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        Induction of bone formation by <i>Escherichia coli</i>‐expressed recombinant human bone morphogenetic protein‐2 using block‐type macroporous biphasic calcium phosphate in orthotopic and ectopic rat models

        Park,,J‐,C.,So,,S‐,S.,Jung,,I‐,H.,Yun,,J‐,H.,Choi,,S‐,H.,Cho,,K‐,S.,Kim,,C‐,S. Blackwell Publishing Ltd 2011 Journal of periodontal research Vol.46 No.6

        <P><I>Park J‐C, So S‐S, Jung I‐H, Yun J‐H, Choi S‐H, Cho K‐S, Kim C‐S. Induction of bone formation by</I> Escherichia coli<I>‐expressed recombinant human bone morphogenetic protein‐2 using block‐type macroporous biphasic calcium phosphate in orthotopic and ectopic rat models. J Periodont Res 2011; 46: 682–690. © 2011 John Wiley & Sons A/S</I></P><P><B>Background and Objective: </B> The potential of the <I>Escherichia coli</I>‐expressed recombinant human bone morphogenetic protein‐2 (ErhBMP‐2) to support new bone formation/maturation using a block‐type of macroporous biphasic calcium phosphate (bMBCP) carrier was evaluated in an orthotopic and ectopic rat model.</P><P><B>Material and Methods: </B> Critical‐size (Φ 8 mm) calvarial defects and subcutaneous pockets in 32 Sprague–Dawley rats received implants of rhBMP‐2 (2.5 μg) in a bMBCP carrier or bMBCP alone (control). Implant sites were evaluated using histological and histometric analysis following 2‐ and 8‐wk healing intervals (eight animals/group/interval).</P><P><B>Results: </B> ErhBMP‐2/bMBCP supported significantly greater bone formation at 2 and 8 wk (10.8% and 25.4%, respectively) than the control at 2 and 8 wk (5.3% and 14.0%, respectively) in calvarial defects (<I>p</I> < 0.01). Bone formation was only observed for the ErhBMP‐2/bMBCP ectopic sites and was significantly greater at 8 wk (7.5%) than at 2 wk (4.5%) (<I>p</I> < 0.01). Appositional and endochondral bone formation was usually associated with a significant increase in fatty marrow at 8 wk. The bMBCP carrier showed no evidence of bioresorption.</P><P><B>Conclusion: </B> ErhBMP‐2/bMBCP induced significant bone formation in both calvarial and ectopic sites. Further study appears to be required to evaluate the relevance of the bMBCP carrier.</P>

      • <i>CYP2A6</i> and <i>ERCC1</i> polymorphisms correlate with efficacy of S-1 plus cisplatin in metastatic gastric cancer patients

        Park,,S,R,Kong,,S-Y,Nam,,B-H,Choi,,I,J,Kim,,C,G,Lee,,J,Y,Cho,,S,J,Kim,,Y,W,Ryu,,K,W,Lee,,J,H,Rhee,,J,Park,,Y-I,Kim,,N,K Nature Publishing Group 2011 The British journal of cancer Vol.104 No.7

