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      • Prognostic Factors in Adult Patients with Solid Cancers and Bone Marrow Metastases

        Hung,,Yu-Shin,Chou,,Wen-Chi,Chen,,Tai-Di,Chen,,Tse-Ching,Wang,,Po-Nan,Chang,,Hung,Hsu,,Hung-Chih,Shen,,Wen-Chi,Cheng,,Wei-Hong,Chen,,Jen-Shi Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

        Background: Solid cancers with bone marrow metastases are rare but lethal. This study aimed to identify clinical factors predictive of survival in adult patients with solid cancers and bone marrow metastases. Methods: A total of 83 patients were enrolled consecutively between January 1, 2000 and December 31, 2012. Bone marrow metastases were confirmed by biopsies. Patient clinical features and laboratory data were analyzed for associations. Results: The median age of the patients was 54 years (range, 23-88 years), and 58% were male. The 3 most common primary tumor locations were the stomach (32 patients, 39%), prostate (16 patients, 19%), and lungs (12 patients, 15%). The median overall survival was 49 days (range, 3-1423 days). Patients with Eastern Cooperative Oncology Group performance status 1, cancers of prostate origin, platelet counts over 50,000/ml, and undergoing antitumor therapies had a significantly better prognosis in the multivariate analysis. The median survival times were 173 and 33 days for patients with 2-3 more favorable parameters (n=24) and those with 0-1 (n=69), respectively (hazard ratio 0.30; 95% CI 0.17-0.52, p<0.001). Conclusions: Solid cancers with bone marrow metastases are dismal and incurable diseases. Understanding prognostic factors to these diseases helps medical personnel to provide appropriate treatments and better inform patients about outcomes. Antitumor therapies may improve outcomes in selected patient cohorts.

      • KCI등재SCOPUS

        Role of Salivary Immune Parameters in Patients With Primary Sjögren's Syndrome

        Yu-Hung,Hung,Yung-Hung,Lee,Pei-Pei,Chen,Yuan-Zhao,Lin,Chia-Hui,Lin,Jeng-Hsien,Yen 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1

        Background: Several factors, including clinical manifestations and laboratory data, have been used to evaluate the disease activity of Sjögren's syndrome (SS). We investigated saliva indicators of disease activity in primary SS patients. Methods: We enrolled 138 Taiwanese patients with primary SS and 100 Taiwanese normal controls. Interleukin (IL)-6, IL-17A, tumor necrosis factor-alpha (TNF-α), and rheumatoid factor (RF)-IgA levels in saliva samples were measured using ELISA or fluorescent enzyme-linked immunoassay. Serum IgG, IgA, and IgM levels were measured by nephelometry. Erythrocyte sedimentation rate (ESR) was measured with an automatic ESR analyzer. The t-test and Pearson correlation test were used. Results: IL-6 level was higher in primary SS patients than in normal controls (14.23±14.77 vs 9.87±7.32, P=0.012), but there were no significant differences in IL-17A, TNF-α, and RF-IgA levels. In primary SS patients, IL-6 level correlated weakly with ESR and IgG levels (r=0.252, P=0.015, and r=0.248, P=0.017, respectively), and TNF-α level correlated weakly with IgG level (r=0.231, P=0.024). Conclusions: IL-6 may play a role in SS pathogenesis. Saliva IL-6 might be an indicator of disease activity in primary SS patients.

      • Trajectory Tracking Control Of Omnidirectional Mobile Robot Using Sliding Mode Controller

        Pham,Hung,Kim,Khanh,Nguyen,Thanh,Trung,Phuc,Thinh,Doan,Nguyen,Hung 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10

        In this paper, a new tracking controller that integrates a kinematic controller (KC) with a new integral sliding mode dynamic controller (NISMC) is designed for an omnidirectional mobile robot (OMR) to track a desired trajectory at a desired velocity. First, a posture tracking error vector is defined, and kinematic controller (KC) is chosen to make the posture tracking error vector go to zero asymptotically. Second, an integral sliding surface vector is defined based on the angular velocity tracking error vector and its integral term. A new integral sliding mode dynamic controller (NISMC) is designed to make the integral sliding surface vector and the angular velocity tracking error vector go to zero asymptotically. The above controllers are obtained based on Lyapunov stability theory. The simulation results are presented to illustrate effectiveness of the proposed tracking controller.

      • KCI등재

        Sensitive Colorimetric Detection of Prostate Specific Antigen Using a Peroxidase-Mimicking Anti-PSA Antibody Coated Au Nanoparticle

        Xuan-Hung,Pham,함은일,Kim-Hung,Huynh,Byung,Sung,Son,Hyung-Mo,Kim,전봉현 한국바이오칩학회 2020 BioChip Journal Vol.14 No.2

        The use of colorimetric bioassays for protein detection is one of the most promising diagnostic approaches, but their relatively poor detection limits have been a critical issue. In this study, we developed an efficient colorimetric bioassay based on antibody-coated peroxidase-mimicking Au nanoparticles (Au NPs) for the detection of prostate-specific antigen (PSA), which is one of the most widely used protein biomarkers for the diagnosis of prostate and breast cancers. Anti-PSA antibody adsorption on the Au NP surface result in 65% of the peroxidasemimicking properties of Au NPs was suppressed to maximize sensitivity of the assay. Anti-PSA antibody adsorption on the Au NP was optimized at 150 µg/mL anti-PSA4 antibody for 1 h incubation, and their surface was blocked with 2% BSA. The experimental conditions of the immunoassay detection were also investigated. A highest assay value was obtained at 10 µg/mL anti-PSA1 capture antibody using 3% BSA for surface blocking and at 2.5 pM anti- PSA4-Ab coated Au NPs for 1 h incubation with PSA antigen. As a result, PSA was detected at a wide range of 0.25 to 2,500 ng/mL with a detection limit of 0.23 ng/mL. The anti-PSA-Ab coated Au NP- based assay was simple, easy to operate, and sensitive. The proposed peroxidase-mimicking anti-PSA Ab-coated Au NPbased assay could be further developed to detect other protein biomarkers.

