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Ying-Ying Yang,Pin-Hsiang Huang,Ling-Yu Yang,Chia-Chang Huang,Chih-Wei Liu,Shiau-Shian Huang,Chen-Huan Chen,Fa-Yauh Lee,Shou-Yen Kao,Boaz Shulruf 한국보건의료인국가시험원 2022 보건의료교육평가 Vol.19 No.-
Purpose Undertaking a standard-setting exercise is a common method for setting pass/fail cut scores for high-stakes examinations. The recently introduced equal Z standard-setting method (EZ method) has been found to be a valid and effective alternative for the commonly used Angoff and Hofstee methods and their variants. The current study aims to estimate the minimum number of panelists required for obtaining acceptable and reliable cut scores using the EZ method. Methods The primary data were extracted from 31 panelists who used the EZ method for setting cut scores for a 12-station of medical school’s final objective structured clinical examination (OSCE) in Taiwan. For this study, a new data set composed of 1,000 random samples of different panel sizes, ranging from 5 to 25 panelists, was established and analyzed. Analysis of variance was performed to measure the differences in the cut scores set by the sampled groups, across all sizes within each station. Results On average, a panel of 10 experts or more yielded cut scores with confidence more than or equal to 90% and 15 experts yielded cut scores with confidence more than or equal to 95%. No significant differences in cut scores associated with panel size were identified for panels of 5 or more experts. Conclusion The EZ method was found to be valid and feasible. Less than an hour was required for 12 panelists to assess 12 OSCE stations. Calculating the cut scores required only basic statistical skills.
( Ying Huang ),( Chenjie Xu ),( Tao Zeng ),( Zhongming Li ),( Yanzhi Xia ),( Gaojian Tao ),( Tong Zhu ),( Lijuan Lu ),( Jing Li ),( Taiyuan Huang ),( Hongbo Huai ),( Benxiang Ning ),( Chao Ma ),( Xinx 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.2
Background: Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The treatment of PHN remains a challenge for clinical pain management. Despite the effectiveness of anticonvulsants, antidepressants, and lidocaine patches in reducing PHN, many patients still face intractable pain disorders. In this randomized controlled study, we evaluated whether hydromorphone through intravenous patient-controlled analgesia (IV PCA) was effective in relieving PHN. Methods: Patients with PHN were randomly divided into two groups, one group received oral pregabalin with IV normal saline, another group received oral pregabalin with additional IV PCA hydromorphone for two weeks. Efficacy was evaluated at 1, 4, and 12 weeks after the end of the treatments. Results: Two hundred and one patients were followed up for 12 weeks. After treatment, numerical rating scale (NRS) score of patients in the hydromorphone group was significantly lower than that of the control group, and the difference of NRS scores between the two groups was statistically significant at 4 and 12 weeks after treatment. The frequency of breakthrough pain in the hydromorphone group was significantly lower than that in the control group 1 and 4 weeks after treatment. After treatment, the quality of sleep in the hydromorphone group was significantly improved compared with the control group. The most common adverse reactions in the hydromorphone group were dizziness and nausea, with no significant respiratory depression. Conclusions: IV PCA hydromorphone combined with oral pregabalin provides superior pain relief in patients with PHN, which is worthy of clinical application and promotion.
Ying Huang,Zhengjun Cheng 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.10
Herein, we have reported the synthesis of boron-, sulfur-, and nitrogen-co-doped carbon dots (B/S/ N-CDs) by one-step hydrothermal method using D-(+)-maltose monohydrate, boracic acid, and thiocarbamide as the precursors. The prepared B/S/N-CDs possess good water dispersibility, excellent pH stabilities, and resistance to photobleaching. Furthermore, the transmission electron microscope image indicates that the B/S/N-CDs are homogeneously spherical and show good dispersion. Noticeably, the B/S/N-CDs show bright blue photoluminescence with a quantum yield of 8.9% in aqueous solution and can be used as a potent photoluminescent probe for selective and sensitive detection of sunset yellow (SY). Compared with other food colors, SY can dramatically quench the fluorescence of B/S/N-CDs. Meanwhile, the fluorescence intensity displays a good linear response with SY concentration in the range of 0–70 μM (R2 = 0.9980) and the detection limit is as low as 4.65 nM. The B/S/N-CDs can also be applied for the detection of SY in mineral water and business drink with satisfactory recovery. Our study has demonstrated that the B/S/N-CDs may have wide application values inmedical detection, environmental monitoring, and related researches.
