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Hong, Ji Heon,Jang, Sung Ho,Kim, Oh Lyong,Kim, Seong Ho,Ahn, Sang Ho,Byun, Woo Mok,Hong, Cheol Pyo,Lee, Dong Hoon Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2012 The journal of head trauma rehabilitation Vol.27 No.3
<P>The recent development of diffusion tensor imaging (DTI) allows visualization and estimation of the medial cholinergic pathway (MCP), which originates from the nucleus basalis of Meynert and provides cortical cholinergic innervation to the cerebral cortex. We investigated the injury to the MCP in patients with traumatic axonal injury (TAI), using DTI.</P>
Long Term Results of Microsurgical Dorsal Root Entry Zonotomy for Upper Extremity Spasticity
Hong, Joo-Chul,Kim, Min-Soo,Chang, Chul-Hoon,Kim, Sang-Woo,Kim, Oh-Lyong,Kim, Seong-Ho The Korean Neurosurgical Society 2008 Journal of Korean neurosurgical society Vol.43 No.4
Objective : The purpose of the present study is to assess the long-term results of microsurgical dorsal root entry zonotomy (MDT) for the treatment of medically intractable upper-extremity spasticity. Methods : The records of nine adult patients who underwent MDT by one operating neurosurgeon from March 1999 to June 2004 were retrospectively reviewed by another investigator who had no role in the management of these patients. In all patients, MDT was performed on all roots of the upper limb (from C5 to T1) for spasticity of the upper extremity. The degree of spasticity was measured by the Modified Ashworth Scale (grade 0-4). Severity of the pain level was determined using the Numeric Rating Scale (NRS, score 0-10). Also, patient satisfaction of the post-operative outcome was assessed. Results : Comparing the preoperative and postoperative spasticity using the Modified Ashworth Scale, we observed improvement in all patients, particularly in five of the nine patients (55.6%) who improved by three grades over an average of 66.4 months (range, 40-96). Regarding patient satisfaction, seven patients (77.8%) had affirmative results. None of the patients experienced severe, life-threatening, postoperative complications. We observed a decrease in the intensity of painful spasms to less than three scores as measured by NRS in all four patients with associated pain. Conclusion : This study shows that MDT provides significant, long-term reduction of harmful spasticity and associated pain in the upper limbs.
Kim, Hong Gi,Kim, Kil Lyong Wiley Subscription Services, Inc., A Wiley Company 2007 Journal of neuroscience research Vol.85 No.13
<P>The stress response alters behavior, autonomic function, and secretion of multiple hormones, including corticotropin-releasing factor, adrenocorticotropin hormone, and cortisol, through the hypothalamic-pituitary-adrenal axis. Constitutive stress responses lead to a number of psychiatric disorders, including depression, posttraumatic stress disorder, Alzheimer's disease (AD), and other anxiety disorders through increased stress hormones and other unknown factors. Here, we performed a proteomic analysis of rat brain exposed to restraint stress compared with a nonstress group by using 2D-DIGE and MALDI-TOF analysis. Several proteins were identified by peptide mass fingerprint (PMF), including down-regulated hippocampal cholinergic neurostimulating peptide precursor protein (HCNP-pp). The current study demonstrates that HCNP-pp mRNA and protein expression are decreased in rat hippocampus after stress exposure. The level of HCNP-pp in H19-7, a rat hippocampal cell line, significantly decreases with dexamethasone treatment, a synthetic glucocorticoid. Thus, this finding suggests that HCNP-pp expression may decrease in response to stress exposure. Decreased HCNP-pp from stress exposure may result in lower levels of HCNP that might contribute to a loss of acetylcholine production. © 2007 Wiley-Liss, Inc.</P>
자궁경부암 진단에서 질세포진검사, 질확대경하 조준생검과 최종 조직병리와의 비교 분석
김호룡 ( Kim Ho Lyong ),김형호 ( Kim Hyeong Ho ),천예영 ( Chun Yea Young ),구진영 ( Gu Jin Yeong ),홍선웅 ( Hong Seon Ung ),선진규 ( Sun Jin Gyu ),기광수 ( Kee Kwang Soo ) 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.7
목적 : 자궁경부암의 보다 정확한 진단을 위해 질확대경하 조준생검의 필요성을 알아보고자 한다. 연구 방법 : 1999년 1월부터 2001년 12월까지 본 병원에서 질세포진검사, 질확대경하 조준생검 및 원추생검 또는 전자궁절제술을 시행한 114예를 대상으로 진료기록지 및 조직검사 결과지를 비교분석하였다. 결과 : 질세포진검사와 병리조직학적 진단이 일치한 경우는 66예로 57.9%였으며, 한 단계 이내 일치도는 92예로 80.6%를 차지하였고, 질확대경하 조준생검과 병리조직학적 진단이 일치한 경우는 71예로 62.3%였으며, 한단계 이내 일치도는 97예로 85.1%를 차지하였다. SAS 프로그램의 T-test 상 두 가지 검사 방법에 있어서 통계학적으로 유의한 차이를 보였다. (p<0.001). 결론 : 질확대경하 조준생검과 질세포진검사를 같이 시행하여 자궁경부암의 조기진단의 위음성률을 낮출 수 있다. 그러나 질확대경하 조준생검을 시행하기 전 충분한 교육이 필요할 것으로 사료된다. Objective : To investigate the necessity of colposcopically directed biopsy for more accurate detection of cervical neoplasm. Methods : Cytology and colposcopically directed biopsy were performed in 114 patients and the patients were subsequently underwent conization or hysterectomy from January, 1998 to December, 2001. Results : the complete diagnostic agreement of cytology with permanent biopsy was 57.9% (66 of 114) and the diagnostic agreement within one degree was 80.6% (92 of 114). The complete diagnostic agreement of colposcopically directed biopsy with permanent biopsy was 62.3% (71 of 114) and the diagnostic agreement within one degree was 85.1% (97 of 114). The difference between two tests was statistically significant (p<0.001). Conclusion : We concluded that colposcopically directed biopsy can reduce the false negative rate of cytology for screening test of cervical neoplasm. The difference between colposcopically directed biopsy and permanent biopsy was caused by inappropriate resection of the lesion and unskilled physician.