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      • KCI등재후보

        가브리엘라 미스트랄이 시적으로 개작한 네 가지 고전 동화

        안드레아카살스힐 ( Anerea Casals Hill ),정현주(번역) 방정환연구소 2020 방정환연구 Vol.3 No.-

        안드레아 카살스 힐(Andrea Casals Hill)은 칠레 작가가 시적으로 개작한 이야기, 『백설공주』(Blanca Nieve), 『빨간 모자』(Caperucita Roja), 『신데렐라』(Cenininca), 『잠자는 숲속의 미녀』(La Bella Durmiente)를 소개하고 분석한다. 이 책들은 최근 그림책으로 재출간되어 호평을 받고 있다. 가브리엘라 미스트랄(Gabriela Mistral)은 라틴 아메리카의 작가로는 처음으로 노벨 문학상을 받았다. 카살스 힐에 따르면, 미스트랄이 시적으로 개작한 『백설공주』, 『빨간 모자』, 『신데렐라』, 『잠자는 숲속의 미녀』는 보이지 않고, 버려지고, 학대 받는 젊은 여성 청자의 자율권(empowerment)을 가능하게 하려는 미스트랄의 윤리적인 헌신을 반영한다. Andrea Casals Hill presents and analyzes the acclaimed Chilean author’s poetic retellings of Snow White, Little Red Riding Hood, Cinderella, and Sleeping Beauty, which have been recently republished as illustrated books. Gabriela Mistral was the first Latin American author to receive a Nobel Prize in Literature. Casals Hill asserts that her poetic retellings of Caperucita Roja, Blanca Nieve, Cenicienta, and La Bella Durmiente reflect Mistral’s ethical commitment to enable the empowerment of her invisible, abandoned, and abused young female audience.

      • SCOPUSKCI등재

        반복유산을 경험한 환자에서 임신중 태반항원과 동종항원에 노출된 모체 림프구면역반응은 언제부터 소실되나?

        최범채,Choi, Bum-Chae,Hill, Joseph A. 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.2

        The maintenance of a viable pregnancy has long been viewed as an immunological paradox. The deveolping embryo and trophoblast are immunologically foreign to the maternal immune system due to their maternally inherited genes products and tissue-specific differentiation antigens (Hill & Anderson, 1988). Therefore, speculation has arisen that spontaneous abortion may be caused by impaired maternal immune tolerance to the semiallogenic conceptus (Hill, 1990). Loss of recall antigen has been reported in immunosuppressed transplant recipients and is associated with graft survival (Muluk et al., 1991; Schulik et al., 1994). Progesterone $(10^{-5}M)$ has immunosuppressive capabilities (Szekeres-Bartho et al., 1985). Previous study showed that fertile women, but not women with unexplained recurrent abortion (URA), lose their immune response to recall antigens when pregnant (Bermas & Hill, 1997). Therefore, we hypothesized that immunosuppressive doses of progesterone may affect proliferative response of lymphocytes to trophoblast antigen and alloantigen. Proliferative responses using $^3H$-thymidine ($^3H$-TdR) incorporation of peripheral blood mononuclear cells (PBMCs) to the irradiated allogeneic periperal blood mononuclear cells as alloantigen, trophoblast extract and Flu as recall antigen, and PHA as mitogen were serially checked in 9 women who had experienced unexplained recurrent miscarriage. Progesterone vaginal suppositories (100mg b.i.d; Utrogestan, Organon) beginning 3 days after ovulation were given to 9 women with unexplained RSA who had prior evidence of Th1 immunity to trophoblast. We checked proliferation responses to conception cycle before and after progesterone supplementation once a week through the first 7 weeks of pregnancy. All patients of alloantigen and PHA had a positive proliferation response that occmed in the baseline phase. But 4 out of 9 patients (44.4%) of trophoblast antigen and Flu antigen had a positive proliferative response. The suppression of proliferation response to each antigen were started after proliferative phase and during pregnancy cycles. Our data demonstrated that since in vivo progesterone treated PBMCs suppressed more T-lymphocyte activation and $^3H$-TdR incorporation compare to PBMCs, which are not influenced by progesterone. This data suggested that it might be influenced by immunosuppressive effect of progesterone. In conclusion, progesterone may play an important immunological role in regulating local immune response in the fetal-placental unit. Furthermore, in the 9 women given progesterone during a conception cycle, Only two (22%) repeat pregnancy losses occured in these 9 women despite loss of antigen responsiveness (one chemical pregnancy loss and one loss at 8 weeks of growth which was karyotyped as a Trisomy 4). These finding suggested that pregnancy loss due to fetal aneuploidy is not associated with immunological phenomena.