Huang, Kuo-Ying,Yoo, Hee Young,Jho, YongSeok,Han, Songi,Hwang, Dong Soo American Chemical Society 2016 ACS NANO Vol.10 No.5
<P>An exceptionally low interfacial tension of a dense fluid of concentrated polyelectrolyte complexes, phase separated from a biphasic fluid known as complex coacervates, represents a unique and highly sought-after materials property that inspires novel applications from superior coating to wet adhesion. Despite extensive studies and broad interest, the molecular and structural bases for the unique properties of complex coacervates are unclear. Here, a microphase-separated complex coacervate fluid generated by mixing a recombinant mussel foot protein-1 (mfp-1) as the polycation and hyaluronic acid (HA) as the polyanion at stoichiometric ratios was macroscopically phase-separated into a dense complex coacervate and a dilute supernatant phase to enable separate characterization of the two fluid phases. Surprisingly, despite up to 4 orders of magnitude differing density of the polyelectrolytes, the diffusivity of water in these two phases was found to be indistinguishable. The presence of unbound, bulk-like, water in the dense fluid can be reconciled with a water population that is only weakly perturbed by the polyelectrolyte interface and network. This hypothesis was experimentally validated by cryo-TEM of the macroscopically phase-separated dense complex coacervate phase that was found to be a bicontinuous and biphasic nanostructured network, in which one of the phases was confirmed by staining techniques to be water and the other polyelectrolyte complexes. We conclude that a weak cohesive energy between water water and water polyelectrolytes manifests itself in a bicontinuous network, and is responsible for the exceptionally low interfacial energy of this complex fluid phase with respect to virtually any surface within an aqueous medium.</P>
Ying Sun,Yuxian Huang,Liming Chen 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.1
Fiber-connected distributed antenna systems (DAS) have been recognized as an effective means to accommodate the coverage and capacity demands of future heterogeneous networks (HetNet). Among various opportunities realized by the architecture, our focus in this paper is on the spectral efficiency (SE) advantages achieved by cooperative transmission and the associated power consumption that may affect the energy efficiency (EE) of the system. A detailed power model is developed to benchmark the various sources of energy consumption in fiber-connected DAS. Then a simple but efficient pre-coding scheme is proposed to reduce the computation complexity associated with cooperative transmission, thus lowering the power consumed by baseband processing while at the same time maintaining a high throughput performance. Through detailed and extensive simulations, this paper demonstrates the SE and EE advantages of the application of fiber-connected DAS in HetNet.
Motion Planning of Robot Manipulator Based on Improved NSGA-II
Ying Huang,Minrui Fei 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4
In this paper, the trajectory of a robot manipulator is planned using the non-dominated sorting genetic algorithm II (NSGA-II). Moreover, consumed time, Cartesian trajectory length, and smooth movement are used as the multi-objective to be optimized [1, 2]. The Pareto optimal solution set is obtained through NSGA-II, and simulation is used to obtain and verify the results. In an actual engineering case, the optimal solution of the Pareto solution set can be selected as the optimal path of a robot manipulator. Results show that the relationship between consumed time and joint jerk is a priority solution to practical engineering selection. Moreover, the spatial distribution of the optimal solution set is improved by enhancing the proposed crowding distance mechanism in the conventional NSGA-II algorithm.
Association of RASSF1A Promoter Methylation with Lung Cancer Risk: a Meta-analysis
Huang, Ying-Ze,Wu, Wei,Wu, Kun,Xu, Xiao-Ning,Tang, Wen-Ru Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
RASSF1A, regarded as a candidate tumor suppressor, is frequently silenced and inactivated by methylation of its promoter region in many human tumors. However, the association between RASSF1A promoter methylation and lung cancer risk remains unclear. To provide a more reliable estimate we conducted a meta-analysis of cohort studies to evaluate the potential role of RASSF1A promoter methylation in lung carcinogenesis. Relevant studies were identified by searches of PubMed, Web of Science, ProQest and Medline databases using the following key words: 'lung cancer or lung neoplasm or lung carcinoma', 'RASSF1A methylation' or 'RASSF1A hypermethylation'. According to the selection standard, 15 articles were identified and analysised by STATA 12.0 software. Combined odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association between RASSF1A promoter methylation and lung cancer risk. A chi-square-based Q test and sensitivity analyses were performed to test between-study heterogeneity and the contributions of single studies to the final results, respectively. Funnel plots were carried out to evaluate publication bias. Overall, a significant relationship between RASSF1A promoter methylation and lung cancer risk (OR, 16.12; 95%CI, 11.40-22.81; p<0.001) with no between-study heterogeneity. In subgroup analyses, increased risk of RASSF1A methylation in cases than controls was found for the NSCLC group (OR, 13.66, 95%CI, 9.529-19.57) and in the SCLC group (OR, 314.85, 95%CI, 48.93-2026.2).
Huang Ching Ying 서울대학교 교육연구소 2018 Asia Pacific Education Review Vol.19 No.3
University–industry collaboration (UIC) has been booming for several decades worldwide. Integrating knowledge and resources from universities and industries has become a common method to maintain the innovation capacities of the industries. UIC activities have been promoted in Taiwan through various incentive policies for more than 20 years. However, most university faculty members still obtain research resources from government-related organizations much more than from the industries. Thus, this study focuses on the mechanism between faculty inputs and UIC outputs and tries to answer how faculty characteristics, background, motivation, and the collaboration patterns between universities and industries affect the work outputs of university faculty members. The sample consisted of 2031 questionnaires, and 376 traceable questionnaires were deemed valid and were analyzed. The results showed that age, gender, universities, work experience, award records, seniority of the faculty member, and the strength of social ties between the collaborative teams indeed had significant effects on the UIC outputs. The results of this study may be informative for the industries when business organizations are interested in seeking academia partners to achieve their expected collaboration outputs.