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Stakeholders Driven Requirements Engineering Approach for Data Warehouse Development
Kumar, Manoj,Gosain, Anjana,Singh, Yogesh Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.3
Most of the data warehouse (DW) requirements engineering approaches have not distinguished the early requirements engineering phase from the late requirements engineering phase. There are very few approaches seen in the literature that explicitly model the early & late requirements for a DW. In this paper, we propose an AGDI (Agent-Goal-Decision-Information) model to support the early and late requirements for the development of DWs. Here, the notion of agent refers to the stakeholders of the organization and the dependency among agents refers to the dependencies among stakeholders for fulfilling their organizational goals. The proposed AGDI model also supports three interrelated modeling activities namely, organization modeling, decision modeling and information modeling. Here, early requirements are modeled by performing organization modeling and decision modeling activities, whereas late requirements are modeled by performing information modeling activities. The proposed approach has been illustrated to capture the early and late requirements for the development of a university data warehouse exemplifying our model's ability of supporting its decisional goals by providing decisional information.
Dual Mechanism of Action of 5-Nitro-1,10-Phenanthroline against Mycobacterium tuberculosis
Kidwai, Saqib,Park, Chan-Yong,Mawatwal, Shradha,Tiwari, Prabhakar,Jung, Myung Geun,Gosain, Tannu Priya,Kumar, Pradeep,Alland, David,Kumar, Sandeep,Bajaj, Avinash,Hwang, Yun-Kyung,Song, Chang Sik,Dhima American Society for Microbiology 2017 Antimicrobial Agents and Chemotherapy Vol.61 No.11
<B>ABSTRACT</B><P>New chemotherapeutic agents with novel mechanisms of action are urgently required to combat the challenge imposed by the emergence of drug-resistant mycobacteria. In this study, a phenotypic whole-cell screen identified 5-nitro-1,10-phenanthroline (5NP) as a lead compound. 5NP-resistant isolates harbored mutations that were mapped to <I>fbiB</I> and were also resistant to the bicyclic nitroimidazole PA-824. Mechanistic studies confirmed that 5NP is activated in an F420-dependent manner, resulting in the formation of 1,10-phenanthroline and 1,10-phenanthrolin-5-amine as major metabolites in bacteria. Interestingly, 5NP also killed naturally resistant intracellular bacteria by inducing autophagy in macrophages. Structure-activity relationship studies revealed the essentiality of the nitro group for <I>in vitro</I> activity, and an analog, 3-methyl-6-nitro-1,10-phenanthroline, that had improved <I>in vitro</I> activity and <I>in vivo</I> efficacy in mice compared with that of 5NP was designed. These findings demonstrate that, in addition to a direct mechanism of action against Mycobacterium tuberculosis, 5NP also modulates the host machinery to kill intracellular pathogens.</P>