TNF-α로 유도된 혈관내피세포의 혈관염증에 미치는 오적산(五積散)의 억제 효과

한병혁 ( Byung Hyuk Han ),윤정주 ( Jung Joo Yoon ),김혜윰 ( Hye Yoom Kim ),안유미 ( You Mee Ahn ),홍미현 ( Mi Hyeon Hong ),손찬옥 ( Chan Ok Son ),나세원 ( Se Won Na ),이윤정 ( Yun Jung Lee ),강대길 ( Ho Sub Lee ),이호섭 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4

Objectives : Ojeoksan, originally recorded in an ancient Korean medicinal book named “Donguibogam” and has been used for the treatment of circulation disorder of blood which was called blood accumulation (血積) in Korean medicine. Therefore, this study was carried out to investigate the beneficial effect of OJS on vascular inflammation in HUVECs. Methods : We evaluated the effect of OJS on the expression of cell adhesion molecules and protective role in HUVEC stimulated by TNF-α by using Western blot. Results : Pretreatment with OJS decreased the adhesion of HL-60 cells to TNF-α-induced HUVEC. OJS suppressed TNF-α-induced expression level of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1(VCAM-1), and endothelial cell selectin (E-selectin). Moreover, OJS significantly decreased TNF-α-induced production of intracellular reactive oxygen species (ROS); and inhibited the phosphorylation of IκB-α in the cytoplasm compared to the experimental group. Pretreatment with OJS inhibited the trans-location of NF-κB p65 to the nucleus. OJS also inhibited phosphorylation of MAPKs compared to the experimental group. OJS significantly increased the protein expression of Nrf2 and HO-1. Conclusions : Ojeoksan has a protective effect on vascular inflammation, and might be a potential therapeutic agent for early atherosclerosis.

기어의 자동설계와 검증에 관한 연구

한민식,김승현,송호봉,전언찬 한국공작기계학회 2009 한국공작기계학회 춘계학술대회논문집 Vol.2009 No.-

Gear is main machine element which is used for the power transmit device when it si short in the gear. We use a standard goods in the case of the gear. But in case of special purpose, we need to manufacture the gear that have different angles. In this paper, we manufactured standard gears using W-EDM and Hobbing machine. We got a 3D shape doing reverse engineering manufactured gears. And then compared CAD data and measured data. Finally we verified ADS through comparing ADS data and KISSsoft data.

위상 및 음압 레벨제어를 이용한 스테레오 음상 확대에 관한 연구

한찬호,박양우,장주석 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

Three-dimensional sound is a technique for generating or recreating sounds so they are perceived as emanating from locations in a three-dimensional space. Three dimensional sound has the potential of increasing the feeling of realism in music or movie soundtracks. Three-dimensional sound effects depend on psychoacoustic spectral and phase cues being presented in a reproduced signal. In this paper we propose an effective algorithm for the sound image expansion in television system using stereo image enhancement techniques. In this algorithm, a lower frequency band sound is expanded by phase control and a higher frequency band sound is expanded by cross-talk cancelation. Compared to the other techniques of three-dimensional sound, the proposed algorithm use only two speakers to enhance the sound image expansion, while maintaining the original sound characteristics.

선착효과 및 반사음을 이용한 스테레오 음상확대

한찬호,최덕규 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

In the AV system, to produce a realistic sound effect is very difficult because the distance between stereo speakers is very narrow. Many signal processing method of widening the sound image for spatial impression have been studied. Most of the typical methods of widening the sound image are related to the phase shifting. but this method was not effective in the concrete wall structure with high reflectivity. In this paper, we proposed an effective method of extending stereo sound image using Precedence Effect and reflected sound. In experiments we confirm the usefulness of the method for extending stereo sound image of a conventional AV system in wider listening area of a room.

