일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.

Effects of the Combination Herbal Extract on Working Memory and White Matter Integrity in Healthy Individuals with Subjective Memory Complaints : A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Kwon, Oran,Lee, Sunho,Ban, Soonhyun,Im, Jooyeon J.,Lee, Doo Suk,Lee, Eun Hee,Kim, Joohee,Lim, Soo Mee,Lee, Sang Gon,Kang, Ilhyang,Kim, Kyung-Hee,Yoon, Sujung,Lee, Sun Hea The Korean Society of Biological Psychiatry 2015 생물정신의학 Vol.22 No.2

Objectives The combination extract of four kinds of herbs, Gastrodia elata, Liriope platyphylla, Dimocarpus longan, and Salvia miltiorrhiza, has shown to have memory improving effects in mice. The aim of this study was to investigate the efficacy and safety of the herbal mixture for improving working memory as well as microstructural changes in white matter integrity in individuals with subjective memory complaints. Methods Seventy-five individuals with subjective memory complaints were assigned to receive either placebo (n = 15) or herbal mixture (low-dose group, n = 30 and high-dose group, n = 30) supplementation in an 8-week, randomized, double-blind, placebo-controlled clinical trial. Changes in working memory performance and fractional anisotropy (FA) values reflecting white matter integrity from baseline to 8-week endpoint were assessed. Results The herbal mixture group showed an increase in working memory performance compared to the placebo group (p for interaction = 0.001). In addition, the herbal mixture group showed an increase in FA values in the temporo-parietal regions (corrected p < 0.05), which are crucially involved in working memory function and are among the most affected regions in patients with cognitive impairments. Conclusions Findings from this study indicate that the herbal mixture may be a promising therapeutic option for individuals with subjective memory complaints.

생쥐 뇌 N-type 칼슘 채널 α1B Subunit의 cDNA Cloning

권혜수,조경혜 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.8 No.-

생체내에서 칼슘이온은 이차 정보전달자의 하나로서 생체현상을 조절하는 매우 중요한 물질중의 하나이다. 칼슘 이온의 유입은 주로 전압의존형 칼슘 채널에 의하여 이루어지며 막 홍분성, 효소활성, 호르몬 분비, 근육수축, 신경 전달물질의 전달 등의 세포내 다양한 기능을 조절한다. 이 전압 의존형 칼슘 채널은 그 전기생리학적, 약리학적 특성에 따라 4가지 타입(L-, P-, N-, T- type)으로 구분된다. 이중에서도 신경계에 특이적으로 분포하여 미성숙 뉴런의 이동이나 신경 전달 물질의 분비에 중요한 역할을 하는 N-타입 칼슘 채널의 연구가 많이 이루어지고 있다. 각 칼슘채널을 이루는 4개의 subunit 중에서 칼슘의 유입을 조절하는 역할을 담당하는 al subunit의 연구는 중요하며 활발히 진행되고 있다. 이미 알려진 흰쥐나 토끼의 N-타입 칼슘 채널과 마찬가지로 생쥐에서도 신경특이적인 N-타입 칼슘 채널의 역할이 중요하리라고 보여진다. 따라서 본 연구에서는 아직 완전하게 cDNA가 클론 되어있지 않은 생쥐의 뇌를 시료로 하여 cDNA를 합성한 후 rbB-I을 탐침으로 사용하여 검색하여 3가지의 클론을 얻었다. 그리고 클론 각각이 가지고 있는 insert를 restriction mapping으로 확인한 후 제한효소의 반응위치를 이용, 유전자 조작을 거듭하여 생쥐 N-타입 칼슘 채널 alB subunit cDNA의 full clone을 얻어ㅐㄴ었다. 그 발현양상은 Northern blotting을 이용하여 조직별, 발생별로 연구되어야 하고 그외 돌연변이를 이용한 기능연구 등이 수행되어야 하겠다. Influx of calcium through voltage-dependent calcium channels plays a vital role in the regulation of a variety of cellular functions, including muscle contraction, axonal outgrowth, hormone release, and neurotransmitter release. On the basis of electrophysiological and pharmacological properties, at least four types of calcium channel (designated T-, L-, N-, and P-type) have been distinguished and each type is composed of 4 or 5 subunits(??, ??, ??, ??, and ??). The ?? subunit of each type has been a focus of research since it controls the entry of calcium ions. Among the four major types of calcium channels, N-type calcium channels are unipue in that they are found specifically in neurons, have been correlated with control of neurotransmitter release, and are blocked by ??-conotoxin. Recently, many studies of N-type calcium channels have been done and are progressing. Mouse N-type ??B subunit is expected to play an essential role in migration of immature neurons and neurotransmitter release in considering the roles of rat and rabbit N-type ??B subunit. In this study, mouse brain cDNA library was prepared and screened with rbB-I DNA rpobe. Through gene manipulation, we obtained full-length cDNA clone of the ??B subunit of mouse N-type calcium channel. And through Northern boltting of mouse tissues and mutagenesis studies, we will study how the N-type ??B subunits of mouse are expressed and regulated.

