http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles
Ankamreddy, Harinarayana,Min, Hyehyun,Kim, Jae Yoon,Yang, Xiao,Cho, Eui-Sic,Kim, Un-Kyung,Bok, Jinwoong The Company of Biologists Limited 2019 Development (Cambridge) Vol.146 No.2
<P>Defects in the middle ear ossicles – malleus, incus and stapes – can lead to conductive hearing loss. During development, neural crest cells (NCCs) migrate from the dorsal hindbrain to specific locations in pharyngeal arch (PA) 1 and 2, to form the malleus-incus and stapes, respectively. It is unclear how migratory NCCs reach their proper destination in the PA and initiate mesenchymal condensation to form specific ossicles. We show that secreted molecules sonic hedgehog (SHH) and bone morphogenetic protein 4 (BMP4) emanating from the pharyngeal endoderm are important in instructing region-specific NCC condensation to form malleus-incus and stapes, respectively, in mouse. Tissue-specific knockout of <I>Shh</I> in the pharyngeal endoderm or <I>Smo</I> (a transducer of SHH signaling) in NCCs causes the loss of malleus-incus condensation in PA1 but only affects the maintenance of stapes condensation in PA2. By contrast, knockout of <I>Bmp4</I> in the pharyngeal endoderm or <I>Smad4</I> (a transducer of TGFβ/BMP signaling) in the NCCs disrupts NCC migration into the stapes region in PA2, affecting stapes formation. These results indicate that region-specific endodermal signals direct formation of specific middle ear ossicles.</P><P><B>Summary:</B> Tissue-specific mouse knockouts reveal specific roles for endodermal SHH and BMP4 signals in development of the malleus-incus in pharyngeal arch 1 and the stapes in pharyngeal arch 2, respectively.</P>
Vaidya, Praveenkumar,Harinarayana, N.S. Korea Institute of Science and Technology Informat 2019 Journal of Information Science Theory and Practice Vol.7 No.1
Information retrieval is the challenge of the Web 2.0 world. The experiment of knowledge organisation in the context of abundant information available from various sources proves a major hurdle in obtaining information retrieval with greater precision and recall. The fast-changing landscape of information organisation through social networking sites at a personal level creates a world of opportunities for data scientists and also library professionals to assimilate the social data with expert created data. Thus, folksonomies or social tags play a vital role in information organisation and retrieval. The comparison of these user-created tags with expert-created index terms, author keywords and title words, will throw light on the differentiation between these sets of data. Such comparative studies show revelation of a new set of terms to enhance subject access and reflect the extent of similarity between user-generated tags and other set of terms. The CiteULike tags extracted from 5,150 scholarly journal articles in marine science were compared with corresponding Aquatic Science and Fisheries Abstracts descriptors, author keywords, and title terms. The Jaccard similarity coefficient method was employed to compare the social tags with the above mentioned wordsets, and results proved the presence of user-generated keywords in Aquatic Science and Fisheries Abstracts descriptors, author keywords, and title words. While using information retrieval techniques like stemmer and lemmatization, the results were found to enhance keywords to subject access.
Pattanashetti, D.M.,Harinarayana, N.S. Korea Institute of Science and Technology Informat 2017 Journal of Information Science Theory and Practice Vol.5 No.2
This study examined the mechanical engineering research output from India, Japan, and South Korea on different parameters including growth, collaboration indices, and activity index. The purpose of the study is to understand the overall development of mechanical engineering through analytical approaches applied on the scholarly outcome of the countries considered for the study. The study focuses on analysing the articles published by India, Japan, and South Korea, and is restricted to articles indexed in the Science Citation Index - Web of Science for the period 2000 to 2014. The ratios of number of paper to citations for India, Japan, and Korea are 20,836: 1,97,679; 24,494: 2,04,393; and 30,578: 2,66,902 respectively for the period 2000-2014. The findings show that there is a decline in Japanese publications in mechanical engineering, whereas other two countries have recorded an increasing trend. While India has tripled its publications in a span of 15 years, South Korea, on the other hand, has doubled its publications in the same span of time. There has been an increasing trend towards collaboration in almost all fields of science and technology. However, the extent of collaboration and their rate of growth varied for one subject to another, one branch to another branch of the same subject, and from one country to another country. The present study analyses the growth of research publications of the mechanical engineering domain including authorship distribution, collaboration indices, prominent journals, and activity index.
Shin, Jeong-Oh,Ankamreddy, Harinarayana,Jakka, Naga Mahesh,Lee, Seokwon,Kim, Un-Kyung,Bok, Jinwoong UPV/EHU Press 2017 The international journal of developmental biology Vol.61 No.8
<P>The mammalian inner ear is a complex organ responsible for balance and hearing. Sonic hedgehog (Shh), a member of the Hedgehog (Hh) family of secreted proteins, has been shown to play important roles in several aspects of inner ear development, including dorsoventral axial specification, cochlear elongation, tonotopic patterning, and hair cell differentiation. Hh proteins initiate a downstream signaling cascade by binding to the Patched 1 (Ptch1) receptor. Recent studies have revealed that other types of co-receptors can also mediate Hh signaling, including growth arrest-specific 1 (Gas1), cell-adhesion molecules-related/down-regulated by oncogenes (Cdon), and biregional Cdon binding protein (Boc). However, little is known about the role of these Hh co-receptors in inner ear development. In this study, we examined the expression patterns of Gas1, Cdon, and Boc, as well as that of Ptch1, in the developing mouse inner ear from otocyst (embryonic day (E) 9.5) until birth and in the developing middle ear at E15.5. Ptch1, a readout of Hh signaling, was expressed in a graded pattern in response to Shh signaling throughout development. Expression patterns of Gas1, Cdon, and Boc differed from that of Ptch1, and each Hh co-receptor was expressed in specific cells and domains in the developing inner and middle ear. These unique and differential expression patterns of Hh co-receptors suggest their roles in mediating various time-and space-specific functions of Shh during ear development.</P>