자궁내막암 환자의 재발여부 확인에 있어 FDG-PET scan 의 유용성에 대한 고찰

홍성진 ( Hong Seong Jin ),이삼미 ( Lee Sam Mi ),박천숙 ( Park Cheon Sug ),김호아 ( Kim Ho A ),김법종 ( Kim Beob Jong ),김문홍 ( Kim Mun Hong ),최석철 ( Choe Seog Cheol ),유상영 ( Yu Sang Yeong ),이경희 ( Lee Gyeong Hui ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.2

목적 : Inhibin은 α-subunit와 β-subunit로 구성된 이질 이량체의 당단백으로 β-subunit의 차이에 의해 inhibin A (α-βA)와 inhibin B (α-βA)로 구분된다. 여성에서 inhibin은 주로 난소의 과립막세포 및 황체에서 생산되어 뇌하수체의 FSH 분비를 억제한다고 알려져 왔으나, 임신중 태반과 남성의 고환에서도 생산된다는 사실이 밝혀져 다양한 생리적 작용이 추정되고 있으며 최근에 inhibin A와 B를 분리 측정할 수 있는 방법이 개발되어 inhibin에 대한 연구가 활발히 진행되고 있다. 이에 저자들은 정상 월경주기를 가진 가임기 여성, 폐경이행기 여성, 폐경후기 여성에서 inhibin A와 inhibin B의 농도를 측정하여 월경주기에 따른 정상치의 변화와 노화에 따른 농도 변화를 관찰하고, 난소에서 면역조직화학적 염색법으로 inhibin A와 inhibin B의 발현 양상과 변화를 비교 관찰하여 inhibin의 정확한 생리작용, 폐경이행기에서 inhibin의 역할 및 폐경이행기와 폐경의 예측 지표의 사용 가능성을 알아보고자 하였다. 연구 방법 : 월경주기와 난소기능이 정상이면서 난소종양이 없는 정상 가임기 여성 160명, 폐경이행기 여성 60명, 폐경후기 여성 20명에서 정맥혈을 채혈하여 혈중 inhibin A와 inhibin B 농도를 ELISA로 측정하였고, 그중 정상 가임기 여성 35명, 폐경이행기 여성 20명, 폐경기 여성 5명의 난소 조직을 inhibin α, βA 및 βB subunit에 대한 단클론 항체를 이용하여 면역조직화학적 염식을 시행하였다. 결과 : 1. 정상 가임기 여성에서 혈중 inhibin A 농도는 중증식기까지 낮은 농도를 유지하다 후증식기 (16.53±1.57 pg/ml)부터 증가하기 시작하여, 중분비기 (45.85±2.08 pg/ml)에 최고치에 이른 후 서서히 감소하는 경향을 보였다. Inhibin B 농도는 전증식기 (65.40±4.08 pg/ml)부터 증가하기 시작하여 증식기 동안 계속 높은 농도를 유지하다가 배란기 (110.74±9.83 pg/ml)에 최고치에 이른 다음 분비기에 급격히 감소하였다. 2. 폐경이행기 여성에서 혈중 inhibin A 농도는 증식기에 6.68±0.53 pg/ml, 분비기에 21.78±3.61 pg/ml로 모두 정상 가임기 여성과 비교하여 유의하게 낮았다 (P<0.01). Inhibin B의 농도는 증식기에 52.16±7.46 pg/ml, 분비기에 22.41±6.73 pg/ml로 모두 정상 가임기 여성과 비교하여 유의하게 낮았다 (각각 P<0.01, P=0.025). 3. 폐경후기 여성에서 inhibin A와 inhibin B 농도는 모두 검출되어 않았다. 4. 정상 가임기 여성에서 inhibin α subunit의 면역염색반응은 과립막세포, 난포막세포 및 황체에서 강하게 발현되었다. Inhibin βA의 면역염색반응은 난포에서는 거의 발현되지 않았으나 황체에서는 관찰되었다. Inhibin βB의 면역염색반응은 일차난포에서 처음 발현되어 성장난포와 성숙난포의 과립막세포와 난포막세포에서 관찰되었으나 Inhibin α보다는 약했고 황체에서는 거의 관찰되지 않았다. 5. 폐경이행기 여성에서 inhibin subunit들의 면역염색반응은, 정상 가임기 여성과 같은 양상으로 발현되었으나, 발현정도는 약했다. 모든 면역염색반응은 과립막세포보다 난포막세포에서 더 강하게 나타났다. 6. 폐경후기 여성에서 inhibin subunit들의 면역염색반응은 전혀 관찰되지 않았다. 결론 : Inhibin A는 후증식기 성숙난포에서 처음 생산되기 시작하여 배란 후 황체에서 주로 생산되며, Inhibin B는 일차난포에서 생성되기 시작하여 배란 시까지 분비되므로 inhibin A는 황체기능을, inhibin B는 난포의 기능을 반영한다. 폐경이행기가 되면 inhibin A와 B의 분비는 급속히 감소하게 되어 폐경 후에는 난소에서 생성되지 않는다. 