        <P><B>Background:</B></P><P>We evaluated the association between polymorphisms of cytochrome P450 2A6 (<I>CYP2A6</I>)/excision repair cross-complementation group 1 (<I>ERCC1</I>)/X-ray repair cross-complementing group 1(<I>XRCC1</I>) and treatment outcomes of metastatic gastric cancer (MGC) patients treated with S-1/cisplatin.</P><P><B>Methods:</B></P><P>Among MGC patients (<I>n</I>=108), who received S-1 (40 mg m<SUP>−2</SUP> b.i.d., days 1–14) and cisplatin (60 mg m<SUP>−2</SUP>, day 1) every 3 weeks, we analysed the wild-type allele (<I>W</I>) and variants (<I>V</I>) of <I>CYP2A6</I> (<I>*4</I>, <I>*7, *9, *10</I>), and the polymorphisms of <I>ERCC1</I> (rs11615, rs3212986) and <I>XRCC1</I> (rs25487).</P><P><B>Results:</B></P><P>Patients having fewer <I>CYP2A6</I> variants had better response rates (<I>W</I>/<I>W vs W</I>/<I>V</I> other than <I>*1/*4 vs V</I>/<I>V</I> or <I>*1/*4</I>=66.7 <I>vs</I> 58.3 <I>vs</I> 32.3% <I>P</I>=0.008), time to progression (TTP) (7.2 <I>vs</I> 6.1 <I>vs</I> 3.5 months, <I>P</I>=0.021), and overall survival (23.2 <I>vs</I> 15.4 <I>vs</I> 12.0 months, <I>P</I>=0.004). <I>ERCC1 19442C</I>><I>A</I> (rs3212986) was also associated with response rate (<I>C/C</I>, 46.7% <I>vs C/A</I>, 55.3% <I>vs A/A</I>, 87.5%) (<I>P</I>=0.048) and TTP (4.4 <I>vs</I> 7.6 <I>vs</I> 7.9 months) (<I>P</I>=0.012). Patients carrying both risk genotypes of <I>CYP2A6</I> (<I>V</I>/<I>V</I> or <I>1/*4</I>) and <I>ERCC1 19442C</I>><I>A</I> (<I>C/C</I>) <I>vs</I> those carrying none showed an adjusted odds ratio of 0.113 (<I>P</I>=0.004) for response, and adjusted hazard ratios of 3.748 (<I>P</I>=0.0001) for TTP and 2.961 (<I>P</I>=0.006) for death.</P><P><B>Conclusion:</B></P><P>Polymorphisms of <I>CYP2A6</I> and <I>ERCC1 19442C</I>><I>A</I> correlated with the efficacy of S-1/cisplatin.</P>

      • Bacteriophage cocktail and multi-strain probiotics in the feed for weanling pigs: effects on intestine morphology and targeted intestinal coliforms and <i>Clostridium</i>

        Kim,,J.,S.,Hosseindoust,,A.,Lee,,S.,H.,Choi,,Y.,H.,Kim,,M.,J.,Lee,,J.,H.,Kwon,,I.,K.,Chae,,B.,J. Cambridge University Press 2017 Animal Vol.11 No.1

        <P>Two experiments were conducted to investigate the effects of dietary supplementation of bacteriophage cocktail, probiotics and a combination of these two supplements on performance and gut health of weanling pigs. In Experiment 1, 150 weaned piglets were randomly allotted to three treatments on the basis of BW. The dietary treatments included a basal diet supplemented with 0 (control), 1.0 and 1.5 g/kg bacteriophage cocktail. Pigs fed 1.0 and 1.5 g/kg bacteriophage product had greater (<I>P</I><0.05) average daily gain (ADG), apparent total tract digestibility of dry matter from day 22 to 35, ileal <I>Lactobacillus</I> spp., villus height (duodenum and jejunum), and fewer coliforms (ileum) and <I>Clostridium</I> spp. (ileum). In Experiment 2, 200 weaned piglets were randomly allotted to four treatments. Dietary treatments included basal diet, basal diet supplemented with 3.0 g/kg fermented probiotic product (P), 1.0 g/kg bacteriophage cocktail (B) and combination of 1.0 g/kg bacteriophage cocktail and 3.0 g/kg fermented probiotic product. Pigs fed bacteriophage cocktail diets had greater (<I>P</I><0.05) overall ADG, gain to feed ratio (G : F), fecal score from day 8 to day 21, and pigs fed bacteriophage cocktail diets had fewer coliforms (ileum) <I>Clostridium</I> spp. (ileum and cecum). Probiotics significantly increased G : F, colonization of <I>Lactobacillus</I> spp. in ileum. At day 35, bacteriophage treatment group showed greater (<I>P</I><0.05) villus height of the duodenum, but a deeper crypt in duodenum. The present results indicate that the bacteriophage cocktail had a potential to enhance the performance and gut health of weanling pigs, however their combination with probiotics did not show an interaction.</P>

