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cAMP 농도에 영향을 미치는 수종약물이 파골세포형성에 미치는 영향
소영,고성희,백정화,김관식,정동균 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.2
To study the effect of cAMP on the generation of osteoclasts from their precursor cells, the bone marrow cells were isolated from 7 to 9 week-old male mice. The femur and tibia were dissected aseptically and the marrow cavity was flushed with 1 ㎖ of α-minimum essential medium by slow injection. Collected marrow cells were cultured at 1.5-2.0×10^6 cells/well in 24-well plate for 8 days. In experimental group, PGE_2(5×10^-6, 10^-5M), forskolin(10^-5M) or IBMX(10^-4, 10^-5M) were added singly or in combination from the 1st day culture. After cultures, staining for tartrate-resistant acid phosphatase(TRACP)-marker enzyme of osteoclast-was performed according to the modified method of Burstone. The TRACP-positive multinucleated cells(MNC), which have 3 or more nuclei, were counted. The observed results were as follows. 1. In control group. TRACP-positive mononuclear cells were present, but no TRACP-positive multinucleated cells appeared. 2. PGE_2(5×10^-6M) or forskolin(10^-5M) significantly stimulated the formation of TRACP-positive MNC. Moreover, forskolin potentiated the TRACP-positive MNC formation induced by PGE_2 when added simultaneously. 3. IBMX(10^-4, 10^-5M), when added alone, significantly stimulated the formation of TRACP-positive MNC. However, IBMX(10^-5M) added in combination of PGE_2(10^-5M) partially inhibited the TRACP-positive MNC formation induced by PGE_2.
신향근,양기열,정권수,송영무 順天大學校 師範大學 附屬 科學敎育硏究所 1996 科學과 敎育 Vol.4 No.-
Since the academic year of 1994, the Scholatic Ability Test(abbr. S.A.T) was given for students who wanted to get adimssions from universities and colleges in Korea. This test has revolutionized the pattern of teaching and learning mathematics in most highschool classrooms. In this paper, we will show a feature of S.A.T. and analyze mathematics problems of 1997's S.A.T.
개량 A7075-T73 합금의 고주기 피로 및 피로 균열 전파 거동
김관영 ( Gwan Yeong Kim ),김규식 ( Kyu Sik Kim ),박중철 ( Joong Cheol Park ),김세광 ( Shae K Kim ),윤영옥 ( Young Ok Yoon ),이기안 ( Kee Ahn Lee ) 대한금속재료학회(구 대한금속학회) 2014 대한금속·재료학회지 Vol.52 No.4
The high cycle fatigue and fatigue crack propagation behaviors of the recently developed modified A7075-T73 alloy are investigated. This alloy is manufactured using Eco-Mg (including CaO) instead of a magnesium element. The alloy consists of an Al matrix, Al2CuMg, MgZn2, minute amounts of Ca phases and reduced Fe-based intermetallic or oxide. The modified A7075 alloy exhibits superior strengths (YS: 492 MPa, TS: 548 MPa) with a similar elongation (12.8%) compared with the conventional A7075. Furthermore, the high cycle fatigue properties are significantly improved (fatigue limit of 330 MPa at 107 cycles) compared with those of the conventional alloys. The fatigue crack propagation rate of the modified A7075 is similar or somewhat lower (higher resistance) than those of the conventional alloys. The superior tensile and fatigue properties of the modified A7075-T73 alloy are primarily attributed to the grain size refinement, evenly distributed strengthening phases (MgZn2 precipitates), and reduction of detrimental effects of the Fe- intermetallic phases and oxides.
Im, Yeong-Gwan,Kim, Jae-Hyung,Kim, Byung-Gook Korean Academy of Orofacial Pain and Oral Medicine 2015 Journal of Oral Medicine and Pain Vol.40 No.3
Purpose: The aim of this study was to elucidate the coordination patterns of the sternocleidomastoid and posterior cervical muscles in response to symmetrical and asymmetrical jaw functions in normal adults. Methods: Twenty-seven healthy volunteers (8 females, 19 males; mean age, $30.4{\pm}2.5$ years) participated in this study. Surface electromyography (EMG) was used to record activities in the masseter, suprahyoid, sternocleidomastoid, and posterior cervical muscles at rest and during maximum tooth clenching, biting of a cotton roll with the anterior teeth, unilateral biting of a cotton roll with the posterior teeth, bilateral biting of cotton rolls with the posterior teeth, and jaw opening while seated. Normalized amplitude, activity indices, and asymmetry indices were compared between the muscles and the jaw tasks. Results: During symmetrical jaw functions (e.g., tooth clenching, biting with the anterior teeth, bilateral biting with the posterior teeth, jaw opening), the sternocleidomastoid and posterior cervical muscles showed elevated EMG amplitudes compared with the resting condition. The co-activation pattern of the sternocleidomastoid muscle was more pronounced than those of the posterior cervical muscles during these tasks. During asymmetrical jaw functions (e.g., unilateral biting with the posterior teeth), the ipsilateral sternocleidomastoid and masseter muscles showed higher contraction activity than did the contralateral muscles, but the contralateral posterior cervical muscles were more active than the ipsilateral muscles. Conclusions: The sternocleidomastoid and posterior cervical muscles were shown to be co-activated and coordinated anteroposteriorly or bilaterally according to symmetrical or asymmetrical jaw function. These results suggest an integrated neural control mechanism for the jaw and neck muscles, and provide further evidence supporting the intimate functional coupling between the trigeminal and cervical neuromuscular systems.
