Effect of Astaxanthin on Anti-Inflammatory and Anti-Oxidative Effects of Astaxanthin Treatment for Atopic Dermatitis-induced Mice

Park, Jin Woo,Song, Ho-Sueb Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.4

Background: This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods: Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1. Results: AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased. Conclusion: In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD.

PbMoO₄단결정의 광학적성질에 대한 연구

이호섭,오인환 國立 昌原大學校 産業技術硏究所 1989 産技硏論文集 Vol.3 No.-

The excitation and emission spectra of photoluminescence of Lead Molybdate single crystals and its annealing effect are investigated. The photoluminescence spectra of Lead Molybdata are measured by time resolved spectroscopy using Nd-YAG pulse laser(=1.064㎛) as exciting radiation source. The near edge absorption of (100) and (001) plate are 3.28 eV and 3.21 eV respectively, and shift towards the UV region as annealing time increase. In present experiment we obtained broad band photoluminescence spectra of the crystals at 520 nm.

Low Frequency Dielectric Anomaly of Tris-Sarcosine Calcium Manganese Chloride ( ( CH3NHCH2COOH ) 3 Ca1-x MnxCl3 ) Mixed Crystals

Ho Sueb Lee 기초과학연구소 1996 기초과학논문집 Vol.8 No.-

Low Frequency Dielectric Anomaly of Tris-Sarcosine Calcium Manganese Chloride (((CH₃NHCH₂COOH)₃??) Mixed Crystals.

Lee, Ho Sueb 昌原大學校 基礎科學硏究所 1996 基礎科學硏究所論文集 Vol.8 No.-

(CH₃NHCH₂COOH)₃??혼정(x=0, 0.05 및 0.1)의 저주파수 유전특성을 조사하였다. 순수한 (CH₃NHCH₂COOH)₃CaCl₂의 유전상수와 손실은 Tc근방에서 예리한 peak를 보인 반면 Mn을x=0.05 및 0.1 치환시킨 혼정에서는 그 anomaly가 broader하였다. 특히 Mn이 10mol% 첨가한 시료에서는 임계영역안에서 극소점이 나타났으며 이는 (CH₃NHCH₂COOH)₃CaCl₂의 상전이 기구가 임계영역내에서는 질서무질서형 거동하는 것을 뒷받침 하였다.

FREQUENCY AND TEMPERATURE DEPENDENCE OF ELECTRICAL PROPERTIES IN PURE AND Nb-DOPED Bi4Ti3O12 CERAMICS

Park, Jong-Ho,Back, Nam Kwon,Yoo, Dae-Hwang,Kim, Chung-Sik,Yang, Ho-Soon,Choi, Byung Chun,Moon, Byung Kee,Seo, Hyo Jin,Lee, Ho-Sueb,Hong, K. S. Gordon and Breach Science Publishers 2006 Integrated ferroelectrics Vol.79 No.-

<P> Pure and Nb-doped Bi4Ti3O12 ceramics were prepared by using the conventional solid state reaction method. The dielectric permittivity and electrical modulus in pure and Nb-doped Bi4Ti3O12 ceramics were measured in the temperature range of 30 ∼ 700 °C and the frequency range of 1 Hz∼1 MHz through an impedance spectroscopy method. The obtained results showed well-defined relaxation peaks. The conductivity relaxation times are determined from the peaks of the modulus. The activation energies associated with hopping condition are 0.42 eV and 0.53 eV in pure and Nb-doped Bi4Ti3O12 ceramics, respectively.</P>

Gd₂(MoO₄)₃단결정의 적외선 반사스펙트럼

이호섭 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-

Infrared reflection spectra of Gd₂(MoO₄)₃single crystals are measured in the range 600-??????. The spectra are analysed with dielectric dispersion analysis and Kramers-Kronig relation. Optical phonon modes TO and LO phonon modes of B₁and B₂show very strong oscillator strengths and small damping constants, whreras A₁polar mode have shows large damping constant. The frequency inversion between TO and LO phonons are observed near the TO phonon with large oscillator strength.

Gd₂(MoO₄)₃단결성의 자발복굴절현상

이호섭,김상수 國立昌原大學校 基礎科學硏究所 1992 基礎科學硏究所論文集 Vol.3 No.-

Spontaneous Birefringence and Electro-Optical properties of Gd₂(MoO₄)₃single crystals were studied. Electro-Optic coefficient and its temperature dependence and Spontaneous Birefringence near the Curie temperature and measured by using the Babinet-Soleil compensator with A/D converter. The value of ??? is 4×??? m/V at room temperature and decreased to zero at phase transition one. The values of temperature and electric field dependence near the phase transition point are presented as hysterosis phenomena.

