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      • 韓國産 모기의 生態學的 硏究 : 第二編 韓國産 Anpheles屬 모기의 生態學的 硏究

        元炳徽,洪漢基 東國大學校 1968 論文集 Vol.5 No.-

        Biological investigations were carried out in the western plain area of Okku-gun, Cholla-pukdo province in 1964, in the hilly area of Asan-gun, Chungchong-namdo province in 1965, and in mountinous area of Andong-gun in 1966, Chongsong-gun in 1967 and Yongju-gun, Kyonsang-Pukdo province in 1963 and 1968. 1. Anopheline mosquitoes found during the investigation period are as follows: 1) Anopheles sinensis Wiedemann. 1825 2) Anopheles yatsushiroensis Miyasaki. 1951 3) Anopheles sineroides Yamada. 1925 4) Anopheles koreicus Yamada & Watanabe. 1918 5) Anopheles lindesayi japonicus Yamada. 1918 1),2),3) among the five species of Anophline mosquitoes were distributed in all of the studied areas, however 4) and 5) were found in the mountinous area. 2. Population density and seasonal appearance of Anopheline mosquitoes. A. sinensis is the widely distributed and predominant species in the all investigated areas, and shows the higher density in the plain area than the mountinous area. This species is to be appeared from begining of march and to be disappeared in October, and shows the peak population density in July during the mosquito season. A. yatsushiroensis is a widely distributed common species, and to be appeared from May to October with two peaks in June and September. The population density of this species in mountinous area is higher than the plain area. A. sineroides is widely distributed species but rare. Seasonal appearance of this species was from May to October and higher population was shown in mountinous area. A. koreicus and A. lindesayi japonicus is the species to be appeared in mountinous area and colledted from May to October, however A. lindesayi japonicus is very rare and limited breeding species in the mountinous area. 3. Feeding habits of Anopheline mosquitoes In the early spring A. sinensis was collected in open air by daytime cowbiting collection under the low temperature and earlier day of catching was the third of March and latest day was the 14th of May. The total average number of A. sinensis collected by per day was 5.7 mosquitoes in Sangchapo village and 7.5 in Hachapo in 1966. The number of A. sinensis collected in the afternoon was higher than the morning and fair day was higher than cloudy. The feeding activity at night was continued throughout the night. The peak period of feeding activity through the noght had shown in different time in each month such as between 21.00-22.00 hours in June, 24.00-01.00 hours in July, 03.00-04.00 hours in August and 21.00-22.00 hours in September. The minimum temperature for feeding activity was 14℃ and optimum was between 24-25℃ in the field. Night time feeding activity of A. yatsushiroensis was throughout the night and shown two peak periods at two hours before and after from the sun-rise and the sun-set. The other species of sineriodes and loreicus were not shown the special peak period of feeding at night. A. sinensis shown the zoophilism, however in Okku area the human biting rate was the 16 times higher than Asan area, and a number of biting mosquito in out door were 1.3 times higher than indoor. The light attraction of A. sinensis is 2.5 times higher by one candle food. The human biting rate of A. yatsushiroensis was 13.4% higher than A. sinensis by experimental feeding test. 4. Resting habits of Anopheles mosquites Anopheline mosquitoes were collected in most of the places in house, but the main resting places were cow shed (82.1%) and pigsty(12.4%). Out of 7.125 Anopheline mosquitoes collected from the houses since from 1964 to 1967, and A. sinensis was 88.2% A. yatsushiroensis 1.4%, A. sineroides 3.5% and koreicus 6.9%. From the resting place collections in outdoor, A. sinensis and A. yatsushiroensis are 61.6% and 52.4% from parsley field, 9.1% and 24.0% from seed bed of rice field, and other 11% and 9% fromother resting places such as bean field, vegetable, potatoes and so on. In the Experimental trap but collection, the collected number of A. sinensis in exit window trap were 76.4% in July and 81.3% in August, and 95.7% in July and 97.1% in August for A. yatsushiroensis. 5. Out of 1349 female of A. sinensis released from DDT sprayed room(DDT 2g/㎡), 29% of A.sinensis were collected from exit window trap and 42% of A. sinensis were dead mosquitoes in the sprayed room. 24 hours survival test of A. sinensis which was collected from exit window trap showed the 74% mortality and 8% of total released mosquitoes was only alived. 6. Parous rate of A. sinensis in Asan area were 50.5% in June, 64.4% in July, 82.7% in August, 93.5% in September and the parous rate of A. yatsushiroensis were 71.9% in June, 74.3% in July, 87.9% in August. 7. Main breeding place of Anopheline mosquitoes were rice field, stream, pond and parsley field. 8. Malaria in fection of Anopheline mosquitoes Two A. sinensis were found to be positive for sporozoite from salivary gland dissection out of 4018 females in 1967 and one A. yatsushiroensis was found to be positive for oocyst from stomach dissection out of 89 females in 1966. In 1968 four species of Anopheline mosquites were tested for experimental infection of malaria (p. vivax), and one A. sinensis was infected for oocyst among eight females tested and three A. yatsushiroensis were infected for one oocyst and two sporozoite among nine tested females. Other species were not infected. 9. Filaria (B. malayi) infection of mosqitoes One female of A. yatsushiroensis was found to be infective of filarial larvae out of 89 dissected mosquitoes in 1966 and six females of A. sinensis were found to be positive out of 1380 dissected females in 1967. Experimental infection of microfilariae(B. malayi) to the Anopheline mosquitoes were carred out in 1968. Twelve females of A. sinensis were infected among thirty five tested females, ten females of A. yatsushirionsis were infected (62.5%) out of the sexteen, and nine of A. sineroides were infected (90%) among ten females.

