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만성 간질환에 대한 DDB(Biphenyl Dimethyl Dicaboxylate)의 임상적 효과
이헌영,임의혁,김성걸,김진희,육은주,성자원,김병호,정형용,강대영,김영건 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2
To investigate the effects of short-term administration of DDB(Biphenyl Dimethyl Dicarboxylate) for decreasing elevated serum aminotransferase levels in chronic liver diseases, authors applied 3 capsules of DDB per day at each meal time for 35 patients and compared with 35 patients treated with other conservative management. The following results were obtained. 1. Serum alanine aminotransferase (ALT) levels significantly decreased from 247.1± 180.0 IU/L of pretreatment level to 96.6±126.0 IU/L, 61.1±62.7 IU/L and 38.0±26.8 IU/L after 1, 3 and 6 months of treatment(p<0.05) and effective rates were observed in 60.0%, 71.4% and 88.6% of patients after 1, 3 and 6 months of treatment. 2. Serum aspartate aminotransferase (AST) levels decreased also significantly from 167.8±96.9 IU/L of pretreatment levels to 124.4±155.0 IU/L, 77.9±49.6 IU/L, 60.6± 46.9 IU/L after 1, 3 and 6 months of treatment(p<0.05), but decreasing pattern of serum AST was less significant than that of serum ALT. 3. No significant difference were observed in the serum ALT and AST changes according to the cause and duration of hepatitis. 4. No significant adverse effects were observed in whole patients treated with DDB. It is suggested that small dose administration of DDB is effective for decreasing serum aminotrans ferase levels in chronic liver disease in which other conservative management was not effective.
신장내과 조기의뢰가 혈액투석 예후에 미치는 영향 : 단일 임상 기관 연구
강우헌 ( Woo Heon Kang ),오하영 ( Ha Young Oh ),신유정 ( You Jung Shin ),설정숙 ( Jeong Sook Seol ),강문자 ( Moon Ja Kang ),탁은영 ( Eun Young Tak ),이남선 ( Nam Sun Lee ),이미경 ( Mi Kyoung Lee ),류로사 ( Ro Sa Ryu ),송영혜 ( You 대한신장학회 2006 Kidney Research and Clinical Practice Vol.25 No.2
Inhibitory effects of Polygoni cuspidati rhizoma on Mast Cell-Mediated Anaphylactic Reaction
Kang, Tae-Hee,Jeung, Eun-Suk,Choi, In-Young,Jeong, Hyun-Ja,Um, Jea-Young,Kim, Hyung-Min,Hong, Seung-Heon The Korean Society of Oriental Pharmacy 2008 Journal of oriental pharmacy Vol.1 No.1
Polygoni cuspidati Rhizoma (PCRH) has been used in treatment of menoxenia, skin burn, gallstone, hepatitis, hyperlipidaemia, favus athlete's foot, supperative dermatitis and inflammation. However, its effect in experimental models remains unknown. In this present study, the effect of PCRH for stability on mast cell was analyzed. Two g/kg PCRH inhibited the compound 48/80-induced anaphylaxis by 75%. In addition, PCRH inhibited the tumor necrosis factor-$\alpha$ and interleukin-8 secretion as compared with the phorbol 12-myristate 13-acetate plus calcium ionophore A23187 stimulated human mast cell line, HMC-1 cells. These results suggested PCRH may inhibit mast cell-mediated anaphylactic reaction.