수축저감제 혼입률 변화에 따른 콘크리트의 공학적 특성에 관한 연구

한민철,金光華,정규문,정평유,윤성노,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In this paper, tests are carried out using concrete incorporating shrinkage reducing agent(SR) in order to investigate the engineering properties of concrete. The contents of SR and W/C are varied. According to test results, as for fresh concrete, as SR content increases, slump and air content shows decline tendency, and setting time is accelerated with increase of SR content and decrease of W/C. As for compressive strength, as SR contents increases compressive strength shows to be decreased. As for the effect of SR on drying shrinkage, it shows to be reduced with increase of SR content. This is due to the reduced surface tensile strength of water and tensile strength of capillary pore in concrete.

수축저감제와 혼화재를 병용한 콘크리트의 공학적 특성

金光華,김종,한민철,정평유,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objective of this paper is to investigate the physical and mechanical properties of concrete incorporating shrinkage reducing admixture(SRA) and mineral admixture(MA) such as fly ash and blast furnace slag powder. According to results, for fresh concrete properties, increase of SRA content leaded to reduce the fluidity and air content sharply. For setting time, use of SRA caused concrete to accelerate setting time, and compared with plain concrete it retarded by incorporating MA. Compressive strength decreased with an increase in SRA content, and when incorporating MA, compared with plain concrete, it shows lower compressive strength in early age but similar or increase by the elapse of age due to the pozzolanic and latent hydration reaction. For drying shrinkage, concrete shows decline tendency with an increase in SRA content due to the relaxation effect at the capillary tension in concrete by SRA. In the scope of this paper, it is found that the use of SRA with 1.0% has optimum effects on the various properties of concrete, and the combinations of SRA and fly ash will ensure the stability for drying shrinkage.

류마티스 관절염과 전신경화증의 중복증후군 1예

이은지,서광원,유충헌,박봉수,허민영,김지현,김혜란,김동욱 인제대학교 2008 仁濟醫學 Vol.29 No.-

Overlap syndrome is a disease that combines major features of more than one rheumatic disease in the same patient. A 58 year-old female who was diagnosed as rheumatoid arthritis (RA) developed skin thickening and dyspnea. Clinical and laboratory findings revealed that she was affected by systemic sclerosis (SSc) and interstitial lung disease. Finally, she was diagnosed as overlap syndrome consistent with RA combined with SSc. The authors report a case of RA-SSc overlap syndrome with relevant literatures.

급성 골수성 백혈병 환자에서 관해 유도 항암 화학요법 후 발생한 베르니케 뇌증

황진원,정재현,서광원,최병진,송영진,김종윤,이은지,임홍규,이상민 인제대학교 2009 仁濟醫學 Vol.30 No.-

Wernicke's encephalopathy is characterized by the triad of ocular symptoms, ataxia, and mental confusion and neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, hyperemesis gravidarum, anorexia nervosa, hemodialysis, uremia, and acquired immunodeficiency syndrome(AIDS). Chemotherapy in patient with malignanacy and long term total parenteral nutrition following bone marrow transplantation are related with Wernicke's encephalopathy. A 48-year-old woman had been treated with Daunorubicin and Cytarabine for remission induction chemotherapy of acute myeloblastic leukemia and intravenous hyperalimentation due to persistent hematochezia and ileus caused by infiltration of leukemic cell in terminal ileum. She suddenly complained of diplopia, tremor, and mental confusion at 32th day after chemotherapy and generalized tonic-clonic seizure at 34th day after chemotherapy. The diagnosis of Wernicke's encephalopathy was made with clinical presentations and brain MRI. Brain MR T2-weighted & Flair image revealed a high signal intensity lesions bilaterally at the medial thalamus and peri-acueductal grey matter of the midbrain. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after remission induction chemotherapy followed by intravenous hyperalirnentation in a patient with acute myeloblastic leukemia.

Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities

Guang-Yu Yang,Jia-Meng Dai,Zhen-Jie Li,Jin Wang,Feng-Xian Yang,Xin Liu,Jing Li,Qian Gao,Xue-Mei Li,Yin-Ke Li,Wei-Guang Wang,Min Zhou,Qiu-Fen Hu 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8

