Anti-diabetic Effect of Fermented Angelica gigas Nakai on blood glucose in StreptozotocininducedDiabetic Rats

Jae-Hyoek CHOI,Hee-Young AHN,Yu-Ra KIM,Kyu-Rim PARK,Young-Su CHO 한국생물공학회 2014 한국생물공학회 학술대회 Vol.2014 No.4

The Role of Mucosal Biopsy in the Diagnosis of Chronic Diarrhea: Value of Multiple Biopsies when Colonoscopic Finding is Normal or Nonspecific

( Joon Hyoek Lee ),( Poong Lyul Rhee ),( Jae Jun Kim ),( Kwang Chul Koh ),( Seung Woon Paik ),( Joung Ho Han ),( Howe J. Ree ),( Jong Chul Rhee ) 대한내과학회 1997 The Korean Journal of Internal Medicine Vol.12 No.2

Antioxidant Activity of Ethanol Extracts from Gyeongnam Native Plant, Corydalis speciosa Maxim

Jay Hyoek Choi(최재혁),Yong Nam Cho(조용남),Keyng Lag Choi(최경락),Yeong Bin Kim(김영빈),Jae Ki Song(송재기),Young Ho Chang(장영호),Tae Won Kim(김태원) 한국약용작물학회 2020 한국약용작물학회 학술대회논문집 Vol.2020 No.1

Relationship between hair loss pattern and health behavior according to Basic and Specific (BASP) classification

( Chung Hyoek Lee ),( Won-soo Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Health behavior is a motivation for action or an action taken by a person to maintain, attain, or regain good health and to prevent illness. However, the relationship between health behavior and pattern hair loss is not well studied. Objectives: This study was aimed at identifying health behavior of patients with pattern hair loss according to their BASP classification Methods: Questionnaires were collected from patients with pattern hair loss at our clinic from June 2017 to July 2018. The questionnaire included the hair loss pattern and health behavior. And analyzed the relationship between hair loss pattern and health behaviors. Results: Overall, 339 questionnaires were collected. There were 258 males and 81 females with an average age of 57 years. Patients were classified into three groups according to severity of hair loss. Mild to moderate group was 269, moderate to severe group was 50, and severe group was 20. As the severity is increased, there was a tendency to access medical treatment and increase willingness to treatment and compliance. However, only significant correlations were found between severity and access to accurate information sources. Conclusion: in patients with severe hair loss, favorable health behaviors are expected. Especially, there is an increased willingness to access an accurate information source. It is essential to give patients to accurate medical information to increase treatment compliance.

