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Ahn, Hyo-Jin,Kim, Youn-Su,Shim, Hee-Sang,Park, Byung Kyu,Moon, Won-Jin,Bae Kim, Won,Seong, Tae-Yeon American Scientific Publishers 2010 Journal of nanoscience and nanotechnology Vol.10 No.12
<P>We have one-pot fabricated Si-based nanocomposite electrodes containing Ag nano-dots for thin-film Li rechargeable batteries by a co-sputtering method. The structural and electrochemical properties of the Si/Ag nanocomposite electrodes are investigated via transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and cycler. The TEM and XRD results show that crystalline Ag nano-dots (approximately 5-9 in size) are well-dispersed within an amorpohous Si matrix. It is shown that the Si/Ag nanocomposite electrode shows much better structural stability than the Si only sample. It is also shown that the Si/Ag nanocomposite electrode shows superior capacity retention compared to the Si only electrode. The results indicate that the presence of the Ag nano-dots is important minimizing the formation of cracks in the electrode, so leading to the better life-time for thin-film Li rechargeable batteries.</P>
Original Article : Serum transferrin as Liver fibrosis biomarkerin patients with chronic hepatitis B
( Hyo Jung Cho ),( Soon Sun Kim ),( Seun Joo Ahn ),( Joo Han Park ),( Dong Joon Kim ),( Young Bae Kim ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Background/Aims: Transferrin and alpha-1 antitrypsin are reportedly associated with liver fibrosis. We evaluated the usefulness of serum transferrin and alpha-1 antitrypsin as new liver fibrosis markers in patients with chronic hepatitis B. Methods: The study included 293 patients with chronic hepatitis B who underwent a liver biopsy between October 2005 and June 2009, and who had no history of hepatocellular carcinoma. Serum markers and liver fibrosis stages were compared. Results: Univariate analysis revealed that age (P<0.001), serum platelet count (P<0.001), and serum alkaline phosphatase level (P=0.003) differed significantly between the patients with and without liver cirrhosis. Serum transferrin levels were significantly lower in advanced fibrosis than in mild fibrosis in both univariate analysis (P=0.002) and multivariate analysis (P=0.009). In addition, the serum transferrin level was significantly lower in cirrhotic patients than in noncirrhotic patients (P=0.020). However, the serum level of alpha-1 antitrypsin was not significantly associated with liver cirrhosis in patients with chronic hepatitis B. Conclusions: Serum transferrin could be promising serum marker for predicting advanced liver fibrosis in patients with chronic hepatitis B.
( Hyo Jung Cho ),( Sun Young Park ),( Ga Won Song ),( Seun Joo Ahn ),( Ho Joong Kim ),( Joo An Hwang ),( Soon Sun Kim ),( Sung Won Cho ),( Jae Youn Cheong ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background/aims: Liver biopsy remains the gold standard to assess hepatic fibrosis. To identify new candidate markers for liver fibrosis, we performed serum based proteomic approach in patients with chronic hepatitis B (CHB). Methods: Sera were obtained from 12 patients with CHB at the time of liver biopsy. Batt-Ludwig classification was used for staging liver fibrosis. Proteins in pooled sera of mild fibrosis (F1 or F2, n=6) and liver cirrhosis (F4, n=6) were compared and analyzed by using 2D gel electrophoresis. Protein spots varying among two groups were excised, digested and submitted for tandem mass spectrometry for protein identification. Validation study was done for new markers among 293 CHB patients who underwent liver biopsies. Results: We identified 147 proteins which were increased or decreased significantly in hepatic cirrhosis. Among these 147 proteins, we found 7 candidate biomarkers which were supposed to be correlated with liver fibrosis. Alpha2-macroglobulin, kininogen1, transferrin and alph1-antitrypsin (A1AT) were increased whereas inter-alpha inhibitor H2, apolipoprotein A4 and apolipoprotein A1 were decreased in patients with cirrhosis. We performed validation study for A1AT and transferrin which were suitable for quantification in 293 patients with CHB. However, A1AT and trasnferrin were not significantly associated with liver cirrhosis in validation cohort. Conclusions: We identified several candidate biomarkers for predicting liver cirrhosis in patients with CHB using proteomics technology, but could not be confirmed in large validation cohort. Further advances in proteomics techniques and establishment of simple and quantitative methods are required to identify non-invasive diagnostic marker of liver fibrosis.
