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Song, K.J.,Ko, R.K.,Kim, H.S.,Ha, H.S.,Ha, D.W.,Oh, S.S.,Park, C.,Yoo, S.-I.,Kim, M.W.,Kim, C.J.,Joo, J.H. Institute of Electrical and Electronics Engineers 2007 IEEE transactions on applied superconductivity Vol.17 No.2
<P>The degree of ferromagnetism of Ni-W<SUB>y</SUB> alloys decreases as W-content y increases. Both the saturation magnetization <I>M</I> <SUB>sat</SUB> and Curie temperature <I>T</I> <SUB>c</SUB> decrease linearly with W-content y, and both <I>M</I> <SUB>sat</SUB> and <I>T</I> <SUB>c</SUB> go to zero at critical concentration of y<SUB>c</SUB> ~9.50 at.% W. To compare with Ni-W alloys, the magnetic properties of a series of both as-rolled (non-textured) and annealed (biaxially textured) [Ni<SUB>97at.%</SUB>-W<SUB>3at.%</SUB>]<SUB>100-x</SUB>-Cu<SUB>x</SUB> alloy tapes with compositions x = 0, 1, 3, 5, and 7 at.%, were studied. Characterization methods included XRD analyses to investigate the biaxial texturing of the annealed [Ni-W]-Cu alloy tapes and studies of the magnetization for both as-rolled and annealed [Ni-W]-Cu alloy tapes. Both the isothermal mass magnetizations <I>M</I>(<I>H</I>) of a series of samples at different fixed temperatures and <I>M</I>(<I>T</I>) in fixed field, were measured. The effect of Cu addition on both the saturation magnetization and Curie temperature T<SUB>c</SUB> of the Ni<SUB>97at.%</SUB>-W<SUB>3at.%</SUB> alloy was investigated.</P>
Park, S R,Kong, S-Y,Nam, B-H,Choi, I J,Kim, C G,Lee, J Y,Cho, S J,Kim, Y W,Ryu, K W,Lee, J H,Rhee, J,Park, Y-I,Kim, N K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7
<P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>
Anoop, G.,Cho, I. H.,Suh, D. W.,Yoo, J. S. WILEY‐VCH Verlag 2012 Physica status solidi. PSS. A, Applications and ma Vol.209 No.12
<P><B>Abstract</B></P><P>Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were synthesized using high temperature solid state reaction. The effect of Ba incorporation on the structural and luminescence characteristics of SrSi<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors were studied. The phosphors were crystallized in triclinic crystal structure and the cell volume increases monotonically with Ba addition. The PL emission peak wavelength red shifts with Ba up to <I>x</I> = 0.50 beyond which no red shift is observed. The XPS analysis shows that nitrogen is being incorporated into the host lattice along with Ba addition up to <I>x</I> = 0.50. The as synthesized phosphors show high thermal stability. Phosphor converted light emitting diodes were realized using Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu<SUP>2+</SUP> phosphors (<I>x</I> = 0 and <I>x</I> = 0.40) showing luminance efficacies of 108 and 101 lm W<SUP>−1</SUP>. </P><P>The CIE chromaticity coordinates of Sr<SUB>1−<I>x</I></SUB>Ba<SUB><I>x</I></SUB>Si<SUB>2</SUB>O<SUB>2</SUB>N<SUB>2</SUB>:Eu (<I>x</I> = 0 and <I>x</I> = 0.40) phosphors.</P>
Brogan, C. L.,Goss, W. M.,Hunter, T. R.,Richards, A. M. S.,Chandler, C. J.,Lazendic, J. S.,Koo, B.-C.,Hoffman, I. M.,Claussen, M. J. IOP Publishing 2013 The Astrophysical journal Vol.771 No.2
<P>We present a comprehensive view of the W51B H II region complex and the W51C supernova remnant (SNR) using new radio observations from the VLA, VLBA, MERLIN, JCMT, and CSO along with archival data from Spitzer, ROSAT, ASCA, and Chandra. Our VLA data include the first lambda = 400 cm (74 MHz) continuum image of W51 at high resolution (88 ''). The 400 cm image shows non-thermal emission surrounding the G49.2-0.3 H II region, and a compact source of non-thermal emission (W51B_NT) coincident with the previously-identified OH (1720 MHz) maser spots, non-thermal 21 and 90 cm emission, and a hard X-ray source. W51B_NT falls within the region of high likelihood for the position of TeV gamma-ray emission. Using the VLBA, three OH (1720 MHz) maser spots are detected in the vicinity of W51B_NT with sizes of 60-300 AU and Zeeman effect magnetic field strengths of 1.5-2.2 mG. The multiwavelength data demonstrate that the northern end of the W51B HII region complex has been partly enveloped by the advancing W51C SNR and this interaction explains the presence of W51B_NT and the OH masers. This interaction also appears in the thermal molecular gas which partially encircles W51B_NT and exhibits narrow pre-shock (Delta v similar to 5 km s(-1)) and broad post-shock (Delta v similar to 20 km s(-1)) velocity components. RADEX radiative transfer modeling of these two components yield physical conditions consistent with the passage of a non-dissociative C-type shock. Confirmation of the W51B/W51C interaction provides additional evidence in favor of this region being one of the best candidates for hadronic particle acceleration known thus far.</P>
Baek, J.O.,Seo, J.W.,Kwon, O.,Park, S.M.,Kim, C.H.,Kim, I.H. Elsevier 2012 Enzyme and microbial technology Vol.50 No.3