      • Influence of <i>CYP2D6*10</i> on the pharmacokinetics of metoprolol in healthy Korean volunteers

        Jin,,S.,K.,Chung,,H.,J.,Chung,,M.,W.,Kim,,J.-I.,Kang,,J.-H.,Woo,,S.,W.,Bang,,S.,Lee,,S.,H.,Lee,,H.,J.,Roh,,J. Blackwell Publishing Ltd 2008 Journal of clinical pharmacy and therapeutics Vol.33 No.5

        <P>Summary</P><P>Background and objective: </P><P>Genetic polymorphism of <I>CYP2D6</I> leads to differences in pharmacokinetics of CYP2D6 substrates. The <I>CYP2D6*10</I> allele is clinically important in Koreans because of its high frequency in Asians. We investigated whether the pharmacokinetics of metoprolol was altered by the presence of the <I>CYP2D6*10</I> allele in Korean subjects.</P><P>Methods: </P><P>One hundred and seven volunteers were recruited and grouped as <I>CYP2D6*1/*1</I>, <I>CYP2D6*1/*10</I> and <I>CYP2D6*10/*10</I> according to their genotypes. Metoprolol tartrate 100 mg (Betaloc<SUP>®</SUP>) was administered orally once to each subject in these three groups (<I>n</I> = 6, 7 and 5, respectively). The pharmacokinetic parameters of metoprolol and its metabolite, &agr;-hydroxymetoprolol, and the metabolic ratio for the three groups were estimated and compared.</P><P>Results and discussion: </P><P>The area under the plasma concentration–time curve (AUC<SUB>0→∞</SUB>), the maximum plasma concentration (<I>C</I><SUB>max</SUB>) and the elimination half-life (<I>T</I><SUB>1/2</SUB>) of metoprolol and &agr;-hydroxymetoprolol for the <I>CYP2D6*10/*10</I> group were all significantly different from those of the <I>CYP2D6*1/*1</I> group (<I>P</I> < 0·05). The AUC<SUB>0→∞</SUB>s of metoprolol were 443·7 ± 168·1, 995·6 ± 321·4 and 2545·3 ± 632·0 ng·h/mL, and the AUC<SUB>0→∞</SUB>s of &agr;-hydroxymetoprolol were 1232·0 ± 311·2, 1344·0 ± 288·1 and 877·4 ± 103·4 ng·h/mL for groups <I>CYP2D6*1/*1</I>, <I>*1/*10</I> and <I>*10/*10</I>, respectively. The corresponding <I>T</I><SUB>1/2</SUB> values of metoprolol were 2·7 ± 0·5, 3·2 ± 1·3 and 5·0 ± 1·1 h, while those of &agr;-hydroxymetoprolol were 5·4±1·5, 6·0 ± 1·4 and 10·5 ± 4·2 h, respectively. The metabolic ratios of the three groups were significantly different (<I>P</I> < 0·05).</P><P>Conclusion: </P><P>The <I>CYP2D6*10</I> allele altered the pharmacokinetics of metoprolol in Korean subjects and is likely to affect other drugs metabolized by the CYP2D6 enzyme, similarly.</P>

      • Impact of Pretransplant Infections on Clinical Course in Liver Transplant Recipients

        Kim,,Y.J.,Yoon,,J.H.,Kim,,S.I.,Choi,,H.J.,Choi,,J.Y.,Yoon,,S.K.,You,,Y.-K.,Kim,,D.-G. Elsevier 2018 Transplantation proceedings Vol.50 No.4

