정신재활 치료가 정신분열병 환자의 재발율, 입원횟수, 입원일수 그리고 치료 경비에 미치는 효과 : 2년 추적조사 연구

조진석,공지현,김진원,심경순,하준선,김철권,강동호,장정희,변원탄 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 사회기술훈련, 환자교육, 가족교육, 집단치료, 예술치료, 작업치료와 같은 포괄적인 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 정신분열병 환자의 재발율, 입원횟수, 입원일수, 직접 치료경비 등에 어떤 효과가 있는 지를 알아보기 위함이다. 연구방법 : 1993년 9월부터 1995년 2월까지 양산 신경정신병원의 폐쇄병동에서 퇴원한 20∼35세 사이의 정신분열병 환자 173명을 대상으로 46명에게는 6개월동안 정신재활 치료를 시행하였고 127명에게는 통상적인 외래치료만 시행한 후 연구시작 시점을 포함하여 2년동안 양군에 속한 환자들을 대상으로 재발율, 입원횟수, 입원일수, 직접 치료경비 등을 1년 단위로 추적 조사하였으며, 연구시작 시점을 기준으로 전과 후의 매년 평균 입원횟수, 입원일수, 직접 치료경비도 서로 비교하였다. 결 과 : 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 재발율, 입원횟수, 입원일수, 직접 치료비용이 현저히 감소되었다. 그리고 정신재활 치료를 받은 군에서는 치료 전에 비해 치료 후에 재발율, 입원횟수, 입원일수, 직접 치료비용이 유의하게 감소하였지만 통상적인 외래치료만 받은 군에서는 치료 전과 후간에 유의한 변화를 보이지 않았다. 결 론 : 정신분열병 환자들에게 정신재활 치료를 약물치료와 병행할 경우 약물치료만 시행할 때에 비해 환자의 임상적 경과를 호전시킬 뿐 아니라 가족의 경제적 부담도 줄일 수 있다. Objective : We evaluated the clinical efficacy of a comprehensive psychiatric rehabilitation of schizophrenia, including family psychoeducation, patient education, social skills training, group psychotherapy, art therapy, and occupational therapy. Method : From September 1993 to February 1995, 173 chronic schizophrenics who met DSM-IV criteria and were discharged from a locked ward were assigned into the psychiatric rehabilitation service group(psychiatric rehabilitation group, n=46) or the customary out-patient service group(out-patient group, n=127) prospectively, but not randomly. Assignment was based on preferences of patients and their relatives, Each subject included in the psychiatric rehabilitation group received twice weekly patient education, social skills training, family psychoeducation, group psychotherapy, art therapy, occupational therapy and maintenance chemotherapy during a 6-month period. Those in the out-patient group received individual supportive psychotherapy and maintenance chemotherapy according to their clinical needs for 10-20 minutes once per week. After entry into the study, all subjects were assessed for the number of readmission, days of hospitalization, and the direct treatment costs through the first and second year of follow-ups. These outcome variables were also compared pre-and post-2 years at the time point of entry into the study. Aftercare chemotherapy on a weekly to monthly basis continued for the remainder of the two year follow-up period. Results : With regard to the mean number of hospital admissions per year, the mean days of hospitalization per year, and the direct treatment costs per year, the psychiatric rehabilitation group had significantly decreased all clinical outcomes 2 years after compared with before receiving psychiatric rehabilitation. But there were no significant differences in the all clinical outcomes between before and after study intake in the out-patient group. For the number of relapse regardless of drug compliance, 4 patients(9%) during first year and 14 patients(30%) during second year were relapsed in the 46 subjects of the psychiatric rehabilitation group. In contrast, 75 patients(59%) during first year and 90 patients (71%) during second year relapsed in the out-patient group. When considering the effect of drug noncompliance to relapse, 4(9%) and 14 patients(30%) were relapsed while on medication respectively during the first and second year in the 46 of the psychiatric rehabilitation group, vs. 27(34%) of 79 patients on medication during the first year and 31(46%) of 68 patients on medication during the second year were relapsed in the out-patient group. Conclusions : These results indicate that the comprehensive psychiatric rehabilitation can be useful therapeutic intervention both to improve the clinical outcomes of schizophrenic patients and to reduce the economical burden of their relatives.

