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Hiroyuki Yamazaki,Yukiharu Todo,Kenrokuro Mitsube,Hitoshi Hareyama,Chisa Shimada,Hidenori Kato,Katsushige Yamashiro 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.3
Objective: The aim of this study was to evaluate the clinical behavior and management outcome of recurrent endometrial stromal sarcoma (ESS). Methods: A retrospective review of charts of 10 patients with recurrent ESS was performed and relapse-free interval, relapse site, treatment, response to treatment, duration of follow-up and clinical outcome extracted. Survival outcome measures used were post-relapse survival which was defined as the time from first evidence of relapse to death from any cause. Living patients were censored at the date of last follow-up. Results: The median age and median relapse-free interval at the time of initial relapse were 51.5 years and 66.5 months, respectively. The number of relapses ranged from one to five. Sixteen surgical procedures for recurrent disease included nine (56.0%) complete resections. There was no statistically significant difference between initial recurrent tumors and second/ subsequent recurrent tumors in the rate of complete surgery (44.4% vs. 71.4%, respectively, p=0.36). Of the eleven evaluable occasions when hormonal therapy was used for recurrent disease, disease control was achieved in eight (72.7%). There was no difference between initial recurrent tumors and second/subsequent recurrent tumors in disease control rate by hormonal therapy (85.7% vs. 50.0%, respectively, p=0.49). The 10-year post-relapse survival rate was 90.0% and the overall median postrelapse survival 119 months (range, 7 to 216 months). Conclusion: Post-relapse survival of patients with ESS can be expected to be >10 years when treated by repeated surgical resection and hormonal therapy or both.
Yamashita, N.,Gasnault, O.,Forni, O.,d'Uston, C.,Reedy, R.C.,Karouji, Y.,Kobayashi, S.,Hareyama, M.,Nagaoka, H.,Hasebe, N.,Kim, K.J. Elsevier 2012 Earth and planetary science letters Vol.353 No.-
<P><B>Abstract</B></P> <P>The first unambiguous global distribution of Ca on the Moon has been revealed by the Kaguya Gamma-Ray Spectrometer. The observation of the 3737keV gamma rays from <SUP>40</SUP>Ca with a high energy resolution Ge detector, corrected for fast neutrons, improved greatly our confidence in these remote sensing data. While the derived Ca abundance generally confirms the mare-highland dichotomy, we found that the eastern mare regions such as Crisium, Nectaris, and Fecunditatis exhibit unexpected high Ca abundances. This may be explained by regional concentrations of high-Ca clinopyroxene. Our Ca map also shows that the lowest CaO abundance found in the returned samples (∼8wt%) may actually be common in Oceanus Procellarum, suggesting the possible sampling bias of Apollo and Luna missions. These observational results on Ca serve as a complementary criterion for better characterization of mare regions on the Moon.</P> <P><B>Highlights:</B></P> <P>► Global distribution of Ca on the Moon is derived from Kaguya GRS data. ► Observation by high precision Ge detector greatly improved confidence in measurement. ► Ca was found to be more abundant in the east mare region than in the west. ► Selective concentration of high-Ca pyroxene in the eastern mare region is implied. ► Ca provides a complementary criterion to characterize the lunar thermal history.</P>