        <P><B>Abstract</B></P> <P><B>Background</B></P> <P>Uncontrolled infections are known to be an absolute contraindication for liver transplantation; however, the posttransplant prognosis of recipients treated for pretransplant infection is unclear. The aim of this study was to analyze pretransplant infections among liver transplant recipients and to determine their impact on posttransplant clinical outcomes.</P> <P><B>Methods</B></P> <P>This study retrospectively analyzed 357 subjects who had undergone living-donor liver transplantation between January 2008 and May 2014.</P> <P><B>Results</B></P> <P>Among 357 recipients, 71 patients (19.8%) had 74 episodes of infectious complications before liver transplantation. These complications consisted of pneumonia (n = 13), spontaneous bacterial peritonitis (n = 12), catheter-related infection (n = 10), urinary tract infection (n = 12), biliary tract infection (n = 6), and skin and soft-tissue infection (n = 3). Twenty-six patients experienced 29 episodes of bacteremia, and the most common pathogens were coagulase-negative staphylococci (n = 8), followed by <I>Klebsiella pneumoniae</I> (n = 7), <I>Staphylococcus aureus</I> (n = 4), and <I>Streptococcus</I> species (n = 3). Twenty-one bacteremic episodes (70%) occurred within 1 month before transplantation (n = 4). Recipients with pretransplant infections had significantly more frequent posttransplant infections (71.8% [51 of 71] vs 47.2% [35 of 286]; <I>P</I> = .0001), posttransplant bacteremia (33.8% [24 of 71] vs 20.3% [58 of 286]; <I>P</I> = .015), and longer posttransplant intensive care unit stays (11.2 ± 10.7 days vs 7.3 ± 4.2 days; <I>P</I> = .0004) than those without pretransplant infections. However, episodes of rejection (<I>P</I> = .36), length of hospitalization (<I>P</I> = .10), 28-day mortality (<I>P</I> = .31), and 1-year mortality (<I>P</I> = .61) after transplantation were not significantly different between the 2 groups.</P> <P><B>Conclusions</B></P> <P>Pretransplant infection had an impact on posttransplant morbidity, although not on rejection and mortality. Alertness for posttransplant infection and proper management (including effective antimicrobial coverage) would improve patient morbidity.</P>

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        A genetic variation in microRNA target site of <i>KRT81</i> gene is associated with survival in early-stage non-small-cell lung cancer

        Lee,,S.,Y.,Choi,,J.,E.,Jeon,,H.,S.,Hong,,M.,J.,Choi,,Y.,Y.,Kang,,H.,G.,Yoo,,S.,S.,Lee,,E.,B.,Jeong,,J.,Y.,Lee,,W.,K.,Lee,,J.,Cha,,S.,I.,Kim,,C.,H.,Kim,,Y.,T.,Jheon,,S.,Son,,J.,W.,Park,,J.,Y. Oxford University Press 2015 ANNALS OF ONCOLOGY Vol.26 No.6

        <P>In this study, <I>KRT81</I> rs3660G>C was associated with survival of patients with NSCLC after surgical resection. Mechanistic study suggested that the G-to-C change caused reduced binding efficiency of miRNA, leading to decreased translational repression, thereby increased <I>KRT81</I> expression. The <I>KRT81</I> rs3660G>C may be a useful prognostic biomarker in early-stage NSCLC patients.</P><P><B>Background</B></P><P>MicroRNAs (miRNAs) have a key role in carcinogenesis through negative regulation of their target genes. Therefore, genetic variations in miRNAs or their target sites may affect miRNA–mRNA interactions, thereby result in altered expression of target genes. This study was conducted to investigate the associations between single-nucleotide polymorphisms (SNP) located in the miRNA target sites (poly-miRTSs) and survival of patients with early-stage non-small-cell lung cancer (NSCLC).</P><P><B>Methods</B></P><P>Using public SNP database and miRNA target sites prediction program, 354 poly-miRTSs were selected for genotyping. Among these, 154 SNPs applicable to Sequenom's MassARRAY platform were investigated in 357 patients. A replication study was carried out on an independent patient population (<I>n</I> = 479). <I>Renilla</I> luciferase assay and reverse transcription-polymerase chain reaction were conducted to examine functional relevance of potentially functional poly-miRTSs.</P><P><B>Results</B></P><P>Of the 154 SNPs analyzed in a discovery set, 14 SNPs were significantly associated with survival outcomes. Among these, <I>KRT81</I> rs3660G>C was found to be associated with survival outcomes in the validation cohort. In the combined analysis, patients with the rs3660 GC + CC genotype had a significantly better overall survival compared with those with GG genotype [adjusted hazard ratio (aHR) for OS, 0.65; 95% confidence interval (CI) 0.50–0.85; <I>P</I> = 0.001]. An increased expression of the reporter gene for the C allele of rs3660 compared with the G allele was observed by luciferase assay. Consistently, the C allele was associated with higher relative expression level of <I>KRT81</I> in tumor tissues.</P><P><B>Conclusion</B></P><P>The rs3660G>C affects KRT81 expression and thus influences survival in early-stage NSCLC. The analysis of the rs3660G>C polymorphism may be useful to identify patients at high risk of a poor disease outcome.</P>