      • 동적 그룹 지원을 위한 계층적 그룹통신 프로토콜

        이광휘,조현주,김한수 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

        This paper presents a hierarchical group communication based on multicast protocol, HGCMP. Group communication facility has been gradually magnified. As an object oriented approach has been introduced in designing the system, it provides an application programmer with the means to develop a new application facility without having to build the detail functions. In this paper, some requirements for multicast communication, the structure of the system, and service primitives will be described in detail. As the number of manager can be dynamically created and destroyed relying on the requirement, the system can efficiently be operated. Also the use of hierarchical structure has a advantage. Appropriate management functions can be allocalted to each management level. The manager in the highest domain totally performs configuration, fault, name service and perfomance management functions. The lower managers perform these management functions on the managed objects in the corresponding level host machine. Multicast facility designed in this paper is for supporting a distributed network management system.

      • C++를 이용한 통신 시뮬레이터의 설계 및 구현

        이광휘,정상국,안정희,김한경,이종근 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

        In this paper, we are designed and implemented communication simulator, for two systems which communicates in peer-to-peer and simulating for protocol, to verify the interwork not yet designed system Peerl and now being operated Peer2. To begin with, after the investigation in Interworking Standard in Interface Control Document and check the satisfied requirements in each system, the environment of simulator is set up. We examine Interworking Standard in FSM representation. And in protocol design, partial steps follows necessary procedure of protocol engineering. Simulator is implemented in C++ and, to interwork two systems smoothly, the whole system will be merged. Finally, a design and implementation of simulator is completed by confirming simulation results of simulator and Interworking Standard coincide.

      • C-Scan 장치를 이용한 초음파 탐상에 관한 연구(Ⅰ)

        玄淸男,韓熙悳 홍익대학교 산업기술연구소 2003 産業技術 Vol.13 No.-

        In this study, the flaws in the several test specimens are detected by using a C-Scan system. The following results are obtained through this research; 1. How to detect the flows in the specimens 2. How to determine the depth of the flaws in the specimens 3. How to determine the size of the flaws in the specimens 4. How to determine if the specimen is in one piece or not and how to detect defects at the joining part 5. Analysis by using Linear Profile and 3D View In order to determine the depth and size of the flaws in the specimens precisely, it is very important to operate the C-Scan system properly.

      • 분산 네트워크 관리 시스템 지원을 위한 멀티캐스트 프로토콜의 설계 및 구현

        조현주,이광휘,김한수 國立昌原大學校 基礎科學硏究所 1994 基礎科學硏究所論文集 Vol.6 No.-

        This paper presents a new model for group communication facility which is gradually magnified. This model has been implemented in LAN environment and can get the enhancement in performance because a new manager can be dynamically created determined depending on the type of receiving message. As an object oriented approach has been introduced in designing the system, it provides an application programmer with the means to develop a new application facility without having to build the detail functions. As the members in a group are only identified by the index in a table, the overhead for the address referencing can be minimized. In this paper, some requirements for multicast communication, the structure of the system, and service primitives will be describe in detail. As the number of manager can be dynamically created and destroyed relying on the requirement, the system can efficeintly operated. Multicast facility designed in this paper is for supporting a distributed network management system.

      • HGCMP기반 서버 시스템상의 전달지연 연구

        조현주,김한수,이광휘 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

        In this thesis, the message transmission delay on a server system using HGCMP for group communication protocol was analyzed. The queue model of a server system was modeled by queueing theoretic approach. As the feedback structure was imbedded in the queue model, it is difficult to analyze the delay. To solve this problem, the simplification of the queue model was performed. After the simplification process, the queue model was modeled M/M/1. The transmission delay of a server system is calculated using average waiting time and service time in a server system.