      • SCOPUSKCI등재

        Bioactive Constituents from the n-Butanolic Fraction of Aruncus dioicus var. kamtschaticus

        Vo,,Quoc,Hung,Nguyen,,Phi,Hung,Zhao,,Bing,Tian,Thi,,Yen,Nguyen,Nguyen,,Duc,Hung,Kim,,Won,Il,Seo,,U,Min,Min,,Byung,Sun,Woo,,Mi,Hee The Korean Society of Pharmacognosy 2014 Natural Product Sciences Vol.20 No.4

        Six compounds were isolated from the n-BuOH fraction of the aerial parts of Aruncus dioicus var. kamtschaticus including: sambunigrin (1), prunasin (2), aruncide A (3), aruncide C (4), 1-O-caffeoyl-${\beta}$-D-glucopyranose (5), and caffeic acid (6). Their structures were confirmed by comparing the spectral data with those reported in the literature. The isolated compounds (1 - 6) were then examined for their cytotoxic effects towards MCF-7, HL-60, and HeLa cancer cell lines, as well as their DPPH radical scavenging activity. The results indicated that compound 4 possessed the strongest inhibitory effect toward HeLa cell line with $IC_{50}$ value of $5.38{\pm}0.92{\mu}M$. Compound 3 possessed selective cytotoxic activity on HL-60 cells with $IC_{50}$ value of $6.27{\pm}0.17{\mu}M$, compound 5 was found as the best in inhibiting proliferation with $IC_{50}$ value of $2.25{\pm}0.09{\mu}M$, and the other compounds showed significant inhibition with $IC_{50}$ values ranging from 6.10 to $11.27{\mu}M$. Compound 5 also displayed the strongest cytotoxic effect toward MCF-7 cell line ($IC_{50}$ $4.32{\pm}0.15{\mu}M$). Both 5 and 6 demonstrated strong radical scavenging activity ($IC_{50}$ $6.87{\pm}0.03$ and $4.33{\pm}0.22{\mu}M$, respectively). Compounds 1 and 5 were isolated for the first time from this plant.

      • Tracking Controller Design of Omnidirectional Mobile Manipulator System

        Nguyen,Hung,Dae-Hwan,Kim,Hak-Kyeong,Kim,Sang-Bong,Kim 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8

        This paper proposed a tracking controller for an omnidirectional mobile manipulator system, a three-linked manipulator mounted on a three-wheeled omnidirectional mobile platform, to track a desired trajectory with constant desired velocity. An end-effector mounted at the end of a manipulator of the omnidirectional mobile manipulator system is controlled to track a desired trajectory with constant desired velocity. A distributed control method is applied to control the omnidirectional mobile manipulator system that includes two subsystems such as an omnidirectional mobile platform and a manipulator. Two controllers are designed to control two subsystems, respectively. Firstly, based on a tracking error vector between a point of the end-effector and a reference point, a kinematic controller is designed for the end-effector of the manipulator to track a reference point. Secondly, based on a tracking error vector between a target point and a real point of the end-effector, a sliding mode controller based on its dynamic model is designed for the omnidirectional mobile platform to move so that the manipulator tracks the desired posture without its singulariry. The control laws are obtained based on backstepping technique and make the tracking error vectors go to zero asymtotically. The system stability is proved using the Lyapunov stability theory. The simulation results are presented to illustrate the usefulness of the proposed control scheme in the presence uncertainties and external disturbances.

      • KCI등재SSCI

        The social practice of learning: a craft for the 21st century

        David,Hung 서울대학교 교육연구소 2009 Asia Pacific Education Review Vol.10 No.2

        This article argues that the social practice of learning (SPL), involving life-long learning, meta-learning, deep reflection, and dialogue in a community, should be the distinguishing knowledge base of schools in the twenty-first century. This article also analyses the strategies and challenges of the recent education reforms in Singapore through the lens of an SPL education paradigm. Although the Singapore government has done much to train teachers, trim syllabi and introduce new ways of teaching and learning, such as project work, the real challenge is to go beyond the provision of structural changes to the substance of the epistemological reform.

      • KCI등재SCOPUS

        High Efficiency Transformation by Electroporation of Yarrowia lipolytica

        Jia-Hung,Wang,Wenpin,Hung,Shu-Hsien,Tsai 한국미생물학회 2011 The journal of microbiology Vol.49 No.3

        Yarrowia lipolytica was usually transformed by heat shock, but linearized integrative vectors always resulted in a low transformation efficiency when electroporation was used. To develop a high efficiency integrative transformation method by electroporation of Y. lipolytica, we report here that pretreatment of Y. lipolytica with 150 mM LiAc for 1 h before electroporation will approximately 30-fold of increase transformation efficiency. A cell concentration of 1010/ml and instrument settings of 1.5 kV will generate the highest transformation efficiencies. We have developed a procedure to transform Y. lipolytica that will be able to yield an efficiency of 2.1×104 transformants/μg for integrative linear DNA. With our modifications, the electroporation procedures became a very efficient and reliable tool for Y. lipolytica transformation.

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