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양소영 ( Yang So-young ),장선미 ( Jang Sunmee ),권순홍 ( Kwon Sun-hong ),이주연 ( Lee Juyeun ),아영미 ( Ah Youngmi ),강신우 ( Kang Cinoo ),홍성현 ( Hong Sung-hyun ),박혜경 ( Park Hyekyung ) 한국보건사회연구원 2020 保健社會硏究 Vol.40 No.3
본 연구의 목적은 약사가 환자의 거주지를 방문하여 약물 사용의 적절성과 부작용 발생 여부를 파악하고 약물에 대한 정보제공 및 복약지도를 실시하는 ‘올바른 약물 이용지원’ 시범사업의 효과를 평가하는 것이다. 시범사업에서는 다제약물을 복용하는 만성 질환자를 건강보험청구자료를 이용해 선정하여, 사업 참여에 동의한 사람에 대해 총 4차례의 상담교육을 진행하였다. 대상자의 복약순응, 약물 관련 인지, 중복투약 등을 현황을 파악하고, 1차와 4차에서 조사한 현황을 비교하였다. 4차에 걸친 상담 결과, 약물 인지도, 복약순응도, 일반적인 약물 지식 수준이 개선되었으며, 전체적으로 중복투 약 환자 분율이 감소하였다. 의약사 지시에 따른 불용의약품 발생률이 증가하였으며, 자의적 판단으로 불용의약품을 발생시키는 비율이 줄어들었다. 본 시범사업은 환자의 약물 사용을 포괄적으로 관리할 수 있는 새로운 프로그램을 개발했다는 점에서 의의가 있다. 그러나 보건의료 직능 간 협업체계가 제대로 구축되지 않아 약사에 의해 파악된 약물관련문제가 충분히 개선되지 못한 부분이 존재하며, 이는 향후 사업 추진에서 개선 되어야 할 과제이다. 이를 위해 현재 운동과 영양 관리를 수행하고 있는 지역사회일차의 료지원센터에 본사업을 결합시키는 방안도 고려해볼 수 있겠다. The purpose of our study was to evaluate the effectiveness of the pilot project for polypharmacy management, in which pharmacists visit participants’ residences to identify the appropriateness of medication use and the incidence of adverse events, provide medication reconciliation, and educate how to manage medication. In the pilot program, health insurance claims data were used to identify the polypharmacy patients with chronic diseases, and a total of four counseling sessions were conducted for patients who agreed to participate in the program. The status of the patients’ medication adherence, medication-related awareness, and medication duplication was identified, and the results from the first and fourth rounds of consultation were compared. The medication-related awareness, medication adherence, and general knowledge of medication were improved. The incidence rate of unused medication according to the decision of healthcare provides increased, while that of unused medication due to patients’ own decisions decreased. This pilot project is a new comprehensive program for medication management. However, the medicationrelated problems identified by pharmacists have not been sufficiently reconciled due to the lack of a cooperative system among healthcare providers, which is a task to be improved in the future. Combining this program with Community-based Primary Medical Support Center, which currently conducts exercise and nutrition management, can be also considered.
AGR2, a mucinous ovarian cancer marker, promotes cell proliferation and migration
이제호,Kyoungsook Park,Yong Jin Chung,Hyekyung So,김광수,박준수,Mijoung Oh,Minwha Jo,Kyusam Choi,이은주,Yoon-La Choi,Sang Yong Song,배덕수,김병기 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.2
Ovarian cancer is a leading cause of death in women. Early detection of ovarian cancer is essential to decrease mortality. However, the early diagnosis of ovarian cancer is difficult due to a lack of clinical symptoms and suitable molecular diagnostic markers. Thus,identification of meaningful tumor biomarkers with potential clinical application is clearly needed. To search for a biomarker for the early detection of ovarian cancer,we identified human anterior gradient 2 (AGR2)from our systematic analysis of paired normal and ovarian tumor tissue cDNA microarray. We noted a marked overexpression of AGR2 mRNA and protein in early stage mucinous ovarian tumors compared to normal ovarian tissues and serous type ovarian tumors by Western blot analysis and immunohistochemistry. To further elucidate the role of AGR2 in ovarian tumorigenesis,stable 2774 human ovarian cancer cell lines overexpressing AGR2 were established. Forced expression of AGR2 in 2774 cells enhanced the growth and migration of ovarian cancer cells. AGR2 protein was detected in the serum of mucinous ovarian cancer patients by Western blot and ELISA analysis. Thus,AGR2 is a potential biomarker for the diagnosis of mucinous ovarian cancer and an ELISA assay may facilitate the early detection of mucinous ovarian cancer using patient serum.
Chrysanthemum indicum attenuates cisplatin-induced nephrotoxicity both in vivo and in vitro.
Kim, Tae-Won,Kim, Young-Jung,Park, So-Ra,Seo, Chang-Seob,Ha, Hyekyung,Shin, Hyeun-Kyoo,Jung, Ju-Young Natural Product Communications 2015 Natural product communications Vol.10 No.3
<P>Chrysanthemum indicum Linné has been used in traditional medicine to treat various inflammatory diseases in East Asia. The aim of the present study was to investigate the protective effect of C. indicum ethanol extract (CILE) against cisplatin-induced nephrotoxicity. An HPLC-photodiode array method was used for fingerprint analysis of the CILE and ten major constituents were quantitatively analyzed. The protective effect of CILE on cisplatin-induced nephrotoxicity was assessed using both in vitro (porcine kidney cell; PK15 cell) and in vivo (Sprague Dawley rat) experiments. In the in vitro study, CILE enhanced PK15 cell viability after cisplatin treatment with recovered antioxidant status. Moreover, the increased p53 expression after cisplatin treatment was decreased in the CILE pretreated cells. In the in vivo study, SD rats were treated for 28 consecutive days with CILE (0, 100, 300 and 500 mg/kg). On day 23, a single dose of cisplatin (5 mg/kg) was injected to induce nephrotoxicity. The CILE pretreated group showed recovered serum renal function index with ameliorated oxidative stress. Histopathological alterations and apoptosis in the kidney were also decreased in CILE pretreated rats. Taken together, CILE could attenuate cisplatin-induced nephrotoxicity and might be a beneficial agent for acute renal failure management.</P>