In previous studies, several isoindolin-1-oneanalogs that exhibited signifi cant anti-tobacco mosaic virus(anti-TMV) activities were isolated from Nicotiana tabacum . Since gene-editing mutants provide a new sample for thediscovery of active metabolites, we focused on the stems ofYN-18–23 (a mutant N. tabacum for gene editing with thealkaloid metabolic pathway cultivated by Yunnan TobaccoCompany), which led to the isolation of four new ( 1–4 )and four known ( 5–8 ) isoindolin-1-ones. To the best of ourknowledge, nicindole C ( 3 ) is the fi rst subclass of isoindolin-1-one bearing a pentacyclic ketone, while nicindole D ( 4 )is the fi rst example of isoindolin-1-one bearing a methylpyridin-2-(1 H )-one moiety. Compounds 1–4 were testedfor their anti-TMV activities, and the results revealed thatcompounds 1 , 3 , and 4 exhibited high anti-TMV activities atconcentrations of 20 μM with inhibition rates of 48.6, 42.8,and 71.5%, respectively. These rates are higher than the inhibitionrate of the positive control (33.2%). The mechanisticstudy of compound 4 , which had the highest anti-TMV activityrevealed that increased potentiation of defense-related enzyme activities and downregulation of expression of theNtHsp70 protein may induce resistance in tobacco againstthe viral pathogen TMV. Molecular docking studies alsorevealed that the isoindolin-1-one substructure is fundamentalfor anti-TMV activity. The methyl-pyridin-2-(1 H )-onemoiety in compound 4 and the 2-oxopropyl groups in compounds1 and 3 at the N -2 position may increase inhibitoryactivities. This study of the structure–activity relationshipis helpful for fi nding new anti-TMV activity inhibitors. Tostudy whether the isoindolin-1-ones have broader antiviralactivities, compounds 1–4 were also tested for their antirotavirusactivities. Compound 4 exhibited high anti-rotavirusactivity with a therapeutic index (TI) value of 20.7. This TI value is close to that of the positive control (20.2).

Preparation and Characterization of Aripiprazole Cocrystals with Coformers of Multihydroxybenzene Compounds

Cho, Min-Yong,Kim, Paul,Kim, Ga-Young,Lee, Ju-Yeon,Song, Keon-Hyoung,Lee, Min-Jeong,Yoon, Woojin,Yun, Hoseop,Choi, Guang J. The American Chemical Society 2017 CRYSTAL GROWTH AND DESIGN Vol.17 No.12

<P>A novel co-crystal of aripiprazole (ARI), the active substance in the atypical antipsychotic Abilify, with orcinol (ORC) as a coformer, was prepared, characterized, and compared with other ARI co-crystals with dihydroxy- and trihydroxy-benzene coformers [catechol (CAT), resorcinol (RES), and phloroglucinol (PHL)] reported previously (Nanubolu, J. B.; Ravikumar, K. <I>CrystEngComm</I> <B>2016</B>, <I>18</I>, 1024–1038). Three preparation methods were used: neat grinding (NG), liquid-assisted grinding (LAG), and solvent evaporation (SE). Based on single-crystal X-ray diffraction (SC-XRD) measurements, the crystal structure of the ARI–ORC co-crystal was determined to be monoclinic. The melting point of ARI–ORC co-crystal was found to be 184–185 °C, higher than existing ARI co-crystals with multihydroxybenzene coformers. Additionally, the ARI–ORC co-crystal showed the highest dissolution rate among those in the test group in an acetonitrile–water 10/90 cosolvent. We investigated how the co-crystallization pathway and the dissolution behavior might correlate with the coformer moiety, primarily in terms of its chemical structure and melting point. Co-crystallization between ARI and PHL via grinding (NG or LAG) required the highest activation energy, mainly due to the coformer’s higher melting point. The dissolution rate of ARI co-crystals was not obviously correlated with the coformer’s melting point or its molecular weight. However, the high dissolution rate of ARI–ORC co-crystals was possibly associated with the bond angle of D–H···A for O3–H3O···N2 in the co-crystal’s superlattice structure. The stability of ARI co-crystals was examined by aging these powders in a controlled oven at 80 °C/98% relative humidity for 1 week. We observed that all of the co-crystal powders, except for the aripiprazole–catechol (ARI–CAT) pair, underwent no noticeable degradation or physicochemical change upon treatment. In conclusion, we can consider the novel ARI–ORC co-crystal as a potential drug substance with the enhanced dissolution behavior in aqueous media and good stability under stressed conditions.</P><P>A novel co-crystal of aripiprazole (ARI), the active substance in the atypical antipsychotic Abilify, with orcinol (ORC) as a coformer, was prepared, characterized, and compared with other ARI co-crystals with dihydroxy- and trihydroxy-benzene coformers [catechol (CAT), resorcinol (RES), and phloroglucinol (PHL)] reported previously. In conclusion, we can consider the novel ARI−ORC co-crystal as a potential drug substance with the enhanced dissolution behavior in aqueous media and good stability under stressed conditions.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cgdefu/2017/cgdefu.2017.17.issue-12/acs.cgd.7b01281/production/images/medium/cg-2017-01281j_0014.gif'></P>