      • SCOPUSKCI등재

        The Interaction of Cognitive Interference, Standing Surface, and Fatigue on Lower Extremity Muscle Activity

        Hill, Christopher M.,DeBusk, Hunter,Simpson, Jeffrey D.,Miller, Brandon L.,Knight, Adam C.,Garner, John C.,Wade, Chip,Chander, Harish Occupational Safety and Health Research Institute 2019 Safety and health at work Vol.10 No.3

        Background: Performing cognitive tasks and muscular fatigue have been shown to increase muscle activity of the lower extremity during quiet standing. A common intervention to reduce muscular fatigue is to provide a softer shoe-surface interface. However, little is known regarding how muscle activity is affected by softer shoe-surface interfaces during static standing. The purpose of this study was to assess lower extremity muscular activity during erect standing on three different standing surfaces, before and after an acute workload and during cognitive tasks. Methods: Surface electromyography was collected on ankle dorsiflexors and plantarflexors, and knee flexors and extensors of fifteen male participants. Dependent electromyography variables of mean, peak, root mean square, and cocontraction index were calculated and analyzed with a $2{\times}2{\times}3$ within-subject repeated measures analysis of variance. Results: Pre-workload muscle activity did not differ between surfaces and cognitive task conditions. However, greater muscle activity during post-workload balance assessment was found, specifically during the cognitive task. Cognitive task errors did not differ between surface and workload. Conclusions: The cognitive task after workload increased lower extremity muscular activity compared to quite standing, irrespective of the surface condition, suggesting an increased demand was placed on the postural control system as the result of both fatigue and cognitive task.

      • SCOPUS

        Two-photon fluorescence lifetime imaging of intracellular chloride in cockroach salivary glands

        Hille, Carsten,Lahn, Mattes,Lohmannsroben, Hans-Gerd,Dosche, Carsten Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.3

        Although chloride plays an important role in many cellular processes, there is a lack of data about intracellular chloride concentrations $[Cl^-]_i$, particularly due to technical problems. To overcome that, in this study fluorescence lifetime imaging microscopy in the time-domain by using time-correlated single-photon counting was combined with two-photon excitation (2P-FLIM). This 2P-FLIM setup has been successfully used with the $Cl^-$-sensitive fluorescent dye N-(ethoxycarbonylmethyl)-6-methoxy-quinolinium bromide (MQAE) in order to measure $[Cl^-]_i$ in cockroach salivary glands, a well-established model system for studying epithelial ion transport processes. MQAE was well suitable for two-photon excitation, when loaded into cells, and displayed a sufficient dynamic range of its fluorescence decay time changes in response to variation of $[Cl^-]_i$ according to the Stern-Volmer relationship. On this basis a uniform $[Cl^-]_i$ in the range of 42.80 mM with a mean value of $59\;mM{\pm}1\;mM$ was found in resting cockroach salivary ducts, indicating active $Cl^-$ accumulation. However, exposure to $Cl^-$-free saline caused only a moderate $[Cl^-]_i$ drop to $48\;mM{\pm}4\;mM$, suggesting a relatively low basolateral $Cl^-$ permeability in ducts, at least under resting conditions. Additionally, bath application of the biogenic amine dopamine, known to stimulate the saliva modification in the ducts, caused no significant $[Cl^-]_i$ changes. These results suggest a more complex scenario of $[Cl^-]_i$ homeostasis in cockroach salivary ducts. In conclusion, 2P-FLIM seems to be a suitable technique for quantitative $[Cl^-]_i$ measurements in many biological systems.

      • Colloidal polymers from inorganic nanoparticle monomers

        Hill, Lawrence J.,Pinna, Nicola,Char, Kookheon,Pyun, Jeffrey Elsevier 2015 Progress in polymer science Vol.40 No.-

