Magnesium alloy anodized in molten NH4HF2 for controlling biodegradation

Heng Bo Jiang,Guosong Wu,Sang-Bae Lee,Kwang-Mahn Kim 대한치과재료학회 2017 대한치과기재학회 학술대회 Vol.2017 No.4

Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice

Jiang, Shu-Heng,Li, Jun,Dong, Fang-Yuan,Yang, Jian-Yu,Liu, De-Jun,Yang, Xiao-Mei,Wang, Ya-Hui,Yang, Min-Wei,Fu, Xue-Liang,Zhang, Xiao-Xin,Li, Qing,Pang, Xiu-Feng,Huo, Yan-Miao,Li, Jiao,Zhang, Jun-Feng Elsevier 2017 Gastroenterology Vol.153 No.1

<P><B>Background & Aims</B></P> <P>Desmoplasia and poor vascularity cause severe metabolic stress in pancreatic ductal adenocarcinomas (PDACs). Serotonin (5-HT) is a neuromodulator with neurotransmitter and neuroendocrine functions that contributes to tumorigenesis. We investigated the role of 5-HT signaling in the growth of pancreatic tumors.</P> <P><B>Methods</B></P> <P>We measured the levels of proteins that regulate 5-HT synthesis, packaging, and degradation in pancreata from Kras<SUP>G12D/+</SUP>/Trp53<SUP>R172H/+</SUP>/Pdx1-Cre (KPC) mice, which develop pancreatic tumors, as well as in PDAC cell lines and a tissue microarray containing 81 human PDAC samples. We also analyzed expression levels of proteins involved in 5-HT synthesis and degradation by immunohistochemical analysis of a tissue microarray containing 311 PDAC specimens, and associated expression levels with patient survival times. 5-HT level in 14 matched PDAC tumor and non-tumor tissues were analyzed by ELISA. PDAC cell lines were incubated with 5-HT and cell survival and apoptosis were measured. We analyzed expression of the 5-HT receptor HTR2B in PDAC cells and effects of receptor agonists and antagonists, as well as HTR2B knockdown with small hairpin RNAs. We determined the effects of 5-HT stimulation on gene expression profiles of BxPC-3 cells. Regulation of glycolysis by 5-HT signaling via HTR2B was assessed by immunofluorescence and immunoprecipitation analyses, as well as by determination of the extracellular acid ratio, glucose consumption, and lactate production. Primary PDACs, with or without exposure to SB204741 (a selective antagonist of HTR2B), were grown as xenograft tumors in mice, and SB204741 was administered to tumor-bearing KPC mice; tumor growth and metabolism were measured by imaging analyses.</P> <P><B>Results</B></P> <P>In immunohistochemical analysis of a tissue microarray of PDAC specimens, increased levels of TPH1 and decreased level of MAOA, which regulate 5-HT synthesis and degradation, correlated with stage and size of PDACs and shorter patient survival time. We found levels of 5-HT to be increased in human PDAC tissues compared with non-tumor pancreatic tissues, and PDAC cell lines compared with non-transformed pancreatic cells. Incubation of PDAC cell lines with 5-HT increased proliferation and prevented apoptosis. Agonists of HTR2B, but not other 5-HT receptors, promoted proliferation and prevented apoptosis of PDAC cells. Knockdown of HTR2B in PDAC cells, or incubation of cells with HTR2B inhibitors, reduced their growth as xenograft tumors in mice. We observed a correlation between 5-HT and glycolytic flux in PDAC cells; levels of metabolic enzymes involved in glycolysis, the phosphate pentose pathway, and hexosamine biosynthesis pathway increased significantly in PDAC cells following 5-HT stimulation. 5-HT stimulation led to formation of the HTR2B–LYN–p85 complex, which increased PI3K–Akt–mTOR signaling and the Warburg effect by increasing protein levels of MYC and HIF1A. Administration of SB204741 to KPC mice slowed growth and metabolism of established pancreatic tumors and prolonged survival of the mice.</P> <P><B>Conclusions</B></P> <P>Human PDACs have increased levels of 5-HT, and PDAC cells increase expression of its receptor, HTR2B. These increases allow for tumor glycolysis under metabolic stress and promote growth of pancreatic tumors and PDAC xenograft tumors in mice.</P>