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        Photoemission, soft x-ray absorption, and magnetic circular dichroism spectroscopy study of Fe<sub>1−<i>x</i></sub>Cu<sub><i>x</i></sub>Cr<sub>2</sub>S<sub>4</sub> (0.1≤<i>x</i>≤0.5) spinel sulfides

        Han,,S,W,Kang,,J-S,Lee,,S,S,Kim,,G,Kim,,S,J,Kim,,C,S,Kim,,J-Y,Shin,,H,J,Kim,,K,H,Jeong,,J,I,Park,,B-G,Park,,J-H,Min,,B,I IOP Pub 2006 Journal of Physics, Condensed Matter Vol.18 No.31

        <P>The electronic and magnetic structures of Fe<SUB>1−<I>x</I></SUB>Cu<SUB><I>x</I></SUB>Cr<SUB>2</SUB>S<SUB>4</SUB> (0.1≤<I>x</I>≤0.5) spinel sulfides have been investigated systematically by performing photoemission spectroscopy (PES), soft x-ray absorption spectroscopy (XAS), and soft x-ray magnetic circular dichroism (XMCD) measurements using synchrotron radiation. Cr and Cu ions are found to be nearly trivalent (Cr<SUP>3+</SUP>) and monovalent (Cu<SUP>+</SUP>), respectively, and their valence states do not change with <I>x</I>. The Fe 2p XAS spectra of Fe<SUB>1−<I>x</I></SUB>Cu<SUB><I>x</I></SUB>Cr<SUB>2</SUB>S<SUB>4</SUB> are very similar to that of Fe metal, indicating that the Fe 3d electrons are strongly hybridized to other valence electrons. The Fe and Cr 2p XMCD spectra show that the magnetic moments of Cr ions and Fe ions are aligned antiparallel to each other and that both the Cr and Fe magnetic moments increase with increasing <I>x</I>. The valence-band PES study reveals that the Cr<SUP>3+</SUP> (<img SRC='http://ej.iop.org/images/0953-8984/18/31/033/cm224080ieqn1.gif' ALIGN='MIDDLE' ALT='\mathrm {t_{2g}^3} \downarrow '/>) 3d states are located at ∼1.5?eV below <I>E</I><SUB>F</SUB>. The occupied Fe 3d states consist of the broad <img SRC='http://ej.iop.org/images/0953-8984/18/31/033/cm224080ieqn2.gif' ALIGN='MIDDLE' ALT='\mathrm {t_{2g}^3} \uparrow '/> states, the <img SRC='http://ej.iop.org/images/0953-8984/18/31/033/cm224080ieqn3.gif' ALIGN='MIDDLE' ALT='\mathrm {e_g^2} \uparrow '/> states at ∼4?eV below <I>E</I><SUB>F</SUB>, and the <img SRC='http://ej.iop.org/images/0953-8984/18/31/033/cm224080ieqn4.gif' ALIGN='MIDDLE' ALT='\mathrm {e_g} \downarrow '/> states very close to <I>E</I><SUB>F</SUB>. The filled Cu 3d<SUP>10</SUP> states lie at ∼2.5?eV below <I>E</I><SUB>F</SUB>. This study suggests that the hybridized Fe <img SRC='http://ej.iop.org/images/0953-8984/18/31/033/cm224080ieqn4.gif' ALIGN='MIDDLE' ALT='\mathrm {e_g}\downarrow '/> and S 3p states near <I>E</I><SUB>F</SUB> play an important role in determining the transport properties of Fe<SUB>1−<I>x</I></SUB>Cu<SUB><I>x</I></SUB>Cr<SUB>2</SUB>S<SUB>4</SUB> for <I>x</I>≤0.5. </P>