기도이물에 관한 임상적 고찰

한찬수,김태정,김일호,김유재,김천숙,안기량 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

Aspiration of a foreign body in the airway is common cause of sudden obstructive breathing, crouping cough, hoarseness, and wheezing. Especially that caused serious problem in case of the young children. A past history of foreign body aspiration is itself an indication for bronchoscopic examination of the airway, because some children with aspirated foreign bodies are without symptoms and chest X-ray films may not show abnormalities. So the anesthesiologist should take a notice of removing foreign body in the anesthetic procedure. The author have experienced 36 cases removal of foreign bodies in the airway under general anesthesia from July, 1982 to January, 1996 in Chunan Hospital, College of Medicine, Soonchunhyang University. The results were as follows 1) Among the 36 cases, 25 cases(69.7%) were under the age of 5. The ratio of male and female was 1.8 : 1. 2) In duration of lodgement, there was most frequent within one day in 15 cases(41.7%) and the longest duration was 20 days. 3) The most common symptom, sign and auscultation finding were cough 19 cases(52.8%). chest retractions 7 cases(19.4%) and decreased breathing sound 20 cases(55.6%) 4) Abnormalities in the chest X-ray were found in 15 cases(41.7%) among 36 cases. 5) Vegetable foreign bodies, expecially peanut were the most common airway foreign body(28.7%), followed by plastic foreign body(14.4%) and mucous plug(11.3%). 6) The foreign body involved the right bronchus 16 cases(45.7), left bronchus 10 cases(28.6%), trachea 5 cases(14.3%), and larynx 4 cases(11.4%). 7) Foreign body induced complications occurred in 9 cases(25.0%); pneumonia 8 cases and pneumomediastinum 1 case, and all of postoperative complication was pneumonia(25.0%). 8) 34 foreign objects(94.4%) were removed by endoscopy but tracheostomy was required in two patients.

수종보익제가 면역세포의 조절 및 Apoptosis에 미치는 영향

한종현,강성용,정현우,오찬호,권진,은재순 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1

The effects of several tonifying prescriptions on the apoptosis of transplanted L1210 cells and the regulation of immune cells in L1210-transplanted mice were studied. Sa-Mul-Tang(SMT), Sa-Kunja-Tang(SKT), Sipjeon-Daebo-Tang(SDT) accelerated the apoptosis of transplanted L1210 cells, and SMT and SKT reduced the mitochondrial transmembrane potential of transplanted L1210 cells. SMT promoted the proliferation of thymocytes and splenocytes in L1210-transplanted mice. Whereas SMT increased CD8+ T_c/T_S cell, Bojung-Ikki-Tang(BIT) decreased CD4+ T_H cell population in the thymocytes of L1210-transplanted mice. SMT and SKT increased the lucigenin chemiluminescence from peritoneal macrophage of L1210-transplanted mice. These results indicate that SMT and SKT have an inductive action of apoptosis of transplanted L1210 cells and peritoneal macrophage activation.

스피커 특성 및 오차경로의 온라인 인식을 이용한 새로운 적응 능동소음제어

한찬호,최덕규,정영헌 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In active noise control system, the error path transfer function is much more likely to change rapidly due to in temperature or flow rate. The loudspeaker response also changes due to aging and the other factors. Therefore, an improved solution to obtaining both the loudspeaker and the error path transfer functions on an on-line basis is required. In this paper, a new filtered-X least mean square(LMS) algorithm considering the loudspeaker and the error path characteristics is proposed for active noise control system. The transfer functions of the loudspeaker and the error path are obtained by an adaptively estimated error signal and the error path output signal on an on-line basis. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We observed an improvement of about 2.5dB in noise level compared with that obtained using the Eriksson's filtered-X LMS algorithm.

ATSC 비디오 테스트를 위한 최적화질 구현

한찬호,윤태진,장주석 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

ATSC test pattern for evaluating the image quality of ATSC display system has high quality and high compression rate. In this paper, we implemented ATSC test pattern that has high quality and high compression rate by minimizing the number of DCT coefficients block data. To minimize this DCT coefficients, the proposed test pattern is optimized for partition of DCT block. To test variable image quality of ATSC display system, quantization error and display test pattern is included the ATSC test pattern.

전자 빔 프로파일에 의한 밝은 영역에서의 명암 보정

한찬호,정영헌,최덕규 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In this paper, we present a compensation method of contrast loss in highly bright region by CPT beam profile. In the proposed method, the local difference signal for the compensation is transformed according to the local mean of luminance. In computer simulation, clear image is obtained by the compensation of contrast loss in highly bright region.

색누설 오차보정을 사용한 LCD와 CRT의 동일색 재현

한찬호,윤태진,장주석 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

Recently, PC monitor users have been replacing cathode ray tubes (CRT) with liquid crystal displays (LCD). But the chromaticity of the primaries are dependent on RGB input signals. And the colorimetry of LCD changes with gray scale and has a poor performance in color reproduction. In this paper we propose the enhanced algorithm of color reproduction considering color leakage error and black subpixel error in LCD. In order to test performance of this algorithm we use the colors of Macbeth colorcheck. As a result of experiments, it was confirmed that the color difference of the LCD using the proposed algorithm was considerably reduced.