Developed a high-performance sensor based on cumarin derivative for rapid and sensitive detection of palladium ion in organic wastewater

Ai-min Ren,Yu Zhang,Weiwei Yu,Kai Zhao,Zhiru Hu,Zhiquan Zhang,Guodong Feng,Zhi-Guang Song 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-

In this article, a series of coumarin derivativefluorescent probes have been synthesized, which can realizesimple, rapid and sensitive detection of Pd2+. We tested thefluorescence properties of threefluorescentprobes, (E)-N0-(((4-chloropyridin-2-yl) methylene)-7-(diethylamino)-2-oxo-2H-chromene-3-carbohy(CMDCC) has the betterfluorescence properties and anti-interference ability. Then, CMDCC as thefluorescence probe for detection of Pd2+ was systematic studied. Under optimized conditions, this probehas a wide pH range, a lower detection limit (4.4510 8 mol L-1), and a faster response speed (3 min). Inthe Pd2+ concentration range of 0.1 5 mmol L-1, thefluorescence intensity of this probe and concentrationof Pd2+ show a good linear response. In this work, Pd2+ content in organic waste liquid was successfullydetected and a standard addition test was also performed. The satisfactory recovery rate was obtained. Moreover, it can be observed with naked eyes that the palladium ion changes the solution color of CMDCCfrom green to red. This color change can easily be compared with other metal salts. It indicates thatCMDCC can also detect Pd2+ by colorimetric method. Therefore, CMDCC should be used to rapidly,conveniently detect Pd2+ in environmental samples.

Evaluation of characteristics on titanium surface treatment for absorption of functional groups.

Jin, Guang-Chun,Park, Rl-Song,Park, Hyeoung-Ho,Seo, Jae-Min,Lee, Sook-Jeong,Lee, Min-Ho Chinese Medical Assn 2010 Chinese medical journal : CMJ Vol.123 No.21

<P>In order to bind or fix bioactive materials directly to the surface of a Ti implant, the prior binding process of functional groups (FGs, -COOH and -OH) to the implant surface is necessary. Conventional binding processes are so high-cost and complex, so it is essential to find a simple and effective procedure for Ti-FG binding.</P>

Dynamic calibration for the in-line NIR monitoring of film thickness of pharmaceutical tablets processed in a fluid-bed coater

Lee, Min-Jeong,Park, Cho-Rong,Kim, Ah-Young,Kwon, Byung-Soo,Bang, Kyu-Ho,Cho, Young-Sang,Jeong, Myung-Yung,Choi, Guang-Jin Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of Pharmaceutical Sciences Vol.99 No.1

<P>NIR spectroscopy has been extensively employed for the in-line monitoring of pharmaceutical processes as one of the key PAT implementation tools. Nevertheless, pharmaceutical processes such as fluid-bed coating have not fully made the most of the NIR in-line monitoring primarily due to a difficulty in handling random in-line spectra. In this study, novel approaches to develop a reasonable dynamic calibration model were proposed; averaging and clustering. Pharmaceutical test tablets were coated with HPMC-based materials using a fluid-bed processor. During the 160 min coating process under tangential spraying mode, 10 tablets were sampled out at every 10 min mark for actual coating thickness measurements. NIR spectra at and near each 10 min mark were treated and processed by the averaging and clustering operations. Averaging of 21 spectra resulted in a reasonably good dynamic calibration model whose determination coefficient was estimated as high as 0.9916. The PCA-based clustering turned out to be substantially helpful especially when a large number of NIR spectra were averaged. A prediction experiment verified that our dynamic calibration model can control the coating thickness in-line as good as 3% deviated from the actual thickness, which can offer a reasonable end-point for the fluid-bed coating process. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:325–335, 2010</P>

전립선 암 입체적세기변조방사선치료 시 체형 및 에너지 변화에 따른 선량 평가

조광섭,김민우,백민규,채종표,하세민,이상봉,Jo, Guang Sub,Kim, Min Woo,Baek, Min Gyu,Chae, Jong Pyo,Ha, Se Min,Lee, Sang Bong 대한방사선치료학회 2018 대한방사선치료학회지 Vol.30 No.1