<P><B>Abstract</B></P><P>We developed a bacterial expression system to produce human papillomavirus (HPV) type 33 L1 major capsid protein and virus-like particles from a recombinant <I>Bacillus subtilis</I> strain. For the first time, we have isolated self-assembled virus-like particles (VLPs) of HPV type 33 from <I>B. subtilis</I>, a strain generally recognized as safe (GRAS). The gene encoding the major capsid protein L1 of HPV type 33 was amplified from viral DNA isolated from a Korean patient and expressed in <I>B. subtilis</I>; a xylose-induction system was used to control gene activity. HPV33 L1 protein was partially purified by 40% (w/v) sucrose cushion centrifugation and strong cation exchange column chromatography. Eluted samples exhibited immunosignaling in fractions of 0.5–1.0M NaCl. The HPV33 L1 protein was shown to be approximately 56kDa in size by SDS-PAGE and Western blotting; recovery and purity were quantified by indirect immuno-ELISA assay. The final yield and purity were approximately 20.4% and 10.3%, respectively. Transmission electron microscopic analysis of fractions immunoactive by ELISA revealed that the L1 protein formed self-assembled VLPs with a diameter of approximately 20–40nm. Humoral and cellular immune responses provoked by the <I>B. subtilis</I>/HPV33 L1 strain were approximately 100- and 3-fold higher than those of the empty <I>B. subtilis</I> strain as a negative control, respectively. Development of a VLP production and delivery system using <I>B. subtilis</I> will be helpful, in that the vaccine may be convenient production as an antigen delivery system. VLPs thus produced will be safer for human use than those purified from Gram-negative strains such as <I>Escherichia coli</I>. Also, use of <I>B. subtilis</I> as a host may aid in the development of either live or whole cell vaccines administered by antigen delivery system.</P>
Liyanage, D.S.,Omeka, W.K.M.,Yang, Hyerim,Godahewa, G.I.,Kwon, Hyukjae,Nam, Bo-Hye,Lee, Jehee Elsevier 2019 Fish & shellfish immunology Vol.86 No.-
<P><B>Abstract</B></P> <P>Thioredoxin domain-containing protein 17 (TXNDC17) is a small protein (∼14 kDa) involved in maintaining cellular redox homeostasis via a thiol-disulfide reductase activity. In this study, TXNDC17 was identified and characterized from <I>Hippocampus abdominalis</I>. The open reading frame (ORF) consisted of 369 bp and 123 amino acids. Similar to the other thioredoxins, TXNDC17 contained a conserved WCXXC functional motif. The highest spatial mRNA expressions of <I>HaTXNDC17</I> were observed in the muscle, brain, and intestine. Interestingly, the mRNA expression of <I>HaTXNDC17</I> in blood showed significant upregulation at 48 h against all the pathogen associated molecular patterns (PAMPs) and bacteria. Further, <I>HaTXNDC17</I> transcripts in the trunk kidney were significantly upregulated at 24–48 h by bacterial endotoxin lipopolysaccharides (LPS), viral mimic polyinosinic: polycytidylic acid (poly I:C), and gram-negative bacteria (<I>Edwardsiella tarda</I>). The DPPH assay showed that the radical scavenging activity varies in a concentration-dependent manner. The insulin reduction assay demonstrated a significant logarithmic relationship with the concentration of rHaTXNDC17. Moreover, FHM cells treated with recombinant HaTXNDC17 significantly enhanced cellular viability under oxidative stress. Together, these results show that HaTXNDC17 function is important for maintaining cellular redox homeostasis and that it is also involved in the immune mechanism in seahorses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Big-belly seahorse thioredoxin domain containing protein 17 maintain redox homeostasis. </LI> <LI> TXNDC17 is ubiquitously found in cytosol and extracellular space. </LI> <LI> Thiol active CXXC conserved motif consists in HaTXNDC17. </LI> <LI> Spatial and temporal mRNA expression was evaluated. </LI> <LI> Radical scavenging ability, antioxidant activity and cellular viability were measured. </LI> </UL> </P>
W. K. Meegahawaththa(W. K. Meegahawaththa ),I. D. Singhalage(I. D. Singhalage ),D. C. Mudannayake(D. C. Mudannayake ) 한국축산식품학회 2020 Food and Life Vol.2020 No.2
Lycopene is the principle carotenoid responsible for red pigment in tomato. Lycopene is proven to indicate many health promoting properties due to its free radical quenching effects in human body. Tomato peel is a rich source of lycopene which can be used as a natural antioxidant and colorant in foods. Tomato peels were freeze dried, pulverized and sieved to prepare fine, light orange colored tomato peel powder. Tomato peel powder (TPP) was analyzed for radical scavenging activity (RSA), total phenolic content (TPC) and total carotenoid yield. Fourier transform infra-red spectroscopy (FTIR) and UV-visible (UV-VIS) spectrum analysis were carried out for TPP comparing with extracted and commercial lycopene. Two batches of stirred yoghurts were prepared by adding TPP at levels of 0%, 2%, 4%, 6%, and 8% (w/w), before fermentation and after fermentation and analyzed for RSA and color. RSA (%) and TPC of tomato peel powder were 50.05±0.66% and 0.38±0.01 mg of gallic acid equivalent per gram of sample (mg GAE g–1), respectively. Total carotenoid yield of the TPP was 7.14±0.01 mg g–1. FTIR and UV-VIS spectrum data confirmed the presence of lycopene in TPP. Significantly higher (p <0.05) overall acceptability was shown by the stirred yoghurt contained 2% TPP. RSA of the stirred yoghurt were significantly increased with the increasing level of TPP. Tomato peel powder (8%) added stirred yoghurt showed the highest color value for redness (18.83±0.37). Results revealed that TPP can be successfully incorporated into stirred yoghurt as a natural antioxidant and a colorant.