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Sirolimus and Non-melanoma Skin Cancer Prevention after Kidney Transplantation: A Meta-analysis
Gu, Yu-Hong,Du, Jia-Xin,Ma, Man-Ling Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Background: Whether sirolimus is useful in the prevention of non-melanoma skin cancer (NMSC) remains unclear and we therefore performed this meta-analysis of randomized controlled trials to test the hypothesis that Sirolimus-based immunosuppression is associated with a decrease in NMSC. Methods: The main outcomes were NMSC, squamous-cell carcinoma and basal-cell carcinoma. The pooled risk ratio (RR) with its 95% confidence interval (95%CI) were used to assess the effects. Results: 5 randomized trials involving a total of 1499 patients receiving kidney transplantation were included. Patients undergoing Sirolimus-based immunosuppression had much lower risk of NMSC (RR = 0.49, 95%CI 0.32-0.76, P = 0.001). Subgroup analyses by tumor type showed that Sirolimus-based immunosuppression significantly decreased risk of both squamous-cell carcinoma (RR = 0.58, 95%CI 0.43-0.78, P < 0.001) and basal-cell carcinoma (RR = 0.56, 95%CI 0.37-0.85, P = 0.006). The quality of evidence was high for NMSC, and moderate for squamous-cell carcinoma and basal-cell carcinoma. No evidence of publication bias was observed. Conclusion: High quality evidence suggests that Sirolimus-based immunosuppression decreases risk of non-melanoma skin cancer, and Sirolimus has an antitumoral effect among kidney-transplant recipients.
Zhi-Hong Xin,Li-Tian,Tian-jiao Zhu,Wen-Liang Wang,Lin Du,Yu-chun Fang,Qian-Qun Gu,Wei-Ming Zhu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5α, 8α-epidioxy-23-methyl- (22E, 24R)-ergosta-6, 22-dien-3β-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 µM.
Xin, Zhi-Hong,Tian, Li,Zhu, Tian-Jiao,Wang, Wen-Liang,Du, Lin,Fang, Yu-Chun,Gu, Qian-Qun,Zhu, Wei-Ming 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known $5{\alpha}$, $8{\alpha}-epidioxy-23-methyl-(22E, 24R)-ergosta-6$, $22-dien-3{\beta}-ol$ (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an $IC_{50}$ value of 4.07 ${\mu}M$.
두현철,홍상진,Du, Hyeon Cheol,Hong, Sang Jeen 한국반도체디스플레이기술학회 2021 반도체디스플레이기술학회지 Vol.20 No.2
As the size of semiconductor devices decreases, the etching pattern becomes very narrow and a deep high aspect ratio process becomes important. The cryogenic etching process enables high aspect ratio etching by suppressing the chemical reaction of reactive ions on the sidewall while maintaining the process temperature of -100℃. ESC is an important part for temperature control in cryogenic etching equipment. Through the cooling path inside the ESC, liquid nitrogen is used as cooling water to create a cryogenic environment. And since the ESC directly contacts the wafer, it affects the temperature uniformity of the wafer. The temperature uniformity of the wafer is closely related to the yield. In this study, the cooling path was designed and analyzed so that the wafer could have a uniform temperature distribution. The optimal cooling path conditions were obtained through the analysis of the shape of the cooling path and the change in the speed of the coolant. Through this study, by designing ESC with optimal temperature uniformity, it can be expected to maximize wafer yield in mass production and further contribute to miniaturization and high performance of semiconductor devices.
쇄골하정맥을 이용한 J 형의 전극도자를 가진 심방 Pacemaker 이식치험 2예
이두연,홍승록,이웅구,Lee, Du-Yeon,Hong, Seung-Rok,Lee, Ung-Gu 대한흉부심장혈관외과학회 1983 Journal of Chest Surgery (J Chest Surg) Vol.16 No.2
The management of cardiac arrhythmias by cardiac pacing has increased greatly since the treatment of complete heart block with an external transcutaneous pacemaker in 1952, followed by the use of myocardial wires connected to an external pulse generation, by external transvenous pacing, and then by transvenous pacing with implantable components in thoracic wall.By now, the three bases of modern cardiac pacing for bradyarrhythmias had been established [1] an implantable device [2] the transvenous approach [3] the ability of the pacemaker to sense cardiac activity and modify its own function accordingly. In transvenous implantation of a pacemaker, any one of four vessels at the root of the neck is suitable for passage of the electrode - cephalic vein, external jugular vein, internal jugular vein, costo-axillary branch of the axillary vein. The new technique of direct puncture of the subclavian vein, either percutaneously or after skin incision only has been made, is invaluable & is used routinely. We have experienced one 25 years old patient who had rheumatic mitral stenosis & minimum aortic regurgitation with sinus bradycardia associated with premature atrial tachycardia & another 54 years old female patient who was suffered from sick sinus syndrome with sinus bradycardia & sinus arrest. The 1st patient was taken open mitral commissurotomy & aortic valvuloplasty and then was taken atrlal pace-maker implantation through If subclavian puncture method in post-op 14 days, and the second patient was taken atrial pacemaker implantation through If subclavian puncture method. Their postop course was in uneventful & were discharged, without complication. Their condition have been good to now.
구자예,박장혁,오두석,정홍철,Gu, Ja-Ye,Park, Jang-Hyeok,O, Du-Seok,Jeong, Hong-Cheol 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.6
The breakup of liquid jet is the result of competing, unstable hydrodynamic forces acting on the liquid jet as it exit the nozzle. The nozzle geometry and up-stream injection conditions affect the characteristics of flow inside the nozzle, such as turbulence and cavitation bubbles. A set of calculation of the internal flow in a single hole type nozzle were performed using a two dimensional flow simulation under different nozzle geometry and up-stream flow conditions. The calculation showed that the turbulent intensity and discharge coefficient are related to needle position. The diesel nozzle with sharp inlet under actual engine condition has possibility of cavitation, but round inlet nozzle has no possibility of cavitation.
Lamotrigine 단독 과량복용으로 발생한 횡문근융해증
김건배,구홍두,Kim, Gun-Bea,Gu, Hong-Du 대한임상독성학회 2008 대한임상독성학회지 Vol.6 No.2
Lamotrigine is a newer anti-epileptic drug for adjunctive treatment of refractory epilepsy, partial seizures, generalized tonic-clonic seizures, and bipolar disorder. Lamotrigine overdose causes serious central nervous and cardiovascular problems, but reports are uncommon. Few lamotrigine overdoses have been described because anti-epileptic drug use is limited and usually used with combination of other anti-epileptic drugs. In addition, most patients visit emergency departments with multi-drug overdoses, so few cases of lamotrigine poisoning alone exist. We had a female patient visit our emergency department a couple of hours after a lamotrigine overdose treated with intravenous hydration and urine alkalization by NaHCO3. She recovered successfully without any evidence of renal injury. However, she developed profound rhabdomyolysis, a previously unreported complication of this medication. We suggest that serial creatine kinase levels should be measured after lamotrigine poisoning.