia were 29 cases (24.6%) with highest rate in Obstetrics & Gynecology (13 cases), 38 cases (32.2%) were during medication and/or injection with highest rate in Internal Medicine (18 cases), and 51 cases (43.2%) were during general medical practice with highest rate in pediatrics (19 cases). The most prevalent cause of death was the disease of respiratory system (34.9%, 30 cases) and the diseases of cardiovascular and urogenital system accounted for 31.4% and 11.6% respectively. The main cause of death in Internal medicine was the disease of cardiovascular system (11/24 cases), the respiratory system in pediatrics (15/30 cases) and the disease of urogenital system in Obstetrics & Gynecology (9/27 cases. ) Asphyxial deaths were 7 cases and the death due to adverse drug reaction accounted for 10 cases.

아시아 지역 폐렴 구균의 항균제 내성 현황 및 변화 양상 : Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

정숙인,김나영,손준성,기현균,고관수,서지연,장현하,김연숙,오원섭,백경란,이남용,송재훈,항생제 내성 감시를 위한 아시아 연합 (ANSORP) 대한감염학회 2004 감염과 화학요법 Vol.36 No.1

목적 : 1980년대부터 페니실린을 비롯한 β-lactam 계열과 비 β-lactam 계열 항균제에 대한 폐렴구균의 항생제 내성이 급격하게 증가하여 국내 뿐 아니라 세계적인 문제로 대두되고 있다. ANSORP 에서는 아시아 지역에서 폐렴구균의 항균제 내성과 그 변화 추이, 내성의 기전 및 위험인자를 분석하고자 본 국제 공동 연구를 시행하였다. 재료 및 방법 : 1999년 11월부터 2001년 8월까지 아시아 지역 12개국의 14개 기관에서 폐렴구균 감염증 환자의 임상 검체로 분리된 침습성 폐렴구균을 대상으로 액체배지 미량희석법을 이용하여 16개 항생제의 MIC를 구하였다. 위험인자의 분석을 위하여 폐렴구균 감염증 환자를 대상으로 의무기록지를 조사하였다. Quellung 반응을 통해 혈청형을 결정하였다. 결과 : 총 685균주 중 52.4%가 페니실린에 대하여 비감수성(중등도 내성 22.9%, 내성 29.5%)을 보였고, 그 빈도는 베트남(92.1%), 스리랑카(85.7%), 홍콩(67.9%), 한국(64.5%)의 순이었다. Erythromycin에 대한 비감수성 비율은 베트남(92.1%), 대만(87.7%), 한국(80.6%), 홍콩(76.8%) 등에서 높게 나타났고, 베트남, 대만, 한국, 홍콩 등의 erythromycin의 MIC_(90)이 32㎍/mL를 넘는 고도내성을 보였다. 홍콩, 싱가포르, 대만, 인도에서는 fluoroquinolone에 대한 내성 균주가 출현하였다. 전체 균주 중 다제내성 균주의 비율은 47.7%였다. 혈청형은 19형과 23형이 가장 많았고, 그 외 6형, 14형 등이 있었다. 페니실린 비감수성 감염증의 위험인자로는 5세 미만(OR=1.7; 95%, CI, 1.2-2.4; P=0.002), 기관지폐질환(OR=2.0; 95%, CI, 1.3-3.1; P=0.003), 악성종양(OR=2.3; 95%, CI, 1.2-4.6; P=0.015), 스테로이드의 사용(OR=2.8; 95%, CI, 1.1-7.4; P=0.032)이 확인되었다. 결론 : 침습성 폐렴구균 균주를 대상으로 한 본 연구의 결과 아시아 국가들에서 페니실린, β-lactam 및 macrolide에 대한 폐렴구균의 내성률 및 내성 정도가 급증하고 있음을 확인하였다. Background : Emergence of pneumococcal resistance became a global issue since 1990s. According to the ANSORP studies with clinical isolates and carriage isolates between 1996 and 1999, some Asian countries showed alarmingly high prevalence of resistance to penicillin and other antimicrobial agents. To investigate the changing trends of pneumococcal resistance, ANSORP study group has performed a multinational surveillance study with invasive pneumococcal isolates from Asian countries. Methods : All isolates from various invasive pneumococcal diseases were prospectively collected from 14 centers in 12 countries between November 1999 to August 2001. Broth microdilution tests with 16 antimicrobial agents were performed according to the NCCLS procedures. Serotyping was performed by means of Quelling reaction with use of group-specific antisera. Results : A total of 685 isolates were collected. Overall, 52.4% of invasive isolates from Asian countries were not susceptible to penicillin (intermediate (1), 22.9%, Resistant (R), 29.5%). Vietnam showed the highest prevalence of penicillin non-susceptibility (1 20.6%, R 71.4%) followed by Sri Lanka (1 71.4%, R 14.3%), Hong Kong (1 24.1%, R 76%) and Korea (1 9.7%, R 54.8%). China (I 19.8%, R 23.4%) and Malaysia (1 9.1%, R 29.5%) also showed remarkable increase in penicillin resistance compared with previous ANSORP data, which were less than 10%. Vietnam (92.1%), Taiwan (87.7%), Korea (80.6%), and Hong Kong (76.8%) showed high prevalence of erythromycin resistance. MIG_(90)S for ciprofloxacin were 4 ㎍/mL (Hong Kong) and 2 ㎍/mL (11 Asian countries except Hong Kong), respectively. Conclusion : Compared with previous data from ANSORP studies, antimicrobial resistance among invasive pneumococcal isolates has markedly increased in Vietnam, Sri Lanka, Taiwan, China, and Malaysia. Continuous surveillance of pneumococcal resistance in Asia is strongly warranted.

PTCR 나노 복합기능 소재의 전류 차단 특성 연구

김재철(Jae Chul Kim),박기헌(Gi Hun Park),서수정(Soo Jeung Suh),이영관(Young Kwan Lee),이성재(Seoung Jae Lee),이승재(Seung Jae Lee),남재도(Jae Do Nam) 한국고분자학회 2002 폴리머 Vol.26 No.3