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조무식,김선주,원혜윤,고정관,이경석 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
We report a series of 220 patients with low back pain who visited through neurosurgical out-patient department(OPD) from January 1994 to June 1994. We investigated how they were treated and what was the outcome on December 1995 by telephone interview. During the study period, 176 patients (80%) visited our OPD not more than twice. Frequency of OPD visit was single in 138 patients (62.7%), twice in 38 patients (17.3%), and over twice in 44 patients (20.0%). Twenty six patients (11.8%) were admitted, and 16 patients (7.3%) underwent an operation. Sixteen patients underwent surgery in this hospital, and the other 12 patients underwent surgery in any other hospitals. The rate of revisit was relatively high in patients who had a special study (58.1%), whose impression was herniated lumbar disc (41.2%) or degenerative spondylosis (55.6%), and who received prescriptions for drug (42.1%) or underwent an operation(87.5%). The rate of special study, prescriptions and/or operations of was relatively low in this hospital, which seems to lessen the rate of revisit. More active management seems to be necessary for the patient' satisfaction.
Prednislolne이 골조직에 미치는 영향에 관한 형태학적 연구
송혜정,김무강,김원식,이영호 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1
To study the effects of corticosteroids to the bone tissues, author grouped young(3 weeks affter birth) and adult ICR mouse by dosage, injected intramusculaily prednisolone, a series of corticosteroids, to posterior leg during 6 weeks per day, obtained femurs and tibias, measured the lengths of tibias and femurs. The portions of the distal end of tibial crests were cross-sectioned, general H-E stain was perpormed. The adjacent distal portions of femoral neck were sectioned longitudinally, observed endosteal surface by scanning electron micrscope The results were followings: 1. The adult group injected by large dosage (0.56mg/100g body weight/day) and the young group injected by small dosage(0.14mg/100g body weight/day) from 3 weeks after birth were significantly shorter than the normal group according to statistics. And the adult group injected by small dosage (0.14mg/100g body weight/day) was not different from normal group according to statistics. 2. In the light microscopic sutdy, the adult group injected by large dosage decreased in bone mass of compact bone severely, the adult group injected by small dosage changed a little grade. The young group injected by small dosage from 3 weeks after birth was not severe in bone change, but bone thickness decreased. 3. In the scanning elctron microscopic study, the adult group injected by large dosage and the young group iniected by small dosage from 3 weeks after birth decreased in trabeculae. The trabeculae of the adult group injected by small dosage were decreased slightly. 4. Integrating above all, the changes by prednisolone injection osteoporosis, of young period were more severe than those of adult, too.
NATM 터널 파쇄대암반 주변의 변형여유량 결정에 관한 연구
양해승,박현식 조선대학교 에너지.자원신기술연구소 2003 에너지·자원신기술연구소 논문지 Vol.25 No.1
최근 NATM에 의한 터널건설이 증가됨에 따라 계측의 중요성이 강조되고 있다. 지하에 안전하고 합리적인 터널을 건설하기 위해서는 사전지질조사 결과와는 다른 지질하적 조건에 적합한 지보를 설계하는 것이 필수적이다. 그러므로 계측은 터널 주변암반의 특성을 평가하기 위해서 매우 중요하다 터널굴착의 안정성은 일반적으로 암반의 지질학적 구조(단층, 절리, 파쇄대)에 영향을 받는다. 암반의 거동은 암반내에 존재하는 파쇄대의 역학적 특성과 분포에 의해 좌우된다. 파쇄대가 존재하는 터널내에서 연약한 암반주위의 굴착은 팽창성 지압이 발생하여 터널시공에 어려움을 겪고 있는 실정이다. 본 논문에서는 보조공법이 수행된 파쇄대 주변암반에서 내공변위, 천단침하, rock bolt 축력 그리고 shotcrete 응력의 현장계측이 수행되었으며, 각 계측항목별로 해석치, 현장계측기 그리고 허용기준치로부터 변형여유량을 산정하여 터널굴진에 따른 터널의 안정성을 평가하였다. As the construction of tunnelling by NATM increased, the importance of measurement is being emphasized. For tunnelling safely and reasonably construction in underground, it is essential to design the support suitable to the geological conditions that could be different from the results of pre-investigation. Therefore, it is very important to evaluate the characteristics of rock mass around tunnel in excavating site. The stability of the tunnelling is generally affects by the geological structures(fault, joint and fracture zone) of the rock mass. The behavior of rock mass was dominated by the mechanical properties and distribution of fracture zone within the rock mass. The excavation around the fragile rock mass in the tunnel existing fracture zone is difficult for tunnel construction generated the expansibility earth pressure. In this study, in-situ measurement of convergence, crown settlement, rock bolt axial force and shotcrete stress were conducted in rock mass around fracture zone executed assistant construction method, assessed the stability of tunnel from analysis values, in-situ measurement values and administration criterion values for measurement items. The design of support pattern around fracture zone within the rock mass was appropriated.
