충격파 이론에 의한 이온교환 공정의 해석

金海星 명지대학교 1982 明大論文集 Vol.13 No.-

A theoretical study of the shock wave is presented for ion exchange of one-dimensional, fixed bed, single solute system. Experimental time-domain analysis enables us to demonstrate the validity and usefulness of the shock layer theory by introducing theoretical propagation speed of shock layer into exchange phenomena. Shock wave theory is applied to the Nickel-Cation resin system and valuable informations are discussed quantitatively in the view-points of operation and design of ion exchange column.

용매추출계의 조작특성 연구

金海星 명지대학교 1978 明大論文集 Vol.11 No.-

The dynamic behavior of a pulsed sieve-plate extraction column was investigated in time domain by analyzing the transient response of both diffusion model and backflow model for a step change. The suitability of two models for a pulsed sieve-plate extraction column was examined in HNO_3-Water-30% TBP dodecane system by comparing the transient behavior and steady-state concentration profile of the two models in time domain with those of theoretical results.

액적 형성 기구에 관한 연구

金海星 명지대학교 1983 明大論文集 Vol.14 No.-

액-액계의 용매추출탑에서 맥동에 의한 액정형성기구 및 액적크기 예측을 규명하였다. 본 연구에서는 맥동의 주파수, 진폭 및 맥동 속도의 변화에 따른 액적크기를 kerosene-Sodium hydroxide계에서 Hexamethylene Diamine에 의한 Encapsulation Technique Drop formation models were formulated in the pulsed liquid-liquid contacting column on the basis of force balance and momentum balance, and theoretical values were compared to experimental values which were determined by means of encapsulation technique in the aqueous-kerosene system. Our results conformed that drop formation mechanism is composed of two-step process, and that momentum balance model is superior to force balance model. According to the dependency of drop size on pulsing amplitude and frequency, the drop diameter tended to decrease with the increase of pulse velocity.

적혈구 Pyrimidine 5'-Nucleotidase 활성도의 참고치에 관한 연구

김종연,김해준,장성훈,김광종 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

For the purpose of determining the reference value of erythrocyte pyrimidine 5'-nucleotidase(P5N) activity as a biological indicator to lead exposure, this study was conducted on the total of 225 healthy men who had not been exposed to lead occupationally, in July, 1994. The parameters selected in this study were age, hemoglobin, hematocrit, number of red blood cell, mean corpuscular hemoglobin(MCH), mean corpuscular hemoglobin concentration(MCHC), blood lead, and erythrocyte P5N activity. The blood lead concentrations were measured using a flameless atomic absorption spectrophotometer, and erythrocyte P5N activities by Sakai's simple method using a HPLC(1986). The results were obtained as follows ; 1. The distribution of blood lead concentrations revealed log-normal distribution, and geometric mean and standard deviation of blood lead were 4.09 ㎍/dl and 1.55㎍/dl, respectively. 2. The erythrocyte P5N activity showed normal distribution, and the mean and standard deviation of the erythrocyte P5N activity were 12.34 μmole uridine/h/g Hb, respectively. 3. All of the selected variables including blood lead concentration did not affect the erythrocyte P5N activity. Although the erythrocyte P5N activities were negatively associated with blood lead level, the correlation coefficient was not statistically significant. 4. From the result of this study, 8.7 μmole uridine/h/g Hb was obtained as a reference value of erythrocyte pyrimidine 5'-nucleotidase activity for the healthy adult male who had not been exposed to lead occupationally.

원발성 두개골내 수막종 : 1예 보고 A Case Report

김대호,홍현숙,조준희,박재성,박성진,차장규,백상현,이혜경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Primary intraosseous meningioma of skull is rare, and often confused with a primary bone tumor. We report a case of a 71 years old female patient with an intraosseous calvarial meningioma of frontal bone presenting as a solitary osteolytic skull lesion. Plain skull radiograph, CT and MR images show sharply marginated expansile bony lesion in frontal skull vault, and a small well enhanced soft tissue mass within bone. The mass is extracranially protruded to scalp, and is partially attached to the underlying dura. Outer and inner table of skull vault is slightly bulged out, suggesting intradiploic origin of the tumor. The tumor was treated with surgical excision and cranioplasty. Histological examination revealed fibrous meningioma.

