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김중완,안찬우,전태옥,전언찬,정희균 동아대학교 공과대학부설 생산기술연구소 1996 生産技術硏究所硏究論文集 Vol.1 No.2
Our unicycle has simple mechanical structure.But unicycle's dynamical system is a very sensitive unstable nonlinear system. equations of motion for a simple unicycle robot were derived using Lagrage's method. In this paper, a human fuzzy influence control mechanism was established throught an inquiry into human riding a unicycle, and we developed a hybrid controller to control our unicycle robot. This proposed hybrid controller is consisted with a pure PD and two fuzzy gain scheduled controllers and a direct fuzzy logic controller. Computer simulation results show that our hybrid controller has robust control performnance to unstable nnonlinear unicycle robot system.
Hui-Jeon Jeon,Hyeon-Son Choi,OK-Hwan Lee,You-Jin Jeon,Boo-Yong Lee 한국식품영양과학회 2012 Preventive Nutrition and Food Science Vol.17 No.2
Gelidium (G.) elegans is a red alga inhabiting intertidal areas of North East Asia. We examined anti-oxidative and anti-inflammatory effects of G. elegans, depending on drying and extraction conditions, by determining reactive oxygen species (ROS) and nitric oxide (NO) in 3T3-L1 and RAW 264.7 cells. Extraction yields of samples using hot air drying (HD) and far-infrared ray drying (FID) were significantly higher than those using natural air drying (ND). The 70% ethanol extracts showed the highest total phenol and flavonoid contents compared to other extracts (0, 30, and 50% ethanol) under tested drying conditions. The scavenging activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitrite correlated with total phenol or flavonoid content in the extracts. The greatest DPPH scavenging effect was observed in 70% ethanol extract from FID and HD conditions. The production of ROS and NO in 3T3-L1 and macrophage cells greatly decreased with the 70% ethanol extraction derived from FID. This study suggests that 70% ethanol extraction of G. elegans dried by FID is the most optimal condition to obtain efficiently antioxidant compounds of G. elegans.
Jeon, Hui-Jeon,Choi, Hyeon-Son,Lee, OK-Hwan,Jeon, You-Jin,Lee, Boo-Yong The Korean Society of Food Science and Nutrition 2012 Preventive Nutrition and Food Science Vol.17 No.2
Gelidium (G.) elegans is a red alga inhabiting intertidal areas of North East Asia. We examined anti-oxidative and anti-inflammatory effects of G. elegans, depending on drying and extraction conditions, by determining reactive oxygen species (ROS) and nitric oxide (NO) in 3T3-L1 and RAW 264.7 cells. Extraction yields of samples using hot air drying (HD) and far-infrared ray drying (FID) were significantly higher than those using natural air drying (ND). The 70% ethanol extracts showed the highest total phenol and flavonoid contents compared to other extracts (0, 30, and 50% ethanol) under tested drying conditions. The scavenging activity on 2,2-diphenyl- 1-picrylhydrazyl (DPPH) and nitrite correlated with total phenol or flavonoid content in the extracts. The greatest DPPH scavenging effect was observed in 70% ethanol extract from FID and HD conditions. The production of ROS and NO in 3T3-L1 and macrophage cells greatly decreased with the 70% ethanol extraction derived from FID. This study suggests that 70% ethanol extraction of G. elegans dried by FID is the most optimal condition to obtain efficiently antioxidant compounds of G. elegans.
감태 추출물(Seapolynol)과 Dieckol의 α-Glucosidase 저해 활성과 포도당 및 맥아당 경구 부하 시험
전희전(Hui-Jeon Jeon),김성호(Sung Ho Kim),이부용(Boo-Yong Lee) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.3
감태 추출물인 seapolynol과 dieckol을 활용하여 효과적인 혈당 강하 소재의 기능성을 확인하기 위해 본 연구를 수행하였으며, α-glucosidase 저해 활성을 확인하여 보았을 때 seapolynol은 100 μg/mL의 농도에서, dieckol은 50 μM 및 100 μM의 농도에서 효과적인 저해 활성을 확인하였다. 추가로 db/db mouse를 이용하여 경구 포도당 및 맥아당 부하 시험을 진행하였다. 경구 포도당 부하 시험에서 seapolynol과 dieckol은 고농도 처리군에서 각각 40% 및 35%, 경구 맥아당 부하 시험에서는 seapolynol과 dieckol이 각각 20% 및 35%의 유의적인 혈당 강하를 보였다. 또한, 경구맥아당 부하 시험 시 급격히 증가하는 혈당을 억제하는 기능을 확인할 수 있었다. 이를 통해 섭취한 seapolynol과 dieckol이 혈당조절을 위해 장내 α-glucosidase의 활성을 저해시켜 체내 포도당 섭취를 떨어뜨림과 함께 이당류의 분해작용을 억제하여 급격한 혈당의 증가를 억제하는 작용을 할 것이라 예상한다. 