      • Diagnostic usefulness of a T cell-based assay for latent tuberculosis infection in kidney transplant candidates before transplantation

        Kim,,S.-H.,Lee,,S.-O.,Park,,I.-A.,Park,,S.J.,Choi,,S.-H.,Kim,,Y.S.,Woo,,J.H.,Park,,S.-K.,Park,,J.S.,Kim,,S.C.,Han,,D.J. Blackwell Publishing Inc 2010 Transplant infectious disease Vol.12 No.2

        <P>S.-H. Kim, S.-O. Lee, I.-A. Park, S.J. Park, S.-H. Choi, Y.S. Kim, J.H. Woo, S.-K. Park, J.S. Park, S.C. Kim, D.J. Han. Diagnostic usefulness of a T cell-based assay for latent tuberculosis infection in kidney transplant candidates before transplantation.Transpl Infect Dis 2010: <B>12:</B> 113–119. All rights reserved</P><P>Background</P><P>The presence of latent tuberculosis (TB) infection (LTBI) should be evaluated before kidney transplantation. Although a new T cell-based assay for diagnosing LTBI gave promising results, this assay has not yet been compared with the tuberculin skin test (TST) for diagnosing LTBI in renal transplant candidates before transplantation.</P><P>Patients and methods</P><P>All adult patients admitted to a single institute for renal transplantation over a 1-year period were prospectively enrolled. A clinically predictive risk of LTBI was defined as: (i) recent close contact with a person with pulmonary TB; (ii) abnormal chest radiography; (iii) a history of untreated or inadequately treated TB; or (iv) a new infection (i.e., a recent conversion of TST).</P><P>Results</P><P>Of 209 renal recipients, 47 (22%) had a positive TST≥5 mm, 21 (10%) had a positive TST≥10 mm, 65 (30%) had a positive T-SPOT.<I>TB</I> test, and 25 (12%) had an indeterminate T-SPOT.<I>TB</I> test. The induration size of TST was significantly associated with a high positivity rate on T-SPOT.<I>TB</I> (<I>P</I><0.001). Agreement between T-SPOT.<I>TB</I> test and TST≥10 mm was fair (<I>k</I>=0.24, 95% confidence interval 0.11–0.36). However, neither univariate nor multivariate analysis showed any association between the clinical risk for LTBI and positivity on T-SPOT.<I>TB</I> or TST.</P><P>Conclusion</P><P>T-SPOT.<I>TB</I> test was more frequently positive than TST in renal transplant candidates. However, further longitudinal studies are awaited to determine whether the ability of T-SPOT.<I>TB</I> assay to detect LTBI in renal transplant recipients can better predict the development of TB than can TST after transplantation.</P>

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        All that glitters is not <i>Ramularia</i>

        Videira,,S.I.R.,Groenewald,,J.Z.,Braun,,U.,Shin,,H.D.,Crous,,P.W. CBS PUBLICATIONS 2016 STUDIES IN MYCOLOGY Vol.83 No.-