Alginate 배양내에서 Transglutaminase가 연골막세포에 미치는 영향

박정선,공차배,김충현,안현정,정미현,성상철,김희중,조현철,이상훈,이명철 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

STS에 대한 고등학생들의 견해에 관한 평가도구 개발

임재항,강순민,공영태,최병순,남정희 한국과학교육학회 2004 한국과학교육학회지 Vol.24 No.6

이 연구의 목적은 STS에 대해서 우리 나라 고등학생들이 가지는 견해를 알아보기 위한 평가도구인 HS-VOSTS(Korean students' views on STS)를 개발하는 것이다. HS-VOSIS문항을 개발하기 위해서 다음과 같은 연구과 정을 수행하였다. 우선, 문헌과 선행 연구 고찰을 통해 4가지 범주의 10가지 하위 범주와 관련하여 23개의 논제를 포함하는 STS 범주 체계를 설정하였다. STS 범주 체계는 정의ㆍ과학의 외적 사회학ㆍ과학의 내적 사회학ㆍ인식론의 네 가지의 커다란 범주로 구성되어 있다. 다음은 91f 범주 체계를 기초로 4단계에 걸쳐 문항을 개발하였다. 1단계에서는 각 논제에 대한 짝진술문을 기초로 학생진술 문항지를 작성하여 772명의 고등학생들(16.3세)에게 투입하였다. 2단계에서는 짝진술문 중 하나를 제거하여 문항의 진술문으로 하고, 분류된 공통견해를 답지로 하여 1차 다지선다형 문항지를 구성하였다 3단계에서는 고등학생 28명(16.5세)을 대상으로 반구조화 면담을 실시하여 그 결과 분석을 통해 2차 다지선다형 문항지를 구성하였다. 4단계에서는 2차 다지선다형 문항지를 고등학생 306명에게 적용하여 낮은 반응비율을 보인 답지들을 제거하여 최종 검사도구를 완성하였다. HS-VOSTS는 학생들의 STS에 대한 신념 및 견해를 알아볼 수 있는 유용한 도구로서, 그 결과는 교사뿐만 아니라 교육과정 개발자, 교과서 저자, 교육정책 입안자들에게 많은 시사점을 줄 수 있을 것이라 생각한다. The purpose of this study was to develop HS-VOSTS(High School Students' Views On Science-Technology-Society), which is an instrument that monitors high school students' views on STS. For this study, 23 multiple-choice items were developed on four categories. First, a categorial scheme was constructed. The categorial scheme was based on many instruments that evaluate students' understanding on STS, literature review, and STS learning goal that many researchers had asserted. Second, the multiple-choice items were developed. The development of the items was carried out through four steps. In the first step, some pairs of statement on each subordinate category were formed. Next, the student statement questionaries which were based on the pairs of statement were responded by 772 students. In the second step, the response written by the students were analyzed to common viewpoints and the first multiple-choice items were constructed. In the third step, the semistructured interview with 28 high school students was implemented and the second multiple-choice items were constructed. In the fourth step, the final version of the instrument was developed through the analysis of the students' response on the second multiple-choice items. HS-VOSTS is an useful instrument for monitoring students' beliefs and viewpoints on STS topics. The results of the students' responses to HS-VOSTS items reflect the students' own thoughts directly. These results will give some implications for the curriculum developers, the authors of text books and the educational policy makers as well as the teachers.

