Prevalence, Risk Factors, and Psychological Effects of Primary Nocturnal Enuresis in Chinese Young Adults

Hui Jie Hu,Zhen Wei Zhang,Yu Liang,Yan Yan Luo,Qi Feng Dou,Cui Ping Song,Hui Min Zhang,Ying Zhao,Guang Run Tian,Ke Zhang,Qiu Fang Mao,Jing Gui Song,Soren Rittig,Jian Guo Wen 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.1

Purpose: This study aimed to investigate the prevalence, risk factors, and effects of primary nocturnal enuresis (PNE) on physical and mental health in young adults in mainland China. Methods: An anonymous questionnaire was used to collect information including the sociodemographic characteristics, history of PNE, family history, daytime voiding symptoms, Pittsburgh Sleep Quality Index (PSQI) scores, Self-Esteem Scale (SES), and Self-Rating Depression Scale (SDS). A total of 22,500 university students from 23 provinces and 368 cities in mainland China were included. Results: In total, 21,082 questionnaires were collected, and 20,345 of them qualified for statistical analysis. The PNE prevalence was 1.17%, and the distribution of monosymptomatic nocturnal enuresis (MNE) and nonmonosymptomatic nocturnal enuresis (NMNE) was 66.1% and 33.9%, respectively. In total, 28% of respondents with PNE reported bedwetting daily, 31.6% between 1 and 7 times weekly, and 40.4% between 1 and 4 times monthly; 80% of PNE cases had no history of treatment. The prevalence of PNE in patients with a family history, frequency, urgency, urinary incontinence, and recurrent urinary tract infections was significantly higher than in those without these conditions (P<0.001). PNE was significantly correlated with the PSQI total score (sleep quality) (P=0.011). The SES score was lower and the SDS was higher (P<0.001) in the PNE group than in those without PNE. Conclusions: In mainland China, the PNE prevalence among young adults was found to be high, and PNE had significant effects on physical and mental health. Risk factors included a family history, daytime voiding symptoms, and lack of treatment.

Perioperative Comprehensive Supportive Care Interventions for Chinese Patients with Esophageal Carcinoma: a Prospective Study

Zhang, Xiao-Dan,Zhao, Qing-Yu,Fang, Yi,Chen, Guan-Xuan,Zhang, Hui-Fang,Zhang, Wen-Xiao,Yang, Xiao-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Objective: To assess the effects of perioperative comprehensive supportive care interventions on outcome of Chinese esophageal cancer patients in a prospective study. Methods: 60 patients with primary esophageal carcinoma were randomized into an intervention group (IG, n=31) and a control group (CG, n=29). The Chinese version of symptom checklist-90 (SCL-90) was adopted to assess their psychological status. The interventions, including health education, psychological support, stress management, coping strategies and behavior training, were carried out in 3 phases (preoperative, postoperative I and postoperative II), and psychological effects were thereafter evaluated accordingly before surgery, and 1 week, 4 weeks and 24 weeks post-surgery. Medical costs were estimated at discharge. Survival of patients was estimated each year post-surgery. General health status and satisfaction-with-hospital were surveyed by a follow-up questionnaire 4 years post-surgery. Results: All the subjects demonstrated higher scores in the preoperative phase than the normal range of Chinese population concerning 7 psychological domains including somatization, obsessive-compulsive, depression, anxiety, hostility, phobic anxiety and paranoid ideation. Although no significant difference was observed between the two groups at admission, the scores of IG, which tended to decrease at a faster rate, were generally lower than those of CG at weeks 1, 4 and 24 post-surgery. The length of hospital stay and medical costs of IG were significantly less than those of CG and satisfaction-with-hospital was better. However, there was no significant difference in 4-year survival or health status between two groups. Conclusions: Appropriate perioperative comprehensive supportive care interventions help to improve the psychological state of Chinese patients with esophageal carcinoma, to reduce health care costs and to promote satisfaction of patients and their families with hospital.