        <P><I>Ramularia</I> is a species-rich genus that harbours plant pathogens responsible for yield losses to many important crops, including barley, sugar beet and strawberry. Species of <I>Ramularia</I> are hyphomycetes with hyaline conidiophores and conidia with distinct, thickened, darkened, refractive conidiogenous loci and conidial hila, and <I>Mycosphaerella</I> sexual morphs. Because of its simple morphology and general lack of DNA data in public databases, several allied genera are frequently confused with <I>Ramularia</I>. In order to improve the delimitation of <I>Ramularia</I> from allied genera and the circumscription of species within the genus <I>Ramularia</I>, a polyphasic approach based on multilocus DNA sequences, morphological and cultural data were used in this study. A total of 420 isolates belonging to <I>Ramularia</I> and allied genera were targeted for the amplification and sequencing of six partial genes. Although <I>Ramularia</I> and <I>Ramulariopsis</I> proved to be monophyletic, <I>Cercosporella</I> and <I>Pseudocercosporella</I> were polyphyletic. <I>Phacellium</I> isolates clustered within the <I>Ramularia</I> clade and the genus is thus tentatively reduced to synonymy under <I>Ramularia</I>. <I>Cercosporella</I> and <I>Pseudocercosporella</I> isolates that were not congeneric with the ex-type strains of the type species of those genera were assigned to existing genera or to the newly introduced genera <I>Teratoramularia</I> and <I>Xenoramularia</I>, respectively. <I>Teratoramularia</I> is a genus with ramularia-like morphology belonging to the <I>Teratosphaeriaceae</I>, and <I>Xenoramularia</I> was introduced to accommodate hyphomycetous species closely related to <I>Zymoseptoria</I>. The genera <I>Apseudocercosporella</I>, <I>Epicoleosporium</I>, <I>Filiella</I>, <I>Fusidiella</I>, <I>Neopseudocercosporella</I>, and <I>Mycosphaerelloides</I> were also newly introduced to accommodate species non-congeneric with their purported types. A total of nine new combinations and 24 new species were introduced in this study.</P>

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        <i>ϕ</i>-Meson production at forward rapidity in p–Pb collisions at <sub> s NN </sub> = 5.02 TeV and in pp collisions at s = 2.76 TeV

        Adam,,J.,Adamová,,,D.,Aggarwal,,M.M.,Aglieri,Rinella,,G.,Agnello,,M.,Agrawal,,N.,Ahammed,,Z.,Ahn,,S.U.,Aimo,,I.,Aiola,,S.,Ajaz,,M.,Akindinov,,A.,Alam,,S.N.,Aleksandrov,,D.,Alessandro,,B.,Alexand North-Holland Pub. Co 2017 Physics letters. Section B Vol.768 No.-

        <P><B>Abstract</B></P> <P>The first study of <I>ϕ</I>-meson production in p–Pb collisions at forward and backward rapidity, at a nucleon–nucleon centre-of-mass energy <SUB> s NN </SUB> = 5.02 TeV , has been performed with the ALICE apparatus at the LHC. The <I>ϕ</I>-mesons have been identified in the dimuon decay channel in the transverse momentum ( <SUB> p T </SUB> ) range 1 < <SUB> p T </SUB> < 7 GeV / c , both in the p-going ( 2.03 < y < 3.53 ) and the Pb-going ( − 4.46 < y < − 2.96 ) directions — where <I>y</I> stands for the rapidity in the nucleon–nucleon centre-of-mass — the integrated luminosity amounting to 5.01 ± 0.19 <SUP> nb − 1 </SUP> and 5.81 ± 0.20 <SUP> nb − 1 </SUP> , respectively, for the two data samples. Differential cross sections as a function of transverse momentum and rapidity are presented. The forward–backward ratio for <I>ϕ</I>-meson production is measured for 2.96 < | y | < 3.53 , resulting in a ratio ∼0.5 with no significant <SUB> p T </SUB> dependence within the uncertainties. The <SUB> p T </SUB> dependence of the <I>ϕ</I> nuclear modification factor <SUB> R pPb </SUB> exhibits an enhancement up to a factor 1.6 at <SUB> p T </SUB> = 3 – 4 GeV / c in the Pb-going direction. The <SUB> p T </SUB> dependence of the <I>ϕ</I>-meson cross section in pp collisions at s = 2.76 TeV , which is used to determine a reference for the p–Pb results, is also presented here for 1 < <SUB> p T </SUB> < 5 GeV / c and 2.5 < y < 4 , for a 78 ± 3 <SUP> nb − 1 </SUP> integrated luminosity sample.</P>

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