      • 통합 통신망 관리 시스템 구축 방안 연구

        이종근,임미경,이광휘,김한경,김태수 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

        This paper presents a system for internetworking between different network management protocols. The internetworking system between SNMP(Simple Network Management Protocol) and CMIP(Common Management Information Protocol) has been designed. SNMP has been used as a standard protocol in Internet while CMIP has been selected as management protocol in OSI network. This approach is different from previous researches which convert protocols between management protocols. We have newly defined manage objects structure. Thus, even if a new management protocol would be introduce in addition, the new gateway system needs not be designed. We can achieve it through minimum modification in the interface of the managed objects. So, we can support managed objects defined previously using MOVI(Manage Object View Interface) concept presented in our previous research. Through this research, we have some additional benefits: it is able to internetwork between more complicated network management protocols, to increase usefulness of SNMP and CMIP, also it will use in internetworking between new network management protocols.

      • Prognostic Significance of Preoperative Lymphocyte-Monocyte Ratio in Patients with Resectable Esophageal Squamous Cell Carcinoma

        Han, Li-Hui,Jia, Yi-Bin,Song, Qing-Xu,Wang, Jian-Bo,Wang, Na-Na,Cheng, Yu-Feng Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

        Background: The interaction between tumor cells and inflammatory cells has not been systematically investigated in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to evaluate whether preoperative the lymphocyte-monocyte ratio (LMR), the neutrophil-lymphocyte ratio (NLR), and the platelet-lymphocyte ratio (PLR) could predict the prognosis of ESCC patients undergoing esophagectomy. Materials and Methods: Records from 218 patients with histologically diagnosed ESCC who underwent attempted curative surgery from January 2007 to December 2008 were retrospectively reviewed. Besides clinicopathological prognostic factors, we evaluated the prognostic value of the LMR, the NLR, and the PLR using Kaplan-Meier curves and Cox regression models. Results: The median follow-up was 38.6 months (range 3-71 months). The cut-off values of 2.57 for the LMR, 2.60 for the NLR and 244 for the PLR were chosen as optimal to discriminate between survival and death by applying receiver operating curve (ROC) analysis. Kaplan-Meier survival analysis of patients with low preoperative LMR demonstrated a significant worse prognosis for DFS (p=0.004) and OS (p=0.002) than those with high preoperative LMR. The high NLR cohort had lower DFS (p=0.004) and OS (p=0.011). Marginally reduced DFS (p=0.068) and lower OS (p=0.039) were found in the high PLR cohort. On multivariate analysis, only preoperative LMR was an independent prognostic factor for both DFS (p=0.009, HR=1.639, 95% CI 1.129-2.381) and OS (p=0.004, HR=1.759, 95% CI 1.201-2.576) in ESCC patients. Conclusions: Preoperative LMR better predicts cancer survival compared with the cellular components of systemic inflammation in patients with ESCC undergoing esophagectomy.

      • SCIESCOPUSKCI등재

        Murrayafoline A Induces a G<sub>0</sub>/G<sub>1</sub>-Phase Arrest in Platelet-Derived Growth Factor-Stimulated Vascular Smooth Muscle Cells

        Han, Joo-Hui,Kim, Yohan,Jung, Sang-Hyuk,Lee, Jung-Jin,Park, Hyun-Soo,Song, Gyu-Yong,Nguyen, Manh Cuong,Kim, Young Ho,Myung, Chang-Seon The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.5

        The increased potential for vascular smooth muscle cell (VSMC) growth is a key abnormality in the development of atherosclerosis and post-angioplasty restenosis. Abnormally high activity of platelet-derived growth factor (PDGF) is believed to play a central role in the etiology of these pathophysiological situations. Here, we investigated the anti-proliferative effects and possible mechanism(s) of murrayafoline A, a carbazole alkaloid isolated from Glycosmis stenocarpa Guillamin (Rutaceae), on PDGF-BB-stimulated VSMCs. Murrayafoline A inhibited the PDGF-BB-stimulated proliferation of VSMCs in a concentration-dependent manner, as measured using a non-radioactive colorimetric WST-1 assay and direct cell counting. Furthermore, murrayafoline A suppressed the PDGF-BB-stimulated progression through $G_0/G_1$ to S phase of the cell cycle, as measured by [$^3H$]-thymidine incorporation assay and cell cycle progression analysis. This anti-proliferative action of murrayafoline A, arresting cell cycle progression at $G_0/G_1$ phase in PDGF-BB-stimulated VSMCs, was mediated via down-regulation of the expression of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)2, CDK4, and proliferating cell nuclear antigen (PCNA), and the phosphorylation of retinoblastoma protein (pRb). These results indicate that murrayafoline A may be useful in preventing the progression of vascular complications such as restenosis after percutaneous transluminal coronary angioplasty and atherosclerosis.

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