따라서 inhibin A와 B는 여성의 월경주기에 따라 생산과 분비가 서로 다른 호르몬으로 난자 성숙과 난포발달에 관여하며, 난소의 노화 정도를 측정하는 폐경이행기의 지표로 이용될 수 있을 것이다. Objective : To understand the physiologic effects and secretion pattern of inhibin A and inhibin B during menstrual cycle and menopausal transition, inhibin A and inhibin B levels were measured. And to detect any changes in expression of inhibins in human ovary with age, we examined immunohistochemical staining of α, βA, and βB subunits of inhibin in ovarian tissues. This study was also designed to investigate whether or not inhibin is an early marker for menopausal transition. Methods : Inhibin A and inhibin B levels were measured in 320 samples from normal reproductive women, in 60 from perimenopausal women, and in 20 from menopausal women by ELISA. And we examined the immunohistochemical staining of α, βA, and βB subunits of inhibin in ovarian tissues of 35 normal reproductive, 20 perimenopausal, and 5 menopausal women, respectively. Results : In the normal reproductive women, inhibin A begins to increase in the late proliferative phase (16.53±1.57 pg/ml), reaches the peak in the mid-secretory phase (45.85±2.08 pg/ml), reaches the peak in the ovulatory phase (110.74±9.83 pg/ml), reaches the peak in the ovulatory phase (110.74±9.83 pg/ml), and thereafter declines rapidly. In the perimenopausal women, mean inhibin A serum concentration was 6.68±0.53 pg/ml during proliferative phase and 21.78±3.61 pg/ml during secretory phase, which were significantly lower than that of the same phase in the normal reproductive women (P<0.01). Mean inhibin B serum concentration was 52.16±7.46 pg/ml during proliferative phase and 22.41±6.73 pg/ml during secretory phase, which were significantly lower than that of the same phase in the normal reproductive women (P<0.01, P=0.025). In the menopausal women, both inhibin A and inhibin B were not detected. In the normal reproductive women, we observed strong immunostaining for α subunit in granulosa cells, theca cells, and corpus luteum. Immunostaining for βA subunit was observed in corpus luteum, but not in growing follicles. Immunostaining for βB subunit was observed in primary follicle, granulosa and theca cells of growing follicle, and mature follicle, but less strong than immunostaining for α subunit. No staining for βB subunit was observed in the corpus luteum. In the perimenopausal women, immunostaining for inhibin subunits were observed in the same pattern as that of the normal reproductive women, but weaker. Stronger immunostaining was observed in theca cells than granulosa cells. In the menopausal women, none of the immunostaining of inhibin subunits were observed.

