대관령의 일조시간을 이용한 월별 일사량의 추정

박진기, 오시영, 백신철, 김봉섭, 신형섭, 박종화 忠北大學校 農業科學硏究所 2013 農業科學硏究 Vol.29 No.1

The monthly mean daily global solar radiation and sunshine duration, have been employed in this study to develop correlation model for Daegwallyeong during 2011. The corresponding monthly value of extraterrestrial solar radiation and possible duration of sunshine are calculated for Daegwallyeong meteorological data. Forecasting performance parameters such as coefficient of determination (R2), mean bias error (MBE) and root mean square error (RMSE) are presented as analyzed for the model. The model with multi-linear regression has the highest R2 value of 0.95 and average MBE and RMSE values of −0.11 MJ/m2day and 1.63 MJ/m2day, respectively. The model exhibited negative MBE which shows that the model resulted in underestimation of the global solar radiation relative to the meteorological measured value. The equation could be employed in the estimation of solar radiation at Daegwallyeong, other locations with similar meteorological characteristics.

그라인더(grinder) 사용에 의한 Hand-Arm Vibration Syndrome(HAVS)의 6예

임상혁,김록호,양길승,양정인,김상섭,전형준,박시복 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 수지증상이 있는 진동공구 작업자 8명에 대해 객관적이고 체계화된 진단방법을 이용하여 수지진동 증후군을 진단하고자 시행하였다. 방 법 : 과거병력, 가족력 등의 문진과 혈액 및 소변, 방사선 검사를 통해 다른 원인에 의한 레이노씨병을 배제하였고, 공구 측정 결과를 이용하여 작업과의 관련성을 보았으며, 냉수 침지검사와 근전도 검사를 통하여 수지진동 증후군을 진단하고자 하였다. 결 과 : 수지증상이 있는 진동공구 작업자 8명에 대해 과거병력, 가족력, 약물복용 및 과거 직업력 등 레이노씨병을 유발하는 요인에 대하여 조사하였고 특이점은 발견하지 못하였다. 다른 원인에 의한 레이노씨병을 배제하기 위해 혈액 및 소변, 방사선 검사를 하였고 8명 모두에서 특이 소견을 발견하지 못하였다. 위의 문진과 검사결과로 다른 원인에 의한 레이노씨병을 배제할 수 있었다. 해당사업장의 진동 공구 측정결과를 근거로 피검자의 공구가 ISO의 허용기준을 초과함을 알 수 있었다. 냉수 침지검사와 근전도 검사를 이용하여 피검자 8명중 6명이 말초 혈액순환 장해와 말초 신경염이 있는 것으로 진단되었다. 위의 내용을 근거로 6명은 진동에 의한 수지 진동 증후군으로 진단할 수 있었다. 결 론 : 수지증상이 있는 진동공구 작업자 8명에 대해 객관적이고 체계화된 진단방법을 이용하여 수지진동 증후군을 진단하였다. 해당 사업장의 진동 공구 작업자의 진동에 대한 검진이 필요할 것으로 생각된다. Objectives : To confirm the HAVS In workers exposed to hand-arm vibration with using the objective diagnostic methods. Methods : Several tests were used to help substantiate a clinical diagnosis of HAVS. Some other diseases were excluded by a medical interview, hematologic assessment, urinalysis, X-rays. The hand-arm vibration acceleration level of the grinder was evaluated for considering HAVS. Peripheral vascular changes were examined by a cold provocation test. An electromyography was implemented to ascertain the peripheral neural changes. Results : 8 workers with symptoms in hands & fingers, exposed to hand-arm vibration were examined. Some other diseases (primary Raynaud's disease, secondary Raynaud's disease in not occupational origin) were excluded by a medical interview, hematologic assessment, urinalysis, X-rays. The hand-arm vibration acceleration level of the grinder was 7.9 m/sec2. The recovery time of a skin temperature followed finger cooling was significantly prolonged in 6 workers with HAVS. The nerve conduction velocity was reduced in 6 workers with HAVS. Conclusions : So we report 6 cases of HAVS in grinding workers exposed to hand-arm vibration diagnosed objectively by an exclusion of some other disease, hand- arm vibration acceleration level, cold provocation test, electromyography.

베타-아밀로이드 펩타이드로 유발된 신경세포사와 tau 인산화와의 연관성

김지형,홍혜남,이종환,황승준,박형섭,이흥식,김동호 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.4

갑상선 선지방종 1예

김형일,홍순원<SUP>1<.SUP>,김은경<SUP>2<.SUP>,윤종호<SUP>3<.SUP>,박정수,Hyoung-Il Kim,M.D.,Soon Won Hong,M.D.<SUP>1<.SUP>,Eun Kyung Kim,M.D.<SUP>2<.SUP>,Jong Ho Yoon,M.D.<SUP>3<.SUP> and Cheong Soo Park,M.D. 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.1