신동맥 협착 정도에 따른 도플러 초음파 소견

박재성,이혜경,김대호,최득린,권귀향,홍현숙,임한혁,김기정 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

Renal artery stenosis is the one of causes of hypertension in a small percentage of all patients but is only anatomical cause that can be treated by means of surgery and percutanecous transluminal angioplasty. Angiography is the golden standard for diagnosis of renal artery stenosis, but a little invasive. With the advent of abdominal Doppler ultrasonography, renal artery stenosis could be diagnoed noninvasively. The experienced hands appears to be valuable in the doppler examination, ut some investigators consider it almost useless. The authors studied the effect of stenosis of renal artery on the downstream intrarenal blood flow, a snare was placed around renal artery in 12 rabbits and compressed to create stenosis while Doppler ultraonographic curve and flow index were obtained from main renal and interlobar arteries by means of placement of 10-MHz curved linear tranducer directly on the surface of kidney. The Doppler measurements were compared with the percentage of stenosis on angiograms. The results were as follow: 1. Ten satisfactory angiograms and Doppler ultrasonograms were obtained. 2. Three renal arteries were created stenosis below 70% (Group A), Seven were above 70% (Group B). 3. The ranges of RI (resistance index) were 0.61-0.86 (mean 0.78±0.154) at main renal arteries, 0.57-0.85 (mean 0.77±0.231) at interlobar artery. The range of PS (peak systolic velocity) were 13.1-28.8 (mean 21.65±4.445) m/sex at main renal artery, 5.2-18.1 (mean 11.74±4.095) m/sec at interlobar arteries. The RI of rabbits were higher than those of human (mean 0.58±0.05). 4. The range of RI in stenotic arteries of group B were 0.45-0.74 (mean 0.57±0.143) at main renal artery, 0.52-0.65 (mean 59±0.051) at interlobar arteries. The range of PS were 11.2-21.3 (mean 15.04±3.755) m/sec at main renal arte교, 5.7-11.3 (mean 8.24±2.056) at interlobar artery. The difference were statistical y significant (P=0.0302), but without remarkable change in group A. 5. Doppler ultrasonographic curve during progressive compression of renal artery showed dampened systolic waveform and diagonal upstroke at main renal arteries (71.4%) and interlobar arteries (85.7%) in group B, but without remarkable change in group A. 6. Release of the arterial compression caused higher than normal peak systolic velocity initially, at main renal arteries (42.9%) and interlobar arteries (28.6%). but the curve of all rabbits returned to normal within 5 minutes. The Doppler ultrasonographic index and curve were not changed on follow up Doppler ultrasonogram at 5 min. 10 min. 30 min. and 1 hour. The change of the systolic curves that compressed experimentally is identical to change in the pulsus tardus and parvus waveforms seen in both acute and chronic severe renal artery stenosis in humans, can helpul for the diagnosis of renal artery stenosis and the effects of treatment by percutaneous tranluminal angioplasty and surgery.

CT 유도하의 경피적 폐생검 : 임상적 의의 및 합병증에 관한 연구 A Study of Clinical Significance and Complication

박재성,백상현,차장규,홍현숙,김대호,박성진,조준희,임한혁,이혜경 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose : To determine the diagnostic accuracy and predicting factor of pneumothorax on CT-guided percutaneous transthoracic needle biopsy. Materials and Methods : Using automated biopsy devices, 107 CT-guided percutaneous needle biopsies of pulmonary lesions were performed. Final diagnosis was made with operation or other methods. We retrospectively analyzed the frequency of complications and diagnostic yields of 107 biopsies. The clinical features, treatment, and courses of complications were reviewed, and risk factors of pneumothorax such as depth and size of lesion, CT emphysema score of whole lung and pathway of needle, and the result of pulmonary function test were analyzed. Result : 96 biopsies(89.7%) yielded sufficient tissue for pathologic evaluation. For cases of malignant and benign disease, sensitivity was 91.5% and 87.5% respectively; the corresponding figures for diagnostic accuracy were 88.1% and 77.1%. So, sensitivity and diagnostic accuracy of percutaneous transthoracic needle biopsy was 89.7% and 83.2%. Eighteen(16.8%) of 107 patients developed pneumothorax and 3 of these required application of chest tube or percutaneous catheter drainage. In the group with pneumonthorax, the lesion was significantly smaller(p=0.029) and higher CT emphysema score of pathway of needle(p=0.032). But there were no significant difference between two groups(with or without pneumothorax) for depth of lesion, pulmonary function test(% predictive value of FEV1 and FEV1/FVC) and CT emphysema score of whole lung. Conclusion : CT-guided transthoracic needle biopsy of the pulmonary lesions is safe and easy method of obtaining specimens of good quality and quantity. It may be an useful procedure in the diagnosis of localized pulmonary lesions. For the prediction of pneumothorax, size of lesion and CT emphysema score of pathway of a needle are significant risk factors.