일반논문 : 일제강점기 설화,동화집 수록 지하국 대적퇴치담의 환상성 연구-인물, 공간, 해결방식을 중심으로-

권혁래 ( Hyoek Rae Kwon ) 온지학회 2014 溫知論叢 Vol.0 No.38

이 논문에서 필자는 일제강점기 설화·동화집에 수록된 지하국대적퇴치담 계열 옛이야기 일곱 편을 고찰하면서 등장인물, 공간, 해결방식의 면에서 환상성 요소의 발현양상과 의미를 연구하였다. <장수 되는 물>에서 환상적 요소는 박쥐 도둑, 그 박쥐 도둑이 사는 이상한 섬, 박쥐 도둑이 사용하는 ‘또아리검’이라는 주술 도구, 장수 되는 ‘신기한 물’ 등이다. <머리 셋 가진 중과 포수>의 환상적 요소는 머리 셋 가진 중, 용왕, 용왕의 아들, 딸 등의 인물, 지하동굴세계, 용궁 등의 공간, 꾀꼬리, 연적 등의 주보로 나타난다. <도둑의 이름은 신재복>은 지하국대적퇴치담의 기본구조를 지녔지만, 환상 요소가 약화되었다. <머리 아홉 달린 도적>의 환상적 요소는 머리 아홉 달린 도적와 노파, 도적이 사는 산중 지하동굴이라는 공간, 동자삼과 같은 주보 등이다. <지하국대적퇴치>(1-3)의 환상적 요소는 대적, 마귀, 독수리 도적이라는 인물, 산속 바위밑 지하세계라는 공간, 장수 되는 물, 동삼수, 칼과 같은 주보로 나타난다. 이상의 작품들에서 주목되는 신이인물은 박쥐 괴물, 독수리 괴물, 머리 셋(아홉) 가진 도적 같은 ‘조류형 괴물’이다, 이 조류형 괴물은 지상의 다양한 공간을 마음대로 넘나들며 여자 및 재물을 탈취하는 악인형 괴물 캐릭터이다. 환상공간으로는 서쪽바다의 큰 섬, 지하동굴, 용궁세계, 산속 지하세계 등이 주목된다. 서사 해결방식에서는 ‘장수 되는 샘물, 또아리검, 여덟 구멍 난 연적, 동자삼, 동삼수’과 같은 주보가 파악되었다. 남자들은 도적들이 사는 공간을 찾아가 주보를 사용하여 도적을 죽이고 여자를 찾아왔다. 이 작품들은 옛사람들의 가난, 폭력적 집단에 아내를 빼앗기는 고난, 삶의 문제 해결방식을 환상적 수법으로 그리고 있다. 우리는 이러한 옛이야기에서 옛사람들의 삶의 양상 및 꿈을 이해하고, ‘환상’의 다양한 기법과 의미를 발견하게 된다. I studied fantasy elements in terms of characters, space, and solving approach while studying four Underground Nation Big Enemy Conquest Tale which contained In the Japanese occupation folktales and fairy tales series. In Longevity of Water, fantasy elements are bat thief, strange island where the bat thief lives, a magic tool ``Ttoahri sword`` which bat thief uses, and ``Miraculous Water`` that enables longevity. Fantasy elements in Monk with Three Head and the Gunner indicate character as monk with three head, the Sea King, son and daughter of the Sea King, space as underground world, the Sea Palace, and a magic tool as oriole, and the inkstone water container. The Thief`s Name Is Shin Jae Bok carries basic structure of Underground Nation Big Enemy Conquest Tale, but weakened in fantasy elements. Thief With Nine Head`s fantasy elements are thief with nine head, an old woman, space as underground cave in the mountain where the thief lives, and a magic tool as wild ginseng that looks like child. God figure that noticed in these tales is ``Birds Human`` like bat monster, and the thief with three·nine head. This Birds human is evil type monster character which flying wherever it wants and seizing women and wealth. Big island at West Sea, underground cave and the Sea Palace are noted as fantasy space. In the epic-solving approach, a magic tool such as Longevity Water, Ttoahri sword, inkstone water container with eight holes, and wild ginseng that looks like child were identified. Men find the space where thieves live, use the Magic tool and kill the thieves and find back the women. These stories portray peoples` poverty, hardship that has deprived wife from violent groups, and problem-solving approach in life with fantasy techniques. We can understand peoples` aspects of like and dream, and find a variety of techniques and meaning of ``Fantasy`` in these tales.

Synergistic Use of Immunomodulatory Nanoparticles and Electrical Ablation for Effective Cancer Immunotherapy

Jun-Hyoek HAN,Wooram PARK 한국생물공학회 2023 한국생물공학회 학술대회 Vol.2023 No.4

Testing LAEs and LBGs as tracers of the large-scale structures in the high-z universe

Sang Hyoek Im,Ho Seong Hwang,HR5-ODIN Collaborators 한국천문학회 2023 天文學會報 Vol.48 No.2

난소적출 흰쥐의 골밀도 및 골대사에 쌍화탕가록용(雙和湯加鹿茸)이 미치는 영향

이혁 ( Hyoek Lee ),임형호 ( Hyung Ho Lim ) 한방재활의학과학회 2003 한방재활의학과학회지 Vol.13 No.2

Objectives : As the average span of human life extends, more and more people are at risk of osteoporosis that is one of the typical diseases for the aged people. This thesis presents the effects of Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum on bone density, bone biochemical marker, and fetal calvarial cel(FCC) of the Sprague Dawleys(S.D) Rat that have induced osteoporosis. The purpose is to see how Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum improves the osteoporosis symptoms. Methods : The first experiment is that Sprague Dawleys Rat were dosed with Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum(KS) for 70 days, one time a day. Two different doses were applied high dose(KSH), and low dose(KSL) groups. The results were compared with a comparing group. The second experiment is that the fetal calvarial cells (FCC) obtained from babies inside pregnant Sprague Dawleys Rat were applied with Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum. The FCC from high dosed and low dosed groups were compared with that from a comparing group. Results : 1. Femur bone density increases significantly in KSH, KSL. Tibia bone density increase significantly in KSH. 2. Femur and tibia bone ash density increase significantly in KSH, KSL. 3. Calcium of bone increases significantly in KSH. Magnesium and phosphorus of bone increases significantly in KSH, KSL. 4. Osteocalcin and ALP of serum decreases in KSH, KSL but insignificantly. 5. IL-6 of serum decreases significantly in KSH, KSL. 6. OH-P of urine increases significantly in KSH. 7. Calcium and magnesium of serum increase significantly in KSH, KSL. Phosphorus of serum decreases significantly in KSH, KSL. 8. GOT, GPT, creatinine don`t change significantly. 9. Cell proliferation and ALP activity of FCC increase significantly in KSH. 10. Protein and collagen synthesis of FCC increase significantly in KSH. Conclusion : It was found that Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum have a tendency to make significant increases in bone densities by enhancing bone formation and by retarding bone absorption. It was concluded that Ssanghwa-tang(Shuanghe-tang) added to Cervi cornu parvum activates Osteoblast cells effectively.