Polyphenolic compounds from Korean <i>Lonicera japonica</i> Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells

Park, Kwang Il,Park, Hyeonsoo,Nagappan, Arulkumar,Hong, Gyeong Eun,Yumnam, Silvia,Lee, Ho Jeong,Kim, Eun Hee,Lee, Won Sup,Shin, Sung Chul,Kim, Jin A,Lee, Sang Joon,Ma, Jin Yeul,Min, Taesun,Heo, Jeong D.A. Spandidos 2017 Oncology letters Vol.13 No.4

<P><I>Lonicera japonica</I> Thunb. (<I>L. japonica</I> T.) has historically been used in Korean herbal medicine due to its anticancer and protective effects on the respiratory system. In the present study, the polyphenolic compounds in <I>L. japonica</I> T. were investigated using high-performance liquid chromatography coupled with tandem mass spectrometry, and its anticancer effects on A549 non-small-cell lung cancer cells were studied. Polyphenolic compounds potentially inhibit A549 cells in a dose-dependent manner. Flow cytometry and western blot analysis demonstrated that polyphenolic compounds induce apoptosis by regulating the protein expression levels of caspases, poly-(ADP-ribose) polymerase and the B-cell lymphoma-2-associated X-protein/B-cell lymphoma-extra large ratio. Furthermore, polyphenolic compounds inhibited mitochondrial membrane potential activity. Caspase-3 activity was increased in a dose-dependent manner and polyphenolic compounds inhibited the activation of protein kinase B by dephosphorylation. These results suggest that polyphenolic compounds in A549 cells indicate the anticancer activity through the induction of apoptosis.</P>

간호사의 셀프리더십과 간호업무성과간의 관계

서문경애,장성옥,조경희,김인아,이수정 대한간호학회 간호행정학회 2006 간호행정학회지 Vol.12 No.1

Purpose: This study was undertaken in order to suggest self-leadership as a way to promote organization efficiency of nursing organization. So the relation between self-leadership and outcome of nursing practice inorganization was studied. Method: The subjects of study were nurses as a population who were working for the 2 of university hospitals which have over 500 beds in Kyong Ki Province as well as who have been working for over 6 months. The data was collected by questionnaires from 215 nurses and analyzed using descriptive statistics, perason correlation coefficient, t-test and ANOVA on SAS Program. Results: Self-leadership of nurse got 3.51 grade out of 5 as a mean point. Each of the segments got 3.74 in self-compensation, 3.57 in self-expectation, 3.53 in goal-setting, 3.45 in rehearsal, 3.37 in self-criticism and 3.30 in constructive thinking in order. Independent performance of nursing practice at each items of outcome of nursing practice showed the highest correlations with the self-expectation among self-leadership segments. Constructive thinking, self-compensation, rehearsal, goal-setting were related like this in order, but self-criticism was related just a little. Dependent nursing practice has the highest correlation with the self-expectation, goal-setting, rehearsal, constructive thinking, self-compensation were similar as aboves in order, but self-criticism didn't show any similar correlations. Relationship practice has the highest correlation with the self-expectation, and goal-setting, constructive thinking, self-compensation, rehearsal were similar, while self-criticism did not show any correlations. Conclusion: In conclusion the result was obtained that self-leadership is much correlated with outcome of nursing practice. Therefore, as a way to promote efficiency of nursing organization, the constant study about self-leadership with the various aspects is needed focusing on self-management and inner motivation as a new leadership paradigm.

금매와 매화 잎 추출물의 프리라디칼 억제 활성 및 항암 효과

노규아(Kyu-A Rho),김경지(Gyeong-Ji Kim),지현아(Hyun-A Ji),임한솔(Han-Sol Lim),정강현(Kang-Hyun Chung),이권재(Kwon-Jai Lee),송병춘(Byeong Chun Song),안정희(Jeung Hee An) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.8