Ninjurin1 Deficiency Attenuates Susceptibility of Experimental Autoimmune Encephalomyelitis in Mice
Ahn, Bum Ju,Le, Hoang,Shin, Min Wook,Bae, Sung-Jin,Lee, Eun Ji,Wee, Hee-Jun,Cha, Jong-Ho,Lee, Hyo-Jong,Lee, Hye Shin,Kim, Jeong Hun,Kim, Chang-Yeon,Seo, Ji Hae,Lo, Eng H.,Jeon, Sejin,Lee, Mi-Ni,Oh, Go American Society for Biochemistry and Molecular Bi 2014 The Journal of biological chemistry Vol.289 No.6
<P>Ninjurin1 is a homotypic adhesion molecule that contributes to leukocyte trafficking in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, <I>in vivo</I> gene deficiency animal studies have not yet been done. Here, we constructed Ninjurin1 knock-out (KO) mice and investigated the role of Ninjurin1 on leukocyte trafficking under inflammation conditions such as EAE and endotoxin-induced uveitis. Ninjurin1 KO mice attenuated EAE susceptibility by reducing leukocyte recruitment into the injury regions of the spinal cord and showed less adhesion of leukocytes on inflamed retinal vessels in endotoxin-induced uveitis mice. Moreover, the administration of a custom-made antibody (Ab<SUB>26–37</SUB>) targeting the Ninjurin1 binding domain ameliorated the EAE symptoms, showing the contribution of its adhesion activity to leukocyte trafficking. In addition, we addressed the transendothelial migration (TEM) activity of bone marrow-derived macrophages and Raw264.7 cells according to the expression level of Ninjurin1. TEM activity was decreased in Ninjurin1 KO bone marrow-derived macrophages and siNinj1 Raw264.7 cells. Consistent with this, GFP-tagged mNinj1-overexpressing Raw264.7 cells increased their TEM activity. Taken together, we have clarified the contribution of Ninjurin1 to leukocyte trafficking <I>in vivo</I> and delineated its direct functions to TEM, emphasizing Ninjurin1 as a beneficial therapeutic target against inflammatory diseases such as multiple sclerosis.</P>
A novel case of acute radiodermatitis possibly induced by carbon ion radiotherapy
( Sung Jin Park ),( Min Seok Ham ),( Ji Hyuck Hong ),( Dae Yeon Kim ),( Soo Hong Seo ),( Young Chul Kye ),( Hyo Hyun Ahn ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Radiation dermatitis is defined as skin changes after radiation exposure, which mostly follow certain predictable course dictated by radiation dose, timing, and affected individual cells. Acute radiation dermatitis is mostly characterized as mild erythema and edema which occurs hours after exposure, whereas chronic radiodermatitis occurs after months to years, leading to skin fibrosis and atrophy. Conventional radiation therapy utilizes ionizing radiation, especially known as X-rays and Gamma rays. However, recent studies regarding the other categories of ionizing radiation is actively ongoing. Among them, carbon ion radiation therapy using particle beams is cutting edge issue. A 43-year-old man presented with mild pricky erythematous swelling on left forehead, first appearing 3 days ago. Diagnosed with palate cancer extending to skull base a year before, he was treated with carbon ion radiation therapy (16 times, 64Gy) 9 months ago at Japan. We took a skin biopsy, which turned out to be mild spongiosis with perivascular, periadnexal lymphocytic infiltration. Under the clinical diagnosis of radiodermatitis, patient got no further treatment. Unlike common course of acute radiodermatitis which appears 2-24 hours following exposure, the patient experienced relatively long latency period of 9 months. Proper patient notification regarding adverse dermatological outcome is therefore necessary for whom receiving carbon ion therapy.