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- 저자 : Hansol Park (검색결과 226 건)
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Han Sol,Song Sung Wook,Hong Hansol,김우정,강영준,Park Chang Bae,Kang Jeong Ho,Bu Ji Hwan,이성근,Ko Seo Young,이수훈,Kang Chul-Hoo 대한응급의학회 2023 Clinical and Experimental Emergency Medicine Vol.10 No.2
Objective: This study investigated the hospital diagnoses and characteristics of uncooperative prehospital patients suspected of acute stroke who could not undergo a prehospital stroke screening test (PHSST). Methods: This retrospective observational study was conducted at a single academic hospital with a regional stroke center. We analyzed three scenario-based prehospital stroke screening performances using the final hospital diagnoses: (1) a conservative approach only in patients who underwent the PHSST, (2) a real-world approach that considered all uncooperative patients as screening positive, and (3) a contrapositive approach that all uncooperative patients were considered as negative. Results: Of the 2,836 emergency medical services (EMS)-transported adult patients who met the prehospital criteria for suspicion of acute stroke, 486 (17.1%) were uncooperative, and 570 (20.1%) had a confirmed final diagnosis of acute stroke. The diagnosis in the uncooperative group did not differ from that in the cooperative group (22.0% vs. 19.7%, P=0.246). The diagnostic performances of the PHSST in the conservative approach were as follows: 79.5% sensitivity (95% confidence interval [CI], 75.5%–83.1%), 90.2% specificity (95% CI, 88.8%–91.6%), and 0.849 area under the receiver operating characteristic curve (AUC; 95% CI, 0.829–0.868). The sensitivity and specificity were 83.3% (95% CI, 80.0%–86.3%) and 75.2% (95% CI, 73.3%–76.9%), respectively, in the real-world approach and 64.6% (95% CI, 60.5%–68.5%) and 91.9% (95% CI, 90.7%–93.0%), respectively, in the contrapositive approach. No significant difference was evident in the AUC between the real-world approach and the contrapositive approach (0.792 [95% CI, 0.775–0.810] vs. 0.782 [95% CI, 0.762–0.803], P>0.05). Conclusion: We found overestimation (false positive) and underestimation (false negative) in the uncooperative group depending on the scenario-based EMS stroke screening policy for uncooperative prehospital patients suspected of acute stroke.
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Effective subgroup method employing macro level grid optimization for LWR applications
Park, Hansol,Joo, Han Gyu Elsevier 2019 Annals of nuclear energy Vol.129 No.-
<P><B>Abstract</B></P> <P>The Macro Level Grid scheme for the efficient application of the subgroup method is presented, that employs the number density consideration factor and the temperature consideration factor for the treatment of non-uniform number densities and temperature distributions in a core. This scheme provides the efficient resonance treatment in direct whole core calculations of power reactors that involve thermal feedback and isotopic depletion. The new method solves the subgroup fixed source problem only 8 times per energy group with 8 macroscopic subgroup levels, regardless of the number of resonance isotopes in the problem of interest. The escape cross section of each isotope is obtained by interpolation using the pre-calculated ones at the specified macroscopic subgroup levels. This scheme turns out to be superior to the conventional scheme in terms of computing time and accuracy. More than 30% of the computing time for fixed source problems is saved compared to the conventional one with negligible reactivity errors of about a few pcm, whereas the conventional one has consistent reactivity errors of about +60 ∼ +150 pcm for typical pin-cell problems in a light water reactor. Moreover, it turns out that the new method provides high accuracy not only for very heterogeneous uranium dioxide and mixed oxide pin-cell checkerboard problems, but also for the depletion calculation of a multi-assembly problem involving hot full power thermal feedback with significantly shortened times.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Macroscopic escape XSs are computed at common grid, called macro level grid. </LI> <LI> Isotopewise escape XSs are interpolated from the macro level grid. </LI> <LI> Optimum number of subgroup levels for the grid turns out to be 8 for LWR geometry. </LI> <LI> Total number of SGFSPs are fixed regardless of number of isotopes and their levels. </LI> <LI> Same accuracy as original isotopewise SGFSP scheme and reduced computing time. </LI> <LI> Verified at 3 by 3 assembly checkerboard with HFP thermal feedback. </LI> </UL> </P>
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Hansol Park,권오열,류근갑 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.9
Various substituted phenols and phenylenediamines were enzymatically polymerized by horseradish peroxidase in 80% (v/v) organic solvents-aqueous buffer (100 mM sodium acetate, pH 5) mixtures with H2O2 as the oxidant. The thermal stability of the polymers was investigated by thermogravimetric analysis (TGA) and represented by the char yield (wt% of the initial polymer mass) after being heated at 800 oC. Poly(p-phenylphenol) had the highest thermal stability among the synthesized polymers with a char yield of 47 wt%. The polymers containing amino groups such as poly(p-aminophenol) and polyphenylenediamines were also shown to possess high thermal stabilities. The activation energies for the thermal degradation of the polymers determined by derivative thermogravimetric analysis (DTG) using Horowitz-Metzger’s pseudo-first-order kinetics were in the range between 23-65 kJ/mol and comparable to those of the chemically synthesized polymers. Dynamic structural changes of the enzymatically synthesized polymers upon heating were studied by differential scanning calorimetry (DSC). The DSC curves of poly(p-phenylphenol) showed a broad exothermic peaks between 150-250 oC, indicating that the polymer undergoes complex structural transitions in the temperature range. On the other hand, the DSC curves of the poly(p-aminophenol) and the poly(p-phenylenediamine) which contain amino groups showed strong sharp endothermic peaks near 150 oC, implying that these polymers possess homogeneous oriented structures which undergo a concerted structural disintegration upon heating.