만성 정신분열병 환자에서 다음증과 물중독 위험군의 임상적 특성-표준화 일중체중증가를 이용하여
김차식,김혜남,백기청 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4
연구배경 : 만성 정신분열병 환자들에서 다음증과 물중독은 임상가의 인식부족 등의 이유로 흔히 간과되어 왔으며, 이들의 임상적 특성에 대해서는 논란이 되고 있다. 본 연구는 다음증과 물중독의 위험군을 검색하는 방법으로 경제적이고 간편하다고 알려진 표준화 일증체중증가를 이용하여 비정상적인 일중체중증가를 보이는 만성 정신분열병 환자들의 임상적 특성을 알아 보고자 하였다. 방법 : 1995년 7월에서 1995년 10월 사이에 국립서울정신병원에 입원한 2년 이상된 정신분열증 환자 156명을 대상으로 3주간 매주 1회씩 7 a. m.과 4 p.m.에 각각 체중을 측정하여 표준화 일중체중증가를 구하였다.표준화 일중체중증가는 오전 체중에 대한 오후 체중의 증가비율로서 4 a.m. 체중에서 7 p.m.체중을 뺀 후 100을 곱하였고 그 값을 7 p.m. 체중으로 나눈 값(%)인데, 비정상적 표준화 일중체중증가는 1.2% 이상을 기준으로 하였다. 이와 함께 향정신병 약물, 정신분열병의 예후예측변인 및 체형을 조사하여 비교하였다. 결과 : 대상 환자가운데 비정상적인 일중체중증가를 보이는 환자들은 35.9%를 차지하였고, 이들은 남자, 저역가 약물복용, 흡연, 장기간의 입원경력 및 상대적으로 마른 체형 등의 임상적 특성을 보였다. 결론 : 이상의 임상적 특성을 보이는 만성 정신분열병 환자들은 다음증과 물중독의 위험군이라 볼 수 있으며, 따라서 실제 임상에서 이러한 특성을 보이는 만성 정신분열병 환자들은 다음증 및 물중독의 위험에 관한 임상가의 인식이 필요하다. Objects : Polydipsia and water intoxication among chronic schizophrenic patients is poorly understood and underdiagnosed due to lack of awareness among clinicians, and their clinical characteristics are controversial issues at present. We attempted to identify clinical characteristics of chronic schizphrenic inpatients who had abnormal normalized diurnal weight gain, an economic and easy method for screening the risk group of polydipsia and water intoxication. We also assessed the factors that may contribute to abnormal normalized diurnal weight gain. Methods : One hundred fifty-six chronic schizophrenic inpatients(From July, 1995 to October,1995) at Seoul National Mental Hospital were studied. They were weighed at 7 a.m. and 4 p.m. weekly for 3 weeks. We normalized the diurnal weight gain as a percentage by substracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and dividing the result by the 7 a.m. weight. We defined the abnormal normalized diurnal weight gain as above1.2%, according to the previous study of Davidson et al(1976). We estimated current psycho-tropic medication, prognostic factors of schizophrenia and body type, and compared those with normalized diurnal weight gain values. Results : About thirty-six percent of the subjects had abnormal normalized diurnal weight gain values. The chronic schizophrenic inpatients with abnormal normalized diurnal weight gain were clinically characterized by being male, using low potency antipsychotics, smoking, extended hospitalization and relatively low body mass index score. Conclusions : We suggest that the risk of polydipsia and water intoxication in chronic schigophrenic inpatients are increased, by being male, using low potency antipsychotics, smoking and having extended hospitalizations and relatively low body mass index score. Therefore in psychiatric practice, clinician's awareness about these correlations are warranted.
