KHFe(CO)_4-HCHO系를 利用한 Nitro 및 Nitroso化合物의 환원 N-메칠화 반응

沈相喆,閔庚隱,嚴在國,洪錫 경북대학교 1978 논문집 Vol.10 No.-

The reduction of nitro and nitroso compounds using tetracarbonylhydridoferrate-formaldehyde under mild conditions (at room temperature and then 60℃ under CO) gives the corresponding N, N-dimethylation via N-methylation in good to excellent yields. The reaction mechanism via immonium salt is assumed.

원외부 전대뇌 동맥 동맥류의 외과적 치료

심재홍,김수천,이선일 인제대학교 1993 仁濟醫學 Vol.14 No.1

1982년 1월부터 1991년 12월까지 인제대학교 부산백병원 신경외과에서 총 809례의 뇌동맥에 대한 수술을 경험하였으며, 이 중 비교적 드물다고 알려진 원위부 전대뇌 동맥 동맥류 26례에 대한 임상적 특징 및 수술에 있어서의 문제점 등을 연구 분석하고 문헌 고찰과 함께 보고하고자 한다. Of eight-hundreds and nine patients with intracranial aneurysms who underwent operation at Inje University Pusan Paik Hospital between Jan. 1982 and Dec. 1992, twenty-six had aneurysms of distal anterior cerebral artery(DACA). Of these twenty-six patients, twenty-one had only ruptured DACA aneurysm. But, five had multiple aneurysms, and DACA aneurysms were responsible for subarachnoid hemorrhage in three. There were two incidental DACA aneurysms associated with ruptured aneurysms at other locations. All patient underwent direct surgery under the surgical microscope, if possibly within 48hrs after the last subarachnoid hemorrhage. This paper deals with clinical features, surgical techniques and problems in direct approach, and the results in our cases.

다각형 크리핑 알고리즘에 관한 연구

심재홍 光云大學校 1989 論文集 Vol.18 No.-

Clipping is required to display a particular view of the object. It is the process of determining how much of given line lies within the boundaries of the display window. It can be implemented in hardware, software or hybrid method. This paper suggest that a few method of the ploygon clipping which is one of variety faculty of the clipping and concern with its algorithms.

한글 ·한자 Word processing 시스템에 關한 硏究

沈在洪,柳煌彬 光云大學校 1984 論文集 Vol.13 No.-

In this paper, a Word processing system which processes the sentences composed by Korea, Chinese and English words is studied. In this system, every word is coded uniformly in two bytes and especially Chinese words are processed by dictionary. Thus, we can enhance many properties : at least as much as half memory size can be saved, more over high processing speed, program modulization and automata design for additional commands can be achieved. In order to implement this processing system efficiently, an algorithm and program explanation for output form of end-user destination are added.

紅景天(Rhodiola sachlinensis)에서 항균성 물질의 분리 및 동정

심창주,이규희,정재홍,이상덕,김영호,오만진 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2004 한국식품저장유통학회지 Vol.11 No.1