Surface Characteristics of modified pure Mg by MgF₂ coating

Jiang Heng Bo,김유경,이용호,양태호,Sankara Narayanan,지정희,박일송,배태성,이민호 대한치과재료학회 2013 대한치과기재학회 학술대회 Vol.2013 No.4

Achieving controllable degradation of a biomedical magnesium alloy by anodizing in molten ammonium bifluoride

Jiang, Heng Bo,Wu, Guosong,Lee, Sang-Bae,Kim, Kwang-Mahn Elsevier 2017 Surface & coatings technology Vol.313 No.-

<P><B>Abstract</B></P> <P>Magnesium (Mg) and its alloys as biodegradable metallic materials have attracted fundamental research in the field of orthopedics and cardiovascular materials. However, magnesium implants exhibit poor corrosion resistance, especially in the physiological environment, which limits medical applications. To improve the corrosion resistance of the Mg, anodization was applied to an ultra-high concentration of fluoride electrolyte. Then, surface morphology, coating thickness and composition were determined, and the corrosion behavior of anodized Mg alloys was evaluated. The results of coating by anodization showed that a porosity structure with a pore size of 600–900nm and thickness of 1–14μm is generated on the Mg alloy substrate, and this coating component is magnesium fluoride. In electrochemical corrosion tests and immersion corrosion tests, the anodized Mg alloy was tested, and the anodized Mg alloy shows significantly improved corrosion resistance compared with untreated Mg alloy in simulated body fluid (SBF).</P> <P><B>Highlights</B></P> <P> <UL> <LI> A porous MgF<SUB>2</SUB> coating is created on Mg alloy by anodization in molten fluoride salt. </LI> <LI> The anodizing time is <30s. </LI> <LI> Corrosion resistance of the anodized Mg alloy is obviously improved. </LI> </UL> </P>

A Fully Integrated SoC for Smart Capsule Providing In-Body Continuous pH and Temperature Monitoring

Heng Liu,Hanjun Jiang,Jingpei Xia,Zhexiang Chi,Fule Li,Zhihua Wang 대한전자공학회 2016 Journal of semiconductor technology and science Vol.16 No.5

This paper presents a SoC (System-on-a-Chip) dedicated for a single-chip smart capsule which can be used to continuously monitor human alimentary canal pH and temperature values. The SoC is composed of the pH and temperature sensor interface circuit, a wireless transceiver, the power management circuit and the flow control logic. Fabricated in 0.18 μm standard CMOS technology, the SoC occupies a die area of ~9 mm². The SoC consumes 6.15 mW from a 3 V power supply, guaranteeing the smart capsule battery life is no less than 24 hours when using 50 mAh coin batteries. The experimental results show that measurement accuracy of the smart capsule is ±0.1 pH and ±0.2°C for pH and temperature sensing, respectively, which meets the requirement of in-body pH and temperature monitoring in clinical practice.

A Data Transmission Method for Resource Monitoring under Cloud Computing Environment

Ying Jiang,Heng Sun,Jiaman Ding,Yingli Liu 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.2

Currently, the combined push-pull model is usually applied in the resource monitoring under cloud computing environment. However, the quantity of data gathered by the producers is much less than those received by the monitor so that a lot of resource is wasted. In order to maintain the data consistency of real time system, an improved adaptive algorithm based on combined push-pull model is proposed. The adaptive strategy is added on the producers that aims to predict when refreshes data came from the monitor using the history data. Experimental result shows that the algorithm can decrease the resource consumption while exchanging data effectively.

Synthesis and Characterization of Waterborne Polyurethane Modified by Acrylate/nano-ZnO for Dyeing of Cotton Fabrics

Huiyu Jiang,Yujiao Wang,Heng Quan,Wei Li 한국섬유공학회 2018 Fibers and polymers Vol.19 No.4

Waterborne polyurethane modified by acrylate/nano-ZnO (PUA/ZnO) was synthesized and used to improve the wet rubbing fastness of reactive dyed cotton fabric. The reaction conditions were optimized and the products were characterized by FT-IR, TG, DSC, SEM, and particle size distribution. The dyed cotton fabrics were finished with PUA/ZnO emulsion and the rubbing fastness, ultraviolet resistant property, and wearability of treated fabrics were measured. The wet rubbing fastness of treated fabrics was increased by about 0.5-1 rate to achieve 3-4 rate, and the ultraviolet protection factor (UPF) achieved 50+ level. The whiteness, air permeability, and elongation at break of treated fabric were not decreased significantly. SEM showed that the smooth and reticular coating on the surface of treated fabric reduced the mechanical friction force between dyed fabric and rubbing cloth, and thus improved the rubbing fastness. The decomposition temperature of finished fabric was increased by 50-80 oC.