Scutellaria baicalensis Extract Alleviates Pain and Inflammation in Animal Models

Haeni Seo,Ho-Sueb Song 대한침구의학회 2023 대한침구의학회지 Vol.40 No.1

Background: This study aimed to examine the effect of Scutellaria baicalensis extract (SBE) on ameliorating pain response and inflammation in an animal model. Methods: The effects of SBE on joint inflammation-induced rats and pain writhing response were measured. In rats with monosodium iodoacetate (MIA)-induced knee osteoarthritis (OA), the weight-bearing distribution of the hind legs was measured, the actual joint condition was visually confirmed, and serum cytokines were extracted from whole blood and measured. In addition, the acetic acid-induced pain was measured by the number of abdominal wall contractions and writhing responses. Results: 1. The weight-bearing distribution of the hind limbs of the SBE group was remarkably improved compared with that of the control group 7 days after MIA treatment, and the SBE 300 group was improved similarly to that of the indomethacin group. 2. Cartilage erosion was significantly recovered in the SBE and indomethacin groups, and the degree of healing of cartilage erosion by SBE was similar to that by indomethacin. 3. The serum levels of cytokines interleukin-1β, tumor necrosis factor-α, and interleukin-6 were significantly decreased in the SBE group compared with that in the control group, and the SBE 300 group had reduced levels of cytokines similar to the indomethacin group. 4. As regards acetic acid-induced writhing response, the number of writhes was significantly reduced in the SBE and ibuprofen groups, and the SBE 600 group had fewer writhes than the ibuprofen group. Conclusion: SBE significantly improves knee OA and pain and is expected to show similar therapeutic effects to indomethacin and ibuprofen.

금주 동맹의 참여에 영향을 미치는 주정 중독환자의 변인에 관한 예비적 연구

석재호,박유문,윤정섭 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3

The author investigated the background of alcoholic patients which seemed to influence the participation of alcoholic patients to Alcoholics Anonymous. The subject of this study were 59 patients with alcoholic patients who had been admitted to Kangdong Sacred Heart Hospital from July, 1988 to September, 1990. This study was performed by the review of inpatient records and interview through telephone. The results were as follows : 1. As we compared the group of maintaining sobriety with the alcoholic group which had drank alcohol continusously after discharge. 1) The alcoholic patients who had professional job were more difficult to be abstinent than the other group(p=0.046). 2) There was a tendency that the continuously drinking group had significantly domineering mother and weak father(p=0.037). 2. As we compared participating group with non-participating group. 1) Alcoholic patients with drinking history over 15 years revealed resistance to participate in alcoholic anonymous(p=0.034). 2) Well-educted alcoholic patients attended alcoholic anonymous more than patients with lower educational level(p=0.0389). 3) Alcoholic patients in higher socioecconomic status had higher tendency to participate alcoholic anonymous than those in lower socioecconomic status(p=0.031). 4) those who eagerly participated alcoholic anonymous seems to maintain sobreity more than those who did not showed interest in alcoholic anonymous(p=0.0045).

Effects of Scutellaria baicalensis Extract on Gout-Induced Rats

Eunchang Lee,Ho-Sueb Song 대한침구의학회 2023 대한침구의학회지 Vol.40 No.2

Background: This study aimed to investigate hyperuricemia, renal inflammation, and xanthine oxidase (XO) activity improvement in a rat model treated with Scutellaria baicalensis extract (SBE). Methods: The rats were divided into 4 groups (n = 5 each), including sham, potassium oxonate (PO) injected hyperuricemia (control group), PO + 10 mg/kg allopurinol administrated (allopurinol group), and a PO + 50 mg/kg SBE administrated (SBE group), to investigate the effectiveness and molecular mechanisms of SBE. The effects of SBE on PO-induced hyperuricemia rats, renal inflammation, and XO activity were measured. Body weight and organ index of the kidney and liver were measured in PO-induced hyperuricemia rats, and serum uric acid level was extracted from whole blood and was measured. Renal inflammation was observed under a microscope after sections. XO activity was measured by liver tissue and serum XO levels. Results: Organ indexes of the kidney and liver in rats were significantly decreased in the allopurinol group than in the control group and with no significant difference in the SBE group. A PO injection for 5 days significantly increased serum uric acid levels in the control group compared to the sham group. Meanwhile, the SBE and allopurinol groups have significantly decreased serum uric acid levels compared to the control group. The SBE group revealed effectively improved renal histopathological changes compared to the control group. The XO inhibitor, allopurinol, significantly decreased XO activity. Additionally, SBE significantly lowered XO activity in rats. Conclusion: SBE can be used as an effective treatment for gout in the future.