Simulation and Experiments on Cutting Forces and Cutting Temperature in High Speed Milling of 300M Steel under CMQL and Dry Conditions

Hui-Ping Zhang,Qing-Yu Zhang,Yi Ren,Tony Shay,Guo-Liang Liu 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.8

The effects of cryogenic minimum quantity lubrication (CMQL) on cutting forces and cutting temperature are analyzed in high speed milling of 300M steel. The influences of cutting parameters on cutting forces and cutting temperature are predicted by analogue simulation. Based on single-factor comparative test, the variation laws of cutting forces F and cutting temperature T with cutting parameters are studied in high speed milling of 300M steel under dry and CMQL conditions. Under the condition of CMQL, the influence of cutting parameters (cutting speed v, feed per tooth fz, cutting depth ap and cutting width ae) on cutting forces and the cutting temperature are analyzed by orthogonal test, and the prediction models of cutting forces and cutting temperature are established. The results show that CMQL condition can effectively reduce cutting forces and cutting temperature in the cutting process. Under the condition of CMQL, the cutting depth on the cutting forces is most significant, and the cutting speed has the greatest influence on the cutting temperature. The prediction model of cutting forces and cutting temperature is established, which can be a valuable reference for actual machining.

스포츠 브랜드 플래그십 스토어의 공간체험 디자인 특성에 관한 연구

장회평(Hui Ping Zhang),강재철(Jae Cheol Kang) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.3

플래그십 스토어의 공간 디자인은 방문 소비자의 브랜드 이미지에 영향을 미치고, 이는 다시 소비자의 구매의도에 영향을 미친다. 따라서 본 연구에서는 소비자의 관심을 끌기 위해 경험 디자인을 이론적 근거로 삼아 스포츠 브랜드의 플래그십 스토어 공간 디자인의 특성인 비일상성, 상호작용성, 역동성 및 연상성이 브랜드 이미지와 구매의도에 미치는 영향을 연구하는 것을 목적으로 한다. 본 연구의 목적을 달성하기 위해 NIKE와 ADIDAS의 두 스포츠 브랜드플래그십 스토어 공간을 조사사례로 선정하여 스포츠 브랜드 플래그십 스토어를 방문한 소비자를 대상으로 설문조사를 실시하였으며 최종적으로 302개의 유효한 설문지를 회수하였다. 설문지에서 수집된 데이터를SPSS26.0 및 AMOS24.0 통계 프로그램을 사용하여 빈도 분석, 신뢰성 분석, 검증 요인 분석, 상관 관계 분석 및 회귀 분석을 수행한 결과 스포츠 브랜드 플래그십 스토어 공간 경험디자인의 특성인 비일상성, 상호작용성, 역동성, 연상성이 브랜드 이미지에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 마찬가지로 브랜드 이미지는 구매 의도에 정(+)의 영향을 미치는 것으로 나타났다. 이에 따라 본 연구는 스포츠 브랜드 플래그십 스토어의 공간 기획에 대한 실증 데이터 및 이론적 지원을 제공할 수 있는 것에 그 의의가 있다. Flagship shop space design influences the brand image of visiting consumers, which in turn affects purchase intention. Therefore, in order to attract consumers, this study takes experience design as the theoretical basis and aims to investigate the influence of experience design characteristics (non-daily, interactive, dynamic and associative) on brand image and purchase intention in the design of sports brand flagship shop space. In order to meet the purpose of this study, two sports brand flagship shop spaces, NIKE and ADIDAS, were selected as investigation cases, and a questionnaire survey was carried out with the group of consumers visiting the sports brand flagship shops, and 302 valid questionnaires were finally returned, and the collected data were analysed by frequency analysis, reliability analysis, validation factor analysis, correlation analysis, and regression analysis using the statistical programs of SPSS26.0 and AMOS 24.0. analysis and regression analysis. The results of the study are as follows: (1) The spatial experience design characteristics of flagship shops of sports brands (non-routine, interactivity, dynamism and associativity) have a positive impact on brand image. (2) Brand image has a positive effect on consumers' purchase intention. The results of this study can provide empirical data and theoretical support for the spatial planning of sports brand flagship shops.

