심근경색 모델 흰쥐에서 스트레스가 B-type Natriuretic Peptide 발현 및 심박변이율 변화에 미치는 영향

이삼윤(Sam Youn Lee),이미경(Mi Kyoung Lee),김남호(Nam-ho Kim),주민철(Min Cheol Joo),조항정(Hyang Jeong Jo),강지숙(Ji Sook Kang),김병숙(Byung Sook Kim),윤선식(Sun Sik Yoon),최을식(Eul Sig Choi),이문영(Moon Young Lee) 대한스트레스학회 2010 스트레스硏究 Vol.18 No.3

심박변이율의 감소는 심근 경색 환자에서 예후의 악화와 관련되어 있다. 심박변이율 중 very low frequency가 심부전환자의 예후를 판단할 수 있는 독립적 인자로서 사용이 가능하다고 보고된 바 있으며, 심실의 압력 증가에 반응해서 생성되는 B-type natriuretic peptide가 심근 경색의 예후 인자로서 사용할 수 있음 역시 보고된 바 있다. 본 연구에서는 심근경색 모델을 제작하여 일정의 회복 기간을 거친 다음 다시 일정 기간의 스트레스를 겪게 한 후 심박변이율의 변화 및 심실 조직에서의 BNP 발현 정도를 비교하여 스트레스에 의한 영향을 관찰하고자 하였다. Sprague-Dawley계 수컷 흰쥐 15마리를 대상으로 하였다. 실험동물은 인위적 스트레스 및 수술을 받지 않은 대조군(CON, n=5), 심근경색 수술을 받은 후 restraint stress를 받지 않은 군(MI+No Stress, n=5), 심근경색 수술을 받은 후 1주일 동안 restraint stress를 받은 군(MI+Stress, n=5)으로 분류하였다. 심근경색 모델 제작 직후 15분 이상 심전도의 변화를 기록하였으며, 2개월 정도 후 심근경색 수술을 받은 동물을 두 군으로 나누어 그 중 한 군에는 1주일 동안 restraint stress를 가한 후 restraint stress를 가하지 않은 동물과 심박변이율을 비교 분석하였다. 심실 조직은 좌심실 전벽 부위의 위축을 관찰할 수 있었고, 대식세포에 의하여 응고, 괴사된 심근세포의 탐식과 혈관이 풍부한 육아조직 및 섬유 변화를 볼 수 있었다. 심박변이율은 심근경색 수술을 받은 직후 심박수는 유의한 증가를 보였고, standard deviation of the normal to normal intervals (SDNN), very low frequency (VLF) 및 low frequency (LF)의 유의한 감소를 보였다. 심근경색 수술을 받았던 동물에서 두 달 정도의 회복 기간을 거친 후 스트레스를 받지 않은 군은 심박수 및 기타 심박변이율 분석에서 SDNN 값을 제외하고는 정상군과 유의한 차이를 관찰할 수 없었던 반면 1주일 동안 스트레스를 받은 군에서는 심박수가 다시 유의하게 증가했을 뿐만 아니라 SDNN, VLF 및 LF 역시 정상군과 유의한 차이를 보였다. 이상의 결과를 종합하면 심근경색 동물에 대해 1주일 동안 스트레스를 가한 결과 심박변이율이 감소하고 심실에서의 BNP 발현은 더욱 증가하여 악화함을 보여주고 있다. Diminished heart rate variability (HRV) is associated with less favorable prognosis after myocardial infarction (MI). It has been reported that very low frequency (VLF) power in HRV analysis is an independent risk predictor in patients with congestive heart failure and B-type natriuretic peptide (BNP) can be used as a prognostic factor of MI. The purpose of this study was to investigate whether stress has an effect to the changes of BNP expression and/or heart rate variability in MI model in rats. Male Sprague-Dawley rats were divided into 3 groups: control group (CON), MI group (MI+No Stress), and MI followed by stress group (MI+Stress). MI+Stress group rats were raised for a two month recovery period after the operation, followed by being exposed to restraint stress for 2 hours per day for 1 week. Electrocardiogram was recorded after the operation and the last day after 1 week of stress. The frequency components of HRV were calculated in the frequency domain such as VLF, low frequency (LF), high frequency (HF) and so on. In HRV analysis, standard deviation of the normal to normal intervals (SDNN) was significantly reduced in both groups compared to the control group. VLF and LF also were significantly reduced in MI+Stress group compared to the control groups. In addition, BNP expression in western blotting was shown the strongest bands in MI+ Stress group among experimental groups. These results suggest that BNP and HRV were aggravated by stress in MI rat model. (Korean J Str Res 2010;18:275∼285)