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Park, Hansol,Jae, Woojin,Kim, Jongsik Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.767 No.-
<P><B>Abstract</B></P> <P>Lithium vanadate (Li<SUB>3</SUB>VO<SUB>4</SUB>) is one of the most promising anode materials for lithium-ion batteries because of its relatively high capacity (about 394 mA h g<SUP>−1</SUP>), small volume change, safe working voltage, and low cost. However, Li<SUB>3</SUB>VO<SUB>4</SUB> suffers from unsatisfactory cycling and rate performances owing to its low electrical conductivity. In this study, nitrogen-doped carbon-coated Li<SUB>3</SUB>VO<SUB>4</SUB> particles are synthesized using dopamine as the single source of both carbon and nitrogen. In particular, the thickness of the nitrogen-doped carbon coating layers can be controlled by simply modulating the polymerization degree of dopamine. The prepared Li<SUB>3</SUB>VO<SUB>4</SUB> anode exhibits enhanced reversible capacity of ∼426 mA h g<SUP>−1</SUP> after 100 cycles at 0.5 C in the voltage range 0.01–3.0 V. Its redox reaction kinetics is also superior to that of bare Li<SUB>3</SUB>VO<SUB>4</SUB> in terms of rate capability, cyclic voltammetry, and impedance characteristics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nitrogen-doped carbon-coated Li<SUB>3</SUB>VO<SUB>4</SUB> particles are synthesized successfully. </LI> <LI> Dopamine is used as the single source of both N and C. </LI> <LI> Carbon coating layers are controlled by controlling the polymerization of dopamine. </LI> <LI> Carbon-coated Li<SUB>3</SUB>VO<SUB>4</SUB> shows improved electrochemical performance than bare Li<SUB>3</SUB>VO<SUB>4</SUB>. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Park, Miji,Shim, Jae-Hyun,Kim, Hanah,Park, Hansol,Kim, Namyeong,Kim, Jongsik Elsevier 2018 Journal of Power Sources Vol.396 No.-
<P><B>Abstract</B></P> <P>FeOF/reduced graphene oxide (r-GO) nanocomposites are synthesized with approximately 8 and 13 wt% r-GO. The FeOF nanoparticles are fabricated using FeSiF<SUB>6</SUB>⋅6H<SUB>2</SUB>O as a precursor through solvothermal treatment with 1-propanol. This method provides a more reliable and facile wet-chemical route to synthesize phase-pure FeOF without FeF<SUB>2</SUB> and Fe<SUB>2</SUB>O<SUB>3</SUB> impurities, as compared to the annealing process in air. The FeF<SUB>2</SUB> phase is formed as an intermediate during the synthetic process. The prepared FeOF/r-GO sample with 13 wt% r-GO (FeG20) exhibits improved discharge capacity, cycling stability, and rate performance as a cathode material in sodium-ion batteries, compared to the bare FeOF at 1.2–4.0 V. The enhanced electrochemical properties for sodium-ion storage are mainly attributed to the size-controlled FeOF nanoparticles and their intimate contact with the conductive r-GO matrix.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ellipsoidal FeOF nanoparticles anchored on r-GO were fabricated in a mild condition. </LI> <LI> The particle size of FeOF was decreased with the r-GO contents in the FeOF/r-GO composites. </LI> <LI> The FeOF/r-GO composites show superior electrochemical performances to those of bare FeOF. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Hansol KIM,Kiyoung PARK,Youngran CHO,Ho Don JEONG,Hyun Gyu PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
We herein describe a novel method to identify protein/small molecule interactions by utilizing the CRISPR/Cas12a collateral cleavage activity to realize the full potential of the CRISPR/Cas system and expand its applicability up to the detection of molecular interactions. This technique employs a single-stranded activator DNA modified with a specific small molecule, which would switch on the CRISPR/Cas12a collateral cleavage activity upon binding to crRNA within the CRISPR/Cas12a system. When the target protein binds to the small molecule on the activator DNA, the bound protein sterically hinders the access of the activator DNA to crRNA, thereby promoting less collateral cleavage activity of CRISPR/Cas12a. As a consequence, fewer reporter probes nearby are cleaved to produce accordingly reduced fluorescence signals in response to target protein. Based on this unique design principle, the two model protein/small molecule interactions (streptavidin/biotin and antidigoxigenin/digoxigenin) were successfully determined down to 0.03 nM and 0.09 nM, respectively, with a fast and simple detection workflow (11 min). The practical applicability of this method was also verified by reliably detecting target streptavidin spiked in heterogeneous human serum. This work would provide great insight to construct novel strategies to identify protein/small molecule interaction by taking full advantage of the CRISPR/Cas12a system beyond its outstanding capabilities in genome editing and molecular diagnostics.
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