본 연구는 금매와 매화 잎의 열수, 냉수, 아세톤, 에탄올, 에틸아세테이트, 클로르포름, 헥산 추출물의 총 폴리페놀, 플라보노이드, 탄닌 함량을 측정하고 DPPH와 ABTS 라디칼소거활성, 환원력을 측정하였으며 세포보호 효과 및 항암활성을 분석하였다. 총 폴리페놀 함량은 금매와 매화 잎의 에탄올추출물에서 각각 336.41과 523 mg GAE/100 g의 가장 높은 함량을 보였다. 총 플라보노이드와 탄닌 함량은 금매보다 매화 잎이 전체적으로 높은 함량을 나타냈다. DPPH 라디칼과 ABTS 소거능에서는 금매의 농도가 증가함에 따라 활성이 증가하였다. 매화 잎 에탄올추출물은 200 μg/mL 농도에서 DPPH 라디칼 소거능이 65.48%로 가장 높았고 ABTS라디칼 소거능에서는 매화 잎의 전 추출물에서 높은 활성을 보여주었다. 환원력에서는 금매와 매화 잎의 농도가 증가함에 따라 활성이 증가하였다. H₂O₂에 의해 유도된 산화적 손상에 대한 세포의 보호 효과에서 금매는 보호 효과가 나타나지 않았으나 매화 잎의 전 추출물에서 보호 효과를 보였다. 금매와 매화 잎은 에틸아세테이트, 클로르포름, 헥산, 에탄올 추출물에서 A549, HeLa, U87 세포의 높은 종양 억제능을 보였으나 에틸아세테이트, 클로르포름, 헥산 추출물은 간 정상세포(BNLCL2)에서 세포 독성을 보였으나 에탄올추출물만 간 정상세포에서 안정한 세포 생존율을 보였다. 본 연구의 결과, 금매와 매화 잎의 추출물에서 높은 항산화력은 폴리페놀 함량이 밀접하게 관여한 것으로 보인다. 본 연구에서는 금매와 매화 잎의 추출물은 항산화와 항암 기능성식품 소재로서의 개발 가능성이 있다고 보인다. This study investigated the free radical-scavenging and antitumor activities of hot water, water, acetone, ethanol, ethyl acetate, chloroform, and hexane extracts of fruits and leaves from Prunus mume. The various extracts were evaluated for their total polyphenol, flavonoid, and tannin contents, scavenging activities by DPPH and ABTS analyses, reducing power, protective effects against oxidative stress in L-132 cells, and antitumor activities against A549, HeLa, and U87 cancer cells. Ethanol extracts of fruits and leaves showed the highest total polyphenol content (336.41 and 523 mg GAE/100 g, respectively). DPPH and ABTS radical-scavenging activities increased according to concentration of fruit. DPPH radical-scavenging activity of ethanol extracts from leaves was 65.48% at 200 μg/mL. All extract fractions of leaves showed high ABTS radical-scavenging activities. The reducing power activities increased according to increasing concentration of fruits and leaves. All extracts of leaves performed better than extracts of fruits in terms of protective effects against oxidative stress in L-132 cells. Ethyl acetate, chloroform, hexane, ethanol extracts of fruits and leaves showed anticancer activities against A549, HeLa, and U87 cancer cells. However, ethanol extracts of fruits and leaves showed no toxicity in normal cells (BNLCL2). This study suggests that antioxidant activities of fruits and leaves from P. mume depend on polyphenol contents. Thus, fruits and leaves from P. mume can be useful as natural antioxidant compounds.

예비유아교사를 위한 디지털 역량 증진 교육 프로그램 개발 및 효과

박소영,권승아,김민지,김한빛,이혜린,한나경,윤소망,정문경 이화여자대학교 교육과학연구소 2023 교육과학연구 Vol.54 No.4

본 연구는 예비유아교사 대상의 디지털 역량 증진 교육 프로그램을 ADDIE 모형에 근거해 개발하고 효과를 분석함으로써, 예비유아교사가 향후 교육현장에서 디지털 매체와 테크놀로지를 수업설계, 교수ㆍ학습과 놀이지원 등에 원활하게 적용하고 발현적으로 활용할 수 있도록 하는 데 목적을 두고 있다. 이를 위해 선행연구 및 문헌고찰을 통해 예비유아교사의 디지털 역량을 디지털 기기의 교수적 활용, 디지털 정보 활용, 디지털 콘텐츠 제작 및 플랫폼 활용, 디지털 페다고지로 설정하고, 각 역량별로 하위역량을 설정하였다. 또한 학습자 분석을 위해 A대학 유아교육학과 2, 3학년에 재학 중인 106명의 학생을 조사하였고, 교육 프로그램의 설계 및 개발 단계에서는 전문가 7인의 두 차례 검토를 거쳐 교육목표와 교육내용, 수업 주제와 방법, 수업의 구체적인 내용을 도출하였다. 최종 교육 프로그램은 총 5주간 10시간에 걸쳐 총 45명의 예비유아교사를 대상으로 시행되었으며, 교육의 효과성 및 학습자의 내면 변화를 파악하기 위해 37개 문항으로 구성된 디지털 역량 측정도구로 교육 전과 후로 2회 평가를 시행하였으며, 교육 종료 후 학습자의 성찰일지를 분석하였다. 교육 후 모든 디지털 역량 및 하위역량에서 교육의 효과가 있는 것으로 나타났으며, 성찰일지 분석 결과 교육 프로그램 이수 후 디지털 역량과 관련해 학습자 내면의 긍정적 변화가 일어난 것을 확인할 수 있었다. 향후 예비유아교사가 유아교육기관에서 디지털 매체와 최신 테크놀로지를 활용하여 교육 활동을 수행하기 위해서는 실제와 경험을 기반으로 한 디지털 역량 교육이 필요하며, 이에 대한 교육적 대안을 제시했다는 점에서 연구의 의의가 있다. This study aimed to develop an educational program to promote the digital competence of pre-service early childhood teachers based on the ADDIE model and help them apply digital media and technologies smoothly to their lesson designs, teaching and learning, and play supports in the field of education and make use of them in an emergent manner. For these purposes, the study reviewed previous studies and pieces of literature and set the digital competence of pre-service early childhood teachers as the instructional utilization of digital devices, the utilization of digital information, digital content creation and platform utilization, and digital pedagogy before defining the subcompetences of each competence. For the analysis of learners, the researchers surveyed 106 sophomores and juniors in the Department of Early Childhood Education at A University in Korea. In the educational program design and development stage, researchers identified educational goals and content, lesson topics and methods, and the specific content of a lesson based on two reviews by seven experts. The final educational program was implemented with 45 pre-service early childhood teachers for a total of ten hours over five weeks. They took an evaluation test before and after educational program with a digital competence inventory of 37 items to determine its effectiveness and the internal changes of the learners, whose self-reflection journals were analyzed after the program ended. The findings show that the students experienced the effects of education in all the types of digital competence and their subcompetences after receiving the training. The analysis results of the learners’ self-reflection journals indicate that the educational program positively affected their digital. Pre-service early childhood teachers need to receive digital competence training based on current realities and experience so that they can provide educational activities with digital media and the latest technologies in early childhood education institutions. The present study is significant in that it proposed such an educational alternative.