Human Papillomavirus Infection and Prognostic Predictors in Patients with Oropharyngeal Squamous Cell Carcinoma

Huang, Hui,Zhang, Bin,Chen, Wen,Zhou, Shuang-Mei,Zhang, Yong-Xia,Gao, Li,Xu, Zhen-Gang,Qiao, You-Lin,Tang, Ping-Zhang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

This study focused on infection rates and subtypes of human papillomavirus (HPV) in patients with oropharyngeal squamous cell carcinoma (OSCC), and the relationship between HPV status and prognosis of the disease. We evaluated sixty-six OSCC patients who met the enrollment criteria during the period from January 1999 to December 2009. The presence or absence of oncogenic HPV types in tumors was determined using the SPF10 LiPA25 assay. Overall survival (OS) and disease specific survival (DSS) for HPV positive and HPV negative patients were estimated using Kaplan-Meier analysis. The Cox regression model was applied for multivariate analysis. HPV-DNA was detected in 11(16.7%) of all specimens. Among them, 7 were type HPV-16, while other types were HPV-16/11, HPV-35, HPV-58/52, and HPV-33/52/54. Patients with HPV positive tumors were more likely to be female, non-smokers and non-drinkers (p=0.002, 0.001 and 0.001, respectively). After a median follow-up of 24.5 months, patients with HPV positive tumors had significantly better overall survival (HR=0.106[95%CI=0.014-0.787], p=0.016,) and disease specific survival (HR=0.121[95%CI=0.016-0.906], p=0.030). Patients with HPV positive OSCC have significantly better prognosis than patients with HPV negative tumors. HPV infection is an independent prognostic factor.

인터랙티브가 적용된 스포츠 의류 전문점에 대한 연구

장회평(Hui Ping Zhang),강재철(Jae Cheol Kang) 한국디자인리서치학회 2023 한국디자인리서치 Vol.8 No.2

과학과 기술의 지속적인 발전과 응용에 따라 설치미술(Installation Art)은 새로운 기술과 뉴미디어를 융합하여 새로운 표현의 형식을 보여주고 있으며, 인터랙티브 장치(Interactive Installation)는 전통적인 설치미술과 현대 기술의 결합으로 점차 실내 공간에 적용되고 있다. 본 논문은 의류전문점 공간에 인터랙티브 장치의 적용에 대해 연구하였으며, 구체적으로 인터랙티브 장치의 특성(상호작용성, 체험성, 과학 기술성, 오락성)이 소비자의 감정 체험 및 지각된 유용성에 미치는 영향, 또한 인터랙티브 장치가 적용한 의류전문점 공간이 소비자의 구매 의사에 미치는 영향에 대해 분석 및 연구하였다. 본 연구는 20~60세 의류전문점을 자주 이용한 소비자를 연구 대상으로 삼아 SPSS 25.0 프로그램을 활용하여 수집된 252개의 유효 설문지 데이터를 분석하였다. 분석한 결과에 따라 의류전문점 공간의 인터랙티브 장치의 특성인 상호작용성, 체험성, 과학 기술성, 오락성이 소비자의 감정 체험과 지각된 유용성에 유의한 정(+)의 영향을 미치는 동시에 감정 체험과 지각된 유용성이 구매 의사에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 이 연구는 의류 판매장 공간의 형태를 다양화할 수 있으면서 소비자를 유치하여 소비 가능성을 높일 수 있다. 또한 의류 판매장 공간에 인터랙티브 장치를 합리적으로 적용할 수 있도록 이론적 참고 자료를 제공할 수 있다. With the development and application of science and technology, Installation Art integrates new technology and media, and Interactive Installation, as a combination of traditional installation art and modern technology, is gradually applied in indoor space. The purpose of this thesis is to study the application of interactive devices in clothing store space, to analyze the effects of interactive devices on consumers' emotional experience and perceived usefulness. The results show that the interactive, experiential, technological and entertainment of the interactive devices in the clothing store space have positive effects on the emotional experience and perceived usefulness. This research can enrich the space form of clothing store and attract consumers to increase the possibility of consumer consumption, and provide some theoretical reference for the rational use of interactive devices in clothing store space.