Role of Hyperinsulinemia and Glucose Intolerance in the Pathogenesis of Nonalcoholic Fatty Liver in Patients with Normal Body Weight

(Joon Hyoek Lee),(Poong Lyul Rhee),(Jong Kyun Lee),(Kyu Taek Lee),(Jae Jun Kim),(Kwang Cheol Koh),(Seung Woon Paik),(Jong Chul Rhee),(Kyu Wan Choi) 대한내과학회 1998 The Korean Journal of Internal Medicine Vol.13 No.1

N/A Objectives : The pathogenesis of nonalcoholic fatty liver in non - obese persons is poorly understood. We aimed to elucidate whether hyperinsulinemia and glucose intolerance are associated with development of fatty liver in patients with normal body weight Methods : Forty - seven ents with fatty liver were divided into non-obese (n=25) and obese groups (n=22) according to age adjusted body mass index. Inclusion criteria were as follows: (I) elevated transaminase levels during more than 3 months of follow up period, (2) no detectable HBsAg or anti-HCV in the serum, (3) alcohol consumption less than 40 gm/week, (4) no use of potential hepatotoxic drugs within 3 months and (4) sonographic evidence of fatty liver(moderate to severe degree). Baseline insulin levels and oral glucose tolerance test using 75gm of glucose were performed and the results were compared in each group of patients. Results : Mean baseline insulin levels were elevated in both groups above the reference value, 9.3± 3.5 μU/L in non-obese group and 9.9±3.5 μU/L in obese group (p=0.26). Seventeen of non-obese patients (68%) had elevated basal insulin level and 16 of obese patients (73%) had elevated basal insulin level (p=0.39). In oral glucose tolerance test, there was no difference in glucose level between non-obese and obese groups from O minute to 180 minutes (p > 0.05). Eleven patients from the non-obese group (44%) and 8 patients from the obese group (36%) had either impaired glucose tolerance or diabetes (p=0.29). Conclusion : Our data suggest that hyperinsulinemia and glucose intolerance may play a role in the pathogenesis of fatty liver in patients with normal body weight as well as in patients with obesity.

저등급 악성도 위 MALT 림프종의 임상적 고찰

이준혁(Joon Hyoek Lee),백승운(Seung Woon Paik),심상군(Sang Goon Shim),류광현(Kwang Hyun Ryu),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),이석호(Suk Ho Lee),이규택(Kyu Taek Lee),이종균(Jong 대한내과학회 1999 대한내과학회지 Vol.57 No.1

N/A Low-grade gastric MALT lymphoma arises from long-standing Helicobacter pylori(Hp) infection. High remission rates for these lymphoma have been observed after H. pylori eradication. There was debates on the optimal treatment of low-grade gastric MALT lymphoma. The purpose of this study is to investigate clinical and endoscopic characteristics of primary low-grade gastric MALT lymphoma and to assess short-term clinical outcome of various modalities of treatment. Methods : 30 patients(14 male, 16 female, mean age 44.9 years, range 26-76, mean follow-up 22.9 months) with primary low-grade gastric MALT lymphoma, diagnosed at the Samsung Medical Center from March 1995 to September 1998, were evaluated in a retrospective study. We evaluated patient's presenting symptoms, endoscopic finding, Hp status, staging by Musshoff system, and recurrence rate according to treatment mordalities. Results : The most common symptom is epigastric discomfort or pain(36.7%). Endoscopic appearances of gastric MALT lymphoma shows the wide variation from mucosal thickening to overt malignancy. The most common site of gastric MALT lymphoma is the gastric antrum and lower body(9 and 6 patients). Histologically, 70% were found to be Hp infected. Of 21 Hp(+) patients, 11 patients were clinical stage IE and received Hp eradication by PPI-based triple regimens. 81.8%(9/11) showed complete remission. Among 11 patients, 6 patients studied by PCR. After Hp eradication, 5 in 6 patients showed persistent IgH rearangement by PCR. The mean follow-up time is 22.8 months(range 3 to 36 months), One patient, who showed complete histologic regression during second endoscopy, relapsed MALT lymphoma after 6 months. The other one patient showed no change of lymphoma and underwent surgery. 12 patients underwent surgical treatment and showed no evidence of relapse. The mean follow-up time is 35.9 months. 2 patients received chemotherapy with CHOP regimen and showed complete remission. The mean follow-up time is 6.7 months. 2 patients received radiotherapy and showed no evidence of relapse. The mean follow-up time is 15 months. Conclusion ' Our study shows that complete remission rate after Hp eradication is as high as some studies recently reported. This suggest that Hp eradication may be considered as first-line therapy of low-grade gastric MALT lymphoma of stage IE.