The Effects of Surfactants on the Biosynthesis of Galactolipid and the Composition of Fatty Acids in Chloroplast Envelope rind Thylakoid Membrane of Chlorella ellipsoidea

Choe, Eun-A,Cheong, Gyeong-Suk,Lee, Cheong-Sam The Korean Society for Integrative Biology 1998 Korean journal of biological sciences Vol.2 No.3

To analyze the effects of surfactants on the biosynthesis of galactolipid and the composition of fatty acids, the chloroplast envelope and thylakoid membrane were cultivated in medium treated with anionic surfactants, such as linear alkylbenzene sulfonate (0.002%, LAS), a-olefin sulfonate (O.01%, AOS), and sodium lauryl ether sulfate (0.08%, SLES), respectively. During the cultivation, the chloroplast envelope and thylakoid membrane were isolated from the cells collected at the early and middle phase of the culture and the contents of their fatty acid composition were compared with the control. When treated with surfactants, the contents of total lipid MDGD methylesters, and DGDG methylesters decreased significantly when compared with the control. It was also confirmed that more unsaturated fatty acids were involved in the biosynthesis of galactolipid. The fatty acids utilized in the biosynthesis of MGDG were in the chloroplast envelope and in the control, and linoleic acid in LAS, linolenic acid and oleic acid in AOS, and linolenic acid and oleic acid in SLES. The fatty acids in the biosynthesis of DGDG were linolenic acid and oleic acid in the control linolenic acid and stearic acid in LAS, oleic acid and linolenic acid in AOS, oleic acid and linolenic acid in SLES. In the thylakoid membrane, the major fatty acids in the biosynthesis of MGDG were linolenic acid and oleic acid in the control, oleic acid and linolenic acid in LAS, linolenic acid and linoleic acid in AOS, linolenic acid and palmitoleic acid in SLES. The fatty acids in the biosynthesis of DGDG were linolenic acid and oleic acid in the control, oleic acid and linolenic acid in LAS, linolenic acid and linoleic acid in AOS, palmitoleic acid and oleic acid in SLES.

Preparation of Pseudotetragonal $ZrO_{0.75}S$ and Its Electric Responses on Temperature and Frequency Related to Microstructural Relaxation

로영아,김성진,이유경,김자형,Ro, Yeong A,Kim, Seong Jin,Lee, Yu Gyeong,Kim, Ja Hyeong Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.11

