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RISS 인기검색어
- 검색키워드
- 저자 : Greeley, Jeffrey (검색결과 3 건)
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Trivalent M-related protein as a component of next generation group A streptococcal vaccines
Harry S. Courtney,Shannon E. Niedermeyer,Thomas A. Penfound,Claudia M. Hohn,Adam Greeley,James B. Dale 대한백신학회 2017 Clinical and Experimental Vaccine Research Vol.6 No.1
Purpose: There is a need to broaden protective coverage of M protein–based vaccines against group A streptococci (GAS) because coverage of the current 30-valent M protein vaccine does not extend to all emm types. An additional GAS antigen and virulence factor that could potentially extend vaccine coverage is M-related protein (Mrp). Previous work indicated that there are three structurally related families of Mrp (MrpI, MrpII, and MrpIII) and peptides of all three elicited bactericidal antibodies against multiple emm types. The purpose of this study was to determine if a recombinant form containing Mrp from the three families would evoke bactericidal antiserum and to determine if this antiserum could enhance the effectiveness of antisera to the 30-valent M protein vaccine. Materials and Methods: A trivalent recombinant Mrp (trMrp) protein containing N-terminal fragments from the three families (trMrp) was constructed, purified and used to immunize rabbits. Anti-trMrp sera contained high titers of antibodies against the trMrp immunogen and recombinant forms representing MrpI, MrpII, and MrpIII. Results: The antisera opsonized emm types of GAS representing each Mrp family and also opsonized emm types not covered by the 30-valent M protein–based vaccine. Importantly, a combination of trMrp and 30-valent M protein antiserum resulted in higher levels of opsonization of GAS than either antiserum alone. Conclusion: These findings suggest that trMrp may be an effective addition to future constructs of GAS vaccines.
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Magnetism in lithium-oxygen discharge product.
Lu, Jun,Jung, Hun-Ji,Lau, Kah Chun,Zhang, Zhengcheng,Schlueter, John A,Du, Peng,Assary, Rajeev S,Greeley, Jeffrey,Ferguson, Glen A,Wang, Hsien-Hau,Hassoun, Jusef,Iddir, Hakim,Zhou, Jigang,Zuin, Lucia Wiley-VCH 2013 ChemSusChem Vol.6 No.7
<P>Nonaqueous lithium-oxygen batteries have a much superior theoretical gravimetric energy density compared to conventional lithium-ion batteries, and thus could render long-range electric vehicles a reality. A molecular-level understanding of the reversible formation of lithium peroxide in these batteries, the properties of major/minor discharge products, and the stability of the nonaqueous electrolytes is required to achieve successful lithium-oxygen batteries. We demonstrate that the major discharge product formed in the lithium-oxygen cell, lithium peroxide, exhibits a magnetic moment. These results are based on dc-magnetization measurements and a lithium-oxygen cell containing an ether-based electrolyte. The results are unexpected because bulk lithium peroxide has a significant band gap. Density functional calculations predict that superoxide-type surface oxygen groups with unpaired electrons exist on stoichiometric lithium peroxide crystalline surfaces and on nanoparticle surfaces; these computational results are consistent with the magnetic measurement of the discharged lithium peroxide product as well as EPR measurements on commercial lithium peroxide. The presence of superoxide-type surface oxygen groups with spin can play a role in the reversible formation and decomposition of lithium peroxide as well as the reversible formation and decomposition of electrolyte molecules.</P>
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Zhang, Zhengcheng,Lu, Jun,Assary, Rajeev S.,Du, Peng,Wang, Hsien-Hau,Sun, Yang-Kook,Qin, Yan,Lau, Kah Chun,Greeley, Jeffrey,Redfern, Paul C.,Iddir, Hakim,Curtiss, Larry A.,Amine, Khalil American Chemical Society 2011 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.115 No.51
<P>The successful development of Li-air batteries would significantly increase the possibility of extending the range of electric vehicles. There is much evidence that typical organic carbonate based electrolytes used in lithium ion batteries form lithium carbonates from reaction with oxygen reduction products during discharge in lithium-air cells so more stable electrolytes need to be found. This combined experimental and computational study of an electrolyte based on a tri(ethylene glycol)-substituted trimethylsilane (<ext-link xlink:type='simple'>1NM3</ext-link>) provides evidence that the ethers are more stable toward oxygen reduction discharge species. X-ray photoelectron spectroscopy (XPS) and FTIR experiments show that only lithium oxides and no carbonates are formed when <ext-link xlink:type='simple'>1NM3</ext-link> electrolyte is used. In contrast XPS shows that propylene carbonate (PC) in the same cell configuration decomposes to form lithium carbonates during discharge. Density functional calculations of probable decomposition reaction pathways involving solvated oxygen reduction species confirm that oligoether substituted silanes, as well as other ethers, are more stable to the oxygen reduction products than propylene carbonate. These results indicate that the choice of electrolyte plays a key role in the performance of Li-air batteries.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2011/jpccck.2011.115.issue-51/jp2087412/production/images/medium/jp-2011-087412_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp2087412'>ACS Electronic Supporting Info</A></P>
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