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I Chun Ma,Kao Chin Chen,Wei Tseng Chen,Hsin Chun Tsai,Chien-Chou Su,Ru-Band Lu,Po See Chen,Wei Hung Chang,Yen Kuang Yang 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4
Objective: Hospitalization of patients with delirium after visiting the emergency department (ED) is often required. However, the readmission risk after discharge from the ED should also be considered. This study aimed to explore whether (i) immediate hospitalization influences the readmission risk of patients with delirium; (ii) the readmission risk is affected by various risk factors; and (iii) the healthcare cost differs between groups within 28 days of the first ED visit. Methods: Using the National Health Insurance Research Database, the data of 2,780 subjects presenting with delirium at an ED visit from 2000 to 2008 were examined. The readmission risks of the groups of patients (i.e., patients who were and were not admitted within 24 hours of an ED visit) within 28 days were compared, and the effects of the severities of different comorbidities (using Charlson’s comorbidity index, CCI), age, gender, diagnosis and differences in medical healthcare cost were analyzed. Results: Patients without immediate hospitalization had a higher risk of readmission within 3, 7, 14, or 28 days of discharge from the ED, especially subjects with more severe comorbidities (CCI≥3) or older patients (≥65 years). Subjects with more severe comorbidities or older subjects who were not admitted immediately also incurred a greater healthcare cost for re-hospitalization within the 28-day follow-up period. Conclusion: Patients with delirium with a higher CCI or of a greater age should be carefully considered for immediate hospitalization from ED for further examination in order to reduce the risk of re-hospitalization and cost of healthcare.
Dermal Lipogenesis Inhibits Adiponectin Production in Hs68 Fibroblasts
( Kai-chen Hu ),( Tsung-yan Tsai ),( Chu-wen Shao ),( Hsin-i Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Adiponectin is one of the most abundant adipokines from the subcutaneous fat, and regulates multiple activities through endocrine, paracrine, or autocrine mechanisms. However, its expression in adipogenic induced fibroblasts, and the potential role in photoaging has not been determined. Here, human dermal fibroblasts, Hs68, were presented as a cell model of dermal lipogenesis through stimulation of adipogenic differentiation medium (ADM). Similar to other studies in murine pre-adipocyte models (i.e., 3T3-L1), Hs68 fibroblasts showed a tendency to lipogenesis based on lipid accumulation, triglyceride formation, and the expressions of PPAR-γ, lipoprotein lipase (LPL), and FABP4 mRNA. As expected, ADM-treated fibroblasts displayed a reduction on adiponectin expression. Overall, these results suggest that dermal lipogenesis may inhibit the expression of adiponectin.
Yuan-Hao Chen,Yung-Hsiao Chiang,Hsin-I Ma 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.2
Background and Purpose Hypoxia, or ischemia, is a common cause of neurological deficits in the elderly. This study elucidated the mechanisms underlying ischemia-induced brain injury that results in neurological sequelae. Methods Cerebral ischemia was induced in male Sprague-Dawley rats by transient ligationof the left carotid artery followed by 60 min of hypoxia. A two-dimensional differential proteome analysis was performed using matrix-assisted laser desorption ionization-time-of-flightmass spectrometry to compare changes in protein expression on the lesioned side of the cortexrelative to that on the contralateral side at 0, 6, and 24 h after ischemia. Results The expressions of the following five proteins were up-regulated in the ipsilateralcortex at 24 h after ischemia-reperfusion injury compared to the contralateral (i.e., control)side: aconitase 2, neurotensin-related peptide, hypothetical protein XP-212759, 60-kDa heatshock protein, and aldolase A. The expression of one protein, dynamin-1, was up-regulatedonly at the 6-h time point. The level of 78-kDa glucose-regulated protein precursor on the lesioned side of the cerebral cortex was found to be high initially, but then down-regulated by 24 hafter the induction of ischemia-reperfusion injury. The expressions of several metabolic enzymes and translational factors were also perturbed soon after brain ischemia. Conclusions These findings provide insights into the mechanisms underlying the neurodegenerative events that occur following cerebral ischemia.