Pseudotetragonal ZrO0.75S whose space group is P212121 was synthesized and the cell dimensions were a=5.110(2) $\AA$, b=5.110(7) $\AA$, and c=5.198(8) $\AA.$ The space group P212121 seems to be resulted from lowering the symmetry of cubic ZrOS structure with P213 space group by lattice distortion due to the oxygen defects. In the distorted structure, bond shortening between metal-nonmetal by reduction of cell volume and alternation of Zr-Zr distance were observed. Dielectric constant and loss data of the bulk material in temperature range -170 to 20 $^{\circ}C$ and frequency range 50 Hz to 1 MHz showed that there was dielectric transition at around -70 $^{\circ}C$ originated from the relaxation of Zr-S segment. Comparing with ZrO2 exhibited the dielectirc constants, 9.0 at room temperature, ZrO0.75S showed high dielectric constant, k = 200.2 at 100 kHz. The activation energy of relaxation time due to dielectric relaxation of Zr-S was 0.47 eV (11.3 kcal/mole). According to the impedance spectra, ZrO0.75S showed more parallel circuit character between the resistance and capacitance components at the temperature (-70 $^{\circ}C)$ that the Zr-S dielectric relaxation was observed.

혈액 투석 환자에서 2년간 추적 관찰시 Lipoprotein(a)의 변화에 끼치는 요인의 분석

김경아,송준호,이경주,박영주,이승우,김문재 대한신장학회 2000 대한신장학회잡지 Vol.19 No.4

바이오차 처리 후 토양 잔류 Endosulfan의 경시적 변화에 관한 통계학적 접근

정건희 ( Gun-hee Jung ),이상범 ( Sang-beom Lee ),김경진 ( Gyeong-jin Kim ),문보연 ( Bo-yeon Moon ),송아름 ( A-reum Song ),이효섭 ( Hyo-sub Lee ),류송희 ( Song-hee Ryu ),최근형 ( Geun-hyoung Choi ),박상원 ( Sangwon Park ) 한국환경농학회 2020 한국환경농학회 학술대회집 Vol.2020 No.-

The Ginseng (Panax ginseng C, A, Meyer) is a perennial plant that uses many pesticides to prevent diseases. According to the National Quality Management Service, pesticides such as Endosulfan, Chloropyriphos and Procymidone were detected in ginseng. The Endosulfan used in this study is an organic chlorine pesticide that adversely affects the human central nervous system and was banned from use and manufacture in 2004. This study was carried out to examine reduction product (biochar) and the residual pattern of Endosulfan in ginseng growing filed. Endosulfan detected was quantitated using the analytical methods validated by recovery tests with a GC-μECD/MSD. Repeated Measures ANOVA is used to compare the temporal change of soil residual Endosulfan after Biochar treatment. The repeated measures ANOVA is a member of the ANOVA family. ANOVA is short for Analysis of variance. All ANOVAs compare one or more mean scores with each other; they are tests for the difference in mean scores. The repeated measures ANOVA compares means across one or more variables that are based on repeated observations. A repeated measures ANOVA model can also include zero or more independent variables. Again, a repeated measures ANOVA has at least 1 dependent variable that has more than one observation. According to Repeated Measures ANOVA, the residual concentration of Endosulfan, which was artificially treated in a ginseng cultivated area, was decomposed over time. It has been found that the degradation rate after reducing agents Biochar is enhanced. And the treatment of about 0.8% Biochar based on soil weight is 50% reduction effect of the absorption and transfer of Endosulfan to ginseng.

담낭절제술 후 발현된 간, 신장 및 복막을 침범한 유전분증 1예

김성연,김덕영,김경아,송준호,이승우,한지영,김문재 대한내과학회 2003 대한내과학회지 Vol.65 No.1

저자 등은 최근 담낭절제술을 시행받은 후에 발생된 간기능 이상과 조절되지 않는 복수를 주소로 내원한 환자에서 진단된 유전분증 1예를 경험하였기에 보고하는 바이다. Amyloidosis is a heterogenous group of often fatal disorders characterized by extracellular deposition of a proteinaceous material with a unique fibrillar form in various tissues and organs. Deposition of amyloid may cause widespread dysfunction of the involved organs. Recently, we experienced a case of 40-year-old male patient with nephrotic syndrome, uncontrolled ascites and jaundice, which developed after cholecystectomy. We confirmed systemic amyloidosis involving kidney, liver and peritoneum by kidney and liver and peritoneum biopsy. The case that, having about a month of incubation period after cholecystectomy, amyloidosis occurred in a healthy man before the operation, and that amyloid was deposited in the peritoneum site incised during the operation provides grounds that amyloidosis may be triggered by cholecystectomy. Given the rarity of this case, the following is a report of this case and a review of the relevant literatures.