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Kim, Heonjo,Chae, Youngjoo,Lee, Duck Hyun,Kim, Minsik,Huh, Jiyoung,Kim, Youngki,Kim, Hyunjin,Kim, Hyun Jung,Kim, Sang Ouk,Baik, Hionsuck,Choi, Kihang,Kim, Jong Seung,Yi, Gi-Ra,Lee, Kwangyeol WILEY-VCH Verlag 2010 Angewandte Chemie Vol.122 No.33
<B>Graphic Abstract</B> <P>Eine doppelte Rolle spielen Pd-Nanopartikel bei der Umwandlung von Fe-Nanopartikeln und einer P-Quelle in Fe<SUB>2</SUB>P-Nanostäbchen: als Katalysatoren, die Fe-Nanopartikel unter Bildung löslicher Vorstufen destabilisieren, und als Katalysezentren für das Wachstum von Nanostäbchen (siehe Bild). Durchmesser und Länge der Nanostäbchen lassen sich über den Durchmesser der Pd-Nanopartikel bzw. das Fe/Pd-Verhältnis einstellen. <img src='wiley_img_2010/00448249-2010-122-33-ANGE201001822-content.gif' alt='wiley_img_2010/00448249-2010-122-33-ANGE201001822-content'> </P>
Kim, Heonjo,Chae, Youngjoo,Lee, Duck Hyun,Kim, Minsik,Huh, Jiyoung,Kim, Youngki,Kim, Hyunjin,Kim, Hyun Jung,Kim, Sang Ouk,Baik, Hionsuck,Choi, Kihang,Kim, Jong Seung,Yi, Gi-Ra,Lee, Kwangyeol WILEY-VCH Verlag 2010 Angewandte Chemie Vol.49 No.33
<B>Graphic Abstract</B> <P>Playing a dual role as a catalyst that destabilizes Fe nanoparticles to form soluble precursors in situ and as a catalytic center for nanorod growth allows Pd nanoparticles to transform Fe nanoparticles and a P source into Fe<SUB>2</SUB>P nanorods (see scheme). The diameter and length of the Fe<SUB>2</SUB>P nanorods can be fine-tuned by means of the diameter of the Pd nanoparticles and the Fe/Pd ratio, respectively. <img src='wiley_img_2010/14337851-2010-49-33-ANIE201001822-content.gif' alt='wiley_img_2010/14337851-2010-49-33-ANIE201001822-content'> </P>
Kim, Hyunjin,Dae, Hyun-Mi,Park, Cheongsoo,Kim, Eun Ock,Kim, Daehong,Kim, In-Hoo,Kim, Yun-Hee,Choi, Yongdoo Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.21
<P>A superparamagnetic iron oxide nanoparticle (SPION) was coupled to 2-aminoethyl-trimethyl ammonium (TMA) in a 2-step ligand exchange reaction to produce TMA–SPION. This particle, which has a strong positive charge, was investigated as the basis for a simple and efficient method for labelling human mesenchymal stem cells (hMSCs) for noninvasive monitoring by magnetic resonance imaging (MRI). TMA–SPION has a <I>ζ</I> potential of +40 mV and a hydrodynamic size of 101 nm. In addition to its long-term stability in an aqueous solution, TMA–SPION has a low cytotoxicity and favourable magnetic properties as a <I>T</I><SUB>2</SUB> contrast agent due to its high relaxivity. The <I>T</I><SUB>2</SUB> relaxivity of TMA–SPION is 4.4 times greater than the commercially available Feridex® I.V. magnetic resonance agent. Despite a short labelling time of 4 h, hMSCs are efficiently labelled with TMA–SPION without the need for a transfection agent. An <I>in vivo</I> MRI study of a brain infarction model confirmed the utility of TMA–SPION as an MRI tracking marker of administered hMSCs.</P> <P>Graphic Abstract</P><P>Superparamagnetic magnetite nanoparticle with high r2 relaxivity (728.23 mM<SUP>-1</SUP> s<SUP>-1</SUP>) and zeta potential (+40 mV) was synthesized and evaluated <I>in vitro</I> and <I>in vivo</I>. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm10247h'> </P>
Repeated oral dose toxicity and genotoxicity of a standardized Quisqualis indica extract
Kim Jeong-Won,Kim Hyunjun,Park Hyunjin,Yoon Ji-Soo,Kim Myeong-Il,Ko Je-Won,Kim Tae-Won 한국독성학회 2022 Toxicological Research Vol.38 No.4
Quisqualis indica L. of Combretaceae family is a traditional medicine that is widely used for various gastrointestinal discomfort including stomach pain, constipation, and digestive problem. In this study, the potential repeated dose toxicity and genotoxicity of a standardized Quisqualis indica L. extract (HU033) were determined under good laboratory practice conditions. For the repeated dose toxicity test, HU033 was orally administered to Sprague–Dawley (SD) rats at doses of 500, 1000, and 2000 mg/kg/day for 13 consecutive weeks. The genotoxicity of HU033 was determined with a standard battery of genotoxicity test, including an in vitro bacterial reverse mutation test, an in vitro chromosomal aberration test, and an in vivo micronucleus test. After 13 weeks of repeated dose of HU033 by oral administration, there was no treatment related adverse clinical sign including food consumption, organ weights, and histopathological findings or significant decrement in bodyweight. The no-observed-adverse-effect level of HU033 was higher than 2000 mg/kg in both male and female SD rats. No target organs were identified. In addition, no evidence of HU033 genotoxicity was detected based on results from the bacterial reverse mutation test, chromosomal aberration test, and micronucleus test. Based on results of this study, HU033 could be safely used in food and medical products within the tested dose range.