김채원의 〈겨울의 환〉에 나타난 문학치료적 성격 분석

류미향(Ryu, Mi-Hyang) 한국어문학회 2017 語文學 Vol.0 No.137

This article redefines the significance of motherhood expressed in Kim Ch’ae-Wǒn’s novel entitled Kyǒul ǔi hwan , which represents motherhood as a force of vitality, transcendence, and spirituality. By employing the bibliotherapic approach toward literature, I observed that the literary representation of motherhood is connected to heal human wounds. The contemporary society prevails with the mental and psychological problems, as epitomized in the concept of “fatigue society” in Han Byǒng-Ch’ǒl’s writing. Han argues for the positive side of the “fatigue society” in which people focus on deliberation and contemplation. Such pursuit of the contemplative life is suggested in Illusion of winter. Specifically, this article focuses on the expression of motherhood as an instrument of healing, and I concentrate on the two particular scenes concerning the representation of motherhood: The mother who prepares a meal and sets the table, and the mother patiently waits for her family at the door. Specifically, the mother’s preparation of food symbolizes the vitality of life, while her waiting at the door captures the transcendental personality or spirituality of the mother character. Such portrayals serve to wrap and heal the wounds and scars, since motherhood occupies the inherent and sacred realm of humanity, where pain can never reach. The vitality and spiritual nature of life and nourishment in the Illusion of winter therefore suggests its significance in modern society. Conclusively, this study illuminates the literary representation of motherhood as a site of healing.

자궁경부 상피내 병변 환자에서 LEETZ 원추절제술 후 HPV DNA Test 추적 검사의 임상적 의의

김미향,이태화,오영림,이천준,김원규 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Objective: This study was performed to investigate the clinical significance and timing of HPV test for follow up of patients after LEETZ treatment in CIN lesion Methods: From January 2005 to December 2008, 105 patients with CIN were treated with LLETZ at Kosin university gospel hospital, Busan, Korea. After LEETZ, HPV test and Pap smear were done after 3months. Every HPV typing was done by HPV DNA chip. Results: A total of 105 cases were enrolled in this study. There were 25 patients with CINⅠ, 38 with CINⅡ, 42 with CINⅢ. Mean age was 41.95 years (range, 23-71 years) at the time of LEETZ. Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). During follow up after LEETZ, 65.6% had negative result after 3 month, 72.1% after 6 month, 73.9% after 9 month, 77.1% after 12 month, 79.2% after 15 month, 79.6% after 18 month, and 80.4% after 24 month. There were 2 cases of abnormal pap smear among persistent positive HPV DNA cases and no abnormal pap smear results in negative HPV DNA cases during follow up. Conclusion: Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). We suggest that HPV DNA test is recommended per 6 Months, and close observation is recommended in persistent positive HPV DNA test cases.

근첨하 분절 골절단술을 병행한 Ⅲ급 양악 전돌증의 교정치료 증례

정미향,남동석 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.3

양악 전돌은 흔히 접하는 부정교합 증례로서, 대부분 상하순의 전돌에 의한 안모 심미성의 손상을 주소로 내원한다. 이러한 증례는 제1소구치를 발거하고 그 공간을 이용하여 전치부를 견인하여 치료하는 경우가 많으며, 성공적인 치료결과를 얻을 수 있다. 그러나, 성인 환자의 경우에는 환자의 협조도 불량으로 인한 악외 고정원 사용의 불량, 치료기간의 장기화, 치조골이 충분하지 못한 경우등에 있어서의 치근 흡수량의 증가, 구외 장치 사용으로 인한 환자의 사회심리적 부담감등의 부작용이 있다. 이의 해결방안의 하나인 근첨하 분절 골절단술은 고정원의 절대 보존, 치료기간의 단축, 구외 고정원 사용 필요성 제거 및 이를 통한 환자의 협조도 증가 등의 장점을 가지고 있다. 이에, 제 1소구치 발거 및 이 부위를 이용한 근첨하분절 골절단술을 병행하여 치료한 치아치조 전돌의 증례를 치료 전후의 두부 방사선 계측 사진 및 연구 모형을 통해 비교분석하여 변화를 살펴보고. 이의 장단점을 고찰해 보도록 하고자 한다. Bimaxillary protrusion can be treated effectively in growing patients and in adults with conventional orthodontic therapy. However, In the adult patient, combined surgical and orthodontic treatment modalities may offer distinct advantages over such conventional therapy. In those cases complicate by vertical jaw dysplasia, sagittal dysplasia, or transverse skeletal discrepancy in addition to bimaxillary protrusion, the possibilities of obtaining successful results through orthodontic treatment alone greatly diminish. Surgical retraction of both maxillary and mandibular anterior segments with subapical osteotomies and ostectomies in the extraction site may be a good treatment alternative. Treatment time and possible adverse effects of lengthy orthodontic therapy may be reduced and optimum esthetic improvement may be facilitated. On the following cases, patient who had bimaxillary protrusion with Angle Class III malocclusion was treated with combined orthodontic - surgical therapy by anterior subapical segmental osteotomies.