목 적 : 전립선 암 환자의 입체적세기변조방사선치료(VMAT)시 복부체형 및 에너지 변화에 따른 선량을 비교하였다. 대상 및 방법 : 전립선암으로 본원에 내원한 7명의 환자를 대상으로 하였으며, 복부체형을 -2.0 cm에서 2 cm까지 0.5 cm씩 변화시키는 동시에 6, 10, 15 MV 각각의 에너지에서 VMAT 치료계획을 수립하였다. 체형변화에 따른 표적장기 내 선량변화를 평가하기 위해 PTV의 선량도(Conformal index, CI), 선량균등도(Homogeneous index, HI), $D_{max}$ $D_{95%}$, $D_{50%}$, $D_{2%}$를 조사하였고, 정상조직 내 선량 변화를 평가하기 위해 직장과 방광의 $V_{70Gy}$, 대퇴부 머리의 $D_{max}$를 분석하였다. 결 과 : PTV 내의 $D_{max}$ 값 중 6 MV에서는 1.0 cm의 체형 감소에서 107.2 %로 선량이 상승하였고, 10 MV와 15 MV에서는 1.5 cm 체형 감소에서 각각 107.1 %, 107.0 %로 선량이 증가하였다. PTV 내의 $D_{50%}$ 값 중 6MV에서는 1.0 cm의 체형 증가에서 99.64 %로 선량이 감소하였고, 10 MV와 15 MV에서는 1.5 cm 체형 증가에서 각각 99.78 %, 99.97 %로 선량이 감소하였다. 2.0 cm 체형 증가에서는 각각 99.30 %, 99.52 %로 선량 감소를 보였다. 직장과 방광에 대한 선량은 체형이 감소됨에 따라 점차적으로 선량이 증가하였고, 체형이 증가됨에 따라 선량이 감소하였다. 6 MV에서 가장 급격한 선량 감소를 보였으며, 10 MV에서 직장 $V_{70Gy}$는 체형이 2.0 cm 줄어들 때 11.50 %에서 12.76 %로 증가했다. 방광 $V_{70Gy}$도 14.0 %에서 15.2 %로 증가했다. 또한 대퇴부 머리에서도 체형이 감소됨에 따라 선량이 증가함을 나타내었다. 결 론 : VMAT 치료시 복부체형 변화에 따라 선량분포 결과가 바뀔 수 있는데, 치료 시 SSD 및 CBCT를 이용하여 6 MV에서는 체형이 1 cm 이상 감소되거나 1.0 cm 이상 증가되었을 때, 10 MV와 15 MV에서는 1.5 cm 감소 또는 1.5 cm 증가되었을 시 re-simulation을 통해 치료계획을 새로 세워야 할 것으로 사료되어진다. Purpose : To compare the radiation doses of prostate cancer patients according to changes in abdominal body shape and energy during Volumetric modulated arc therapy(VMAT). Materials and Methods : Seven patients with prostate cancer were enrolled in this study. VMAT treatment plan was established at 6, 10, and 15 MV while changing from -2.0 cm to 2 cm by 0.5 cm. Conformal index(CI), homogeneous index(HI), $D_{max}$, $D_{95%}$, $D_{50%}$ and $D_{2%}$ of PTV were examined in order to evaluate the change of dose in the target organ according to body shape change. Normal organ of the femoral head, rectum and bladder was analyzed to evaluate dose changes. Results : The dose of $D_{max}$ 6 MV in PTV increased to 107.2 % in 1.0 cm body shape reduction, and 10 MV and 15 MV dose increased to 107.1 % and 107.0 % in 1.5 cm body reduction, respectively. The dose of $D_{50%}$ 6 MV in PTV decreased to 99.64 % in 1.0 cm body shape increase, and in 10 MV and 15 MV dose decreased to 99.79 % and 99.97 % in 1.5 cm body increase, respectively. In 2.0 cm body type increase, the dose was decreased to 99.30 % and 99.52 %, respectively. Doses for rectum and bladder gradually increased with decreasing weight, and dose decreased with decreasing weight. 6 MV, and $V_{70Gy}$ at 10 MV increased from 11.50 % to 12.76 % when the external shape decreased by 2.0 cm. The bladder $V_{70Gy}$ also increased from 14.0 % to 15.2 %. It was also shown that the dose increased as the body weight decreased in the femoral head. Conclusion : In the treatment of VMAT, dose distribution can be changed according to the change of abdominal shape. SSD and CBCT were used to decrease the body shape by more than 1cm or more than 1.0 cm at 6 MV and the body shape by more than 1.5 cm or more than 1.5 cm at 10 MV or 15 MV. It is considered that a new treatment plan should be established through re-simulation.