Kim, Tae-Hyeong,Lim, Minji,Park, Juhee,Oh, Jung Min,Kim, Hyeongeun,Jeong, Hyunjin,Lee, Sun Ju,Park, Hee Chul,Jung, Sungmok,Kim, Byung Chul,Lee, Kyusang,Kim, Mi-Hyun,Park, Do Youn,Kim, Gwang Ha,Cho, Yo American Chemical Society 2017 ANALYTICAL CHEMISTRY - Vol.89 No.2
<P>Circulating tumor cells (CTCs) have great potential to provide minimally invasive ways for the early detection of cancer metastasis and for the response monitoring of various cancer treatments. Despite the clinical importance and progress of CTC-based cancer diagnostics, most of the current methods of enriching CTCs are difficult to implement in general hospital settings due to complex and time-consuming protocols. Among existing technologies, size-based isolation methods provide antibody-independent, relatively simple, and high throughput protocols. However, the clogging issues and lower than desired recovery rates and purity are the key challenges. In this work, inspired by antifouling membranes with liquid-filled pores in nature, clog-free, highly sensitive (95.9 +/- 3.1% recovery rate), selective (>2.5 log depletion of white blood cells), rapid (>3 mL/min), and label-free isolation of viable CTCs from whole blood without prior sample treatment is achieved using a stand-alone lab-on-a-disc system equipped with fluid-assisted separation technology (FAST). Numerical simulation and experiments show that this method provides uniform, clog-free, ultrafast cell enrichment with pressure drops much less than in conventional size-based filtration, at 1 kPa. We demonstrate the clinical utility of the point-of-care detection of CTCs with samples taken from 142 patients suffering from breast, stomach, or lung cancer.</P>
Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
Kim, Joo-Yeon,Lee, Mak-Soon,Jung, Sunyoon,Joo, Hyunjin,Kim, Chong-Tai,Kim, In-Hwan,Seo, Sangjin,Oh, Soojung,Kim, Yangha Dove Medical Press 2014 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.9 No.-
<P><B>Purpose</B></P><P>This study determined the effects of oleoresin capsicum (OC) and nanoemulsion OC (NOC) on obesity in obese rats fed a high-fat diet.</P><P><B>Methods</B></P><P>The rats were randomly separated into three groups: a high-fat (HF) diet group, HF + OC diet group, and HF + NOC diet group. All groups were fed the diet and water ad libitum for 14 weeks.</P><P><B>Results</B></P><P>NOC reduced the body weight and adipose tissue mass, whereas OC did not. OC and NOC reduced mRNA levels of adipogenic genes, including peroxisome proliferator-activated receptor (<I>PPAR</I>)-γ, sterol regulatory element-binding protein-1c, and fatty acid-binding protein in white adipose tissue. The mRNA levels of genes related to β-oxidation or thermogenesis including <I>PPAR</I>-<I>α</I>, palmitoyltransferase-1α, and uncoupling protein-2 were increased by the OC and NOC relative to the HF group. Both OC and NOC clearly stimulated AMP-activated protein kinase (AMPK) activity. In particular, <I>PPAR</I>-<I>α</I>, palmitoyltransferase-1α, uncoupling protein-2 expression, and AMPK activity were significantly increased in the NOC group compared to in the OC group. NOC decreased glycerol-3-phosphate dehydrogenase activity whereas OC did not.</P><P><B>Conclusion</B></P><P>From these results, NOC could be suggested as a potential anti-obesity agent in obese rats fed a HF diet. The effects of the NOC on obesity were associated with changes of multiple gene expression, activation of AMPK, and inhibition of glycerol-3-phosphate dehydrogenase in white adipose tissue.</P>