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea

Hea Yoon Kwon,Jae Hyoung Im,Yun-Kyu Park,Areum Durey,Jin-Soo Lee,Ji Hyeon Baek 대한기생충학열대의학회 2018 The Korean Journal of Parasitology Vol.56 No.6

Poster Session : PS 0315 ; Hematology : A Case of Lead Poisoning Mimicking Porphyria Caused by Korean Herbal Medicine

( Hea Yoon Kwon ),( Yeon Sook Moon ),( Jun Hyeok Lim ),( Yeong Hoon Park ),( Ju Han Lim ),( Chul Soo Kim ),( Hyeong Gyu Yi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Before 1980s, the main cause of lead poisoning was associated to occupation such as building bridge, smelting and foundry. After 1980s, lead poisoning occurs from non-occupational causes such as from ingestion of herbal supplements. We encountered a 37-year-old male who visited the hospital for general weakness and abdominal pain. He had been taking Korean herbal medicine for two months to relieve anal fistula pain. Laboratory evaluation demonstrated hemoglobin 8. 3 g/dL hematocrit 24. 0%, retibulocyte 2. 91%, and peripheral blood smear showed normocytic michromic anemia with basophilic stippling. Also, serum aspartate aminotransferase and alaninetransaminase were elevated to 43 IU/L and 123 IU/L, respectively. Both duodenoscopy and colonoscopy were performed, which showed negative results except chronic superfi cial gastritis and anal fi stula. Initially, porphyria was suspected for because abdominal pain with persistent anemia, elevated reticulocyte count and abnormal liver function tests were not explained by evaluation for frequent diseases. Subsequent tests of porphyria, porphobilinogen and delta-aminolevulinic acid were elevated. However, history of herbal medication led us to measure the concentration of serum lead, which was increased to 54. 6 μg/dL. He was successfully treated with lead chelating agent. We report a case of lead poisoning with similar clinical manifestation to porphyria caused by ingestion of Korean herbal medicine, which implies the importance of evaluation of lead poisoning in certain clinical setting. Since both porphyria and lead poisoning usually manifest nonspecifi c symptoms such as anemia, hepatitis and acute abdomen pain, physicians` suspicion according to patient`s history is important in diagnosis such rare diseases.

α-Directing Effect in Glycosylations by the Remote Participation of 4-O-Acyl Groups of Galactosyl Donors

Hea-Won Kwon,Kwan Soo Kim. 한국당과학회 2011 한국당과학회 학술대회 Vol.2011 No.1

Previously, we reported the a-directing effect due to the remote participation of 3-O-acyl and 6-O-acetyl groups of donors in mannosylations. Herein we report the a-directing effect by remote participation of 4-O-acyl groups of galactose donors in galactosylations. Galactosyldonors possessing benzylsulfonyl, benzoyl, p-methoxybenzoyl, and acetyl groups were prepared. The outcome of the stereochemistry in glycosylations of various acceptors with these donors indicated that 4-O-acyl groups of galactose donors participated during glycosylations. The outcome of the stereochemistry of the galactosylations could be interpreted either by the remoteparticipation of acylgroups or by the reaction between the acceptor and the galactosyl oxocarbeniumion in 4H3 or 3H4 comformation. Detection by the mass spectrometry of the bicyclic product with a seven-membered trichlorooxazepine ring, resulting from the activation of phenyl 1-thio-4-trichloroacetimidoyl galactoside with BSP and Tf2O, is provided a further evidence for the participation of 4-O-acyl groups in the galactosylation. Galactosylations were conducted by treatment of thioglycosides possessing electron-withdrawing groups at O-4 with BSP and Tf2O at -60℃.

Human PEP-1-ribosomal protein S3 protects against UV-induced skin cell death

Choi, Soo Hyun,Kim, So Young,An, Jae Jin,Lee, Sun Hwa,Kim, Dae Won,Ryu, Hea Jin,Lee, Nam Il,Yeo, Seung Il,Jang, Sang Ho,Won, Moo Ho,Kang, Tae-Cheon,Kwon, Hyung Joo,Cho, Sung-Woo,Kim, Joon,Lee, Kil Soo Elsevier 2006 FEBS letters Vol.580 No.30