자주달개비 미세핵 분석법을 이용한 비스페놀 에이 및 감마선의 생물학적 영향 비교 연구

신해식,송희섭,현성희,이진홍,김진규 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.2

합성화학물질의 몇몇은 고등동물의 내분비계를 교란하는 물질로 작용하는 것이 알려져 있다. 다이옥신,디디티,피시비 및 비스페놀 에이 등이 내분비계 장애물질로 분류되어 선진 각국에서는 엄격한 통제하에 관리되고 있다. 본 연구는 자주달개비 미세핵 분석법을 이용하여 염색체이상 유발에 있어서의 BPA와 방사선의 상대적 효과를 비교하기 위하여 시행되었다 흡수처리를 위하여 자주달개비 4430클론의 절취화서를 각각의 농도로 조제된 BPA용액에 여섯시간 동안 침지하고 폭기를 실시하였다. 한편 방사선의 영향을 평가하기 위하여 동일 식물체의 화서군을 양액에 침지한 상태로 O∼0.5 Gy까지 선량별로 조사하였다. 실험선량의 범위에서 미세핵 생성률은 분명한 선량-반응 관계를 나타내었으며 BPA 실험농도 범위에 대해서도 농도-반응 관계를 나타내었다. 이들 두가지 반응 관계식을 이용하여 동일한 미세핵 빈도를 유발하는 방사선량과 비스페놀 에이 농도를 산출할 수가 있는데, BPAll.8μM은 방사선 피폭후 임상증상이 나타나기 시작하는 선량인 0.25Gy에 상응하는 염색체 이상을 유발하는 것으로 확인되었다. 본 연구의 결과를 통하여 자주달개비 화분모세포는 비스페놀 에이, 욱틸페놀 또는 노닐페놀 등의 내분비계 장애물질의 생물학적 독성을 평가하는데 유용하게 활용할 수 있는 생물말단 점이라는 것이 입증되었다. Some of synthetic chemicals can act as an endocrine disrupting substance in higher animals. Dioxins, DDT, PCBs and bisphenol A (BPA) are classified into endocrine disruptors and are under a strict control in many countries. This research was designed to compare the clastogenic effects of BPA to those of ionizng radiation to establish the relative effectiveness of BPA by means of Tradescantia micronucleus assay. For the uptake of the BPA through the stems, groups of fresh cuttings of Tradescantia BNL 4430 were placed in BPA solutions of 0 to 4 ??M for 6 hours under continuous aeration. The other groups of the cuttings were irradiated with 0 to 0.5 Gy of gamma-rays. The frequencies of micronucleus showed a positive dose-response relationship in the range of 0 to 0.5 Gy, and a clear concentration-response relationship in the experimental range of BPA concentrations. By comparing the two experimental results, it is possible to estimate the BPA concentration and its equivalent radiation dose for a fixed value of MCN frequency. BPA of 11.8 ??M can give rise to 53.3 MCN/100 tetrads, which is the same frequency induced by 25 cGy of gamma-rays. It is of biological importance that clinical symptoms start to develop after a whole body exposure to radiation higher than 25 cGy. The results indicate that the pollen mother cells are an excellent biological end-point for toxicity test of suspected endocrine disrupting chemicals such as bisphenol A, cotylphenol and nonylphenol.

간질발작후 MRI 영상에서 뇌 종창을 보인 3예 보고

홍현숙,김대호,이혜경,박재성,박성진,조준희,차장규,백상현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

We report seizure induced brain swelling in three patients. MRI revealed a cortical, subcortical(3/3), and basal ganglia(2/3) high signal intensity on T2- weighted and FLAIR images. The lesion shows low signal on T1-weighted image, and enhanced after contrast administration. Follow up study after 27 days in one case revealed complete resolution of the lesion. The reversible MRI findings may be the results of a local brain swelling, breakdown of blood-brain permeability, and a defect of cerebral autoregulation during seizure activity. The transient nature of such findings have to be considered in the differential diagnosis such as reversible ischemia, migraine, inflammation and infection.

Caffeic Acid의 ONOO^(-) 제거활성

이지영,성도유,노재경,김유정,제정환,김민선,최재수,정해영,이경희 대한암예방학회 2003 Journal of cancer prevention Vol.8 No.3