Collagen 성숙가교 생성에 관한 기초연구

김미향 신라대학교 자연과학연구소 1999 自然科學論文集 Vol.7 No.-

Collagen, the major constituent of connective tissue fibriles, is the most common protein in the animal world. It is widely distributed in the various tissues of vertebrates and responsible for their distinctive physiological functions. Normal tensile strength in collagen fibrils is due to intermolecular and intramolecular cross-links, which are known to alter in aging. The initial step in the formation of collagen cross-links is the deamination of specific lysyl and hydroxylysyl residues by lysyl oxidase, yielding reactive aldehydes, allysine and hydroxyallysine. Pyridinoline, a mature cross-link which is stable and non-reducible, is derived from two hydroxyallysine and one hydroxylysine residues of collagen fibrils. L-Ascorbic acid(AsA), commonly known as vitamin C, is an essential vitamin for humans, primates, and guinea pigs. AsA had important biochemical functions with various hydroxylations. In the synthesis of collagens, the enzymatic hydroxylations of proline and lysine are necessary for the production of a stable extracellular matrix and cross-links in the fibrils, respectively. To clarify the specificity of AsA in in vitro aging containing enzymatic reaction, lysyl oxidase was partially purified from the aorta of bovine. When AsA were added to the reaction mixture, pyridinoline contents were lower than the control. Moreover, it was observed that AsA is rapidly oxidized within 24 hr under this experimental condition. Supplementation with AsA may decreased pyridionline formation in the early stage of enzymatic reaction in vitro.

언어시험의 모형 고찰

한미향 동아대학교 인문과학대학 영어영문학과 1997 동아영어영문학 Vol.13 No.-

The past decade has seen the development of a theoretical view that considers language proficiency to be multicomponential and recognizes the effects of the test method and test taker characteristics on test performance. Reviewing the development, this paper surveys Oller's, Canale & Swain's, Cummins' and Bachman's models of language test performance. After then, it describes mostly Bachman's interactive model. The framework includes three components, language proficiency, test method and testee's characteristics. First, language proficiency consists of three components: language competence, strategic competence, and psychophysiological mechanism. Moreover these components of language proficiency interact with the language use context and language user's knowledge structure, or schema. Second, the facets of test method are grouped into five sets: testing environment, test rubric, input, expected response and relationship between input and expected response. Lastly, test performance is also affected by individual attributes that are not part of test taker's language ability. These may include test takers' cognitive and affective characteristics, their real world knowledge, and factors such as their age, sex, native language, educational and socio-economic background What is suggested from this discussion is that taking into account this framework, more empirical research on the practical effect of test methods and testee's attributes on language test performance needs to be conducted to develop more valid tests, especially for EFL students in Korea.

중년기 여성의 상체부 특성

나미향 권윤희 청주대학교 학술연구소 2009 淸大學術論集 Vol.14 No.-

The purpose of study is research on breast shape and suitable bressiere for middle aged women. For this purpose, numerous antropometric measurements and other related data 200 subjects were analyzed by various statistical methods. Changes in the somatotype of the upper body were studied according to age group through classifying middle aged women into three age categories of Aged 35 to 44, Aged 45 to 54, Aged 55 to 64 and the measured anthropometry. It appears that the physical stance of the aging female becomes more bent and their body structures become smaller due to the bending and stretching of upper body during the process of ageing of each somatotype. The results of the comparative analysis of anthropolatric data from three groups(Groups Ⅰ: Aged 35 to 44, Group Ⅱ: Aged 45 to 54, Group Ⅲ: Aged 55 to 64)show that getting older, breast heights are decreased significantly and widths, depths and bust girths are increased. Various length measurements related to the drooping degree of breast are increased.

