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      • KCI등재후보

        비만 Zucker(fa/fa) 랫드에서 주령에 따른 지방대사 관련 혈액 생화학성분, 호르몬 및 체지방 합성 유전자의 변화

        장인석(InSurk Jang),황대연(Dae Youn Hwang),채갑용(Kab Ryong Chae),이주은(Ju Eun Lee),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2

        The aim of the present study was to investigate the age-related onset of obesity in obese Zucker(fa/fa) rats as indicated by adipogenic biomarkers and genes. The Zucker rats aged 6, 8, 10, 12, and 16 wk were used to determine age-related changes in biochemical components including triglyceride, glucose, cholesterol, insulin and leptin in serum, and the expression of adipogenic genes such as acetyl CoA carboxylase (ACC) and peroxisome proliferator activated receptor y (PPARγ) in the epididymal fat pads. As a result, the serum levels of glucose and cholesterol did not significantly affected by ages. However, the level of triglyceride in serum resulted in a significant (p<0.05) increase after 8 wk of age and stayed at this level till 16 wk of age we examined. The level of insulin at 6 wk of age was significantly (p<0.05) lower than any other ages examined. Also, the Zucker rats aged 16 wk showed a markedly (p<0.05) higher serum leptin level when compared with the rats aged 6 and 8 wk. Especially, leptin level at 16 wk of age increased by a two-fold as compared with that at 6 wk old. We also observed age-related differences in the expressions of ACC and PPARy in the epididymal fats. In particular, ACC mRNA expression did show much of an age-associated alteration in fat tissues. The PPARγ expression in rats aged 6 wk was to be much lower (p<0.05) compared with the rats aged 8, 10, 12 and 16 wk. From the evidences we observed here, it is suggested that preobese status at 6 wkold Zucker(fa/fa) rats rapidly developed obesity around at 8 wk of age as indicated by biomarkers and consequently showed pathophysiological symptom of obesity after 8 wk of age.

      • KCI등재

        육계 사료 내 매실 및 오미자 첨가가 성장, 혈액 생화학 성분 및 항산화 작용에 미치는 영향

        고영현(Young-Hyun Ko),문양수(Yang-Soo Moon),손시환(Sea-Hwan Sohn),정장용(Chang-yong Jung),장인석(Insurk Jang) 韓國家禽學會 2012 韓國家禽學會誌 Vol.39 No.2

        To investigate the effect of dietary supplementation of freeze-dried plum (Prunus mume Siebold and Zucc., PMS) or omija meal (Schizandra chinensis Baill.; SCB) on growth performance, organ weights, blood biochemical profiles and antioxidant defense system, a total of 96, 3-day-old male broiler chickens were assigned to three dietary groups: (1) control diet, (2) control diet supplemented with PMS at 0.2%, (3) control diet supplemented with SCB at 0.2%. In vitro antioxidant activity, plum and omija extracts showed a significantly higher radical scavenging activity (RSA). In particular, omija extract showed much higher RSA than plum extract. Dietary addition of plum or omija did not affect body weight, feed intake, feed conversion and the relative weight of digestive organ in birds. Plasma triglyceride significantly (P<0.05) increased in birds fed the diet supplemented with omija compared with those fed control diet without affecting the other blood biochemical components. Furthermore, reduced form of glutathione (GSH) in the liver or muscle significantly (P<0.05) increased in birds fed the diet fortified with plum and omija. However, the specific activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) and MDA (malondealdehyde) in the intestine, liver and muscle were not altered by dietary antioxidant sources. In conclusion, dietary plum and omija resulted in a positive effect on some antioxidant indicators such as increased in vitro RAS in extracts and in vivo GSH level in the liver and muscle without affecting growth performance. Therefore, dietary addition of 0.2% of plum or omija could be applicable as potential antioxidant sources in broiler chick production.

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