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주한나(Ju, Han-Nah),이현수(Lee, Hyun-Soo) 한국실내디자인학회 2013 한국실내디자인학회 학술대회논문집 Vol.15 No.1
Hanok has become popular in public since 2000, as issue of eco design has grown rapidly among architecture field. The range of materials has to be categorized and defined in order to apply in interior spaces. The following results are defined; Three elements are selected from five categories from the references as Modern Hanok; Hayllu(Korean wave) Architecture, Han-style Architecture, and Hanok of Architect. Total 6 cases(2 for each category) was analyzed in a material framework which is consisted on wood, fabric, polymer, metal, nonferrous metal, stone, cement, plastic clay, glass, painting. Most of materials are used in Hallyu(Korean wave) architecture and Han-style Architecture except for a stone in interior spaces. On the other hand, most of wood and fabric are used in Hanok of Architect even though plastic clay, glass, and painting are rarely used. Materials can be used widely for a foundation of source if more specific investigation is defined and categorized and increasing numbers of study.
발달성협응장애(Developmental Coordination Disorder) 의 선별과 진단
양한나,김의수 서울대학교 스포츠과학연구소 2007 스포츠과학리뷰 Vol.1 No.2
Deficits of motor development and performance of children with developmental coordination disorder affect negatively to both physical, social, and psychological aspects. According to research tendency of developmental coordination disorder since 2000, study in Korea was few compare to the studies of overseas were plenty. Also, only motor skill test is used to be classified as developmental coordination disorder in Korea whereas at least 3~4 strict tests of screening process is used in overseas. To activate the research about developmental coordination disorder in Korea and to classify developmental coordination disorder with confidence, more various but accurate and standardized tests should be developed. 발달성협응장애(DCD) 아동의 운동발달 지체 및 운동기술의 부족은 신체적, 사회심리학적 측면에 부정적인 영향을 미친다. 국내외 연구 경향을 살펴본 결과 외국에서는 2000년 이후에 다양한 분야에서 활발히 연구가 진행되고 있는 반면 국내의 연구는 매우 부진한 상태이다. 또한 외국의 연구는 발달성협응장애(DCD) 아동의 선별과 진단과정이 엄격하고 최소 3-4단계 이상의 과정을 거치는데 반해 국내의 연구는 운동기술검사만으로 발달성협응장애(DCD)를 선별하고 있다. 국내 발달성협응장애(DCD) 관련 연구의 활성화를 위해서는 보다 정확한 대상자에 대한 선별기준이 설정되어야 하며 보다 다양한 운동기술 검사도구의 한국형 표준화 과정이 이루어져야 할 것이다.
상악동에 발생한 거대한 Cholesterol 육아종 1례
김승찬,박형욱,김용기,나한조,도남용 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1
The cholesterol granuloma is not a specific clinical or pathologic entity but merely a term used to describe a tissue response to cholesterol crystal. The cholesterol granuloma in paranasal sinuses is rare disease. Recently the authors had experienced a case of huge cholesterol granuloma, which involved the right maxillary sinus. The cholesterol granuloma was removed successfully by mean of enucleation through the Caldwell-Luc approach. So, we report a case with brief review of the literature.
Developmental Trajectories of Attention in Normal Korean Population
Han Nah Huh,Sung Hee Kang,Soon Young Hwang,Hanik K. Yoo 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.2
Objectives: This study aimed to investigate the trajectory of change of diverse attention and working memory in Koreans from 4 to 40 years of age. Methods: The data of 912 subjects from 4 to 15 years of age obtained from a previous standardization study of the computerized comprehensive attention test were merged with the newly obtained data of 150 subjects aged 16 to 40 years from this study. We evaluated the various kinds of attention, in which each subtest had five indicators. Working memory, with parameters such as number of correct responses and span, was also measured. Results: Our findings indicated that attention developed as age increased, and it decreased or was maintained after a certain age. Selective and sustained attention developed rapidly in children and adolescents, until mid-teens or 20 s when it ceased development. Divided attention, however, developed up to approximately age 20. In addition, working memory developed until mid-teens or 20 s. Conclusion: We presented the standardized data on diverse kinds of attention and working memory in children, adolescents, and adults in Korea. We could recognize any patterns of change in attention and working memory with increasing age.