Radiosensitivity Enhancement by Arsenic Trioxide in Conjunction with Hyperthermia in the EC-1 Esophageal Carcinoma Cell Line

Cui, Yan-Hui,Liang, Hai-Jun,Zhang, Qing-Qin,Li, Si-Qing,Li, Xiao-Rui,Huo, Xiao-Qing,Yang, Qing-Hui,Li, Wei-Wei,Gu, Jian-Fa,Hua, Qin-Liang,Lu, Ping,Miao, Zhan-Hui Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Objective: To explore the effect on radiosensitivity of arsenic trioxide ($As_20_3$) in conjunction with hyperthermia on the esophageal carcinoma EC-1 cell line. Method: Inhibition of EC-1 cell proliferation at different concentrations of $As_20_3$ was assessed using the methyl thiazolyl blue colorimetric method (MTT method), with calculation of $IC_{50}$ value and choice of 20% of the $IC_{50}$ as the experimental drug concentration. Blank control, $As_20_3$, hyperthermia, radiotherapy group, $As_20_3$ + hyperthermia, $As_20_3$ + radiotherapy, hyperthermia + radiotherapy and $As_20_3$ + hyperthermia + radiotherapy groups were established, and the cell survival fraction (SF) was calculated from flat panel colony forming analysis, and fitted by the 'multitarget click mathematical model'. Flow cytometry (FCM) was used to detect changes in cell apoptosis and the cell cycle. Results: $As_20_3$ exerted inhibitory effects on proliferation of esophageal carcinoma EC-1 cells, with an $IC_{50}$ of 18.7 ${\mu}mol/L$. After joint therapy of $As_20_3$ + hyperthermia + radiotherapy, the results of FCM showed that cells could be arrested in the $G_2$/M phase, and as the ratio of cells in $G_0/G_1$ and S phases decreased, cell death became more pronounced. Conclusion: $As_20_3$ and hyperthermia exert radiosensitivity effects on esophageal carcinoma EC-1 cells, with synergy in combination. Mechanistically, $As_20_3$ and hyperthermia mainly influence the cell cycle distribution of EC-1 esophageal carcinoma cells, decreasing the repair of sublethal damage and inducing apoptosis, thereby enhancing the killing effects of radioactive rays.

Intravenous Tenecteplase for Acute Ischemic Stroke Within 4.5–24 Hours of Onset (ROSE-TNK): A Phase 2, Randomized, Multicenter Study

Wang Lu,Dai Ying-Jie,Cui Yu,Zhang Hong,Jiang Chang-Hao,Duan Ying-Jie,Zhao Yong,Feng Ye-Fang,Geng Shi-Mei,Zhang Zai-Hui,Lu Jiang,Zhang Ping,Zhao Li-Wei,Zhao Hang,Ma Yu-Tong,Song Cheng-Guang,Zhang Yi,Ch 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.3

Background and Purpose Intravenous tenecteplase (TNK) efficacy has not been well demonstrated in acute ischemic stroke (AIS) beyond 4.5 hours after onset. This study aimed to determine the effect of intravenous TNK for AIS within 4.5 to 24 hours of onset. Methods In this pilot trial, eligible AIS patients with diffusion-weighted imaging (DWI)-fluid attenuated inversion recovery (FLAIR) mismatch were randomly allocated to intravenous TNK (0.25 mg/kg) or standard care within 4.5–24 hours of onset. The primary endpoint was excellent functional outcome at 90 days (modified Rankin Scale [mRS] score of 0–1). The primary safety endpoint was symptomatic intracranial hemorrhage (sICH). Results Of the randomly assigned 80 patients, the primary endpoint occurred in 52.5% (21/40) of TNK group and 50.0% (20/40) of control group, with no significant difference (unadjusted odds ratio, 1.11; 95% confidence interval 0.46–2.66; <i>P</i>=0.82). More early neurological improvement occurred in TNK group than in control group (11 vs. 3, <i>P</i>=0.03), but no significant differences were found in other secondary endpoints, such as mRS 0–2 at 90 days, shift analysis of mRS at 90 days, and change in National Institutes of Health Stroke Scale score at 24 hours and 7 days. There were no cases of sICH in this trial; however, asymptomatic intracranial hemorrhage occurred in 3 of the 40 patients (7.5%) in the TNK group. Conclusion This phase 2, randomized, multicenter study suggests that intravenous TNK within 4.5–24 hours of onset may be safe and feasible in AIS patients with a DWI-FLAIR mismatch.