<P><B>Abstract</B></P><P>The consequences of ultraviolet (UV) exposure are implicated in skin aging and cell death. The ribosomal protein S3 (rpS3) is one of the major proteins by which cells counteract the deleterious effects of UV and it plays a role in the repair of damaged DNA. In the present study, we investigated the protective effects of PEP-1-rpS3 fusion protein after UV-induced cell injury. A human rpS3 gene was fused with PEP-1 peptide in a bacterial expression vector to produce a genetic in-frame PEP-1-rpS3 fusion protein. The expressed and purified fusion proteins were efficiently transduced into skin cells in a time- and dose-dependent manner. Once inside the cells, transduced PEP-1-rpS3 fusion protein was stable for 48h. We showed that transduced PEP-1-rpS3 fusion protein increased cell viability and dramatically reduced DNA lesions in the UV exposed skin cells. Immunohistochemical analysis revealed that PEP-1-rpS3 fusion protein efficiently penetrated the epidermis as well as the dermis of the subcutaneous layer when sprayed on animal skin. These results suggest that PEP-1-rpS3 fusion protein can be used in protein therapy for various disorders related to UV, including skin aging and cancer.</P>

The implication of foods and supplements for exercise Performance : Effects of high - fat diet on endurance performance and blood energy substrates

(Deok Soo Shin),(Sang Jik Lee),(Hyun Kuk Kim),(Eung Chan Jang),(Hea Jung Suh),(Hyung Ryul Kim),(Ki Chul Lee),(Tae Dong Kwon) 한국운동영양학회 2000 2000 International Congress on Exercise Nutrition Vol.- No.-

대학생의 식행동, 흡연, 음주실태와 주관적 건강상태와의 관련성

권수진 ( Soo Jin Kwon ),강지혜 ( Ji Hea Kang ),김나정 ( Na Jung Kim ),김려진 ( Rye Jin Kim ),김선영 ( Suhn Young Kim ),김시일 ( Si Il Kim ),한경순 ( Gyeong Soon Han ) 한국치위생과학회 2012 치위생과학회지 Vol.12 No.2

This study aims at investigate dietary behaviors, smoking and drinking status of university students depending on their gender and residential patterns, and analyzing relationships with their subjective health status. The subjects of this study was 538 university students in Metropolitan areas from May 10-31, 2010. Data were analyzed with chi-square test, fisher`s exact test, t-test and stepwise multiple regression SPSS 12.0. Male students higher frequency on the intake of eggs, meats and carbonated drinks than female students. The group residing at one`s own house showed higher frequency on the intake of beans, fruits and milk than the self-boarding group or other groups(p<0.05), while preferring sweet taste the most. Male students were significantly higher than female students in the amount of smoking and drinking(p<0.05). They had positive recognition on their health conditions as they have higher frequency on the intake of potatoes, seaweeds, green tea and milk with less frequency on the intake of eggs, fast foods and drinking amount. Accordingly, it was considered necessary to have continuous education on nutrition and social supports to prevent their dietary behaviors from leaning on convenience or preference.

언어치료학과 학과인증제를 위한 기초 연구

윤혜련(Hea Ryun Yoon),황민아(Min A Hwang),신명선(Myung Sun Shin),권순복(Soon Bok Kwon),김수진(Soo-Jin Kim),배소영(So Yeong Pae) 한국언어치료학회 2010 言語治療硏究 Vol.19 No.2

This study was conducted to identify the appropriate and necessary conditions for a speech pathology certification system in a department of speech therapy by collecting and analyzing data from relevant graduate schools, undergraduate schools and colleges through which speech pathologists are trained and reviewing treatment examples in other countries, while focusing on data from domestic departments of speech therapy and the educational environment. The research was carried out by first examining the actual educational situationincluding educational facilities and equipment, student evaluation systems, and information on relevant professors, and then, by suggesting the conditions for the most appropriate evaluation on the educational environment to cultivate outstanding speech pathologists. Research subjects were 23 schools in total, which granted our request for data on the educational environment for 2007. Regarding educational facilities and equipment, universities which had undergraduate schools and graduate schools were equipped with clinical laboratories and experimental laboratories, while universities which had only graduate schools rarely had clinical and experimental laboratories. Universities also differed in the condition of their experimental and practice equipment; the equipment they had was mostly instruments for voice analysis. Regarding the evaluation of students, universities which had relevant departments maintained 90% or higher rate in the recruitment and enrollment rate. Regarding the passing rate for the relevant qualification examination, around 40% was the prevailing percentage. Also, the employment rate for graduates from the relevant departments was 80% or higher,and thus, it can be said that most of the graduates can be employed in relevant occupations. Regarding professors, the number of full-time speech pathology professors was somewhat small. In fact, five universities with colleges and graduate schools, had no full-time professors who majored in speech language pathology.Finally, in respect of suggesting the conditions for the appropriate evaluation system on the educational environment, we would like to suggest the evaluation percentage to be 30% for educational facilities and equipment, 30% for student evaluation, and 40% for professor evaluation.