姜玟求(Kang Min gu),???(I CHEN Han yue),?勇(ZHANG Yong),薄?(BO Yan),季?昊(JI Ze Hao) 조선대학교 지식경영연구원 2017 기업과 혁신연구 Vol.10 No.2
With the rapid development of E-commerce and growing demand for customized products in China, customization service in E-commerce has increasingly become a way of creating business opportunities. By using the framework of business model canvas, this study conducts explorative case studies with two representative B2C companies (i.e., Kadang and Ybren) that provide customized service in China, and suggests key factors for successful B2C customization service business model.
Kim, D.-W.,Protopapas, P.,Alcock, C.,Byun, Y.-I.,Kyeong, J.,Lee, B.-C.,Wright, N. J.,Axelrod, T.,Bianco, F. B.,Chen, W.-P.,Coehlo, N. K.,Cook, K. H.,Dave, R.,King, S.-K.,Lee, T.,Lehner, M. J.,Lin, H.- American Institute of Physics 2010 The Astronomical journal Vol.139 No.2
<P>We analyzed data accumulated during 2005 and 2006 by the Taiwan-American Occultation Survey (TAOS) in order to detect short-period variable stars (periods of <img entity='lsim' SRC='http://ej.iop.org/icons/Entities/lsim.gif' ALT='lsim' ALIGN='BASELINE' />1 hr) such as δ Scuti. TAOS is designed for the detection of stellar occultation by small-size Kuiper Belt Objects and is operating four 50 cm telescopes at an effective cadence of 5 Hz. The four telescopes simultaneously monitor the same patch of the sky in order to reduce false positives. To detect short-period variables, we used the fast Fourier transform algorithm (FFT) in as much as the data points in TAOS light curves are evenly spaced. Using FFT, we found 41 short-period variables with amplitudes smaller than a few hundredths of a magnitude and periods of about an hour, which suggest that they are low-amplitude δ Scuti stars. The light curves of TAOS δ Scuti stars are accessible online at the Time Series Center Web site (http://timemachine.iic.harvard.edu).</P>
Yu Jun Wong,Vy H. Nguyen,Hwai-I Yang,Jie Li,Michael Huan Le,Wan-Jung Wu,Nicole Xinrong Han,Khi Yung Fong,Elizabeth Chen,Connie Wong,Fajuan Rui,Xiaoming Xu,Qi Xue,Xin Yu Hu,Wei Qiang Leow,George Boon-B 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Background/Aims: Chronic hepatitis B (CHB) and fatty liver (FL) often co-exist, but natural history data of this dual condition (CHB-FL) are sparse. Via a systematic review, conventional meta-analysis (MA) and individual patient-level data MA (IPDMA), we compared liver-related outcomes and mortality between CHB-FL and CHB-no FL patients. Methods: We searched 4 databases from inception to December 2021 and pooled study-level estimates using a random- effects model for conventional MA. For IPDMA, we evaluated outcomes after balancing the two study groups with inverse probability treatment weighting (IPTW) on age, sex, cirrhosis, diabetes, ALT, HBeAg, HBV DNA, and antiviral treatment. Results: We screened 2,157 articles and included 19 eligible studies (17,955 patients: 11,908 CHB-no FL; 6,047 CHB-FL) in conventional MA, which found severe heterogeneity (I2=88–95%) and no significant differences in HCC, cirrhosis, mortality, or HBsAg seroclearance incidence (P=0.27–0.93). IPDMA included 13,262 patients: 8,625 CHB-no FL and 4,637 CHB-FL patients who differed in several characteristics. The IPTW cohort included 6,955 CHB-no FL and 3,346 CHB-FL well-matched patients. CHB-FL patients (vs. CHB-no FL) had significantly lower HCC, cirrhosis, mortality and higher HBsAg seroclearance incidence (all P≤0.002), with consistent results in subgroups. CHB-FL diagnosed by liver biopsy had a higher 10-year cumulative HCC incidence than CHB-FL diagnosed with non-invasive methods (63.6% vs. 4.3%, P<0.0001). Conclusions: IPDMA data with well-matched CHB patient groups showed that FL (vs. no FL) was associated with significantly lower HCC, cirrhosis, and mortality risk and higher HBsAg seroclearance probability.