Periodic Event-triggered Control for Inter-vehicle Communications

Fengyao Jiang,Heng Deng,Liguo Zhang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4

This paper investigates the model-based periodic event-triggered control strategy for Inter-Vehicle Communication (IVC) in the field of cyber-physical transportation system (CPTS). The vehicle needs to periodically broadcast its state information to other vehicles to ensure the traffic safety. Considering the scarcity of communication resources in traffic network, an event-triggered control is introduced to strike a balance between the communication cost and the estimation quality. The state information of the vehicle is calculated by the local estimator through the interacting filtering algorithm, and the scheduling module controls the broadcast behavior of the vehicle. When the channel between the dead reckoning module and the local estimator is activated, the local estimator broadcasts the current estimation results in the vehicular network. Otherwise, the dead reckoning module in neighboring vehicles calculates the computative state based on the available information. In view of the characteristics of event-triggering, a periodic verification is attached to the system to obtain an ideal compromise between conventional periodic sampled-data control and event-triggered control. Furthermore, the probability distribution of estimated states in the dead reckoning module is calculated, which helps to the design of event-triggered strategy and parameter selection. Extensive simulation and real experiments are conducted to illustrate the effectiveness of the proposed communication control strategy.

Pakistani Media on Xinjiang: Development and Opportunities

Maoxia Jiang,Chunxue Yang,Heng Wu 아시아사회과학학회 2023 Jornal of Asia Social Science Vol.10 No.3

With the acceleration of globalization, the Xinjiang Uygur Autonomous Region has increasingly garnered substantial attention from the international community in recent years due to its strategic location and multiculturalism. Foreign media have been actively disseminating reports in various areas in Xinjiang, such as politics, society and economy. Among which Western media reports are often inconsistent with the actual situation. But Pakistani media often exhibit their capacity for independent thought and objective analysis. They neither blindly adhere to the viewpoints of other nations nor allow themselves to be prejudiced by the cordial China-Pakistani relations. While Pakistani media endeavor to maintain a neutral stance, aspiring to explore these subjects concerning Xinjiang in a more balanced and rational manner that transcends simplistic expressions of support or opposition. There are reasons to believe that Pakistani media bring to the international community authentic, colorful, and fascinating coverage of Xinjiang, which not only enhance people's understanding of Xinjiang but also help to build a bridge of cultural communication and to promote exchanges and cooperation between Xinjiang and the world. It is believed that there will be more and more media and countries to gain a deeper understanding of Xinjiang and engage in more extensive exchanges and cooperation with the region in the future to promote harmony, development, and prosperity here.

A Fully Integrated SoC for Smart Capsule Providing In-Body Continuous pH and Temperature Monitoring

Liu, Heng,Jiang, Hanjun,Xia, Jingpei,Chi, Zhexiang,Li, Fule,Wang, Zhihua The Institute of Electronics and Information Engin 2016 Journal of semiconductor technology and science Vol.16 No.5

This paper presents a SoC (System-on-a-Chip) dedicated for a single-chip smart capsule which can be used to continuously monitor human alimentary canal pH and temperature values. The SoC is composed of the pH and temperature sensor interface circuit, a wireless transceiver, the power management circuit and the flow control logic. Fabricated in $0.18{\mu}m$ standard CMOS technology, the SoC occupies a die area of ${\sim}9 mm^2$. The SoC consumes 6.15 mW from a 3 V power supply, guaranteeing the smart capsule battery life is no less than 24 hours when using 50 mAh coin batteries. The experimental results show that measurement accuracy of the smart capsule is ${\pm}0.1$ pH and ${\pm}0.2^{\circ}C$ for pH and temperature sensing, respectively, which meets the requirement of in-body pH and temperature monitoring in clinical practice.