        <P><B>Abstract</B></P> <P>The use of preformed inorganic nanoparticles as “colloidal monomers” has received recent attention for the formation of one-dimensional (1-D) mesostructures, or “colloidal polymers.” These colloidal monomers form linear assemblies through attractive, directional, interparticle interactions, which are similar to covalent or supramolecular interactions in classical polymer science. However, in contrast to the high degree of structural control available in the synthesis of classical molecular polymers, methods to control fundamental structural features such as chain length (DP), composition (copolymers), and architecture (linear, branched, etc.) are still being developed for NP-based colloidal polymer systems. We therefore review the colloidal polymerization of inorganic nanoparticle monomers by applying the conceptual framework provided by polymer science to categorize these novel systems. The descriptive nomenclature used for classical polymers is applied to NP assembly to define more explicitly the types of colloidal polymers formed in terms of DP, architecture, and composition (for binary NP assemblies). This review includes descriptions of inorganic nanoparticle types useful for the formation of colloidal polymers with examples chosen to demonstrate control over mesoscopic structure and composition. The various emergent optical, electrical and electrochemical properties from these materials are also reviewed and correlated with structural control achieved in various colloidal polymer systems.</P>

      • SCIESCOPUS

        Wild waterfowl migration and domestic duck density shape the epidemiology of highly pathogenic H5N8 influenza in the Republic of Korea

        Hill, Sarah C.,Lee, Youn-Jeong,Song, Byung-Min,Kang, Hyun-Mi,Lee, Eun-Kyoung,Hanna, Amanda,Gilbert, Marius,Brown, Ian H.,Pybus, Oliver G. Elsevier Science 2015 INFECTION GENETICS AND EVOLUTION Vol.34 No.-

        <▼1><P><B>Highlights</B></P><P>•<P>Phylogeographic analyses of H5N8, including 49 new sequences from South Korea.</P>•<P>H5N8 movement was mostly among areas dense in wild and domestic ducks.</P>•<P>New viral introductions to South Korea occurred at time of wild bird migration.</P>•<P>H5N8 epidemiology is shaped by wild waterfowl migration and domestic duck density.</P>•<P>H5N8 may have entered Europe at least twice, and Asia at least three times.</P></P></▼1><▼2><P>Highly pathogenic avian influenza (HPAI) viruses threaten human and animal health yet their emergence is poorly understood, partly because sampling of the HPAI Asian-origin H5N1 lineage immediately after its identification in 1996 was comparatively sparse. The discovery of a novel H5N8 virus in 2013 provides a new opportunity to investigate HPAI emergence in greater detail. Here we investigate the origin and transmission of H5N8 in the Republic of Korea, the second country to report the new strain. We reconstruct viral spread using phylogeographic methods and interpret the results in the context of ecological data on poultry density, overwintering wild bird numbers, and bird migration patterns. Our results indicate that wild waterfowl migration and domestic duck density were important to H5N8 epidemiology. Specifically, we infer that H5N8 entered the Republic of Korea via Jeonbuk province, then spread rapidly among western provinces where densities of overwintering waterfowl and domestic ducks are higher, yet rarely persisted in eastern regions. The common ancestor of H5N8 in the Republic of Korea was estimated to have arrived during the peak of inward migration of overwintering birds. Recent virus isolations likely represent re-introductions via bird migration from an as-yet unsampled reservoir. Based on the limited data from outside the Republic of Korea, our data suggest that H5N8 may have entered Europe at least twice, and Asia at least three times from this reservoir, most likely carried by wild migrating birds.</P></▼2>

      • KCI등재

        아시아태평양지역 과학기술을 통한 젠더 평등(APGEST)

        Hill, Stephen 淑明女子大學校 亞細亞女性問題硏究所 2001 아시아여성연구 Vol.40 No.-

        Project Objective 아태지역의 과학과 기술이 여성에 의해 이루어지는 정책과 프로그램이 선택되는 것을 높이기 위함 Project Outcomes ㆍ아태지역에서 정책, 프로그램, 기관과 이와 관련한 여성의 과학과 기술의 접근이 서류화 되고 보급화 되도록 함 ㆍ지역 네트워크를 작용하는 사람, 기관과 네트워크 정책의 지지와 기술 협조를 얻을 수 있어야함. ㆍ재활용 가능한 에너지, 생명공학, 정보과학, green health와 물과 공중위생 등 여성을 위한 경제적 권한의 방법론과 도구들은 발달괴고 보급되어야 함 Project activities ㆍ정책과 기관의 개혁, 프로그램의 계호기의 상세한 조사는 기관과 네트워크의 과학, 공학과 기술분야의 성문제를 정립한다. ㆍ빈곤 퇴치 교육을 위한 APGEN pilot 프로젝트와 UND의 다른 2개의 프로젝트(예 : SAPAP과 태평양 하위 지역)의 기술원조의 공급 지역 전체에서 보급의 결과의 적용의 교훈

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