급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

시험관내에서 당화시킨 인슐린의 생체내 활성

김성완,김성연,조보연,이홍규,고창순,민헌기,이문규,김철희,민용기,장학철,정대원,배철민 대한당뇨병학회 1990 Diabetes and Metabolism Journal Vol.14 No.2

고온에서의 Fe-C-S 합금 중 Cu 의 열역학적 거동에 관한 연구

민동준,허기행,김대환,이창희 대한금속재료학회(대한금속학회) 1998 대한금속·재료학회지 Vol.36 No.12

The thermodynamic behavior of copper in molten Fe-C-S alloy at high temperature was investigated by chemical equilibrating technique. The effects of copper, carbon, sulfur content and temperature on the activity coefficient of copper in molten pure iron and carbon saturated were was determined by measuring the distribution ratio between silver and Fe-C-S-Cu alloy. The activity coefficient of copper in molteniren and carbon saturated iron at infinite dilution of copper were measured 11.02 and 28.50 at 1823K respectively. The interaction parameter between copper and copper, sulfur and carbon in molten iron at 1823K, was estimated as follows; ε^(Cu)_(Cu) = -4.80, ε^S_(Cu) = -2.544, ε^C_(Cu) = -4.60 The dependence of the activity coefficient in molten Fe-C alloy on temperature was determined as follows; For molten pure iron : lnγ^(oFe)_(Cu) = 4370/T For Fe-2wt%C : lnγ^(oFe-2wt%C)_(Cu) = 0.72 + 3840/T For carbon saturated iron : lnγ^(oFe_C)_(Cu) = 1.11 + 4100/T Combining the effect of temperature and the alloying component, the activity coefficient of copper could be expressed as follows ; lnγ^(Fe-C-S)_(Cu) = 4370/T·(1-X_(Cu))² + (2.15 + 4600/T)·2.54·X_s The possibility of removal of copper from steel by slag refing and evaporating technique was discussed.

슬래그중 고체철의 산화거동에 관한 속도론적 고찰

백종문,이홍기,고정호,민동준 대한금속재료학회(대한금속학회) 1998 대한금속·재료학회지 Vol.36 No.12

The kinetic experiments have been made on iron oxidation in slag by oxidizing gases at 1387∼1500℃. The effect of temperature, FeO content and oxygen potential of gas on the reaction rate have been examined. The iron oxidizing rate is considerably increased with increasing temperature and FeO content in slag. It was also found that the rate controlling step of reaction have been depended on the temperature, FeO content in slag and (P_(co₂)/P_(co) as an oxygen potential at gas/slag interface. The dependence of the overall reaction rate constant on temperature and initial FeO content in slag at 1450℃ could be expressed as follows; log k_(overall) = -0.36-10,820/T[㏖/㎠·sec·atm] k_(overall) = 1.04×10^(-7)(wt%FeO)^(0.75)[㏖/㎠·sec·atm] In condition of high oxygen potential such as high FeO content and (P_(co₂)/P_(co)), the chemical reaction at interface between slag and gas might play a important role as a rate controlling step of overall reaction, which is controlled by the dissociation of CO₂ at slag/gas interface. But in case of low (P_(co₂)/P_(co)), mass transfer and chemical reaction at interface between slag and iron become important as a rate controlling step. The reaction mechanism of iron oxidization in slag by gas have been discussed in terms of rate constant for elementary reactions.

지적적(持績的)인슐린 피하투여법에 의한 제일형(第一形)당뇨법(糖尿法)의 치료가 인슈린 감수성에 미치는 영향

민헌기,최수봉,이홍규 대한당뇨병학회 1983 Diabetes and Metabolism Journal Vol.7 No.1

당뇨병 환자에서의 혈중 Apolipoprotein(a)의 농도

김해엽,장학철,김치정,민용기,김상우,안용진,한인권 대한당뇨병학회 1991 Diabetes and Metabolism Journal Vol.15 No.2

당뇨병(糖尿病)내복약의 부작용 및 대책

강성구,민병석 대한당뇨병학회 1984 Diabetes and Metabolism Journal Vol.8 No.1

한강수계의 오염현황에 관한 연구

정팔진,민경석,이찬기 고려대학교 공학기술연구소 1976 고려대학교 생산기술연구소 연구보고 Vol.8 No.1

The water quality of the Han river which has been serving as a major water source for 'the Seoul Metropolitan area is discussed in this paper in terms of D0, BOD and others. The water quality upstream of the Jungryang-chun junction to Paldang was favorable during the investigation period: June 6 to July 27, 1977 with a flow range from 175 to 648㎥/sec. However, DO and BOD values were increased toward the downstream from the Jungryang-chun junction. The water quality downstream of the 2nd Han river bridge could not be simply interpreted due to the tidal effect.

대장 선종과 Apolipoprotein E 유전형과의 관계

김영호,최윤호,손희정,강태욱,최규완,최봉준,이종철,박상종,이지민,배문희,김재준,이풍렬 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1

Background/Aims: Apolipoprotein B polymorphism plays an important role in the metabolism of cholesterol. And bile acids, which may be related to the development of colorectal adenomas, An association between apolipoprotein B genotype and colonic adenomas bas been reparted in a western country. This study was designed to determine whether the apolipopratein S was genotype would be associated with proximal or distal colonic adenomas in Koreans. Methods: On the colonoscopy, colonic adenomas were found in 132 patients. Proxima1 colonic adenoma was found in 35 patients and distal colonic adenoma was found in 97 patients. Serum leveis of total cholesterol, LDL-cholesterol, HDL-cholesterol and trlglyceride were measured. Apolipoprotein E genotype was determined by PCR and allele specific oligonucleotide hybridization. 279 contro1 subjects without an adenoma on the screening sigmoidoscopy were se1ecfed randomly. Results: The serum levels of total choles0'rol, LDL-cholesterol, HDL-cholesterol and triglyceride did not significantiy differ between each adenoma group and control group. The individual frequencies of ε2, ε3 and ε4 alleles in patients with colonic adenomas did not differ from those in control subjects. The frequency of either heterozygote or homozygote for g 4 allele in patients with proximal adenoma was lower than that in control subjects (0.029 vs O.I68, p $lt; 0.05). Conclnsions: The data suggest that g 4 allele may be associated with a lower risk for the development of proximal colonic adenoma in Korean men.

활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적, 생화학적, 병리학적 인자들에 관한 연구

김영호,장재권,김지은,최규완,박동일,도재혁,백승운,고광철,이풍렬,이종철,현재근,안병훈,김재준,류민규 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6

Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.