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Diet, Sleep and Metabolic Syndrome Among a Legal Amazon Population, Brazil
( Poliana Rodrigues Dos Santos ),( Graziele Souza Lira Ferrari ),( Carlos K B Ferrari ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.1
Metabolic syndrome incidence is increasing worldwide then it is important to study the possible risk and protective factors. Our previous study suggested an association between coffee consumption and metabolic syndrome. The aim of this study was to address possible associations between dietary lifestyle factors with metabolic syndrome. In a case-control study we compared 74 metabolic syndrome patients with 176-matched controls attended at a public health central unit. Incident cases diagnosed according to ATP III criteria were matched with control group composed of healthy subjects performing routine examinations. Having lower educational level compared to highest levels tend to increase metabolic syndrome prevalence, which was not statistically significant. Similar pattern was observed for marital status. No difference was found regarding gender and metabolic syndrome odds. Interestingly, daily drinking two to three cups of coffee (OR = 0.0646, 95% CI, 0.0139-0.3005, p = 0.0005) or until 2 cups of milk were inversely associated with metabolic syndrome odds (OR = 0.5368, 95% CI, 0.3139-0.9181, p = 0.0231). Sleeping seven to eight hours per night was also associated with decreased odds of metabolic syndrome (OR = 0.0789, 95% CI, 0.0396-0.1570, p < 0.0001). Eating at least two portions of chocolate was also associated with decreased risk of metabolic syndrome (OR = 0.3475, 95% CI, 0.1865-0.6414, p = 0.0009). Adequate sleeping and dietary intake of some foods materially decreased the metabolic syndrome.
Daniel A. Macedo,Graziele L. Souza,Moisés R. Cesário,Beatriz Cela,Antonio E. Martinelli,Carlos A. Paskocimas,Rubens M. Nascimento 한양대학교 세라믹연구소 2011 Journal of Ceramic Processing Research Vol.12 No.6
In this study, a chemical route was adopted to obtain strontium-doped lanthanum manganite (LaSrMnO3 or LSM) powders in order to prepare LaSrMnO3-4YSZ (4 mol% Y2O3) composite films by the suspension spin coating method onto 4YSZ and 8YSZ/8YSZ-NiO substrates with or without the application of a zirconia interlayer in the film/substrate interface. The multilayers were sintered at 1150 oC for 6 h and the effect of the interlayer on the morphological properties of the films has been investigated by scanning electron microscopy. The results show that in the less roughn substrates the application of the interlayer (~500 nm) not only improved the adhesion in the film/substrate interface, but also avoided new coating failures. All the films were porous, crack-free and with a thickness below 30 μm, desirable features for application as SOFC cathodes.
Cristiane Aguiar da Costa,Dayane Teixeira Ognibene,Viviane Silva Cristino Cordeiro,Graziele Freitas de Bem,Izabelle Barcellos Santos,Ricardo Andrade Soares,Letı´cia L. de Melo Cunha,Lenize C. R.M. Car 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.10
Previously, we have demonstrated that the seeds of Euterpe oleracia Mart. (açaí) are rich in polyphenols with antihypertensive and antioxidant properties. This study evaluated the renal protective effects of the hydroalcoholic extract obtained from the seeds of açaí (ASE) fruits in two-kidney, one-clip (2K1C) renovascular hypertension. Young male Wistar rats were used to obtain 2K1C and sham groups. Animals received ASE (200 mg/(kg·day) in drinking water) or vehicle for 40 days. We evaluated serum and urinary parameters, renal structural changes, and oxidative status. The increase in systolic blood pressure of the 2K1C group was accompanied by a decrease in left kidney volume and number of glomeruli, as well as an increase in glomerular volume and collagen deposition. ASE prevented the alterations of these parameters, except the reduced kidney volume. Serum levels of urea and creatinine and urinary protein excretion were increased in the 2K1C group and treatment with ASE improved all these functional parameters. The increased oxidative damage in the 2K1C group, assessed by lipid and protein oxidation, was prevented by ASE. The nitrite content and both expression and activity of antioxidant enzymes (superoxide dismutase-1, catalase, and glutathione peroxidase) were lower in the 2K1C group and restored by ASE. ASE substantially reduced renal injury and prevented renal dysfunction in 2K1C rats probably through its antihypertensive and antioxidant effects, providing a natural resource for treatment and prevention of renovascular hypertension-related abnormalities.
Knowledge of Diabetes Mellitus: Does Gender Make a Difference?