홍경천의 천연 보존료로서의이용성을 검토하기 위하여 각종 용매로 홍경천 추출물을 제조하고 극성에 따라 순차분획, silica-gel chromatography, thin-layer chromatography, high perfomance liquid chromatography의 분리과정을 거쳐 순수 분리된 각 물질을 GC/MS(EI) spectrum, ¹H-NMR spectrum, ¹³C-NMR spectrum을 이용하여 항균물질을 동정하여 다음과 같은 결과를 얻었다. 홍경천에 대해 acetone, ethyl acetate, ethanol, methanol, chloroform, water의 각 용매로 추출한 결과 항균성분의 추출 용매로는 methanol이 가장 우수하였다. 홍경천 methanol 추출물을 n-hexane, chloroform, ethyl ether, ethyl acetate, n-butyl alcohol로 분획한 결과 ethyl acetate와 n-butyl alcohol 분획에서 우수한 항균력을 나타내었다. 홍경천 methanol 추출물은 그람양성 4균주와 그람음성 4균주에 대해 고체 배지의 경우 대체로 500 μg/mL에서 최소저해를 나타냈으며, 액체배지의 경우 100 μg/mL 내외에서 최소저해를 나타내었다.] Silica gel column chromatography에서 용매의 배율을 높여가며 용출한 결과 chloroform : methanol(8:2, v/v)의 비율에서 항균력이 가장 높게 나타났다. 분리된 항균성분을 silica-gel TLC plate에 용매의 비율을 높여가며 전개시켜 chloroform : methanol(9:1, v/v)에서 9개의 물질군을 얻을 수 있었으며, 그 중 항균력이 확인된 3개의 물질군을 HPLC와 NMR spectrum을 분석한 결과 gallic acid, (-)-epicatechin 및 kaempferol로 동정되었다. gallic acid, (-)-epicatechin 및 kaempferol의 항균물질 각각의 최소저해농도는 Staphylococcus aureus와 Listeria monocytogenes에 대해 gallic acid와 kaempferol 이 500 μg/mL, (-)-epicatechin이 100 μg/mL에서 저해를 나타내었다. The antimicrobial substances from Rhodiola sachalinensis were extracted, isolated and identified. The highest level of antimicrobial activity and its yield were obtained in methanol extract. The minimum inhibition concentrations of the methanol extract were 500 μg/mL on agar plate and 100 μg/mL in broth media for four gram positive and four gram negative microbials. The methanol extract was fractionated by n-hexane, chloroform, ethyl ether, ethyl acetate, and butanol, orderly. The separate was developed on the TLC plate with different solvent system ratio of chloroform and methanol. Nine substances were isolated from chloroform and methanol mixture(9:1, v/v). Among them, three isolates showed antimicrobial activity. Three substances separated by HPLC were identified by GC/MS(EI) spectrum and ^(1)H, ^(13)C-NMR spcetrum. They were gallic acid, (-)-epicatechin and kaempferol. The antimicrobial activites of each substances were shown gallic acid, (-)-epicatechin, kaempferol, orderly.

多段階 在庫시스템에서의 最適 安全在庫 模型

沈宰弘,南相進,金正子 동아대학교 공과대학 부설 한국자원개발연구소 1995 硏究報告 Vol.19 No.1

This research proposed a model for the determination of optimal safety stock for multi-echelon inventory system. The criterion is to minimize expected anaual total cost safety stock of system under service level constraint. The results of numerical examples for three-echelon inventory system are analized and compared with Salameh and Schmidt's model. The heuristic method is presented to find an optimal-tending solution for total variable system cost per year. The numerical examples are illustrated for verification and validation purposes.

간내 간충병에 대한 간절제술 1예

심민철,김홍진,권광보,노성균,이헌주,이태숙,장재천 영남대학교 의과대학 1990 Yeungnam University Journal of Medicine Vol.7 No.1

영남대학교 의과대학 외과학교실에서는 1989년 11월에 한국에서 발병한 간흡충병의 여섯 번째 증례로, 특히 간내 담관에 발생한 첫 증례를 우측 간엽 절제술 및 담낭 적출술로 좋은 결과를 얻었으며, 간내 담관에 발생한 경우에는 간암과의 구별이 요구되어야 한다는 점을 상기 시키면서 증례보고와 더불어 문헌적 고찰을 하였다. Human Fasciola hepatica infection is a rare entity involving infestation of the liver and biliary tree with adult flukes, which can result in hepatitis, cirrhos is and biliary tract inflammation, obstruction and lithiasis. The patient had the typical diagnostic tetrad of fever, eosinophilic leukocytos is, tender hepatomegaly and fluke ova in the stools. Theatment consistes of Emetine hydrochloride administration for hepatic involvement and common bile duct exploration for removal of flukes, with cholecystectomy for associated cholelithiasis. The combination of medical and surgical therapy cal be expected to produce an arrest of this infection. The removed liver revealed eggs of the fasciols species in the intrahepatic bile duct. The clinical history, pathological findings and treatment of this case were described.

비호지킨림프종 환자에서 발생한 폐 효모균증 1예

장재혁,송치원,심병용,이동건,변재호,정정임,이교영,홍영선,신완식,김춘추,이경식 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

저자들은 비호지킨씨 림프종 환자에서 항암 치료 후 질환의 진행성 병변과 감별을 요했던 우폐 중엽의 단발성 종괴를 흉강경하 생검으로 폐 효모균증을 확진하고 amphotericin B와 fluconazole로 치료한 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Non-Hodgkin's lymphoma is monoclonal expansion of malignant B or T cells. The immunocompromised status in this disease is accompanied by many infections. The cryptococcosis, caused by Cryptococcus neoformans, frequently occurs in leukemia, Hodgkin's disease, sarcoidosis, diabetes mellitus, tuberculosis, and long-term steroid-using patients. Recent increasing incidence of fungal infection could be due to the spread of AIDS and transplantation. We experienced one patient with lung mass in Non-Hodgkin's lymphoma after three cycles of chemotherapy, which could not be discriminated from the newly developed lymphoma mass. Cryptococcus neoformans was isolated from the lung tissue obtained by thoracoscopic biopsy. Herein we report this case with brief review of pertinent literature.

