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Can BAP1 expression loss in mesothelial cells be an indicator of malignancy?
Hanife Gulnihal Ozdemir,Sermin Coban Kokten,Nagehan Ozdemir Barisik 대한병리학회 2020 Journal of Pathology and Translational Medicine Vol.54 No.6
Background: Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor. In this study, we aim to investigate the value of BAP1 staining of malignant mesothelioma cases with expression loss and diagnosis in cell block and biopsy tissue. Methods: Between January 2009 and March 2017, 64 mesotheliomas, 117 reactive mesothelial hyperplasias, and 20 fibrinous pleuritis/pericarditis were diagnosed with morphologic and immunohistochemical findings in our pathology clinic and were included in the study. Formalin-fixed, paraffin-embedded tissues were immunohistochemically examined for BAP1. Inflammatory and stromal cells were used as positive internal controls. BAP1 was assessed for nuclear staining in mesothelial cells. Results: Examinations of the relationship between patient diagnosis and BAP1 biopsy status showed that the BAP1 loss rate (76.6%) was significantly higher in malignant mesothelioma cases than in other benign diseases (0%) (p < .001). Sensitivity and specificity were 76.56% and 100%, respectively, for biopsy tissue from malignant mesothelioma. Sensitivity and specificity were both 100% for BAP1 test on cell block tissue. Furthermore, the consistency between BAP1 cell block and biopsy results was excellent (ĸ = 0.90) and the correlation was significant (p < .001). Conclusions: This study shows that BAP1 expression loss in both cytology and biopsy tissue in biopsy-confirmed malignant mesothelioma cases is an essential parameter for malignant mesothelioma diagnosis.
( Hanife Usta Atmaca ),( Feray Akbas ),( Ilker Nihat Okten ),( Eda Nuhoglu Kantarci ),( Berrin Belcik Inal ),( Mustafa Boz ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Obesity is a disease known to stimulate low grade infl ammation. N/L ratio has been started to be used as an indicator of systemic infl ammation. This study aims to examine the relationship between obesity and N/L ratio over anthropometric measurements, obesity grade, and some biochemical parameters. Methods: 96 obese patients (mild-moderate and severe) who are being monitored in obesity outpatient clinic, who have no concomitant disease, and who do not have a history of smoking and drug use, and as the control group, 20 patients of normal weight with the same characteristics were included in the study. Anthropometric measurements were recorded, and BMI was calculated. Biochemical tests and total blood counts were performed. N/L ratio was obtained by dividing neutrophil count by lymphocyte count. The results were evaluated using SPSS statistical analysis program. Results: A signifi cant increase was present in neutrophils and lymphocyte counts of morbid obese group compared to control groups. Due to both increased neutrophil and lymphocyte counts, even though L/N ratio increased, it was not found statistically signifi cant. The increase in total leucocyte count of morbid obese was statistically signifi cant compared to mild obese. While N/L ratio demonstrated a strongly positive correlation with total leucocyte count and neutrophil count, it demonstrated a weakly positive correlation with waist circumference and with hip circumference. Conclusions: N/L ratio increases by obesity grade and reveals that concomitant infl ammatory response increases. High count of circulating neutrophil in obese patients might be considered as an acute infl ammatory response to a chronic infl ammatory state. Therefore, N/L ratio might be used as an infl ammatory marker in obese patients, and might be helpful in the prediction of cardiovascular and metabolic risks for the patient.
Effect of bridging units on the photophysical properties of 4-NEt2-appended salen−indium complexes
Hanif Mubarok,Min Hyung Lee,Sang Woo Kwak,Ji Hye Lee,Hyonseok Hwang,Kang Mun Lee,Youngjo Kim,Myung Hwan Park 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.10
A series of 4-NEt2-appended salenindium complexes bridged by different dii-mine units (ethylene [Et,1], phenylene [Ph,2], and benzonitrile [PhCN,3]) withdifferent electronic effects were prepared in high yields by a one-pot syntheticprocedure. Among them, the solid-state structure of1was identified by X-raycrystallography, featuring a square-pyramidal structure around the indium cen-ter. Ultraviolet–visible (UV/Vis) absorption and emission spectra of1–3showedtypicalππ* electronic transitions centered on the salen ligands, which under-went gradual redshifts as the electron-withdrawing ability of the bridging unitsincreased. Such bathochromic shifts resulted from lowering the energy levelsof the lowest unoccupied molecular orbital (LUMO). In addition, the full widthat half maxima for the emissions of1–4gradually decreased with increasingelectron-accepting property of the bridging units. The observed photophysicalproperties were further supported by theoretical calculations.