김치 관련 연구문헌의 분류분석 및 김치연구의 동향 (Ⅲ)

최홍식,김재이,민병태,전정태,공연희,홍정진,김나영 부산대학교 김치연구소 2002 김치의 과학과 기술 Vol.8 No.-

About 200 research papers and patents on kimchi(Korean fermented vegetable food) published In the years of 1997-2001 were collected and analyzed for the classification and review. This article covers the classified topics on the natures and kinds of raw materials, fermentation and related microorganisms, processing / preservation, kimchi packaging, biochemical changes, enzymes, quality, food chemistry, functional klmchi, general consideration on kimchi, and also some research nerds In the future.

Molecular characterization of the autophagy-related gene Beclin-1 from the olive flounder (<i>Paralichthys olivaceus</i>)

Kong, Hee Jeong,Moon, Ji-Young,Nam, Bo-Hye,Kim, Young-Ok,Kim, Woo-Jin,Lee, Jeong-Ho,Kim, Kyung-Kil,Kim, Bong-Seok,Yeo, Sang-Yeob,Lee, Chang Hoon,Kang, Kwang-Il,Lee, Sang-Jun Elsevier 2011 Fish & shellfish immunology Vol.31 No.2

<P><B>Abstract</B></P><P>Autophagy is an important cellular response to starvation and stress, and plays critical roles in embryogenesis, development, cell death, cancer, and immunity. Beclin-1 is one of the central regulators of autophagy in mammals. In the present study, we isolated a PoBeclin-1 cDNA from the olive flounder (<I>Paralichthys olivaceus</I>) by screening a flounder gill cDNA library and rapid amplification of cDNA ends (RACE). The PoBeclin-1 cDNA we isolated encodes a 447-amino acid polypeptide containing a conserved Bcl-2-binding domain. The deduced amino acid sequence of PoBeclin-1 showed high degrees of sequence identity (80.5–95.3%) with Beclin-1 from human, frog, mouse, zebrafish, and pufferfish. PoBeclin-1 transcripts were detected from 1 day post-hatching and were found to be ubiquitously expressed in the healthy flounder. Expression of PoBeclin-1 mRNA was increased in the kidney and spleen of flounders challenged with viral hemorrhagic septicemia virus (VHSV). When infected with VHSV, PoBeclin-1-overexpressing HINAE cells had low level (about 26%) of VHSV G transcripts compared to control cells. Taken together, these results suggest that PoBeclin-1 may play a role in the innate immune response to viral infection in the flounder.</P> <P><B>Highlights</B></P><P>► PoBeclin-1 cDNA encodes a 447-aa polypeptide containing a conserved BH3 domain. ► Expression of PoBeclin-1 mRNA was increased in flounders challenged with VHSV. ► Overexpression of PoBeclin-1 decreased VHSV-G mRNA levels. ► PoBeclin-1 may play a role in the innate immunity to VHSV infection.</P>

Targeted Erythrocyte Ablation in Tg[RBC:Gal4] Transgenic Zebrafish

Hee Jeong Kong,Jae-Ho Ryu,Ju Lan Kim,Woo-Jin Kim,Hyung Soo Kim,Cheul Min An,Jehee Lee,Sang-Yeob Yeo 한국수산과학회 양식분과 2014 한국수산과학회 양식분과 학술대회 Vol.2014 No.7

The GAL4 enhancer-trap line for analysis of definitive hematopoiesis in zebrafish

Kong, Hee Jeong,Ryu, Jae-Ho,Kim, Woo-Jin,An, Cheul Min,Lim, Kyung-Eun,Lee, Jehee,Ro, Hyunju,Yeo, Sang-Yeob Taylor Francis 2015 Animal cells and systems Vol.19 No.2

<i>Acanthamoeba</i>: Keratopathogenicity of isolates from domestic tap water in Korea

Jeong, Hae Jin,Lee, Sun Joo,Kim, Jeong Hwan,Xuan, Ying Hua,Lee, Keun Hee,Park, Sang Kyun,Choi, Sun Hee,Chung, Dong Il,Kong, Hyun Hee,Ock, Mee Sun,Yu, Hak Sun Elsevier 2007 Experimental parasitology Vol.117 No.4

