[논문]부산 시내 터널 내 총분진 농도 조사

구동철,문지용,정기호 부산대학교 환경문제연구소 2004 環境硏究報 Vol.22 No.-

The Survey of Dust Levels in Tunnels Located in Busan Metropolitan City

대구 성서지역 악취 민원발생일의 기상학적 특성

김해동,구현숙,정우식,최성우,안지숙,박명희 한국환경과학회 2003 한국환경과학회지 Vol.12 No.10

We studied the relationship between a civil affair occurrence of bad smell and meteorological conditions around Seongseo district for recent 2 years. The results were as follows; (1) The civil affair occurrence days of bad smell were concentrated from May to August. (2) Daily mean temperatures were mostly 20~28℃ and daily mean relative humidities were 60~80%. (3) Wind speeds were mostly less than 2m/s(75%). and wind directions were southerly winds(50%). It was hardly occurred for relatively well-ventilated conditions in cases of wind speeds 2m/s over. And the Lagrangian particle dispersion model were used to figure out the transport route in a civil affairoccurrence days of bad smell. It was found that the south-western winds transported the bad smelling materials from Jungni-dong(the place of source) to the housing complex located along a piedmont district.

연골막판으로 싼 정제된 산호의 조직학적 연구

김지수,손대구,한기환,최동원,박관규 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

Autogenous costal cartilage graft has been commonly used for reconstruction of auricular deformity. However, the risk of complication and discomfort at the donor site, as well as distortion of the graft due to morphological change in the cartilage have been serious drawbacks to this procedure. Previous studies examining the chondrogenic potential of perichondrium have suggested that perichondrium may be used as graft for cartilage reconstruction. When a perichondrial flap or a free perichondrium was used as graft, new cartilage formed appositional to the grafted perichondrium. However, the neocartilage was often irregular in shape and varied considerably in quantity. In this study, the feasibility of controlling the shape and the mass of neocartilage was investigated using coral, a porous biomaterial, as a template. A coral a template was wrapped with perichondrial flap from the ears of New Zealand white rabbits and placed into a subcutaneous pocket in the rabbits and placed into a subcutaneous pocket in the rabbit's back by incision. A total of 12 animals were used. Formation of new cartilage was later evaluated by gross and histological examination of the perichondrial flap and the coral template. New cartilage was formed in 11 animals. Immature chondrocytes were visible by 3 weeks after the surgery, and by 8 weeks the immature chondrocytes had formed a cartilage. New cartilage was formed only on the surface of the coral template. These results indicated that the shape and the mass of new cartilage may be controlled by using coral template. Therefore, the desired shape of cartilage may be achieved using a coral template of corresponding shape, and this may help in correcting subtle auricular contour defect and in correcting other structural defects that also require new cartilage formation.

히스토아크릴을 이용한 십이지장 궤양 출혈의 지혈 후 발생한 급성췌장염

유재훈,문원,노지훈,구동영,조영화,김기수,윤준모 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Upper gastrointestinal bleeding is common and potentially life threatening medical emergency. Emergency endoscopy is the first choice of diagnostic and treatment measure for patients with active upper gastrointestinal bleeding. Histoacryl should be considered a second-line treatment modality when conventional treatments were failed. However, it might cause several complications. Herein, we report a case of acute pancreatitis developed after histoacryl injection therapy for active duodenal ulcer bleeding. A 71-year-old man was admitted with melena and hematemesis. On emergency endoscopy, a 2 cm sized active ulcer with bleeding from an exposedvessel was seen at the duodenal bulb. Attempts to arrest the bleeding with hemoclipping and submucosal epinephrine injection were tried, but failed. We changed the method to endoscopic histoacryl injection, and obtained hemostasis immediately. A few hourslater, after successful hemostasis, patient complained diffuse abdominal pain. Ultrasonography revealed hyperechoic heterogenous diffuse pancreatic enlargement and right pararenal space fluid collection, this ultrasonographic findings and elevated serum pancreatic enzymes are compatible with acute pancreatitis.

농촌지역 노인들의 우울증상에 관련된 요인들의 특성

송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2

This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

말끝 부분의 발음 길이가 청자에게 미치는 영향 분석

조동욱(Dong-Uk Cho),최지현(Ji-Hyun Choi),유호석(Ho-Seok You),김동하(Dong-Ha Kim),지호(Ho Ji),김종구(Jong-Gu Kim),김봉현(Bong-Hyun Kim) 한국통신학회 2015 한국통신학회 학술대회논문집 Vol.2015 No.1

Obesity is a risk factor for thyroid cancer in a large, ultrasonographically screened population

Han, Ji Min,Kim, Tae Yong,Jeon, Min Ji,Yim, Ji Hye,Kim, Won Gu,Song, Dong Eun,Hong, Suck Joon,Bae, Sung Jin,Kim, Hong-Kyu,Shin, Myung-Hee,Shong, Young Kee,Kim, Won Bae European Federation of Endocrine Societies 2013 European journal of endocrinology Vol.168 No.6