따라서 seapolynol과 dieckol이 식후 혈당조절 소재로서의 가능성이 있을 것으로 생각된다. Ecklonia cava, a brown seaweed native to the seas of Korea and Japan, includes various polyphenolic compounds. Seapolynol and its major compound dieckol derived from Ecklonia cava have various biological activities; however, their effect as a hypoglycemic agent has not been sufficiently investigated. Therefore, we investigated the effects of seapolynol and dieckol on α-glucosidase inhibition, based on the oral glucose tolerance test (OGTT) and oral maltose tolerance test (OMTT) in in vivo. α-Glucosidase inhibition activities significantly increased in response to 100 μg/mL seapolynol and 50 and 100 μM doses of dieckol. In addition, OGTT and OMTT of seapolynol and dieckol treated C57BL/KsJ-db/db mice were conducted. Specifically, seapolynol and dieckol were administrated at low and high doses for 6 weeks, after which glucose and maltose (1 g/kg body weight) were administrated orally following 12 h of starvation. Blood glucose levels were measured 30, 60, 90, and 120 min after administration of glucose and maltose. Mice that received high doses of seapolynol and dieckol showed significant 40% and 35% reductions in the area under the curve of blood glucose level, respectively. Moreover, blood glucose level of seapolynol (24.9 mmol/L) and dieckol (22.3 mmol/L) high dose groups were reduced compared to control group (31.6 mmol/L) when maltose administrated after 30 min. These results indicate that seapolynol and dieckol have the potential for use as functional materials for the treatment of hyperglycemia.
JEON, SE HUI,KIM, NAM HEE,SHIM, MOON BO,JEON, YOUNG WOOK,AHN, JI HYE,LEE, SOON HO,HWANG, IN GYUN,RHEE, MIN SUK ational Association for Food Protection 2015 Journal of food protection Vol.78 No.4
<P>The present study examined 469 commercially available fermented alcoholic beverages (FABs), including beer (draft, microbrewed, and pasteurized), fruit wine (grape and others), refined rice wine, and yakju (raw and pasteurized). Samples were screened for Escherichia coli and eight foodborne pathogens (Bacillus cereus, Campylobacter jejuni, Clostridium perfringens, Escherichia coli O157:H7, Listeria monocytogenes, Salmonella spp., Staphylococcus aureus, and Yersinia enterocolitica), and the aerobic plate count, lactic acid bacteria, acetic acid bacteria, fungi, and total coliforms were also enumerated. Microbrewed beer contained the highest number of microorganisms (average aerobic plate count, 3.5; lactic acid bacteria, 2.1; acetic acid bacteria, 2.0; and fungi, 3.6 log CFU/ml), followed by draft beer and yakju (P < 0.05), whereas the other FABs contained <25 CFU/25 ml microorganisms. Unexpectedly, neither microbial diversity nor microbial count correlated with the alcohol content (4.7 to 14.1%) or pH (3.4 to 4.2) of the product. Despite the harsh conditions, coliforms (detected in 23.8% of microbrewed beer samples) and B. cereus (detected in all FABs) were present in some products. B. cereus was detected most frequently in microbrewed beer (54.8% of samples) and nonpasteurized yakju (50.0%), followed by pasteurized yakju (28.8%), refined rice wine (25.0%), other fruit wines (12.3%), grape wine (8.6%), draft beer (5.6%), and pasteurized beer (2.2%) (P < 0.05). The finding that spore-forming B. cereus and coliform bacteria can survive the harsh conditions present in alcoholic beverages should be taken into account (alongside traditional quality indicators such as the presence of lactic acid-producing bacteria, acetic acid-producing bacteria, or both) when developing manufacturing systems and methods to prolong the shelf life of high-quality FAB products. New strategic quality management plans for various FABs are needed.</P>
( Hui Kyung Jeon ),( Hyo Suk Ahn ),( Ki Tae Kim ),( Ho Joong Youn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Long-term therapy with doxorubicin is associated with a high incidenceof a cumulative and irreversible dilated cardiomyopathy, despite of its broad anti-neoplastic effectiveness. The goal of this study was to evaluate the cardioprotective effects and safety of seapolyphenol (polyphenol purifi ed from Ecklonia cava) against doxorubicin-induced cardiotoxicity in an animal rat model. Methods and Results: In total 21 rats including doxorubicin and control groups, baseline and 6 weeks follow up echocardiography were practiced. Left ventricular ejection fraction signifi cantly decreased and the left ventricular end diastolic/systolic dimension and LV mass index signifi cantly increased in single doxorubicin group compared to seapolynol plus doxorubicin group. Also, electron microscopic fi nding showed less impaired myofi ber and mitochondria in seapolynol plus doxorubicin group than in single doxorubicin group. Conclusions: Our data showed that seapolynol had cardioprotective effects against doxorubicin-induced cardiotoxicity in an animal rat model with the evidence of electron microscopic fi nding in addition to echocardiographic results.