Adenolipoma of the thyroid gland, also called thyrolipoma, is an extremely rare neoplasm characterized by encapsulated or tumorous mass of admixtures of mature adipose tissue and thyroid tissue. Only a few scattered cases have been reported in English literatures. It should be differentiated with encapsulated papillary carcinoma, follicular neoplasm and liposarcoma. We report an additional case of an adenolipoma of the thyroid gland. (Korean J Endocrine Surg 2003;4:51-54)

Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells

Yoon Hyoung Pai,Chae Seong Lim,Kyung-Ah Park,Hyun Sil Cho,Gyu-Seung Lee,Yong Sup Shin,Hyun-Woo Kim,Byeong Hwa Jeon,Seok Hwa Yoon,Jin Bong Park 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.4

In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the presence of tonic NMDA current (I_NMDA) generated by extrasynaptic NMDA receptors (eNMDARs), the functional significance of tonic I_NMDA in various brain regions remains poorly understood. Here, we demonstrate that activation of eNMDARs that generate INMDA facilitates the α-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptor (AMPAR)-mediated steady-state current in supraoptic nucleus (SON) magnocellular neurosecretory cells (MNCs). In low-Mg²⁺ artificial cerebrospinal fluid (aCSF), glutamate induced an inward shift in I_holding (I_GLU) at a holding potential (V_holding) of –70 mV which was partly blocked by an AMPAR antagonist, NBQX. NBQX-sensitive IGLU was observed even in normal aCSF at V_holding of –40 mV or –20 mV. IGLU was completely abolished by pretreatment with an NMDAR blocker, AP5, under all tested conditions. AMPA induced a reproducible inward shift in Iholding (I_AMPA) in SON MNCs. Pretreatment with AP5 attenuated I_AMPA amplitudes to ~60% of the control levels in low-Mg ²⁺ aCSF, but not in normal aCSF at V_holding of –70 mV. I_AMPA attenuation by AP5 was also prominent in normal aCSF at depolarized holding potentials. Memantine, an eNMDAR blocker, mimicked the AP5-induced I_AMPA attenuation in SON MNCs. Finally, chronic dehydration did not affect I_AMPA attenuation by AP5 in the neurons. These results suggest that tonic INMDA, mediated by eNMDAR, facilitates AMPAR function, changing the postsynaptic response to its agonists in normal and osmotically challenged SON MNCs.

Vitamin C as an Antioxidant and as a Provident

Park,Hyoung Sup 한국지질학회 1999 韓國脂質學會誌 Vol.9 No.1

비소세포폐암과 염증성 폐질환에서 가래와 혈액 및 조직에서 p16^INK4a Promoter 과메틸화

김정표,김경미,권순석,김영균,김관형,문화식,송정섭,박성학,안중현,Kim, Jeong Pyo,Kim, Kyong Mee,Kwon, Soon Seog,Kim, Young Kyoon,Kim, Kwan Hyoung,Moon, Hwa Sik,Song, Jeong Sup,Park, Sung Hak,Ahn, Joong Hyun 대한결핵및호흡기학회 2006 Tuberculosis and Respiratory Diseases Vol.60 No.2