<P><B>Objective</B></P><P>Obesity is a well-known risk factor for many cancers, including those of the esophagus, colon, kidney, breast, and skin. However, there are few reports on the relationship between obesity and thyroid cancer. We conducted this study to determine whether obesity is a risk factor for thyroid cancer by systematically screening a selected population by ultrasonography.</P><P><B>Design and methods</B></P><P>We obtained data from 15 068 subjects that underwent a routine health checkup from 2007 to 2008 at the Health Screening and Promotion Center of Asan Medical Center. Thyroid ultrasonography was included in the checkup, and suspicious nodules were examined by ultrasonography-guided aspiration. Those with a history of thyroid disease or family history of thyroid cancer were excluded from this study.</P><P><B>Results</B></P><P>In total, 15 068 subjects, 8491 men and 6577 women, were screened by thyroid ultrasonography. Fine-needle aspiration cytology was performed in 1427 of these patients based on the predefined criteria and thyroid cancer was diagnosed in 267 patients. The prevalence of thyroid cancer in women was associated with a high BMI (per 5 kg/m<SUP>2</SUP> increase) (odds ratios (OR)=1.63, 95% CI 1.24–2.10, <I>P</I><0.001), after adjustment for age, smoking status, and TSH levels. There was no positive correlation between the prevalence of thyroid cancer in men and a high BMI (OR=1.16, 95% CI 0.85–1.57, <I>P</I>=0.336). There was no association between age, fasting serum insulin, or basal TSH levels and thyroid cancer in either gender.</P><P><B>Conclusions</B></P><P>Obesity was associated with a higher prevalence of thyroid cancer in women when evaluated in a routine health checkup setting. This association between risk factor and disease was unrelated to serum insulin and TSH levels. Additional studies are needed to understand the mechanism(s) behind the association of obesity with thyroid cancer risk.</P>

Association Between Expression of X-Linked Inhibitor of Apoptosis Protein and the Clinical Outcome in a <i>BRAF^V600E</i>-Prevalent Papillary Thyroid Cancer Population

Yim, Ji Hye,Kim, Won Gu,Jeon, Min Ji,Han, Ji Min,Kim, Tae Yong,Yoon, Jong Ho,Hong, Suck Joon,Song, Dong Eun,Gong, Gyungyub,Shong, Young Kee,Kim, Won Bae Mary Ann Liebert 2014 Thyroid Vol.24 No.4

<P>Background: The X-linked inhibitor of apoptosis protein (XIAP) is associated with carcinogenesis, cancer progression, and metastasis through inhibition of the caspase-mediated apoptotic pathway. The BRAF(V600E) mutation is the most common genetic alteration and an established prognostic marker in papillary thyroid cancer (PTC). The prevalence of the BRAF mutation is very high and is up to 80% in Korean PTC patients. In the present study, we evaluated the potential role of XIAP expression as a novel prognostic marker to predict recurrence, in combination with the BRAF(V600E) mutational status. Methods: The study enrolled 164 patients with conventional PTC who underwent bilateral thyroidectomy followed by immediate I-131 ablation. The presence of the BRAF(V600E) mutation was evaluated by direct sequencing. The degree of XIAP expression was evaluated by immunohistochemical (IHC) staining using a monoclonal antibody. Results: The BRAF(V600E) mutation was found in 123 of 164 patients (75%) with classical PTC. XIAP expression was positive in 128 of 164 patients (75%), and positive XIAP expression was significantly associated with the presence of lateral cervical lymph node metastases (p=0.01). XIAP expression was more frequent in BRAF(V600E) mutated PTCs than in BRAF wild type PTCs (p=0.048). The BRAF(V600E) mutation was significantly associated with cancer recurrence in study subjects (hazard ratio=2.98, p=0.039). PTCs positive for the BRAF(V600E) mutation but negative for XIAP expression had a significantly higher rate of recurrent PTC (hazard ratio=4.53, p=0.012). Conclusion: The evaluation of XIAP expression and BRAF mutational analysis was more useful for the prediction of cancer recurrence in patients with PTC than BRAF genotype alone.</P>

인산염 대체제로서 치아씨드가 첨가된 건조 소시지의 품질 특성

신동민(Dong-Min Shin),김예지(Yea Ji Kim),김동현(Dong Hyun Kim),정현수(Hyun Su Jung),한서구(Seo Gu Han),한종현(Jong Hyeon Han),박해정(Hae Jung Park),한성구(Sung Gu Han) 한국축산식품학회 2021 Food and Life Vol.2021 No.3

Phosphate is a widely used food additive for manufacturing processed meat product due to its water holding capacityby increasing the pH of meat batter. However, excessive phosphate consumption has been associated with the occurrenceof some diseases including metabolic bone disease and chronic kidney disease. Therefore, this study evaluatedthe quality properties of chia seed (CS) as a replacement for phosphate in dry sausage. CS [1%–3% (w/w)] was addedto produce dry sausage as a phosphate replacer. Quality characteristics including pH, emulsion stability and lipid oxidationwere significantly improved in CS-added dry sausage, compared with phosphate free-dry sausage (p<0.05). The lowerlightness, redness and yellowness of CS significantly reduced color parameters of dry sausages (p<0.05). Particularly,addition of 3% CS has the highest apparent viscosity and the lowest shear force among the groups (p<0.05). Collectively,our data suggest that CS can replace phosphate in dry sausage without compromising quality characteristics.