인삼첨가 Long Life면의 조직감과 관능적 특성

정재홍,심창주,신영,권효진,이규희,오만진 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

인삼이 밀가루의 아밀로그래프에 의한 호화 성질과 파리노그래프에 의한 반죽 성질에 미치는 영향을 조사하였다. 인삼첨가 LL면의 조직감과 관능적 특성에 미치는 영향을 분석하기 위하여 밀가루에 대하여 인삼을 5.0∼10% 첨가하여 LL면을 제조한 뒤 면의 조직 특성 분석 및 조리시험을 하고 관능검사를 하였다. 인삼을 첨가하면 아밀로그래프의 호화개시 온도를 3.1℃ 지연시켰으며, 최고 점도를 40B.U 감소시켰다. 파리노그래프의 흡수율은 1.2% 증가하였으며, 반죽의 안정도는 인삼의 첨가로 2.0분 길게 측정되었다. Hunter L값은 인삼 첨가량이 증가할수록 낮아졌으며, Hunter a, b값은 반대로 측정되었다. 인삼첨가 LL면의 층밀림 압출력은 첨가량의 증가에 따라 높아져 10.0%의 첨가는 대조구 18.65(㎏f)보다 2.3(㎏f) 높은 23.95(㎏f)로 측정되었으며, 경도도 대조구보다 5.4(㎏f) 높게 측정되었다. 인삼첨가 LL면의 무게 증가는 인삼의 첨가량이 증가할 때 다소 높게 나타났으나. 부피 증가는 오히려 높게 나타나 조직이 다소 치밀한 것으로 나타났다 용출량은 인삼량의 증가에 따라 약간 감소하였다. 미생물은 인삼의 첨가량이 증가할수록 줄어들어서 장기 저장이 가능하였다. 관능 검사 결과는 인삼첨가 LL면이 4.2 및 4.0으로 비교적 좋은 점수를 얻었다. 이같이 LL면 제조시 인삼 첨가량은 7.0%의 수준이 효과가 컸다. The influence of ginseng on the paste or gelatinization properties by amylograph and mixing properties by farinograph of wheat flour, and on quality properties, color, cooking quality, textural and sensory properties, and reducing microbial population of LL (Long Life) noodles was studied. The contents of ginseng used were from 5% to 10% based on flour weight. The viscosity property of wheat flour with ginseng was increased the initial pasting temperature but the amylograph peak viscosity were decreased in vice versa. The farinograph absorption, stability and breakdown were increased by ginseng. The whiteness of LL noodles manufactured with ginseng was lower than that of control. The shear extrusion force and hardness of LL noodles manufactured with ginseng were shown much higher value than those of control. At cooking quality examination of LL noodles manufactured with ginseng, weight of cooked LL noodles was decreased but volume was appeared in vice versa. Extraction amounts of LL noodles manufactured with ginseng during cooking were much smaller than those of control. Total counts of microorganism of LL noodles manufactured with ginseng were decreased during storage at 30℃. Sensory properties of cooked LL noodles which was manufactured with ginseng showed quite acceptable. Based on the cooking and sensory evaluation test, addition of 7.0% ginseng to wheat flour may be suitable for processing LL noodles.

水深變化 및 反射率을 考廬한 港內波高分布에 관한 硏究

이홍식,지환욱,심재설 中央大學校 建設環境硏究所 1997 環境科學硏究 Vol.8 No.-

A numerical model is presented for the prediction of wave height distribution in a harbor due to the linear wave theory. The method is based upon the solution of a time-dependent analysis including wave refraction, diffraction, and arbitrary reflection coefficient by the finite difference approach. The present numerical model has been validated in several stages. The result obtained from wave shoaling effect has been compared with hydraulic experimental result presented by Ito and Tanimoto. The portion of the diffracted wave heights in a harbor has also been compared with the experimental works proposed by Nisimura et. al.. Good agreement was obtained between the present model and previously obtained results. Therefore it is concluded that the model can be applied to predict the wave height distribution in a harbor with varying depth and arbitrary reflection coefficients. Finally, a numerical example of this application for the Hwa-Sun harbor is shown.