연구배경 : 종양억제유전자인 $p16^{INK4a}$는 promoter region의 과메틸화로 인해 비소세포폐암의 발생에 관여하는 것으로 잘 알려져 있지만 폐암의 진단 방법으로 사용할 수 있는지는 아직까지 명확하지 않다. 이에 저자들은 비소세포폐암과 염증성 폐질환 환자의 가래와 혈액 및 조직에서 $p16^{INK4a}$ 메틸화의 발현 정도와 발현 일치 정도를 알아보고자 하였다. 방 법 : 폐종양을 주소로 내원하여 혈액, 가래 및 조직 검사를 시행한 후 최종적으로 비소세포폐암(18명)과 염증성 폐질환(5명) 진단을 받은 23명을 대상으로 하였다. 각 표본에서 DNA를 추출한 후 메틸화 특이성 중합효소연쇄반응법을 이용하여 $p16^{INK4a}$ promoter region의 메틸화 양상을 비교 분석하였다. 결 과 : 혈액에서는 비소세포폐암 그룹(88.9%, 18명중 16명)이 염증성 폐질환 그룹(20.0%, 5명중 1명)보다 $p16^{INK4a}$ 메틸화 발현이 증가하였으며(P=0.008), 가래에서는 비소세포폐암 그룹(12명중 10명)과 염증성 폐질환 그룹(5명중 4명)의 발현 차이는 없었다(P=1.00). 조직은 비소세포폐암 그룹에서 8명중 6명(75.0%)이 $p16^{INK4a}$ 메틸화가 나타났다. 혈액, 가래 및 조직에서 $p16^{INK4a}$ 메틸화의 발현 일치율은 7명 중 4명이 일치한 57.1%를 보였다. 결 론 : 비소세포폐암 그룹에서 염증성 폐질환 그룹보다 혈액의 $p16^{INK4a}$ 메틸화가 증가하였고 조직과의 일치율도 높았다. 따라서 폐암이 의심되는 고 위험 인자가 있는 환자에서 혈액의$p16^{INK4a}$ 과메틸화는 비소세포폐암과 염증성 폐질환을 감별하는데 유용하게 사용될 수 있을 것으로 생각한다. Background : The aberrant promoter hypermethylation of p16INK4a, as a tumor suppressor gene, is contributory factor to non-small cell lung cancer(NSCLC). However, its potential diagnostic impact of lung cancer is unclear. This study measured the level of $p16^{INK4a}$ promoter hypermethylation in the sputum and blood, and compared this with the level measured in the tissue obtained from NSCLC and pulmonary inflammation. Methods : Of the patients who visited the Our Lady of Mercy Hospital in Incheon, Korea for an evaluation of a lung mass and underwent blood, sputum, and tissue tests, 23patients (18 NSCLC, 5 pulmonary inflammation) were enrolled in this study. DNA was extracted from each sample and the level of p16INK4amethylation was determined using methylation-specific polymerase chain reaction. Results : $p16^{INK4a}$ methylation of the blood was observed in 88.9% (16 of 18) and 20.0% (1 of 5) of NSCLC and from pulmonary inflammation samples, respectively (P=0.008). Methylation of the sputum was observed in 83.3% (10 of 12) 80.0% (4 of 5) of NSCLC and pulmonary inflammation samples, respectively (P=1.00). Among the 8 NSCLC tissue samples, methylation changes were detected in 75.0% of samples (6 cases). Four out of seven tissue samples (57.1%) showed concordance, being methylated in both the blood and sputum. Conclusions : There was a higher level of $p16^{INK4a}$ methylation of the blood from NSCLC patients than from pulmonary inflammation. The tissue showed a high concordance with the blood in the NSCLC samples. These findings suggest that $p16^{INK4a}$ promoter hypermethylation of the blood can used to discriminate between NSCLC and pulmonary inflammation.

Transient Increase of Lipocortin 1 in Nuclei of the Hippocampal Pyramidal Neurons in Rats Induced by Immobilization Stress

Park, Hyoung-Sup,Jang, Yeon-Jin,Kim, Dong-Hou,Lee, Su-Ok,Na, Doe-Sun Korean Society for Biochemistry and Molecular Biol 1998 Journal of biochemistry and molecular biology Vol.31 No.2

Changes of lipocortin 1 (LC1) in the brain induced by immobilization stress were investigated in rats. Rats were immobilized for 0,1,2,3,4, and 5 h, and the brain slices were immunostained with anti-human LC1 antibodl (anti-LC1). Immunoreactivity of LCI (iLC1) was most prominent in neuronal cell bodies and processes of hippocampal CA regions and dentate gyrus. At rest without stress, most of the LC1 in the neuron located in the cytoplasm with the nuclei exhibiting relatively scarce immunoreactivity. Immobilization stress changed this intracellular distribution of LC1 by increasing nuclear LC1. The change was apparent in 1 h and reached the peak by 3 h. However, by 5 h of immobilization, the distribution pattern returned to that of the resting state. This transient nuclear translocation of LC1 was most prominent in $CA_1$ pyramidal neurons, and was not observed in areas other than the hippocampus. Adrenalectomy abolished this transient translocation of LC1. The roles of hippocampal LC1 as a mediator of glucocorticoid feedback signal and/or as an intracellar stress signaling protein could be suggested.

Transient Increase of Lipocortin 1 in Nuclei of the Hippocampal Pyramidal Neurons in Rats Induced by Immobilization Stress

( Hyoung Sup Park,Yeon Jin Jang,Dong Hou Kim,Su Ok Lee,Doe Sun Na ) 생화학분자생물학회 1998 BMB Reports Vol.31 No.2

Changes of lipocortin 1 (LCI) in the brain induced byimmobilization stress were investigated in rats. Rats were immobilized for 0,1,2,3,4, and 5h, and the brainslices were immunostained with anti-human LC1 (iLC1) was most prominent in neuronal cell bodies and processes of hippocampal CA regions and dentate gyrus. At rest without stress, most of the LC1 in the neuron located in the cytoplasm with the nuclei exhibiting relatively scarce immunoreactivity. Immobilization stress changed this intracellular distribution of LC1 by increasing nuclear LC1. The change was apparent in 1 h and reached the peak by 3 h. However, by 5 h of immobilization, the distribution pattern returned to that of the resting state. This transient nuclear translocation of LC1 was most prominent in CA₁pyramidal neurons, and was not observed in areas other than the hippocampus. Adrenalectomy abolished this transient translocation of LC1. The roles of hippocampal LC1 as a mediator of glucocorticoid feedback signal and/or as an intracellular stress signaling protein could be suggested.

Antioxidants; Vitamin C as an Antioxidant and as a Provident

Hyoung Sup Park 한국지질동맥경화학회 1999 韓國脂質學會誌 Vol.9 No.1