포플라 Callus의 배양환경에 따른 Anthocyanin 생합성
방혜진,이승우,최근원,정인식,설일환 경희대학교 생명자원과학연구원 1997 遺傳工學論文集 Vol.9 No.-
Studies were carried out to investigate the effects of various cultural and environmental conditions on callus growth and anthocyanin biosynthesis of the callus derived from the leaf discs of the Populus hybrid (Populus nigra × Populus maximowiczii cv. Yanghwangchul). Even though the largest amount of anthocyanin was obtained from the calli grown in the vessels illuminated with white fluorescent light, no significant differences in callus growth could be obtained among other vessels illuminated with different light qualities, i.e., red, yellow, blue, green and dark. Callus growth and anthocyanin biosynthesis were promoted by long-day conditions (16-hour photoperiod or longer). The calli grown in Schenk & Hildebrandt (SH) medium continuously (SH→SH) showed the best growth whereas the highest amount of anthocyanin biosynthesis was obtained in the calli grown in SH→SH or SH→White media.
알레르기성 소인이 없는 정상인에서 특이 알레르겐항체 양성율
남해선,안현철,박준수,황규윤,박춘식 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
This study was designed to evaluate prevalence of allergen-specific antibodies in healthy adults. During Mar. ~ Aug. 2001, 1,925 subjects visited for medical check-up, were inquired to fill out a standardized questionnaire. Among them, 200 subjects who had no current and past allergic disorders were randomly selected for rhe current study and examined for allergen-specific antibodies using Korean inhalant panel of MAST-CLA allergen-specific IgE assay. Among them, 170 persons (85.0%) did not have any positive allergen-specific antibody. Each positive rate of 35 allergen specific antibodies was usually less than 3%, except Cockroach Mix (3.5%), Dermatophagoides farinae(8.5%), Dermatophagoides pteronyssinus(6.0%). Among 30 positive subjects, 19(63.3%) showed one or two allergen-specific antibodies. Although atopic subjects in non-allergic population were not common, few of them showed allergen-specific antibodies in Korean inhalant panel of MAST-CLA. Our results suggested that the standardized questionnaire and MAST-CLA could be an useful tool of a screening test for allergy, showing high specificity and sensitivity.
수정 몬테칼로법에 의한 鐵筋콘크리트 보의 離散形 最適設計
김유식,이해은,박경현 大田産業大學校 1999 한밭대학교 논문집 Vol.16 No.1
In this study, our effort has been made to review the economics design for the discrete optimum design of the R. C. beam section by modified Monte carlo method. In this discrete optimum formulation, the design variables are the overall depth, width and effective depth of beams and area of longitudinal reinforcement. Total weight has been used as the objective function. The constraints include the code requirements such as flexural strength and steel ratio. The proposed algorithm is applied to a test problem for reliability, and the results are compared with the Monte carlo optimum design and the modified Monte carlo optimum design by strength design method As a result of calculation, In the optimum convergence by the each method, it was very earlist on the case of 5cm unit. Optimum weight was very light in the case of 2cm unit. In the study, Our know to possible of design by the optimum design based on modified Monte carlo method.
朴載植,朴海根 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1
It is generally accepted that ethanol has the diuretic action in the human beings by the inhibition of ADH(antidiuretic hormone) secretion. However, contribution of ethanol to body fluid change and blood ethanol curve in the rat has not been studied satisfactorily. Thus, the following experiment was performed to examine the change of blood ethanol concentration and the body fluid after ethanol administration in the Sprague Dawley female rats which were divided into 2 groups: control and ethanol-administered group. A single dose of one ml of 25% ethanol (ethanol group) or water(control group) per 100gm body weight was administered. On the day of experiment, the rat was anesthetized with ether and catheterized in the femoral artery for sampling of arterial blood. The catheter was filled with heparin solution. Blood sampling was done at least 3 hours after the surgery. Blood ethanol concentration was measured by the alcohol dehydrogenase enzyme method and ADH by radioimmunoassay. The results obtained are summarized as follows. The formula representing the blood ethanol concentration, C(mg/dl), after ethanol administration as a function of time, t(hour), was C=126.57(1-e^-2l.036t)-16.59t and showed more rapid absorption and metabolism of ethanol in the rats than in human beings. Plasma ADH concentration was 3.4±0.4pg/ml at rest but was decreased significantly at 30 and 120 minutes after ethanol administration. A gradual decrease in hematocrit was produced by continuous blood sampling but ethanol group showed higher hematocrit values than control. A significant increase of corrected osmolality was observed compared with the control, particularly at 30 and 60 min after ethanol administration and urine volume was also increased in the first 2 hours. From these results it was concluded that in the rats the rates of ethanol absorption and metabolism was rapid and ADH secretion was decreased for 2 hours after ethanol administration. Subsequently, the solute free urine volume and corrected osmolality was increased followed by plasma volume shift from the vessel. After 2 hours, though blood ethanol concentration was still high, corrected osmolality and urine volume was recovered to the original value.