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Enhancement of Human Hair Growth Using Ecklonia cava Polyphenols
( Hyoseung Shin ),( A Ri Cho ),( Dong Young Kim ),( Semchin Munkhbayer ),( Soon Jin Choi ),( Sunhyae Jang ),( Seong Ho Kim ),( Hyeon Cheol Shin ),( Oh Sang Kwon ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.1
Background: Ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. E. cava polyphenols (ECPs) are known to increase fibroblast survival. The human dermal papilla cell (hDPC) has the properties of mesenchymal-origin fibroblasts. Objective: This study aims to investigate the effect of ECPs on human hair growth promotion in vitro and ex vivo. Methods:MTT assays were conducted to examine the effect of ECPs on hDPC proliferation. Hair growth was measured using ex-vivo hair follicle cultures. Real-time polymerase chain reaction was performed to evaluate the mRNA expression of various growth factors in ECP-treated hDPCs. Results: Treatment with 10 μg/ml purified polyphenols from E. cava (PPE) enhanced the proliferation of hDPCs 30. 3% more than in the negative control (p<0. 001). Furthermore, 0. 1 μg/ml PPE extended the human hair shaft 30. 8% longer than the negative control over 9 days (p<0. 05). Insulin-like growth factor-1 (IGF-1) mRNA expression increased 3. 2-fold in hDPCs following treatment with 6 μg/ml PPE (p<0. 05). Vascular endothelial growth factor (VEGF) mRNA expression was also increased 2. 0-fold by 3 μg/ml PPE (p<0. 05). Treatment with 10 μg/ml PPE reduced oxidative stress in hDPCs (p<0. 05). Conclusion: These results suggest that PPE could enhance human hair growth. This can be explained by hDPC proliferation coupled with increases in growth factors such as IGF-1 and VEGF. Reducing oxidative stress is also thought to help increase hDPCs. These favorable results suggest that PPE is a promising therapeutic candidate for hair loss.
( Hyoseung Shin ),( Soon Jin Choi ),( A Ri Cho ),( Dong Young Kim ),( Kyu Han Kim ),( Ohsang Kwon ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5
Background: Stress is a known cause of hair loss in many species. Objective: In this study, we investigated the role of acute stress on hair growth using a rat model. Methods: Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of rat and human dermal papilla cells (hDPCs), as well as serum cortisol and corticotropin-releasing hormone levels, were measured. Mast cell staining was performed on the biopsied tissue. In addition, Western blot and quantitative real time polymerase chain reaction were used to assess mast cell tryptase and cytokine expression, respectively in rat skin biopsies. Results: Stress-serum treatment reduced significantly the number of viable hDPCs and arrested the cell cycle in the G1 phase, compared to serum from unrestrained rats (p<0.05, respectively). Moreover, restrained rats had significantly higher levels of cortisol in serum than unrestrained rats (p<0.01). Acute stress serum increased mast cell numbers and mast cell tryptase expression, as well as inducing interleukin (IL)-6 and IL-1β up-regulation. Conclusion: These results suggest that acute stress also has an inhibitory effect on hair growth via cortisol release in addition to substance P-mast cell pathway. (Ann Dermatol 28(5) 600∼606, 2016)
Pearliness as an Intrinsic Characteristic of Surface
Hyoseung Park,Ye Seul Baek,Youngshin Kwak 한국색채학회 2011 한국색채학회 학술대회 Vol.2011 No.10
The perceived pearliness values of pink colored UV coated polycarbonate samples having three different pearlescent particle sizes and five different densities are investigated to be compared with the previous study using the similar samples. Each sample"s pearliness is estimated in the viewing both illuminated with D65 using magnitude estimation method. In total twenty-one observers estimate thirty samples in the experiment. The data analysis results show that the perceived pearliness values are mostly affected by the average pearl particle sizes than densities. Also comparison between two independent pearliness data sets shows that number of observers and the number of samples can play an important role to decide the pearliness scale. The conventional color measurement data such as gloss and CIELAB cannot predict the perceived pearliness phenomena. Further research is needed to establish the metric to predict the visual pearliness based on the measurement data.