Han Joon Bae,Yun-Kyeong Cho,Hyoung-Seob Park,Hyuck-Jun Yoon,Hyungseop Kim,Seongwook Han,Seung-Ho Hur,Yoon-Nyun Kim,Kwon-Bae Kim,Jae-Kean Ryu,Deug Young Nah,Chang-Wook Nam 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.2
Background/Aims: To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and safety through the prospective Daegu and Gyeongbuk statin registry. Methods: Statin naïve patients who were prescribed statins according to the criteria of Korean Guidelines for Management of Dyslipidemia were enrolled. Clinical and laboratory evaluations were performed at baseline and at week 8, where the efficacy was assessed with the same guidelines. Results: Of 908 patients, atorvastatin and rosuvastatin were most frequently prescribed statins (63.1% and 29.3%, respectively). High intensity statins (atorvastatin 40 mg or rosuvastatin 20 mg) were prescribed in 24.7% of all patients and in 79.5% of high and very high risk groups. The total and low density lipoprotein (LDL) cholesterol levels decreased from 203.7 ± 43.0 to 140.6 ± 28.6 mg/dL and 134.4 ± 35.7 to 79.5 ± 21.3 mg/dL, respectively. The achievement rate of the LDL target goal was 98.6% in low risk, 95.0% in moderate risk, 88.1% in high risk, and 42.1% in very high risk patients (59.7% in overall). There was no significant difference in the efficacy between atorvastatin and rosuvastatin. Adverse events were observed in 12.0% of patients and led to 1.4% of treatment cessation. Conclusions: The efficacy of the usual starting dose of statins in daily practice was relatively insufficient for Korean hypercholesterolemic patients with high or very high risks. Short-term adverse events of statin therapy were not common in Korean patients with a low discontinuation rate.
( Han Nah Seok ),( Eun Young Lee ),( Eun Yeong Choe ),( Woo In Yang ),( Joo Young Kim ),( Dong Yeob Shin ),( Ho Jin Cho ),( Tae Sung Kim ),( Mi Jin Yun ),( Jong Doo Lee ),( Eun Jig Lee ),( Sung Kil Li 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1
Background/Aims: Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods: 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results: Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Consclusions: About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.
P197 : Influence of ceramidase to the human hair follicle and its role in hair cycle
( Han Nah Hong ),( Xing Hai Jin ),( Long Quan Pi ),( Sungjoo Tommy Hwang ),( Won Soo Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Ceramide, a major class of integral hair lipid(IHL), may help determine the physicochemical properties of human hairs.Ceramidase(CDase) plays a crucial role in initiating the protective mechanism as it converts ceramide into nonapoptotic metabolites via the hydrolytic pathway. Objectives: The purpose of current study was to investigate the role of CDase in human hair follicles, especially its association with hair cycle. Methods: We observed that hair follicles express CDase at mRNA levels using real time RT-PCR. Furthermore, we examined whether ceramide accumulation induced by N-oleoylethanolamine(NOE), a competitive inhibitor of CDase, influences human hair growth, a change in hair cycle and proliferation/apoptosis-related molecular expression using immunofluorescence stains. Results: As the transition from anagen to catagen progressed, mRNA expression of aCDase and nCDase decreased. NOE inhibited the human hair growth and promoted transformation from anagen to catagen in organ cultured human hair follicles. When the hair follicles were treated with NOE, ki-67 decreased and TUNEL increased. This implies that the hair follicles treated with NOE experience decreased proliferation and increased apoptosis. Conclusion: According to the results above, it is speculated that the IHL of the hair, ceramide in particular, influences hair cycling. In addition, it could be deduced that ceramide hydrolytic effects of CDase have protective effects on growth of the hair follicle.
Han Nah Cho,Eun Hye Ha 대한소아청소년정신의학회 2019 소아청소년정신의학 Vol.30 No.1
Objectives: The purpose of this study was to analyze the discriminant validity and the clinical cut off scores of the Child Behavior Checklist 1.5-5 (CBCL 1.5-5) in the diagnosis of autism spectrum disorder (ASD) and non-ASD. Methods: In total, 104 ASD and 441 non-ASD infants were included in the study. T-test, discriminant analysis, receiver operating characteristic (ROC) curve analysis, and odds ratio analysis were performed on the data. Results: The discriminant validity was confirmed by mean differences and discriminant analysis on the subscales of Emotionally reactive, Somatic complaints, Withdrawn, Sleep problems, Attention problems, Aggressive behavior, Internalizing problems, Externalizing problems, and Total problems, along with the Diagnostic and Statistical Manual of Mental Disorders (DSM)-oriented scales between the two groups. ROC analysis showed that the following subscales significantly separated ASD from normal infants: Emotionally reactive, Somatic complaints, Withdrawn, Sleep problems, Attention problems, Aggressive behavior, Internalizing problems, Externalizing problems, Total problems, and DSM pervasive developmental problems. Moreover, the clinical cut off score criteria adopted in the Korean-CBCL 1.5-5 were shown to be valid for the subscales Withdrawn, Internalizing problems, Externalizing problems, Total problems, and DSM pervasive developmental problems. Conclusion: The subscales of Withdrawn, Internalizing problems, Externalizing problems, Total problems, and DSM pervasive developmental problems significantly discriminated infants with ASD.
Biomarkers and genetic factors for early prediction of pre-eclampsia
Han nah Kim,Sung Shin Shim 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.2
Pre-eclampsia is known to cause considerable maternal morbidity and mortality. Thus, many studies have examined the etiopathogenesis of pre-eclampsia. While many pathophysiological factors related to pre-eclampsia have been identified, the precise etiopathogenesis of pre-eclampsia remains unclear. Numerous studies have identified factors for the early prediction for pre-eclampsia to lead to preparation and closer observation on pre-eclampsia when it occurs. This article reviews on current studies of biomarkers and genetic factors related to pre-eclampsia, which may be important for developing strategies for early prediction of pre-eclampsia.