PC-766B' and PC-766B, 16-Membered Macrolide Angiogenesis Inhibitors Produced by Nocardia sp. RK97-56

KO, HACK-RYONG,KAKEYA, HIDEAKI,YOSHIDA, ARIKA,ONOSE, RIE,UEKI, MASASHI,MUROI, MAKOTO,TAKATSUKI, AKIRA,MATSUZAKI, HIROSHI,OSADA, HIROYUKI 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.5

Angiogenesis is an essential event in a variety of physiological and pathological processes. Therefore, effective inhibition of event is a promising strategy for treating angiogenesis-related diseases, including cancer. The current study investigated two unique bafilomycin-type macrolide inhibitors of angiogenesis, PC-766B' (1) and PC-766B (2). The strain RK97-56 which produced the inhibitors was identified as Nocardia sp. by chemotaxonomic analyses, and the purification of the inhibitors was guided by their anti-angiogenic actives. PC-766B' (1) and PC-766B (2) exhibited potent inhibitory activities towards endothelial cell migration stimulated by the vascular endothelial growth factor(VEGF).

외상후 발작의 위험인자에 대한 조사

이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.

Growth of iron-doped quartz

김학수 부산대학교 1973 論文集: 自然科學篇 Vol.16 No.-

한국정부의 지방행정조직과 관리분석

李學守 대구효성가톨릭대학교 1996 연구논문집 Vol.53 No.1

In this study organizational structure and adminstrative agencies of local government in Korea are reviewed as a theoretical and empirical survey to see organizational analysis in governmental management. This paper is composed of following chapters. Chapter one is a step on a preface which defines ovjects and method of this study, and chapter two is a step on theoretical analysis and framework of local governmental organizations. Chapter three is a step on empirical basis of organizations, agencies and managment in local government, and chapter four is a conclusion about this paper. The ultimate findings are the follows, that is, that it is important to study between administrative areas and hierarchied in organizational side. And the above results directly have been influesced the composition and managment of administrative agencies in local government. Especially this will be a framework to analyze local organizations and management in Korean government.

組織의 變化 및 行政發展에 關한 硏究

李學守 대구효성가톨릭 대학교 1983 연구논문집 Vol.27 No.1

It is surprising that changes in modern society are not only inevitable, but have vastly accelerated in both pace and diversity. According to such changes organizational change in Public Administration has been required to a high degree. It is because organization is closely related with society. (cf. Figure 3) Generally, organizational change is a phenomenon which is altered from primary state to next state as a result of having an active or passive effect on social change and the factors within an organization, under the character of system composed of achieving certain goals. Organizational change is a function relationship of internal and external variables, and processes of changer consists of four stages, that is, evaluation stage, initiation stage, implementation stage and routinization stage. This paper is composed of following chapers. Chapter one is a step on analysis of inevitability of change, concept analysis, variable analysis levels and processes of organizational change. Chapter two is a step on analysis of relationship between organizational change and administrative development. Chpter three is a step on synthesis of organizational change. Ultimately organizational change brings on administrative developmment which is related to nation's development. At last the ultimate findings of this study is that organization has been changed to adapt and is reached to developmental state through such processes.

한국정부론의 연구영역에 관한 비교 고찰(Ⅰ)

李學守 대구효성가톨릭대학교 1988 연구논문집 Vol.37 No.1

This study analyzes the subjects and objects of Korean government and politics with the reviews of comparative government and politics through domestic and foreign books. And, with the results of this study, I want to have a book of my own about fields of government and politics in Korea. And, with the results of this study, I want to have a book of my own about fields of government and politics in Korea. The method of this study is the literature survey by articles and books about it. Chapter one is the introduction on this study, and chapter two is comparative review of domestic books, and chapter three is comparative review of foreign books. Chapter four is the conclusion, and that it has the proposed contents of study on government and politics in Korea. Ultimately the findings of this study propose the fields of study of government and ploitics in Korea, and that are as follows. 1. Introduction This chapter explains the necessity and role of government, culture, bureaucracy and political environment. 2. Fundamental theory of government. This chapter is analyzed the political socialization and the patterns of major political systems, ideology, methodology, and principles 3. Major tools of control. This chapter is described the controlled tools, which is used, for examples, election and parties, public opinion, recruitment of elites, etc. 4. Structures and operation of government. This chapter is analyzed the structure for managing the government. 5. Changes and development of Korean government. This chapter is reviewed the historical sides of Korean government and politics. 6. Management and policy making of Korean government. This chapter is analyzed the implementation and management with policy management and decision. 7. Prospects of Korean government. This chapter is suggested the future of Korean government.

정부개혁의 배경에 대한 비교고찰

이학수 대구효성가톨릭대학교 현대사상연구소 1999 현대사상연구 Vol.9 No.-

This study has the focus on background of innovations in governmental level. And then I analyze the following fields here. ① as a preface, define the object and scope of study ② characteristics of governmental innovation ③ background of governmental innovation ④ prospects and conclusion Ultimately the goal and direction of governmental innovation are based on high effectiveness, democracy and equality of public management. And additionally the personnel, financial and policy innovation with public organization as well as political, economical and social innovation are included in governmental innovation.

한국행정의 연구(Ⅱ) : 행정조직과 관리론을 중심으로 In Focus on Public Organization and Management

李學守 대구효성가톨릭대학교 1990 연구논문집 Vol.41 No.1

The public organization and management of Korean administration is analyzed in thin study, and this thesis is the continuation of a study on Korean administration (Ⅰ). This paper is composed of following chapters, that is, chapter one is described on the analysis of organizational fields, chapter two is anaylzed the part of organizational management. The purpose of this study is reformed the field-analysis of public organization and management.

음향 임펄스 응답을 이용한 비파괴 검사

김학윤,이근만 청주대학교 산업과학연구소 1998 産業科學硏究 Vol.16 No.-

The acoustic impulse response was studied in order to evaluate qua1ity Initially, the linearity and effects of sample holding conditions on the acoustric signals were demonstrated. Secondly, acoustic signals were obtained at points whlch divide the equator of the sample into 24 equal parts. As a result of the ana1yses, it become evident that the impulse waveform of acoustic signals induced by impact was transmitted along the equator with uniform velocity. The lower transmission velocity in the time domain agreed with the lower peak frequency domain, both theoretically and practically.

벤처기업 성공요인의 중요도

송학진,박영호 동의공업대학 1999 論文集 Vol.25 No.1

This study reports the importance of success factors for high-tech ventures based on the survey of DIT Business Incubator's ventures. We classified the success factors of high-tech ventures into four major groups and inquired about K and D ventures of DIT Business Incubator. The AHP method was applied to analyze the data. The result of analysis shows that the adequate opportunities(market opportunity, technical opportunity) and the resources security(technical resources, man power resources) are very important factors for high-tech ventures' success.