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文錫哉,羅相孝,金宇煥 圓光大學校 漢醫科大學 1984 圓光漢醫大論文集 Vol.- No.2
This study is investigated to examine how efficiently the ultra short wave-cure utensil would be helpful to acupuncture treatment. Through investigation, we abtained the following consequences in result of ultra short wave cure [with acupuncture treatment in the causes of 15 patients (44.12%)] to 34 cases of patients who had come receive treatment in Kwang Ju oriental medical Hospital for 2 months from July to August, 1984 ; 1) According to the proportion of males to females, the number of female patients [21 cases (61.76 %)], is more than that of male patients [13 cases (38.24 %)], and in age the ages between 10 and 29 os the highest in th rate. 2) In term of onset of disease, the cases of 10 days period formed 41.18 %(14 cases) of the total and over 2 years period were second 14 cases (29.41 %). 3) In the frequency of treatment, 10-20 times was 88.24 %(30 cases) of the total and in term, 20-40 days was necessary in treatment. 4) More of abjects were patients in motornervous system. 5) In spite of chronic patients in most objects, significant efficiency was abtained in 70.59 %(24 cases).
( Hyo Seok Na ),( Sang Bum An ),( Hee Pyoung Park ),( Young Jin Lim ),( Jung Won Hwang ),( Young Tae Jeon ),( Seong Won Min ) 대한마취과학회 2011 Korean Journal of Anesthesiology Vol.60 No.1
Background: This randomized controlled study evaluated the efficacy of intravenous patient-controlled analgesia (IV-PCA) with fentanyl and ketorolac for neurosurgical patients, and compared the effectiveness of IV-PCA with intermittent analgesics injection. Methods: The patients undergoing craniotomy were randomly assigned to two groups. Patients of group P (n = 53) received fentanyl (0.2 μg/kg/hr) and ketorolac (0.3 mg/kg/hr) via IV-PCA, and those of group N (n = 53) received intermittent fentanyl or ketorolac injection as needed. Pain was evaluated using a 0-10 visual analogue scale (VAS) at postoperative 1, 4, and 24 hr. The amount of infused analgesic drugs, Glasgow Coma Scale (GCS) score, systolic arterial pressure, heart rate, respiratory rate, and the incidence of nausea and miosis were measured at the same time points. Results: Although VAS of pain (VASp) was comparable at postoperative 1 hr (P = 0.168) between the two groups, the group P had significantly lower VASp at postoperative 4 hr (P = 0.007) and 24 hr (P = 0.017). In group P, less analgesic drugs were administered at postoperative 1 hr, and more analgesic drugs were administered at postoperative 24 hr. There were no differences between two groups with respect to nausea, GCS, systolic arterial pressure, and heart rate. IV-PCA did not further incur respiratory depression or miosis. Conclusions: IV-PCA with fentanyl and ketorolac after craniotomy is more effective analgesic technique, without adverse events, than the intermittent administration of analgesics. (Korean J Anesthesiol 2011; 60: 30-35)
Na, Seok Hyeon,Jeon, Hyejin,Kim, Yoo Jeong,Kwon, Hyo Il,Selasi, Gati Noble,Nicholas, Asiimwe,Yun, Chang-Soo,Lee, Sang Ho,Lee, Je Chul Elsevier 2017 International journal of antimicrobial agents Vol.49 No.1
<P><B>Abstract</B></P> <P>The aim of this study was to screen lead compounds exhibiting potent in vitro antimicrobial activity against multidrug-resistant (MDR) <I>Acinetobacter baumannii</I> strains from a library of chemical compounds. In a high-throughput screening analysis of 7520 compounds representative of 340,000 small molecules, two 4<I>H</I>-4-oxoquinolizine compounds were the most active against <I>A. baumannii</I> ATCC 17978. Subsequent selection and analysis of 70 4<I>H</I>-4-oxoquinolizine compounds revealed that the top 7 compounds were extremely active against extensively drug-resistant (XDR) <I>A. baumannii</I> isolates. These compounds commonly carried a 1-cyclopropyl-7-fluoro-4-oxo-4<I>H</I>-quinolizine-3-carboxylic acid core structure but had different C-8 and/or C-9 moieties. Minimum inhibitory concentrations (MICs) of the seven compounds against fluoroquinolone-resistant <I>A. baumannii</I> isolates were found to be in the range of 0.02–1.70 µg/mL regardless of the mutation types in the quinolone resistance-determining region (QRDR) of GyrA and ParC. Cytotoxicity of the seven compounds was observed in HeLa and U937 cells at a concentration of 50 µg/mL, which was >32.5- to 119-fold higher than the MIC<SUB>90</SUB> for <I>A. baumannii</I> isolates. In conclusion, novel 4<I>H</I>-4-oxoquinolizine compounds represent a promising scaffold on which to develop antimicrobial agents against drug-resistant <I>A. baumannii</I> strains.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Development of new antimicrobials for drug-resistant <I>Acinetobacter baumannii</I> is urgently needed. </LI> <LI> 4<I>H</I>-4-oxoquinolizines were screened against <I>A. baumannii</I> ATCC 17978 by HTS analysis. </LI> <LI> Novel 4<I>H</I>-4-oxoquinolizines were extremely active against XDR <I>A. baumannii</I> isolates. </LI> <LI> Novel 4<I>H</I>-4-oxoquinolizines were active against fluoroquinolone-resistant <I>A. baumannii</I>. </LI> </UL> </P>