Briefs 착용 실태조사 : 20대 여성을 대상으로

나미향 김정하 정복희 청주대학교 학술연구소 2008 淸大學術論集 Vol.10 No.-

This study was made to investigate the real state of wearing briefs of females in their 20's to garner the basic data for pattern design and briefs whose wearing satisfaction is high. finding out the problem of design and sense of wearing. The result is as follows: 1. Cotton-made material was preferred in choosing briefs. This means that in the items concerning the sense of wearing, 'Sweat and secret were well absorbed, 'Sense of wearing was good', 'Material was proper,' 'Sense of wearing was generally fine.' 2. Half line was preferred in waist line, The reason is that it was conducive to action and stability. The result that currently-worn waist line and desired-waist line were in conformity shows that the satisfaction of currently-worn waist line was high in general. 3. For the reason that front form of briefs was good for action and stability, the form of half line was most preferred, and the same result was produced in the desired- wearing line. 4. In the form of hips, line 3 was preferred, which covered comfortably the entire parts of hips, and the styles which were jammed in hips, not sufficiently-covering hips, and uncomfortable to femoral muscle region were not preferred. 5. In purchasing briefs, the design was the first consideration, and then materials, measurement, price, etc. In the form of briefs, the type of pants was preferred, among which triangular pants accounted for 86.2% of preference, with most consumers fond of purchasing them. 6. The most preferred color was pastel tone, and white and ivory came after it. They are mostly sold in special market(road shop), and medium and low priced brand were preferred. key word : underwear, briefs, individuality expression, fashion item

어패럴 패턴구조에 관한 연구(3) : 각 부위별 벌어짐량을 중심으로 Focusing on broadening volume per each part

나미향,민유숙 청주대학교 학술연구소 2005 淸大學術論集 Vol.5 No.-

I have developed a human body into body surface shell in order to find out the characteristics when the dimensional shape of human body is developed on a plane. I have reviewed characteristics of pattern with broadened and folded surface of front, side, and back part shaped along with winding of a human body, I have come to the following result. 1. In light of a front section, there has been a change on a hip for a breast dart volume, upper breast dart volume, under breast No. 1 and 2 dart volume, and abdomen from the aspect of relation among breast volume and type, and breast inclination and structural of a hip. 2. In light of a side section, its pattern structure is classified into three types of folded type, broadened type, and collected type. A broadened type is for a big hip physical shape, folded type for small hip physical shape, and collected type for same gap between waist and hip or no such a gap. 3. In light of a back section, its pattern structure varies depending upon structural characteristics of bending degree; dart volume of rear shoulder was classified into three types of large, medium, and small. A structural pattern of dart volume of a hip on a back abdomen was classified into hip-protruding physical shape, common physical shape, small hip physical shape, and its shaping characteristics were observed in the presence of a type collected to three types, broadened type, and folded type.

어패럴 패턴구조에 관한 연구(2) : 앞ㆍ옆ㆍ뒤의 차를 중심으로 Focusing on gap between front,side, and back

나미향,민유숙 청주대학교 학술연구소 2004 淸大學術論集 Vol.4 No.-

I have manufactured body surface shell using a plastered body shape taken from a real body in order to identify characteristics of body parts based upon the basic torso pattern. After developed body surface shell, I have come to this result by analyzing the result developed into 3physical shape characteristics of front,side, and back. 1. Development of body surface shell As a result of developing body surface shell to find out pattern structure, front board in all experiences formed a breast part space due to breast protrusion centered by B.P., in particular, there was a great amount of space on the sectional side dart volume and down the breast line including down the front lining. On a back, a waist dart was form on perpendicular with arm-hole dart on protrusion part of the scapula (shoulder blade) and there was a dart volume formed on interscye too. 2. Ration and difference between front, back, and side Each circumference of the front, back, and side showed significance in the field of breast, under breast, waist, abdomen, and hip. In addition, the gap between front and back showed significance in the filed of under breast and a hip. Accordingly, when designing tight fit clothing, the distribution of front, back and side should be configured differently per section. Its ratio showed outstandingly differently. 3. Gap between front and back of the pattern The value of body surface development diagram showed significance in four parts other than hip in light of front and back difference. Accordingly, a hip has no gap between front and back, upper breast girth showed bigger shaper in back than front, but front showed bigger value in breast circumference, under breast girth, waist girth, and abdomen circumference.