Globalization and its challenges for developing countries: the case of Turkish higher education
Hanife Akar 서울대학교 교육연구소 2010 Asia Pacific Education Review Vol.11 No.3
This paper examines the challenges faced by the Turkish higher education system and exposes the inequities and realities educators in a developing nation must struggle with as they try to find a prestigious spot in the knowledge-production industry. After a brief overview of the literature that illustrates how globalization penetrated into each stage of development of Turkey's modern institutions of higher education, the paper presents a discussion, based on national and international statistics, of the challenges these institutions face as a result of globalization, namely increasing demands for higher education; faculty shortages; the internationalization of higher education; research and knowledge production; and the process of financing higher education.
Hanif Abdul Rahman,Khadizah Abdul-Mumin,Lin Naing 한국간호과학회 2017 Asian Nursing Research Vol.11 No.1
Purpose: Little evidence estimated the exposure of psychosocial work stressors, work-related fatigue, and musculoskeletal disorders for nurses working in South-East Asian region, and research on this subject is almost nonexistent in Brunei. The main aim of our study was to provide a comprehensive exploration and estimate exposure of the study variables amongst emergency (ER) and critical care (CC) nurses in Brunei. The study also aims to compare whether experiences of ER nurses differ from those of CC nurses. Methods: This cross-sectional study was implemented in the ER and CC departments across Brunei public hospitals from February to April 2016 by using Copenhagen Psychosocial Questionnaire II, Occupational Fatigue Exhaustion Recovery scale, and Cornell Musculoskeletal Discomfort Questionnaire. Results: In total, 201 ER and CC nurses (82.0% response rate) participated in the study. Quantitative demands of CC nurses were significantly higher than ER nurses. Even so, ER nurses were 4.0 times more likely [95% confidence interval (2.21, 7.35)] to experience threats of violence, and 2.8 times more likely [95% confidence interval: (1.50, 5.29)] to experience chronic fatigue. The results revealed that nurses experienced high quantitative demands, work pace, stress, and burnout. High prevalence of chronic and persistent fatigue, threats of violence and bullying, and musculoskeletal pain at the neck, shoulder, upper and lower back, and foot region, was also reported. Conclusion: This study has provided good estimates for the exposure rate of psychosocial work stressors, work-related fatigue, and musculoskeletal disorders among nurses in Brunei. It provided important initial insight for nursing management and policymakers to make informed decisions on current and future planning to provide nurses with a conducive work environment.
( Hanif Adhitya ),( Seung-hwa Yu ),( Xiongzhe Han ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
The main problem with the applying plant treatment using unmanned aerial spraying systems (UASS) is the unpredictability of the environment. In this study, the environmental and operating conditions of the UASS are used as parameters that must be addressed using a control system. By utilizing the SG-10P octocopter sprayer platform, which is attached to an indoor simulator to obtain controlled environmental conditions, simulations are performed to obtain model development datasets. The datasets obtained are the coefficient of variation (CV) values, and model equation development is done by machine learning, with Random Forest Regression as the model with the highest accuracy of 0.9, close to the actual value. Utilizing a baseline CV below 30%, this model can provide commands in the control system to execute nozzle openings to address real-time conditions and minimize pesticide usage.
Polypyrrole multilayer-laminated cellulose for large-scale repeatable mercury ion removal
Hanif, Zahid,Lee, Seyeong,Hussain Qasim, Gullam,Ardiningsih, Indah,Kim, Jeong-Ah,Seon, Jaeyoung,Han, Seunghee,Hong, Sukwon,Yoon, Myung-Han The Royal Society of Chemistry 2016 Journal of materials chemistry. A, Materials for e Vol.4 No.32
<P>In this research, we report a polypyrrole (PPy) multilayer-laminated cellulose network aimed at the cost-effective removal of aqueous potentially toxic metal ions with high adsorption efficiency and good adsorbent recyclability. The preparation of conformal adsorbent coatings on a fibrous cellulose network was accomplished by performing multiple cycles of simple dip-coating of a non-toxic oxidant and vapor-phase polymerization of PPy. The resultant PPy multilayer-deposited cellulose exhibited stable adhesion between the vapor-deposited PPy and the underlying cellulose support even in a strongly acidic solution. Using this non-hazardous hybrid adsorbent, mercury ions could be efficiently adsorbed over a large pH range with a maximum specific adsorption capacity of 31.689 mg g<SUP>−1</SUP>, either in the form of a thick suspended adsorbent for large-scale decontamination or a thin dripper-type membrane for portable water purification. Furthermore, the PPy multilayer-laminated cotton fabric enabled the large-scale repetitive removal of mercury ions (100 ppm, 1 liter) with efficiency above 91%. This study suggests that the PPy-cotton hybrid may serve as a large-scale, economical, and recyclable decontamination platform for efficient removal of highly potentially toxic metal ions (<I>e.g.</I>, Hg(ii) and Cr(vi)), which could be beneficial for water purification, particularly in resource-limited locations.</P>