FC 2-6 : Risk factors for premature hair graying: family history, smoking, and obesity
( Hyoseung Shin ),( Hyeong Ho Ryu ),( Junghee Yoon ),( Seongmoon Jo ),( Sihyeok Jang ),( Mira Choi ),( Ohsang Kwon ),( Seong Jin Jo ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: The risk factors for premature hair graying (PHG) have not been the focus of research. Objectives: This study aimed to identify risk factors for PHG in healthy young Korean males. Methods: We conducted a cross-sectional study using questionnaires in males younger than 30 years. After a pilot study that included 1,069 males, we surveyed 6,390 males about their gray hair status and various socio-clinical characteristics. Results: In the pilot study, body mass index, family history of PHG, and emotional stress were associated with PHG. The age of participants in the main survey was 20.2 ± 1.3 years (mean ± standard deviation). Of the 6,390 participants, 1,618 (25.3%) presented with PHG. Family history of PHG (odds ratio [OR], 12.82), obesity (OR, 2.61), and >5 pack-years history of smoking (OR, 1.61) were significantly associated with the development of PHG. A paternal history of PHG (OR, 14.84; CI, 10.10-21.81) (P <0.001) had a greater association with PHG than a maternal history (OR, 2.92; CI, 1.57-5.43) (P = 0.001). In the multivariate analysis, family history of PHG (OR, 2.63) and obesity (OR, 2.22) correlated with the severity of PHG. Conclusion: Family history of PHG, obesity, and smoking were significantly associated with the incidence of PHG. Smoking and obesity are independently associated with systemic oxidative stress. Our findings imply that hair graying is affected by oxidative stress, which may provide an approach for health education against obesity and smoking.
( Hyoseung Shin ),( Seong Jin Jo ),( Do Hun Kim ),( Seung Kwon Myung ),( Oh Sang Kwon ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Chemotherapy-induced alopecia (CIA) is a highly distressing event for cancer patients. Objectives: We here aimed to assess the efficacy of various interventions in the prevention of CIA Methods: We searched PubMed, EMBASE, and the Cochrane Library, from 20 June 2013 through 31 August 2013. Two of the authors independently reviewed and selected clinical trials that reported the efficacy of any intervention for prevention of CIA compared with that of controls. Relative risks (RRs) and 95% confidential intervals (CIs) were calculated for efficacy of CIA prevention by using random-effect or fixed-effect models. Results: Out of 691 articles retrieved, a total of 8 randomized controlled trials and 9 controlled clinical trials involving 1098 participants (616 interventions and 482 controls), were included in the final analyses. Scalp cooling, scalp compression, a combination of cooling and compression, topical minoxidil, and Panicum miliaceum were used as interventions. The participants were mainly breast cancer patients receiving doxorubicin- or epirubicin-containing chemotherapy. Scalp cooling, which is the most popular preventive method, significantly reduced the risk of CIA (RR = 0.38, 95% CI = 0.32-0.45), whereas topical 2% minoxidil and other interventions did not significantly reduce the risk of CIA. No serious adverse effects associated with scalp cooling were reported. Conclusion: Our results suggest that scalp cooling can prevent CIA in patients receiving chemotherapy.
Hyoseung KIM,Seojeong LEE 국제이네비해양경제학회 2016 International Journal of e-Navigation and Maritime Vol.5 No.1
According to Software Quality Assurance (SQA) and the Human Centred Design (HCD) guidelines for e-navigation by Maritime Safety Committee of International Maritime Organization, software quality related activities and practices will be in demand in the maritime field. To provide high quality software and a usable system to users, e-navigation SQA is supported by Republic of Korea. After merging with the HCD as suggested by Australia, it has been endorsed as IMO Circ.1512 in June 2015. To apply SQA to the maritime industry, it needs to achieve the current status of maritime software related industries. This article introduces the IMO Circ.1512 and the progress of e-navigation SQA so far including the international workshop held in Busan, Korea as previous accomplishments. Also, the result of a survey on the status of software quality management of the Korean domestic maritime IT related industry will be described. The purpose of survey is to find out how SQA is dealt with in domestic industry, what experiences the industry have had so far and what software project related issues they have. The questionnaire is composed of two parts. The first part mainly deals with fundamental knowledge about the scale of the company and the number of development teams s. The second part consists of three sub-parts with Quality Management, Configuration Management, and Process Management. Otherwise, several questions are surveyed with respect to engineering tools for SQA and education support. Approximately 150 cases were gathered. The outcome of the survey shows some points that both of industry and government can contemplate for the future.