Patrı´cio Fernando Lemes dos Santos,Poliana Rodrigues dos Santos,Graziele Souza Lira Ferrari,Gisele Almeida Amaral Fonseca,Carlos Kusano Bucalen Ferrari 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.4
Objective: Diabetes mellitus (DM) is a chronic disease considered an important public health problem. In recent years, its prevalence has been exponentially rising in many developing countries. Chronic complications of DM are important causes of morbidity and mortality among patients, which impair their health and quality of life. Knowledge on disease prevention, etiology, and management is essential to deal with parents, patients, and caregivers. The aim of this study was to evaluate the knowledge regarding DM in an adult population from a Middle-western Brazilian city. Methods: This was a cross-sectional study covering 178 adults, aged 18-64 years, who answered a diabetes knowledge questionnaire. In order to identify the difference between groups, analysis of variance was used. Results: Higher knowledge scores were found regarding the role of sugars on DM causality, diabetic foot care, and the effects of DM on patients (blindness, impaired wound healing, and male sexual dysfunction). However, lower scores were found amongst types of DM, hyperglycemic symptoms, and normal blood glucose levels. Females tended to achieve better knowledge scores than males. Conclusion: Women had better knowledge regarding types of DM, normal blood glucose values, and consequences of hyperglycemia revealed that diabetes education should be improved.
Hepatic and renal damage by alcohol and cigarette smoking in rats
Bandiera Solange,Pulcinelli Rianne R.,Huf Fernanda,Almeida Felipe B.,Halmenschlager Graziele,Bitencourt Paula E. R.,Dallegrave Eliane,C. Fernandes Marilda,Gomez Rosane,Nin Mauricio S. 한국독성학회 2021 Toxicological Research Vol.37 No.2
Chronic use of alcohol and tobacco cigarettes is associated to millions of deaths per year, either by direct or indirect causes. However, few studies have explored the additional risks of the combined use of these drugs. Here we assessed the effect of the combined use of alcohol and cigarette smoke on liver or kidney morphology, and on biochemical parameters in chronically treated rats. Male Wistar rats were allocated to receive 2 g/kg alcohol orally, which was followed by the inhalation of smoke from six cigarettes during 2 h (ALTB group) for 28 days. Other groups received alcohol alone (AL) or were exposed to cigarette smoke (TB) alone and were compared to control (CT) rats, which received water followed by ambient air. On day 29, rats were euthanized and blood samples were collected for aminotransferase enzymes (AST and ALT), creatinine, and urea analysis. Liver and kidney were weighted, dissected, fixed, and stained with hematoxylin and eosin for morphological analysis. Our results showed that necrosis was elevated in the AL, TB, and mainly the ALTB group in both liver and kidney of rats. Serum levels of AST and ALT were reduced by cigarette smoke exposure, independently of alcohol use. Serum creatinine levels increased after tobacco smoke exposure. On the other hand, TB and AL groups decreased serum urea levels, and their association restored that decrease. Absolute liver and kidney weights were lower in the cigarette smoke exposure rats. Lastly, body weight gain was lower in TB group and combined use restored it. Thus, we may infer that the use of alcohol, exposure to tobacco cigarette smoke or, mainly, their association promotes liver and kidney injuries, and this damage is related with biochemical changes in rats.
Giselle Franca da Costa,Dayane Teixeira Ognibene,Cristiane Aguiar da Costa,Michelle Teixeira Teixeira,Viviane da Silva Cristino Cord,Graziele Freitas de Bem,Anibal Sanchez Moura,Angela de Castro Resen 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.1
This study investigated the protective effect of a Vitis vinifera L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP), total cholesterol, triglyceride, and glucose levels, as well as oxidative damage and antioxidant activity in the plasma and kidney, were evaluated in four experimental groups: control Wistar rats (W-C) and SHR-C that received water, and Wistar rats and SHR treated with ACH09 (200 mg/kg/d) in drinking water for 12 weeks (W-ACH09 and SHR-ACH09, respectively). SBP increased in the SHR group compared with the W groups and the treatment with ACH09 prevented the development of hypertension. Plasma triglyceride and total cholesterol levels increased in SHR compared with W-C rats; these changes prevented by treatment with ACH09. Glucose levels did not differ between the groups. The SHR group had increased oxidative damage in plasma, as expressed by 2-thiobarbituric acid reactive substances (TBARS) levels, and this prevented by ACH09. Levels of TBARS in the kidneys were lower in the SHR-ACH09 group than in the SHR-C group. Further, ACH09 increased the superoxide dismutase activity in both the plasma and kidneys of both SHR and Wistar rats. These results suggest that ACH09 is protective against disruption of blood pressures, oxidant status, and lipid profile in SHR, and provide important evidence on the benefits of ACH09 on hypertension and associated cardiovascular complications.