임영관(Yeong-Gwan Im),김지연(Ji-Yeon Kim),김병국(Byung-Gook Kim) 대한치과의사협회 2011 대한치과의사협회지 Vol.49 No.11
Low-level laser therapy (LLLT) is the application of light to pathology to promote tissue regeneration, reduce inflammation, and relieve pain. LLLT has a photochemical effect whereby the light is absorbed and exerts a chemical change. The clinical applications of LLLT include improvement in wound and bone healing processes, control of pain and tooth hypersensitivity, modulation of periodontal inflammation, the prevention and treatment of cancer therapy-induced oral mucositis, management of burning mouth syndrome, and improvement in temporomandibular disorder symptoms. Further research is needed to better elucidate the cellular mechanisms of LLLT and provide a solid scientific basis for the clinical application of LLLT in dentistry.
Modified submental intubation techniques for maxillofacial surgery - A report of five cases -
Jeon Yeong-gwan,Lee Chunui,Hong Dongeui,Jin Younghyun,임현교 대한마취통증의학회 2022 Anesthesia and pain medicine Vol.17 No.3
Background Submental intubation has been the recommended airway management procedure for maxillofacial surgery since proposed by Altemir in 1986. We adopted various submental intubation modifications based on modified intubation protocols and report on the effectiveness and problems of each modified method.Case Among a total of 13 submental intubation cases during the last five years, five representative methods are described. The proximal end of the endotracheal tube was protected by a nelaton catheter in case 1, by a suction connector in case 2, and by a dental needle cap in case 3. In case 4, a nasal speculum was used to expand a single route, and in case 5, a laparoscopic trocar was used to secure a single route.Conclusions Use of a laparoscopic trocar might be the most effective way to obtain a single submental route. However, considering cost, use of a nasal speculum is also an effective suboptimal solution.
Im, Yeong-Gwan,Kim, Byung-Gook,Kim, Jae-Hyung Korean Academy of Orofacial Pain and Oral Medicine 2016 Journal of Oral Medicine and Pain Vol.41 No.1
Purpose: Burning mouth syndrome (BMS) is a chronic pain condition involving the oral and perioral regions, often characterized by a burning sensation and pain in elderly patients. In this study, we investigated the effectiveness of pharmacological agents for the treatment of BMS patients through a retrospective chart review. Methods: We enrolled 61 BMS subjects (57 females, 4 males; $66.4{\pm}10.9$ years of age) from among consecutive patients treated pharmacologically from January 2014 to June 2015 at Chonnam National University Dental Hospital. Patients with secondary BMS associated with local factors were excluded. The treatment period, number of pharmacological agents tried, and effectiveness of the drugs administered to each subject were analyzed. Results: The mean treatment period for the management of BMS was 2.5 months. More than three agents were tried to control BMS symptoms in 17 subjects (27.9%); two agents were used in 10 subjects (16.4%), and a single agent in 24 subjects (39.3%). Clonazepam was prescribed most frequently and was effective at relieving symptoms in 30 of 39 subjects (76.9%). Paroxetine was moderately effective, relieving symptoms in 7 of 17 subjects (41.2%). Some of the subjects benefited from tricyclic antidepressants, gabapentin, and lipoic acid. A topical local anesthetic used to supplement other systemic agents had ameliorating effects in four of six subjects. Conclusions: Within the study limitations, clonazepam was the most effective drug and antidepressants were efficacious in some subjects for relieving the symptoms of BMS. These pharmacological agents could be considered as first-line drugs for the management of BMS.
Rare Odontalgia of Mandibular Teeth Associated with Migraine: A Case Report
Im, Yeong-Gwan,Kang, Jin-Kyu Korean Academy of Orofacial Pain and Oral Medicine 2018 Journal of Oral Medicine and Pain Vol.43 No.3
A 39-year-old male presented with severe pain in right posterior mandibular teeth and temporal area. Initially, the pain in the mandibular teeth was moderate, but the concomitant headache was unbearably severe. His medical history was non-contributory. The clinical and radiographic examination failed to reveal any pathology in the region. There was no tenderness to palpation in the temporalis and masseter muscles or temporomandibular joints. The clinical impression was migraine. The pain in the teeth and headache were aborted using ergotamine tartrate and sumatriptan succinate. Atenolol prevented further pain, while amitriptyline and imipramine had no effect. Migraine can present as non-odontogenic pain in the mandibular teeth, although not as frequently as in the maxillary teeth. A correct diagnosis is essential to avoid unnecessary dental treatments and to manage pain effectively. Clinicians should be able to identify migraine with non-odontogenic dental pain and establish a proper diagnosis through a comprehensive evaluation.