<P><B>Abstract</B></P><P>In a previous study, we reported on the contamination rate of free living amoeba, including <I>Acanthamoeba,</I> isolated from contact lens storage cases (CLSC) and domestic tap water in Korea. In an effort to evaluate the potential kerato-pathogenicity of 5 isolates from CLSC and 17 isolates from domestic tap water, we have conducted an investigation into the morphological features, mitochondrial DNA (mtDNA) restriction fragment length polymorphism (RFLP) phenotypes, 18S rDNA sequences, and drug sensitivities of these isolates, and have compared the results with those of 20 amoebic keratitis (AK) isolates from Korea, as well as 14 reference strains. Cysts from 22 isolates obtained from CLSC and domestic tap water showed typical characteristics of morphological group 2. A total of three and five mtDNA RFLP patterns generated by EcoRI were found in 5 of the isolates from CLSC and 17 of the isolates from domestic tap water, respectively. The mtDNA RFLP patterns of four of the five isolates from the CLSC were found to be identical to those of the isolates from domestic tap water of students who had contaminated CLSC. The majority had mtDNA RFLP patterns identical to those of AK isolates in Korea. The results of 18S rDNA sequencing analysis were also shown to coincide with the results of mtDNA RFLP analysis. KA/WP12 was determined to be profoundly sensitive to chlorhexidine (MCC; 6.25μg/ml), and KAWP2 was the most sensitive strain to polyhexamethylene biguanide (PHMB) (MCC; 4.69μg/ml). Some difference in the cytopathic effects of isolates against human corneal epithelial cells was observed according to their mtDNA genotypes. In conclusion, domestic tap water may constitute a source of <I>Acanthamoeba</I> contamination of CLSC, and most isolates from CLSC and domestic tap water appear to be potentially keratopathogenic.</P>

Molecular and Functional Analyses of the Fast Skeletal Myosin Light Chain2 Gene of the Korean Oily Bitterling, <i>Acheilognathus koreensis</i>

Kong, Hee Jeong,Lee, Ye-Ji,Kim, Woo-Jin,Kim, Hyung Soo,Kim, Bong-Seok,An, Cheul Min,Yeo, Sang-Yeob,Cho, Hyun Kook Molecular Diversity Preservation International (MD 2013 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.14 No.8

<P>We identified and characterized the primary structure of the Korean oily bitterling <I>Acheilognathus koreensis</I> fast skeletal myosin light chain 2 (<I>Akmlc2f</I>), gene. Encoded by seven exons spanning 3955 bp, the deduced 168-amino acid AkMLC2f polypeptide contained an EF-hand calcium-binding motif and showed strong homology (80%–98%) with the MLC2 proteins of <I>Ictalurus punctatus</I> and other species, including mammals. <I>Akmlc2f</I> mRNA was highly enriched in skeletal muscles, and was detectable in other tissues. The upstream regions of <I>Akmlc2f</I> included a TATA box, one copy of a putative MEF-2 binding site and several putative C/EBPβ binding sites. The functional activity of the promoter region of <I>Akmlc2f</I> was examined using luciferase and red fluorescent protein reporters. The <I>Akmlc2f</I> promoter-driven reporter expressions were detected and increased by the C/EBPβ transcription factor in HEK293T cells. The activity of the promoter of <I>Akmlc2f</I> was also confirmed in the developing zebrafish embryo. Although the detailed mechanism underlying the expression of <I>Akmlc2f</I> remains unknown, these results suggest the muscle-specific expression of <I>Akmlc2f</I> transcript and the functional activation of <I>Akmlc2f</I> promoter by C/EBPβ.</P>

Antioxidant and Anti-inflammatory Effects of Plant Extracts in Alveolar Macrophages

Jeong Hee Kong,Jeong Yoon Lee,So Hyuk Kim,Yoo-Hyun Lee 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10