Arrigoni Battaia, F.,Chen, Chian-Chou,Fumagalli, M.,Cai, Zheng,Calistro Rivera, G.,Xu, Jiachuan,Smail, I.,Prochaska, J. X.,Yang, Yujin,De Breuck, C. Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P>In the hierarchical model of structure formation, giant elliptical galaxies form through merging processes within the highest density peaks known as protoclusters. While high-redshift radio galaxies usually pinpoint the location of these environments, we have recently discovered at <I>z</I> ∼ 2−3 three enormous (> 200 kpc) Lyman-<I>α</I> nebulae (ELANe) that host multiple active galactic nuclei (AGN) and that are surrounded by overdensities of Lyman-<I>α</I> emitters (LAE). These regions are prime candidates for massive protoclusters in the early stages of assembly. To characterize the star-forming activity within these rare structures - both on ELAN and protocluster scales - we have initiated an observational campaign with the <I>James Clerk Maxwell</I> Telescope (JCMT) and the Atacama Pathfinder EXperiment (APEX) telescopes. In this paper we report on sensitive SCUBA-2/JCMT 850 and 450 <I>μ</I>m observations of a ∼128 arcmin<SUP>2</SUP> field comprising the ELAN MAMMOTH-1, together with the peak of the hosting BOSS1441 LAE overdensity at <I>z</I> = 2.32. These observations unveil 4.0 ± 1.3 times higher source counts at 850 <I>μ</I>m with respect to blank fields, likely confirming the presence of an overdensity also in obscured tracers. We find a strong detection at 850 <I>μ</I>m associated with the continuum source embedded within the ELAN MAMMOTH-1, which - together with the available data from the literature - allow us to constrain the spectral energy distribution of this source to be of an ultra-luminous infrared galaxy (ULIRG) with a far-infrared luminosity of LFIR<SUP>SF</SUP> = 2.4−2.1<SUP>+7.4</SUP>×10<SUP>12</SUP><I>L</I>⊙, and hosting an obscured AGN. Such a source is thus able to power a hard photoionization plus outflow scenario to explain the extended Lyman-<I>α</I>, He II<I>λ</I>1640, and C IV<I>λ</I>1549 emission, and their kinematics. In addition, the two brightest detections at 850 <I>μ</I>m (<I>f</I>850 > 18 mJy) sit at the density peak of the LAEs’ overdensity, likely pinpointing the core of the protocluster. Future multiwavelength and spectroscopic datasets targeting the full extent of the BOSS1441 overdensity have the potential to firmly characterize a cosmic nursery of giant elliptical galaxies, and ultimately of a massive cluster.</P>
Zhao, K.J.,Nagashima, Y.,Li, F.M.,Shi, Yuejiang,Diamond, P.H.,Dong, J.Q.,Itoh, K.,Itoh, S.-I.,Zhuang, G.,Liu, H.,Chen, Z.P.,Cheng, J.,Nie, L.,Ding, Y.H.,Hu, Q.M.,Chen, Z.Y.,Rao, B.,Cheng, Z.F.,Gao, L. IOP 2017 Nuclear fusion Vol.57 No.12
<P>The temporal-spatial structures of plasma flows and turbulence around tearing mode islands are presented. The experiments were performed using Langmuir probe arrays in the edge plasmas of J-TEXT tokamak. The correlation analyses clearly show that the flows have similar structures of <I>m</I>/<I>n</I> = 3/1 as the magnetic island does (<I>m</I> and <I>n</I> are the poloidal and toroidal mode numbers, respectively). The sign of the potential fluctuations for the flows inverses and the powers significantly reduce at <I>q</I> = 3 surface. Approaching to the last closed flux surface for the magnetic islands, the radially elongated flow structure forms. The flows are concentrated near separatrix and show quadrupole structures. The turbulence is concentrated near X-point and partly trapped inside the magnetic islands.</P>
Seongjae Cho,Chen, R.,Sukmo Koo,Shambat, G.,Lin, H.,Namkyoo Park,Vuckovic, J.,Kamins, T. I.,Byung-Gook Park,Harris, James S. IEEE 2011 IEEE photonics technology letters Vol.23 No.20
<P>In this work, a whispering gallery mode (WGM) microdisk resonator based on Ge<SUB>1-</SUB><I>x</I>Sn<I>x</I> grown by molecular beam epitaxy (MBE) was fabricated and characterized. Various process conditions and different Sn contents (4% and 1%) were explored to confirm the feasibility of Ge<SUB>1-</SUB><I>x</I>Sn<I>x</I> for microcavity device operation. Optical modes with wavelengths in the infrared (IR) range beyond 1550 nm were successfully confined in the devices fabricated with different diameters, and free-spectral ranges (FSRs) near 20 nm were obtained.</P>