Effectiveness and Safety of Pemetrexed Versus Docetaxel as a Treatment for Advanced Non-small Cell Lung Cancer: a Systematic Review and Meta-analysis

Di, Bao-Shan,Wei, Kong-Ping,Tian, Jin-Hui,Xiao, Xiao-Juan,Li, Yan,Zhang, Xu-Hui,Yu, Qin,Yang, Ke-Hu,Ge, Long,Huang, Wen-Hui,Zhang, Fang-Wa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: Our aim was to conduct a meta-analysis to compare the efficacy and safety of pemetrexed and docetaxel for non-small cell lung cancer (NSCLC). Materials and Methods: We systematically searched the Cochrane Library, PubMed, Embase, China Biology Medicine Database for randomized controlled trials (RCTs) comparing the efficacy and toxicities of pemetrexed versus docetaxel as a treatment for advanced NSCLC. We limited the languages to English and Chinese. Two reviewers independently screened articles to identify eligible trials according to the inclusion and exclusion criteria and assessed the methodological quality of included trials, and then extracted data. The meta-analysis was performed using STATA12.0. Results: Six RCTs involving 1,414 patients were identified. We found that there was no statistically significant differences in overall response rate, survival time, progression-free survival, disease control rate, and 1-2yr survival rate (p>0.050) but it is worthy of mention that patients in the pemetrexed arms had significantly higher 3-yr survival rate (P=0.002). With regard to the grade 3 or 4 hematological toxicity, compared with docetaxel, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, and leukocyts toxicity (p<0.001). There was no significant difference in anemia between the two arms (p=0.08). In addition, pemetrexed led to higher rate of grade 3-4 thrombocytopenia toxicity (p=0.03). As for the non-hematological toxicities, compared with docetaxel, pemetrexed group had lower rate of grade 3-4 diarrhea and alopecia. Conclusions: Pemetrexed was almost as effective as docetaxel in patients with advanced NSCLC. At the same time, pemetrexed might increase the 3-yr survival rate. As for safety, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, leukocytes, diarrhea and alopecia toxicity. However, it was associated with a higher rate of grade 3-4 thrombocytopenia.

The Expression Patterns of Cdc25A, Cdc25B, Sox2 and Mnb in Central Nervous System in Early Chicken Embryos

Zhang, Hui,Qin, Junhui,Cao, Jingjing,Hei, Nainan,Xu, Chunsheng,Yang, Ping,Liu, Haili,Chu, Xiaohong,Bao, Huijun,Chen, Qiusheng Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.6

The sense and antisense digoxigenin-labeled RNA probes of four genes, Cdc25A, Cdc25B, Sox2 and Mnb, were produced by using SP6 and T7 RNA polymerases, respectively, and in vitro transcription. Expression patterns of the four genes were detected by in situ hybridization in HH (Hamburger and Hamilton) stage 10 chick embryos. In general, expression patterns of the four genes were similar. mRNA of the four genes was mostly restricted to the entire CNS (central nervous system). All were confined to an identical region, neural tube, neural groove and caudal neural plate, corresponding to the notochord or spinal cord, but there was some distinction in specific region or in concentration, for example in somites. The overlap in expression at the same developmental stage in the CNS suggests that the four genes may be functional similar or related in CNS development. Expression patterns of the four genes support specific roles of these regulators in the developing CNS.